{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T22:56:57Z","timestamp":1784329017507,"version":"3.55.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,5,1]],"date-time":"2017-05-01T00:00:00Z","timestamp":1493596800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Fondo Trieste","award":["2008"],"award-info":[{"award-number":["2008"]}]},{"name":"Regione FVG","award":["L.26.2008"],"award-info":[{"award-number":["L.26.2008"]}]},{"DOI":"10.13039\/501100012306","name":"University of Trieste","doi-asserted-by":"crossref","award":["U22SCFRA15"],"award-info":[{"award-number":["U22SCFRA15"]}],"id":[{"id":"10.13039\/501100012306","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2017,5]]},"DOI":"10.1016\/j.imbio.2017.01.001","type":"journal-article","created":{"date-parts":[[2017,1,12]],"date-time":"2017-01-12T14:45:37Z","timestamp":1484232337000},"page":"704-708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["NLRC5 polymorphism is associated with susceptibility to chronic periodontitis"],"prefix":"10.1016","volume":"222","author":[{"given":"Luisa","family":"Zupin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara Ottavia","family":"Navarra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Robino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Bevilacqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Di Lenarda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Gasparini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Crovella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2017.01.001_bib0005","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.imbio.2017.01.001_bib0010","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/jcpe.12420","article-title":"Prevalence of periodontitis in an adult population from an urban area in North Italy: findings from a cross-sectional population-based epidemiological survey","volume":"42","author":"Aimetti","year":"2015","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann. Periodontol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0020","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1093\/bioinformatics\/btm108","article-title":"GenABEL: an R library for genome-wide association analysis","volume":"23","author":"Aulchenko","year":"2007","journal-title":"Bioinformatics"},{"key":"10.1016\/j.imbio.2017.01.001_bib0025","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.4049\/jimmunol.0903900","article-title":"NLRC5 limits the activation of inflammatory pathways","volume":"185","author":"Benko","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0030","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/nri3167","article-title":"Beyond pattern recognition: five immune checkpoints for scaling the microbial threat","volume":"12","author":"Blander","year":"2012","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0035","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1365-2249.2009.03972.x","article-title":"Expression and regulation of the NALP3 inflammasome complex in periodontal diseases","volume":"157","author":"Bostanci","year":"2009","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0040","doi-asserted-by":"crossref","first-page":"e98899","DOI":"10.1371\/journal.pone.0098899","article-title":"The NOD-like receptor signalling pathway in Helicobacter pylori infection and related gastric cancer: a case-control study and gene expression analyses","volume":"9","author":"Castano-Rodriguez","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2017.01.001_bib0045","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.cell.2010.03.040","article-title":"NLRC5 negatively regulates the NF-kappaB and type I interferon signaling pathways","volume":"141","author":"Cui","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2017.01.001_bib0050","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.4049\/jimmunol.1003111","article-title":"Cutting edge: NLRC5-dependent activation of the inflammasome","volume":"186","author":"Davis","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0055","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1097\/PPO.0000000000000004","article-title":"Complex roles of inflammasomes in carcinogenesis","volume":"19","author":"Drexler","year":"2013","journal-title":"Cancer J."},{"key":"10.1016\/j.imbio.2017.01.001_bib0060","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1111\/prd.12005","article-title":"Periodontal disease immunology: \u2018double indemnity' in protecting the host","volume":"62","author":"Ebersole","year":"2013","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.imbio.2017.01.001_bib0065","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1038\/ejhg.2012.229","article-title":"Genetic characterization of northeastern Italian population isolates in the context of broader European genetic diversity","volume":"21","author":"Esko","year":"2013","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.imbio.2017.01.001_bib0070","doi-asserted-by":"crossref","first-page":"7636","DOI":"10.1128\/JVI.00349-15","article-title":"Respiratory syncytial virus infection upregulates NLRC5 and major histocompatibility complex class I expression through RIG-I induction in airway epithelial cells","volume":"89","author":"Guo","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0075","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1146\/annurev.biochem.74.082803.133347","article-title":"NOD-LRR proteins: role in host-microbial interactions and inflammatory disease","volume":"74","author":"Inohara","year":"2005","journal-title":"Annu. Rev. Biochem"},{"key":"10.1016\/j.imbio.2017.01.001_bib0080","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/nature02168","article-title":"The international HapMap project","volume":"426","author":"International HapMap Consortium","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2017.01.001_bib0085","doi-asserted-by":"crossref","first-page":"1990","DOI":"10.4049\/jimmunol.0900557","article-title":"The nucleotide-binding oligomerization domain-like receptor NLRC5 is involved in IFN-dependent antiviral immune responses","volume":"184","author":"Kuenzel","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0090","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nprot.2009.86","article-title":"Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm","volume":"4","author":"Kumar","year":"2009","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.imbio.2017.01.001_bib0095","doi-asserted-by":"crossref","first-page":"994","DOI":"10.4049\/jimmunol.1002094","article-title":"NLRC5 