{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:20:20Z","timestamp":1789874420105,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Brazilian research funding agencies CNPq and Faperj"},{"name":"Oswaldo Cruz Foundation (Brazil)"},{"name":"FOCEM (Mercosur)"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.imbio.2017.08.001","type":"journal-article","created":{"date-parts":[[2017,8,14]],"date-time":"2017-08-14T20:30:46Z","timestamp":1502742646000},"page":"1053-1063","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["HTLV-1-infected thymic epithelial cells convey the virus to CD4+ T lymphocytes"],"prefix":"10.1016","volume":"222","author":[{"given":"Luciana Rodrigues","family":"Carvalho Barros","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leandra","family":"Linhares-Lacerda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaysa","family":"Moreira-Ramos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Ribeiro-Alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Cristina","family":"Machado Motta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dumith Chequer","family":"Bou-Habib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson","family":"Savino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2017.08.001_bib0005","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.1158\/0008-5472.CAN-04-0496","article-title":"Normalization of real-time quantitative RT-PCR data: a mode-based variance estimation approach to identify genes suited for normalization, applied to bladder and colon cancer data sets","volume":"64","author":"Andersen","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.imbio.2017.08.001_bib0010","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"The Gene Ontology Consortium. Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2011","journal-title":"Nat. Genet."},{"issue":"1","key":"10.1016\/j.imbio.2017.08.001_bib0015","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing author (s): yoav benjamini and yosef hochberg source","volume":"57","author":"Benajmini","year":"1995","journal-title":"J. R. Stati. Soc. Ser. B (Methodol.)"},{"key":"10.1016\/j.imbio.2017.08.001_bib0020","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1111\/j.1541-0420.2010.01383.x","article-title":"Permutation tests for stochastic ordering and ANOVA: theory and applications with r by BASSO, D., PESARIN, F., SALMASO, L., and SOLARI, a","volume":"66","author":"Berger","year":"2010","journal-title":"Biometrics"},{"key":"10.1016\/j.imbio.2017.08.001_bib0025","series-title":"hgug4112a.db: Agilent Human Genome, Whole Annotation Data (chip hgug4112a). R Package Version 3.2.2.","author":"Carlson","year":"2015"},{"key":"10.1016\/j.imbio.2017.08.001_bib0030","doi-asserted-by":"crossref","first-page":"406","DOI":"10.3389\/fmicb.2012.00406","article-title":"HTLV tax: a fascinating multifunctional co-regulator of viral and cellular pathways","volume":"3","author":"Currer","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0035","doi-asserted-by":"crossref","first-page":"2130","DOI":"10.1002\/jmv.24264","article-title":"HTLV-1 viral RNA is detected rarely in plasma of HTLV-1 infected subjects","volume":"87","author":"Demontis","year":"2015","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0040","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1038\/ni723","article-title":"Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self","volume":"2","author":"Derbinski","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0045","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.1182\/blood.V83.11.3245.3245","article-title":"Establishment and characterization of cloned human thymic epithelial cell lines: analysis of adhesion molecule expression and cytokine production","volume":"83","author":"Fern\u00e1ndez","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2017.08.001_bib0050","doi-asserted-by":"crossref","first-page":"4038","DOI":"10.1128\/jvi.70.6.4038-4044.1996","article-title":"Human T-cell leukemia virus infection of human hematopoietic progenitor cells: maintenance of virus infection during differentiation in vitro and in vivo","volume":"70","author":"Feuer","year":"1996","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0055","doi-asserted-by":"crossref","first-page":"3619","DOI":"10.1182\/blood.V86.10.3619.bloodjournal86103619","article-title":"Molecular mechanisms of human T-cell leukemia\/lymphotropic virus type I infection","volume":"86","author":"Franchini","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2017.08.001_bib0060","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2004-5-10-r80","article-title":"Bioconductor: open software development for computational biology and bioinformatics","volume":"5","author":"Gentleman","year":"2004","journal-title":"Genome