{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T16:47:37Z","timestamp":1790527657572,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"University Grants Commission, New Delhi, Govt. of India"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2019,1]]},"DOI":"10.1016\/j.imbio.2018.10.009","type":"journal-article","created":{"date-parts":[[2018,11,20]],"date-time":"2018-11-20T12:00:26Z","timestamp":1542715226000},"page":"42-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["SNPs in 3\u2032-UTR region of MBL2 increases susceptibility to recurrent vulvovaginal infections by altering sMBL levels"],"prefix":"10.1016","volume":"224","author":[{"given":"Namarta","family":"Kalia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatinder","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujata","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manpreet","family":"Kaur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2018.10.009_bib0005","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1111\/bju.12641","article-title":"Genetic polymorphisms modify bladder cancer recurrence and survival in a USA population\u2010based prognostic study","volume":"115","author":"Andrew","year":"2015","journal-title":"BJU Int."},{"key":"10.1016\/j.imbio.2018.10.009_bib0010","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/QAD.0b013e3283021a37","article-title":"Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies","volume":"22","author":"Atashili","year":"2008","journal-title":"AIDS (London, England)"},{"key":"10.1016\/j.imbio.2018.10.009_bib0015","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1086\/377234","article-title":"Relation between recurrent vulvovaginal candidiasis, vaginal concentrations of mannose-binding lectin, and a mannose-binding lectin gene polymorphism in Latvian women","volume":"37","author":"Babula","year":"2003","journal-title":"Clin. Infect. Dis.."},{"key":"10.1016\/j.imbio.2018.10.009_bib0020","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s00439-005-0053-5","article-title":"An analysis of genetic variation across the MBL2 locus in Dutch caucasians indicates that 3\u2032 haplotypes could modify circulating levels of mannose-binding lectin","volume":"118","author":"Bernig","year":"2005","journal-title":"Hum. Genet."},{"key":"10.1016\/j.imbio.2018.10.009_bib0025","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/carcin\/bgl198","article-title":"The mannose-binding lectin (MBL2) haplotype and breast cancer: an association study in African-American and caucasian women","volume":"28","author":"Bernig","year":"2007","journal-title":"Carcinogenesis."},{"key":"10.1016\/j.imbio.2018.10.009_bib0030","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1007\/s12281-013-0135-0","article-title":"Understanding vulvovaginal candidiasis through a community genomics approach","volume":"7","author":"Bradford","year":"2013","journal-title":"Curr. Fungal Infect. Rep."},{"key":"10.1016\/j.imbio.2018.10.009_bib0035","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/1471-2334-8-57","article-title":"MBL2 and hepatitis C virus infection among injection drug users","volume":"8","author":"Brown","year":"2008","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.imbio.2018.10.009_bib0040","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1146\/annurev.genom.9.081307.164258","article-title":"African genetic diversity: implications for human demographic history, modern human origins, and complex disease mapping","volume":"9","author":"Campbell","year":"2008","journal-title":"Annu. Rev. Genomics Hum. Genet."},{"key":"10.1016\/j.imbio.2018.10.009_bib0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/B978-0-12-810420-0.00004-3","article-title":"\u015awierzko AS","author":"Cedzy\u0144ski","year":"2018","journal-title":"Mannose-Binding Lectin. InThe Complement FactsBook"},{"key":"10.1016\/j.imbio.2018.10.009_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0135340","article-title":"Anti-retroviral lectins have modest effects on adherence of trichomonas vaginalis to epithelial cells in vitro and on recovery of tritrichomonas foetus in a mouse vaginal model","volume":"10","author":"Chatterjee","year":"2015","journal-title":"PloS one"},{"key":"10.1016\/j.imbio.2018.10.009_bib0055","doi-asserted-by":"crossref","first-page":"I-106","DOI":"10.1161\/CIRCULATIONAHA.106.679530","article-title":"The MBL2 \u2018LYQA secretor\u2019haplotype is an independent predictor of postoperative myocardial infarction in whites undergoing coronary artery bypass graft surgery","volume":"116","author":"Collard","year":"2007","journal-title":"Circulation."},{"key":"10.1016\/j.imbio.2018.10.009_bib0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2007.04.009","article-title":"The role of mannose-binding lectin gene polymorphisms in women with recurrent bacterial vaginosis","volume":"197","author":"De Seta","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0065","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1111\/j.1471-0528.2008.01830.x","article-title":"Mannose\u2010binding lectin gene polymorphism and resistance to therapy in women with recurrent vulvovaginal candidiasis","volume":"115","author":"Donders","year":"2008","journal-title":"BJOG"},{"key":"10.1016\/j.imbio.2018.10.009_bib0070","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.ijgo.2015.05.031","article-title":"Bacterial vaginosis among women with tubal factor infertility in Nigeria","volume":"131","author":"Durugbo","year":"2015","journal-title":"Int. J. Gynecol. Obstetr."