{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T07:15:56Z","timestamp":1778656556890,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T00:00:00Z","timestamp":1556668800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81702027"],"award-info":[{"award-number":["81702027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81572019"],"award-info":[{"award-number":["81572019"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Priority Academic Program Development of Jiangsu Higher Education Institutions of China","award":["1506"],"award-info":[{"award-number":["1506"]}]},{"name":"Natural Science Foundation of Jiangsu Province of China","award":["BK20171176"],"award-info":[{"award-number":["BK20171176"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2019,5]]},"DOI":"10.1016\/j.imbio.2019.03.004","type":"journal-article","created":{"date-parts":[[2019,3,31]],"date-time":"2019-03-31T09:34:06Z","timestamp":1554024846000},"page":"347-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Membrane-bound IgE on B cells is increased during Clonorchis sinensis infection"],"prefix":"10.1016","volume":"224","author":[{"given":"Qian","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Zhao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Tian","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Cui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren-Xian","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kui-Yang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2019.03.004_bib0005","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1086\/653828","article-title":"Increases in levels of schistosome-specific immunoglobulin E and CD23(+) B cells in a cohort of Kenyan children undergoing repeated treatment and reinfection with Schistosoma mansoni","volume":"202","author":"Black","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.imbio.2019.03.004_bib0010","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s00436-003-0934-2","article-title":"Cytokine responses in mice infected with Clonorchis sinensis","volume":"91","author":"Choi","year":"2003","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.imbio.2019.03.004_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0012581","article-title":"Choice of mouse strain influences the outcome in a mouse model of chemical-induced asthma","volume":"5","author":"De Vooght","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2019.03.004_bib0020","doi-asserted-by":"crossref","first-page":"12686","DOI":"10.1073\/pnas.1207278109","article-title":"Crystal structure of IgE bound to its B-cell receptor CD23 reveals a mechanism of reciprocal allosteric inhibition with high affinity receptor FcepsilonRI","volume":"109","author":"Dhaliwal","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2019.03.004_bib0025","article-title":"A novel recycling mechanism of native IgE-antigen complexes in human B cells facilitates transfer of antigen to dendritic cells for antigen presentation","author":"Engeroff","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2019.03.004_bib0030","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.4049\/jimmunol.175.3.1473","article-title":"IgE enhances antibody and T cell responses in vivo via CD23+ B cells","volume":"175","author":"Getahun","year":"2005","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2019.03.004_bib0035","first-page":"28","article-title":"CD23\/Fc epsilon RII: C-type lectin membrane protein with a split personality?","volume":"29","author":"Gould","year":"1991","journal-title":"Monogr. Allergy"},{"key":"10.1016\/j.imbio.2019.03.004_bib0040","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.4049\/jimmunol.1002709","article-title":"CD23-bound IgE augments and dominates recall responses through human naive B cells","volume":"186","author":"Griffith","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2019.03.004_bib0045","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1084\/jem.20050811","article-title":"The structure of human CD23 and its interactions with IgE and CD21","volume":"202","author":"Hibbert","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2019.03.004_bib0050","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0134089","article-title":"Differential immunometabolic phenotype in Th1 and Th2 dominant mouse strains in response to high-fat feeding","volume":"10","author":"Jovicic","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2019.03.004_bib0055","doi-asserted-by":"crossref","first-page":"7556","DOI":"10.1073\/pnas.86.19.7556","article-title":"Low-affinity IgE receptor (CD23) function on mouse B cells: role in IgE-dependent antigen focusing","volume":"86","author":"Kehry","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2019.03.004_bib0060","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.4049\/jimmunol.167.6.3139","article-title":"Regulation of IgE production requires oligomerization of CD23","volume":"167","author":"Kilmon","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2019.03.004_bib0065","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.parint.2011.07.001","article-title":"Cyst formation, increased anti-inflammatory cytokines and expression of chemokines support for Clonorchis sinensis infection in FVB mice","volume":"61","author":"Kim","year":"2012","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.imbio.2019.03.004_bib0070","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/nri2072","article-title":"New developments in FcepsilonRI regulation, function and inhibition","volume":"7","author":"Kraft","year":"2007","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2019.03.004_bib0075","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0110609","article-title":"Antigen transfer from exosomes to dendritic cells as an explanation for the immune enhancement seen by IgE immune complexes","volume":"9","author":"Martin","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2019.03.004_bib0080","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1186\/s12931-018-0813-0","article-title":"Is IgE or eosinophils the key player in allergic asthma pathogenesis? Are we asking the right question?","volume":"19","author":"Matucci","year":"2018","journal-title":"Respir. Res."