Biol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0065","doi-asserted-by":"crossref","first-page":"6844","DOI":"10.1128\/JVI.02719-05","article-title":"Neuropilin-1 is involved in human T-cell lymphotropic virus type 1 entry","volume":"80","author":"Ghez","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0070","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/icb.2008.87","article-title":"Back to the thymus: peripheral t cells come home","volume":"87","author":"Hale","year":"2009","journal-title":"Immunol. cell Biol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0075","doi-asserted-by":"crossref","first-page":"7588","DOI":"10.1073\/pnas.81.23.7588","article-title":"Infection of human endothelial cells by human T-lymphotropic virus type I","volume":"81","author":"Ho","year":"1984","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2017.08.001_bib0080","doi-asserted-by":"crossref","first-page":"222","DOI":"10.3389\/fmicb.2012.00222","article-title":"Cellular factors involved in HTLV-1 entry and pathogenicit","volume":"3","author":"Hoshino","year":"2012","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0085","doi-asserted-by":"crossref","first-page":"6086","DOI":"10.1128\/JVI.75.13.6086-6094.2001","article-title":"Free major histocompatibility complex class i heavy chain is preferentially targeted for degradation by human T-cell leukemia\/lymphotropic virus type 1 p12 I protein","volume":"75","author":"Johnson","year":"2001","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0090","doi-asserted-by":"crossref","first-page":"12692","DOI":"10.1128\/JVI.79.20.12692-12702.2005","article-title":"Heparan sulfate proteoglycans mediate attachment and entry of human T-cell leukemia virus type 1 virions into CD4+ T cells","volume":"79","author":"Jones","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0095","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nm1745","article-title":"Cell-free HTLV-1 infects dendritic cells leading to transmission and transformation of CD4(+) T cells","volume":"14","author":"Jones","year":"2008","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2017.08.001_bib0100","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1471-2164-12-64","article-title":"Pre-processing and differential expression analysis of Agilent microRNA arrays using the AgiMicroRna Bioconductor library","volume":"12","author":"L\u00f3pez-Romero","year":"2011","journal-title":"BMC Genom."},{"key":"10.1016\/j.imbio.2017.08.001_bib0105","doi-asserted-by":"crossref","first-page":"5545","DOI":"10.1073\/pnas.0700705104","article-title":"Control of human thymocyte migration by Neuropilin-1\/Semaphorin-3A-mediated interactions","volume":"104","author":"Lepelletier","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2017.08.001_bib0110","doi-asserted-by":"crossref","first-page":"9143","DOI":"10.1128\/jvi.71.12.9143-9149.1997","article-title":"Astrocyte-specific expression of human T-cell lymphotropic virus type 1 (HTLV-1) Tax: induction of tumor necrosis factor alpha and susceptibility to lysis by CD8 + HTLV-1-specific cytotoxic T cells","volume":"71","author":"M\u00e9ndez","year":"1997","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0115","doi-asserted-by":"crossref","first-page":"5529","DOI":"10.1128\/jvi.67.9.5529-5537.1993","article-title":"Human T-cell leukemia virus type I-induced proliferation of human immature CD2+CD3- thymocytes","volume":"67","author":"Maguer","year":"1993","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0120","doi-asserted-by":"crossref","first-page":"1444","DOI":"10.1182\/blood.V86.4.1444.bloodjournal8641444","article-title":"Human immature thymocytes as target cells of the leukemogenic activity of human T-cell leukemia virus type I","volume":"86","author":"Maguer-Satta","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2017.08.001_bib0125","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1097\/00126334-200203010-00012","article-title":"Detection of HTLV I tax rex and pol gene sequences of thymus gland in a large group of patients with myastenia gravis","volume":"29","author":"Manca","year":"2002","journal-title":"J. Acquir. Immune Defic. Syndr."