},{"key":"10.1016\/j.imbio.2018.10.009_bib0075","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1086\/379324","article-title":"Impact of mannose-binding lectin on susceptibility to infectious diseases","volume":"37","author":"Eisen","year":"2003","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.imbio.2018.10.009_bib0080","article-title":"Is MBL serum concentration a reliable predictor for recurrent vulvovaginal candidiasis?","author":"Ghazanfari","year":"2017","journal-title":"Mycoses."},{"key":"10.1016\/j.imbio.2018.10.009_bib0085","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1097\/01.AOG.0000260386.17555.a5","article-title":"Mannose-binding lectin gene polymorphism, vulvovaginal candidiasis, and bacterial vaginosis","volume":"109","author":"Giraldo","year":"2007","journal-title":"Obstetr. Gynecol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0090","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3109\/1040841X.2015.1091805","article-title":"Vulvovaginal candidiasis: epidemiology, microbiology and risk factors","volume":"42","author":"Gon\u00e7alves","year":"2016","journal-title":"Crit. Rev. Microbiol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0095","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.ejogrb.2009.10.008","article-title":"Mannan-binding lectin in women with a history of recurrent vulvovaginal candidiasis","volume":"148","author":"Heni\u0107","year":"2010","journal-title":"Eur. J. Obstetr. Gynecol. Reprod. Biology."},{"key":"10.1016\/j.imbio.2018.10.009_bib0100","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1086\/422397","article-title":"Role of mannose-binding lectin in the innate defense against candida albicans: enhancement of complement activation, but lack of opsonic function, in phagocytosis by human dendritic cells","volume":"190","author":"Ip","year":"2004","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.imbio.2018.10.009_bib0105","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1006\/bbrc.2000.3343","article-title":"Promoter variants of the human mannose-binding lectin gene show different binding","volume":"275","author":"J\u00fcliger","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.imbio.2018.10.009_bib0110","first-page":"253","article-title":"Prevalence of vulvovaginal infections and species specific distribution of vulvovaginal candidiasis in married women of north india","volume":"4","author":"Kalia","year":"2015","journal-title":"Int. J. Curr. Microbiol. App. Sci."},{"key":"10.1016\/j.imbio.2018.10.009_bib0115","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1186\/s40064-016-2543-4","article-title":"A comprehensive in silico analysis of non-synonymous and regulatory SNPs of human MBL2 gene","volume":"5","author":"Kalia","year":"2016","journal-title":"Springerplus."},{"key":"10.1016\/j.imbio.2018.10.009_bib0120","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fmicb.2017.00075","article-title":"Genetic and phenotypic screening of mannose-binding lectin in relation to risk of recurrent vulvovaginal infections in women of North India: a prospective cohort study","volume":"8","author":"Kalia","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.3389\/fcimb.2018.00065","article-title":"A comprehensive in silico analysis of regulatory SNPs of human CLEC7A Gene and its validation as genotypic and phenotypic disease marker in recurrent vulvovaginal infections","volume":"8","author":"Kalia","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0130","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.molimm.2014.06.005","article-title":"Restoration of MBL-deficiency: redefining the safety, efficacy and viability of MBL-substitution therapy","volume":"61","author":"Keizer","year":"2014","journal-title":"Molecular Immunol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0135","doi-asserted-by":"crossref","first-page":"21302","DOI":"10.1074\/jbc.M400520200","article-title":"Disease-associated mutations in human mannose-binding lectin compromise oligomerization and activity of the final protein","volume":"279","author":"Larsen","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2018.10.009_bib0140","article-title":"MBL-mediated opsonophagocytosis of candida albicans by human neutrophils is coupled with intracellular dectin-1-triggered ROS production","volume":"7","author":"Li","year":"2012","journal-title":"PLoS One."},{"key":"10.1016\/j.imbio.2018.10.009_bib0145","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.ijgo.2005.08.024","article-title":"Mannose-binding lectin and vulvovaginal candidiasis","volume":"92","author":"Liu","year":"2006","journal-title":"Int. J. Gynecol. Obstetr."},{"key":"10.1016\/j.imbio.2018.10.009_bib0150","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1002\/ijc.28251","article-title":"Genetic variants in c\u2010type lectin genes are associated with colorectal cancer susceptibility and clinical outcome","volume":"133","author":"Lu","year":"2013","journal-title":"International Journal Cancer"},{"key":"10.1016\/j.imbio.2018.10.009_bib0155","doi-asserted-by":"crossref","first-page":"3169","DOI":"10.4049\/jimmunol.161.6.3169","article-title":"Different molecular events result in low protein levels of mannan-binding lectin in populations from southeast Africa and South America","volume":"161","author":"Madsen","year":"1998","journal-title":"J. Immuno."