deficiency does not influence cytokine induction by virus and bacteria infections","volume":"186","author":"Kumar","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0100","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.imbio.2011.08.011","article-title":"Regulation of immune pathways by the NOD-like receptor NLRC5","volume":"217","author":"Lamkanfi","year":"2012","journal-title":"Immunobiology"},{"key":"10.1016\/j.imbio.2017.01.001_bib0105","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.coi.2009.12.004","article-title":"The inflammasomes: mechanisms of activation and function","volume":"22","author":"Latz","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0110","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1038\/nri1997","article-title":"Inflammasome adaptors and sensors: intracellular regulators of infection and inflammation","volume":"7","author":"Mariathasan","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0115","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1146\/annurev.immunol.021908.132715","article-title":"The inflammasomes: guardians of the body","volume":"27","author":"Martinon","year":"2009","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0120","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.immuni.2009.06.004","article-title":"Approaching the asymptote: 20 years later","volume":"30","author":"Medzhitov","year":"2009","journal-title":"Immunity"},{"key":"10.1016\/j.imbio.2017.01.001_bib0125","doi-asserted-by":"crossref","first-page":"13794","DOI":"10.1073\/pnas.1008684107","article-title":"NLR family member NLRC5 is a transcriptional regulator of MHC class I genes","volume":"107","author":"Meissner","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2017.01.001_bib0130","doi-asserted-by":"crossref","first-page":"26223","DOI":"10.1074\/jbc.M110.109736","article-title":"A role for the human nucleotide-binding domain, leucine-rich repeat-containing family member NLRC5 in antiviral responses","volume":"285","author":"Neerincx","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2017.01.001_bib0135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1902\/jop.1972.43.1.38","article-title":"The plaque control record","volume":"43","author":"O'Leary","year":"1972","journal-title":"J. Periodontol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0140","unstructured":"U.S. Department of Health and Human Services. The Health Consequences of Smoking: A Report of the Surgeon General. Atlanta, GA: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, 2004."},{"key":"10.1016\/j.imbio.2017.01.001_bib0145","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.imbio.2017.01.001_bib0150","series-title":"R. A Language and Environment for Statistical Computing","author":"RcoreTeam","year":"2015"},{"key":"10.1016\/j.imbio.2017.01.001_bib0155","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2010.01.040","article-title":"The inflammasomes","volume":"140","author":"Schroder","year":"2010","journal-title":"Cell"},{"issue":"29","key":"10.1016\/j.imbio.2017.01.001_bib0160","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1034\/j.1600-0757.2002.290106.x","article-title":"Periodontal diseases in Europe","author":"Sheiham","year":"2002","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.imbio.2017.01.001_bib0165","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1165\/rcmb.2013-0032OC","article-title":"Rhinovirus-induced calcium flux triggers NLRP3 and NLRC5 activation in bronchial cells","volume":"49","author":"Triantafilou","year":"2013","journal-title":"Am. J. Respir. Cell Mol. Biol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0170","first-page":"3","article-title":"Risk factors for periodontitis","volume":"7","author":"Van Dyke","year":"2005","journal-title":"J. Int. Acad. Periodontol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0175","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1111\/j.1600-051X.2006.00953.x","article-title":"Java project on periodontal diseases. The natural development of periodontitis: risk factors: risk predictors and risk determinants","volume":"33","author":"Van der Velden","year":"2006","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.imbio.2017.01.001_bib0180","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.gde.2004.04.008","article-title":"Isolates and their potential use in complex gene mapping efforts","volume":"14","author":"Varilo","year":"2004","journal-title":"Curr. Opin. Genet. Dev."},{"key":"10.1016\/j.imbio.2017.01.001_bib0185","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1101\/gr.6981507","article-title":"The influence of genetic variation on gene expression","volume":"17","author":"Williams","year":"2007","journal-title":"Genome Res."},{"key":"10.1016\/j.imbio.2017.01.001_bib0190","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1111\/prd.12084","article-title":"The inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity","volume":"69","author":"Yilmaz","year":"2015","journal-title":"Periodontol. 2000"},{"key":"10.1016\/j.imbio.2017.01.001_bib0195","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1111\/j.1462-5822.2009.01390.x","article-title":"ATP-dependent activation of an inflammasome in primary gingival epithelial cells infected by Porphyromonas gingivalis","volume":"12","author":"Yilmaz","year":"2010","journal-title":"Cell. Microbiol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298517300013?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298517300013?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:42:03Z","timestamp":1759250523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298517300013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,5]]}},"alternative-id":["S0171298517300013"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2017.01.001","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2017,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NLRC5 polymorphism is associated with susceptibility to chronic periodontitis","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2017.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}