},{"key":"10.1016\/j.imbio.2017.08.001_bib0130","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/S0092-8674(03)00881-X","article-title":"The ubiquitous glucose transporter GLUT-1 is a receptor for HTLV","volume":"115","author":"Manel","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2017.08.001_bib0135","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nrc2111","article-title":"Human T-cell leukaemia virus type 1 (HTLV-1) infectivity and cellular transformation","volume":"7","author":"Matsuoka","year":"2007","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.imbio.2017.08.001_bib0140","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1590\/S0074-02762011000600018","article-title":"Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?","volume":"106","author":"Moreira-Ramos","year":"2011","journal-title":"Mem. Inst. Oswaldo Cruz"},{"key":"10.1016\/j.imbio.2017.08.001_bib0145","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/13550280390194028","article-title":"Human T-cell lymphotropic virus type I and neurological diseases","volume":"9","author":"Nagai","year":"2003","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0150","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4049\/jimmunol.0902152","article-title":"Dissemination of mycobacteria to the thymus renders newly generated T cells tolerant to the invading pathogen","volume":"184","author":"Nobrega","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2017.08.001_bib0155","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nm.2065","article-title":"Biofilm-like extracellular viral assemblies mediate HTLV-1 cell-to-cell transmission at virological synapses","volume":"16","author":"Pais-Correia","year":"2010","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2017.08.001_bib0160","series-title":"Human T-cell Leukemia Virus Type 1 p8 Protein Increases Cellular Conduits and Virus Transmission","author":"Prooyen","year":"2010"},{"key":"10.1016\/j.imbio.2017.08.001_bib0165","first-page":"1","article-title":"A comparison of normalization methods for high density oligonucleotide array data based on variance and bias","volume":"19","author":"R","year":"2002","journal-title":"Group"},{"key":"10.1016\/j.imbio.2017.08.001_bib0170","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1093\/bioinformatics\/btn227","article-title":"qpcR: An R package for sigmoidal model selection in quantitative real-time polymerase chain reaction analysis","volume":"24","author":"Ritz","year":"2008","journal-title":"Bioinformatics"},{"key":"10.1016\/j.imbio.2017.08.001_bib0175","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000258708","article-title":"Intrathymic T cell migration is a multivectorial process under a complex neuroendocrine control","volume":"17","author":"Savino","year":"2010","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.imbio.2017.08.001_bib0180","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/0014-4827(66)90079-6","article-title":"Sensitivity os cultured humam lymhoblasts (CCRF-CEM cells) to inhibition by thymidine","volume":"43","author":"Schachtschabel","year":"1966","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.imbio.2017.08.001_bib0185","series-title":"Limma: Linear Models for Microarray Data. Bioinforma. Comput. Biol. Solut. Using R Bioconductor","first-page":"397","author":"Smith","year":"2005"},{"key":"10.1016\/j.imbio.2017.08.001_bib0190","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.actatropica.2012.09.012","article-title":"Proviral load and the balance of serum cytokines in HTLV-1-asymptomatic infection and in HTLV-1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP)","volume":"125","author":"Starling","year":"2013","journal-title":"Acta Trop."},{"key":"10.1016\/j.imbio.2017.08.001_bib0195","first-page":"2014","article-title":"Thymic epithelial cell development and its dysfunction in human diseases","author":"Sun","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.imbio.2017.08.001_bib0200","doi-asserted-by":"crossref","first-page":"6047","DOI":"10.1038\/sj.onc.1208979","article-title":"Natural history of adult T-cell leukemia\/lymphoma and approaches to therapy","volume":"24","author":"Taylor","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.imbio.2017.08.001_bib0205","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.mam.2010.07.001","article-title":"Hijacking the T-cell communication network by the human T-cell leukemia\/lymphoma virus type 1 (HTLV-1) p12 and p8 proteins","volume":"31","author":"Van Prooyen","year":"2010","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.imbio.2017.08.001_bib0210","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele","year":"2002","journal-title":"Genome Biol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017129851730116X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017129851730116X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:42:50Z","timestamp":1759250570000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S017129851730116X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S017129851730116X"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2017.08.001","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"HTLV-1-infected thymic epithelial cells convey the virus to CD4+ T lymphocytes","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2017.08.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}