},{"key":"10.1016\/j.imbio.2019.03.004_bib0085","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1086\/595792","article-title":"Circulating CD23+ B cell subset correlates with the development of resistance to Schistosoma mansoni reinfection in occupationally exposed adults who have undergone multiple treatments","volume":"199","author":"Mwinzi","year":"2009","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.imbio.2019.03.004_bib0090","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/j.jaci.2016.04.009","article-title":"Fifty years later: emerging functions of IgE antibodies in host defense, immune regulation, and allergic diseases","volume":"137","author":"Oettgen","year":"2016","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2019.03.004_bib0095","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1002\/eji.1830200721","article-title":"IgE-dependent antigen focusing by human B lymphocytes is mediated by the low-affinity receptor for IgE","volume":"20","author":"Pirron","year":"1990","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2019.03.004_bib0100","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S0140-6736(15)60313-0","article-title":"Clonorchiasis","volume":"387","author":"Qian","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.imbio.2019.03.004_bib0105","first-page":"137","article-title":"Effects of lysed Enterococcus faecalis FK-23 on allergen-induced peritoneal accumulation of eosinophils and serum total IgE concentration in inbred mice","volume":"26","author":"Shimada","year":"2008","journal-title":"Asian Pac. J. Allergy Immunol."},{"key":"10.1016\/j.imbio.2019.03.004_bib0110","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/imr.12340","article-title":"Structure and dynamics of IgE-receptor interactions: FcepsilonRI and CD23\/FcepsilonRII","volume":"268","author":"Sutton","year":"2015","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.imbio.2019.03.004_bib0115","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.parint.2011.07.002","article-title":"Strain variation in the susceptibility and immune response to Clonorchis sinensis infection in mice","volume":"61","author":"Uddin","year":"2012","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.imbio.2019.03.004_bib0120","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/338649a0","article-title":"The B-cell binding site on human immunoglobulin E","volume":"338","author":"Vercelli","year":"1989","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2019.03.004_bib0125","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1097\/01.shk.0000142249.08135.e9","article-title":"Innate immune response in Th1- and Th2-dominant mouse strains","volume":"22","author":"Watanabe","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.imbio.2019.03.004_bib0130","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/nri3632","article-title":"The production and regulation of IgE by the immune system","volume":"14","author":"Wu","year":"2014","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2019.03.004_bib0135","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143217","article-title":"The dynamics of Treg\/Th17 and the imbalance of Treg\/Th17 in Clonorchis sinensis-infected mice","volume":"10","author":"Yan","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2019.03.004_bib0140","doi-asserted-by":"crossref","first-page":"3909","DOI":"10.1038\/s41598-017-04018-8","article-title":"The roles of Toll-like receptor 4 in the pathogenesis of pathogen-associated biliary fibrosis caused by Clonorchis sinensis","volume":"7","author":"Yan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.imbio.2019.03.004_bib0145","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.immuni.2012.02.009","article-title":"Fluorescent in vivo detection reveals that IgE(+) B cells are restrained by an intrinsic cell fate predisposition","volume":"36","author":"Yang","year":"2012","journal-title":"Immunity"},{"key":"10.1016\/j.imbio.2019.03.004_bib0150","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1292\/jvms.63.421","article-title":"Infectivity and pathological changes in murine clonorchiasis: comparison in immunocompetent and immunodeficient mice","volume":"63","author":"Yoon","year":"2001","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.imbio.2019.03.004_bib0155","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1007\/s00436-016-4974-9","article-title":"Expression and potential roles of IL-33\/ST2 in the immune regulation during Clonorchis sinensis infection","volume":"115","author":"Yu","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.imbio.2019.03.004_bib0160","doi-asserted-by":"crossref","first-page":"21667","DOI":"10.1074\/jbc.M113.480657","article-title":"Ca2+-dependent structural changes in the B-cell receptor CD23 increase its affinity for human immunoglobulin E","volume":"288","author":"Yuan","year":"2013","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2019.03.004_bib0165","article-title":"Increased hepatic Th2 and Treg subsets are associated with biliary fibrosis in different strains of mice caused by Clonorchis sinensis","volume":"12","author":"Zhang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2019.03.004_bib0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0006251","article-title":"Clonorchis sinensis adult-derived proteins elicit Th2 immune responses by regulating dendritic cells via mannose receptor","volume":"12","author":"Zhao","year":"2018","journal-title":"PLoS Negl. Trop. Dis."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298519300269?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298519300269?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:44:50Z","timestamp":1759250690000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298519300269"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2019,5]]}},"alternative-id":["S0171298519300269"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2019.03.004","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2019,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Membrane-bound IgE on B cells is increased during Clonorchis sinensis infection","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2019.03.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}]}}