{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T00:55:24Z","timestamp":1790470524542,"version":"4.1.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.imbio.2019.03.002","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T03:10:08Z","timestamp":1553224208000},"page":"355-361","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":62,"title":["Depletion of tumor-associated macrophages enhances the anti-tumor effect of docetaxel in a murine epithelial ovarian cancer"],"prefix":"10.1016","volume":"224","author":[{"given":"Xiaofen","family":"Lu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tengteng","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2019.03.002_bib0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.critrevonc.2007.07.004","article-title":"The inflammatory micro-environment in tumor progression: the role of tumor-associated macrophages","volume":"66","author":"Allavena","year":"2008","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.imbio.2019.03.002_bib0010","doi-asserted-by":"crossref","first-page":"6063","DOI":"10.18632\/oncotarget.2168","article-title":"Dietary energy balance modulates ovarian cancer progression and metastasis","volume":"5","author":"Al-Wahab","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.imbio.2019.03.002_bib0015","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/nature13862","article-title":"Cessation of CCL2 inhibition accelerates breast cancer metastasis by promoting angiogenesis","volume":"515","author":"Bonapace","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2019.03.002_bib0020","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fcell.2018.00038","article-title":"Targeting tumor-associated macrophages as a potential strategy to enhance the response to immune checkpoint inhibitors","volume":"6","author":"Cassetta","year":"2018","journal-title":"Front Cell Dev. Biol."},{"key":"10.1016\/j.imbio.2019.03.002_bib0025","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1158\/2326-6066.CIR-16-0309","article-title":"Depletion of tumor-associated macrophages with a CSF-1R kinase inhibitor enhances antitumor immunity and survival induced by DC immunotherapy","volume":"5","author":"Dammeijer","year":"2017","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.imbio.2019.03.002_bib0030","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ccr.2013.02.013","article-title":"Macrophage regulation of tumor responses to anticancer therapies","volume":"23","author":"De Palma","year":"2013","journal-title":"Cancer Cell"},{"key":"10.1016\/j.imbio.2019.03.002_bib0035","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ccr.2009.06.018","article-title":"CD4(+) T cells regulate pulmonary metastasis of mammary carcinomas by enhancing protumor properties of macrophages","volume":"16","author":"DeNardo","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.imbio.2019.03.002_bib0040","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1158\/2159-8274.CD-10-0028","article-title":"Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy","volume":"1","author":"DeNardo","year":"2011","journal-title":"Cancer Discov."},{"key":"10.1016\/j.imbio.2019.03.002_bib0045","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/2045-824X-5-20","article-title":"The role of tumor-associated macrophages in tumor vascularization","volume":"5","author":"Guo","year":"2013","journal-title":"Vasc Cell"},{"key":"10.1016\/j.imbio.2019.03.002_bib0050","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.clon.2005.05.009","article-title":"Epithelial ovarian cancer: a review of current management","volume":"17","author":"Guppy","year":"2005","journal-title":"Clin. Oncol. (R. Coll. Radiol.)"},{"key":"10.1016\/j.imbio.2019.03.002_bib0055","doi-asserted-by":"crossref","first-page":"17462","DOI":"10.18632\/oncotarget.3958","article-title":"CD4+ and CD8+ T cells have opposing roles in breast cancer progression and outcome","volume":"6","author":"Huang","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.imbio.2019.03.002_bib0060","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1182\/blood-2011-09-379214","article-title":"Therapeutic applications of macrophage colony-stimulating factor-1 (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling","volume":"119","author":"Hume","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2019.03.002_bib0065","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1177\/1758834012449685","article-title":"Overcoming docetaxel resistance in prostate cancer: a perspective review","volume":"4","author":"Hwang","year":"2012","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"Suppl.3","key":"10.1016\/j.imbio.2019.03.002_bib0070","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1038\/sj.bjc.6601495","article-title":"Docetaxel: an alternative taxane in ovarian cancer","volume":"89","author":"Katsumata","year":"2003","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.imbio.2019.03.002_bib0075","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1756-9966-31-14","article-title":"Therapeutic strategies in epithelial ovarian cancer","volume":"31","author":"Kim","year":"2012","journal-title":"J. Exp. Clin. Cancer Res."},{"key":"10.1016\/j.imbio.2019.03.002_bib0080","doi-asserted-by":"crossref","first-page":"4617","DOI":"10.2147\/OTT.S132558","article-title":"The influence of vascular endothelial growth factor-A and matrix metalloproteinase-2 and -9 in angiogenesis, metastasis, and prognosis of endometrial cancer","volume":"10","author":"Mahecha","year":"2017","journal-title":"OncoTargets Ther."