},{"key":"10.1016\/j.imbio.2018.10.009_bib0160","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1111\/j.1600-0897.2007.00549.x","article-title":"MBL2 genetic screening in patients with recurrent vaginal infections","volume":"59","author":"Milanese","year":"2008","journal-title":"Am. J. Reprod. Immunol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0165","article-title":"Genetic polymorphisms in host innate immune sensor genes and the risk of nasopharyngeal carcinoma in North Africa. G3: genes, genomes","author":"Moumad","year":"2013","journal-title":"Genetics"},{"key":"10.1016\/j.imbio.2018.10.009_bib0170","series-title":"2 (NFHS 2) 1998-99, India","author":"National Family Health Survey","year":"1999"},{"key":"10.1016\/j.imbio.2018.10.009_bib0175","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13223-016-0152-y","article-title":"Genetic susceptibility to allergic bronchopulmonary aspergillosis in asthma: a genetic association study","volume":"12","author":"Overton","year":"2016","journal-title":"Allergy Asthma Clin. Immunol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0180","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/iji.12312","article-title":"Genetic susceptibility to severe asthma with fungal sensitization","volume":"44","author":"Overton","year":"2017","journal-title":"Int. J. Immunogenet."},{"key":"10.1016\/j.imbio.2018.10.009_bib0185","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1365-2249.2005.02660.x","article-title":"Mannose binding lectin and C3 act as recognition molecules for infectious agents in the vagina","volume":"139","author":"Pellis","year":"2005","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0190","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.bpobgyn.2014.07.006","article-title":"Recurrent vulvovaginitis","volume":"28","author":"Powell","year":"2014","journal-title":"Best Pract. Res. Clin. Obstetr. Gynaecol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0195","first-page":"381","article-title":"Bacterial vaginosis-a risk factor for preterm labour: a case-control study","volume":"4","author":"Rose","year":"2017","journal-title":"Indian J. Obstetr. Gynecol. Res."},{"key":"10.1016\/j.imbio.2018.10.009_bib0200","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nrc2867","article-title":"Genetic variation in microRNA networks: the implications for cancer research","volume":"10","author":"Ryan","year":"2010","journal-title":"Nature Reviews Cancer"},{"key":"10.1016\/j.imbio.2018.10.009_bib0205","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.vaccine.2009.12.056","article-title":"Polymorphisms in innate immunity genes and patients response to dendritic cell-based HIV immuno-treatment","volume":"28","author":"Segat","year":"2010","journal-title":"Vaccine."},{"issue":"22","key":"10.1016\/j.imbio.2018.10.009_bib0210","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1258\/ijsa.2011.011012","article-title":"European (IUSTI\/WHO) guideline on the management of vaginal discharge","volume":"2011","author":"Sherrard","year":"2011","journal-title":"Int. J. STD AIDS"},{"key":"10.1016\/j.imbio.2018.10.009_bib0215","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s11908-013-0325-5","article-title":"Mixed vaginitis\u2014more than coinfection and with therapeutic implications","volume":"15","author":"Sobel","year":"2013","journal-title":"Current Infectious Disease Rep."},{"key":"10.1016\/j.imbio.2018.10.009_bib0220","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1111\/j.1365-2141.2011.08912.x","article-title":"MBL2 and fever during neutropenia in children with acute lymphoblastic leukaemia","volume":"157","author":"te Poele","year":"2012","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0225","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0161-5890(03)00155-X","article-title":"The role of mannose-binding lectin in health and disease","volume":"40","author":"Turner","year":"2003","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0230","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1186\/1471-2180-8-229","article-title":"Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells","volume":"8","author":"Van Asbeck","year":"2008","journal-title":"BMC Microbiol."},{"key":"10.1016\/j.imbio.2018.10.009_bib0235","doi-asserted-by":"crossref","first-page":"79","DOI":"10.59566\/IJBS.2017.13079","article-title":"Lack of association between mannose-binding lectin 2 codons 54 and 57 Gene polymorphisms and cervicovaginal infections in Mexican women","volume":"13","author":"Velazquez-Hernandez","year":"2017","journal-title":"Int. J. Biomed. Sci."},{"key":"10.1016\/j.imbio.2018.10.009_bib0240","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00404-011-1920-z","article-title":"Association between mannose-binding lectin and interleukin-1 receptor antagonist gene polymorphisms and recurrent vulvovaginal candidiasis","volume":"285","author":"Wojitani","year":"2012","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.imbio.2018.10.009_bib0245","series-title":"Sexually Transmitted Diseases Treatment Guidelines, 2015. MMWR. Recommendations and Reports: Morbidity And Mortality Weekly Report. Recommendations and Reports.","author":"Workowski","year":"2015"},{"key":"10.1016\/j.imbio.2018.10.009_bib0250","doi-asserted-by":"crossref","DOI":"10.1158\/0008-5472.CAN-11-3073","article-title":"3\u2032-UTR and functional secretor haplotypes in mannose-binding lectin 2 are associated with increased colon cancer risk in African americans","author":"Zanetti","year":"2012","journal-title":"Cancer Res."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298518301074?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298518301074?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:44:29Z","timestamp":1759250669000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298518301074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,1]]}},"alternative-id":["S0171298518301074"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2018.10.009","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2019,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SNPs in 3\u2032-UTR region of MBL2 increases susceptibility to recurrent vulvovaginal infections by altering sMBL levels","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2018.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}