},{"key":"10.1016\/j.imbio.2019.03.002_bib0085","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrclinonc.2016.217","article-title":"Tumour-associated macrophages as treatment targets in oncology","volume":"14","author":"Mantovani","year":"2017","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.imbio.2019.03.002_bib0090","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1158\/0008-5472.CAN-12-2731","article-title":"Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses","volume":"73","author":"Mitchem","year":"2013","journal-title":"Cancer Res."},{"key":"10.1016\/j.imbio.2019.03.002_bib0095","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9624760","article-title":"Macrophages as key drivers of Cancer progression and metastasis","volume":"2017","author":"Nielsen","year":"2017","journal-title":"Mediators Inflamm."},{"key":"10.1016\/j.imbio.2019.03.002_bib0100","doi-asserted-by":"crossref","first-page":"E4041","DOI":"10.1073\/pnas.1720948115","article-title":"Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment","volume":"115","author":"Peranzoni","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2019.03.002_bib0105","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1038\/nm.3337","article-title":"CSF-1R inhibition alters macrophage polarization and blocks glioma progression","volume":"19","author":"Pyonteck","year":"2013","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2019.03.002_bib0110","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cell.2010.03.014","article-title":"Macrophage diversity enhances tumor progression and metastasis","volume":"141","author":"Qian","year":"2010","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2019.03.002_bib0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.20892\/j.issn.2095-3941.2016.0084","article-title":"Epidemiology of ovarian cancer: a review","volume":"14","author":"Reid","year":"2017","journal-title":"Cancer Biol. Med."},{"key":"10.1016\/j.imbio.2019.03.002_bib0120","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3389\/fphys.2014.00075","article-title":"Role of tumor associated macrophages in tumor angiogenesis and lymphangiogenesis","volume":"5","author":"Riabov","year":"2014","journal-title":"Front. Physiol."},{"key":"10.1016\/j.imbio.2019.03.002_bib0125","first-page":"865","article-title":"Macrophage-colony stimulating factor (CSF1) predicts breast cancer progression and mortality","volume":"35","author":"Richardsen","year":"2015","journal-title":"Anticancer Res."},{"key":"10.1016\/j.imbio.2019.03.002_bib0130","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.ccr.2014.05.016","article-title":"Targeting tumor-associated macrophages with anti-CSF-1R antibody reveals a strategy for cancer therapy","volume":"25","author":"Ries","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.imbio.2019.03.002_bib0135","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.4161\/hv.29275","article-title":"Depletion of tumor-associated macrophages enhances the anti-tumor immunity induced by a toll-like receptor agonist-conjugated peptide","volume":"10","author":"Shen","year":"2014","journal-title":"Hum. Vaccin. Immunother."},{"key":"10.1016\/j.imbio.2019.03.002_bib0140","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.ejca.2006.01.003","article-title":"Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: potential targets of anti-cancer therapy","volume":"42","author":"Sica","year":"2006","journal-title":"Eur. J. Cancer"},{"key":"10.1016\/j.imbio.2019.03.002_bib0145","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021857","article-title":"CSF-1 receptor signaling in myeloid cells","volume":"6","author":"Stanley","year":"2014","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.imbio.2019.03.002_bib0150","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/imm.12023","article-title":"Anti-tumour strategies aiming to target tumour-associated macrophages","volume":"138","author":"Tang","year":"2013","journal-title":"Immunology"},{"key":"10.1016\/j.imbio.2019.03.002_bib0155","doi-asserted-by":"crossref","first-page":"6002","DOI":"10.4049\/jimmunol.1100232","article-title":"Phagosomal degradation increases TLR access to bacterial ligands and enhances macrophage sensitivity to bacteria","volume":"187","author":"Wolf","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2019.03.002_bib0160","doi-asserted-by":"crossref","DOI":"10.4161\/21624011.2014.941734","article-title":"TAM macrophages promote growth and metastasis within the cancer ecosystem","volume":"3","author":"Zarif","year":"2014","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.imbio.2019.03.002_bib0165","first-page":"3579","article-title":"Expressions of MMP-2, MMP-9 and VEGF are closely linked to growth, invasion, metastasis and angiogenesis of gastric carcinoma","volume":"26","author":"Zheng","year":"2006","journal-title":"Anticancer Res."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298519300713?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298519300713?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:46:01Z","timestamp":1759250761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298519300713"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0171298519300713"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2019.03.002","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Depletion of tumor-associated macrophages enhances the anti-tumor effect of docetaxel in a murine epithelial ovarian cancer","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2019.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}