{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T09:06:14Z","timestamp":1777712774160,"version":"3.51.4"},"reference-count":30,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.imbio.2019.05.010","type":"journal-article","created":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T01:43:43Z","timestamp":1559353423000},"page":"706-709","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Mast cells: A key component in the pathogenesis of Neuromyelitis Optica Spectrum Disorder?"],"prefix":"10.1016","volume":"224","author":[{"suffix":"Junior","given":"Washigton Luiz Gomes de","family":"Medeiros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle Pastor","family":"Bandeira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9 Eduardo de Almeida","family":"Franzoi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wesley Nogueira","family":"Brand\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Carolina Cardoso dos","family":"Santos Dur\u00e3o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus Vin\u00edcius Magno","family":"Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2019.05.010_bib0005","doi-asserted-by":"crossref","first-page":"303","DOI":"10.2147\/NDT.S185336","article-title":"Cytokines and chemokines expression in serum of patients with neuromyelitis optica","volume":"15","author":"Ai","year":"2019","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.imbio.2019.05.010_bib0010","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ni1430","article-title":"CNS myeloid DCs presenting endogenous myelin peptides \u201cpreferentially\u201d polarize CD4+TH-17 cells in relapsing EAE","volume":"8","author":"Bailey","year":"2007","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0015","first-page":"11","article-title":"Mast cell Toll-like receptors (TLRs)","volume":"64","author":"Brzezi\u0144ska-b\u0142aszczyk","year":"2010","journal-title":"Postepy. Hig. Med. Dosw."},{"issue":"May\u2013Jun (3)","key":"10.1016\/j.imbio.2019.05.010_bib0020","first-page":"449","article-title":"New concepts in neuroinflammation: mast cells pro-inflammatory and anti-inflammatory cytokine mediators","volume":"32","author":"Caraffa","year":"2018","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.imbio.2019.05.010_bib0025","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.imlet.2016.07.003","article-title":"Mast cells as effector cells of innate immunity and regulators of adaptive immunity","volume":"178","author":"Cardamone","year":"2016","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imbio.2019.05.010_bib0030","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jaut.2012.11.003","article-title":"Mast cell activation and neutrophil recruitment promotes early and robust inflammation in the meninges in EAE","volume":"42","author":"Christy","year":"2013","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.imbio.2019.05.010_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-04717-4","article-title":"C-terminal truncation of IFN-\u03b3 inhibits proinflammatory macrophage responses and is deficient in autoimmune disease","volume":"9","author":"Dufour","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imbio.2019.05.010_bib0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ni1158","article-title":"Mast cells in the development of adaptive immune responses","volume":"6","author":"Galli","year":"2005","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0045","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.bbi.2017.06.017","article-title":"Immunoregulatory effect of mast cells influenced by microbes in neurodegenerative diseases","volume":"65","author":"Girolamo","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.imbio.2019.05.010_bib0050","doi-asserted-by":"crossref","first-page":"3478","DOI":"10.1002\/eji.200535271","article-title":"Mast cells are required for optimal autoreactive T cell responses in a murine model of multiple sclerosis","volume":"35","author":"Gregory","year":"2005","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0055","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neubiorev.2017.05.001","article-title":"Mast cells in neuroinflammation and brain disorders","volume":"79","author":"Hendriksen","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.imbio.2019.05.010_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-0625.2001.100101.x","article-title":"Mast cells as initiators of immunity and host defense","volume":"10","author":"Henz","year":"2001","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0065","first-page":"1","article-title":"Mast cell proteases activate astrocytes and glia-neurons and release interleukin-33 by activating p38 and ERK1\/2 MAPKs and NF-\u03baB","author":"Kempuraj","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0070","doi-asserted-by":"crossref","first-page":"273","DOI":"10.4049\/jimmunol.1000991","article-title":"Signaling pathways in the activation of mast cells cocultured with astrocytes and colocalization of both cells in experimental allergic encephalomyelitis","volume":"185","author":"Kim","year":"2010","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0075","first-page":"213","article-title":"Immunopathogenesis of neuromyelitis optica","volume":"6","author":"Levy","year":"2014","journal-title":"Adv. Immunol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2013.10.004","article-title":"Neuroinflammation: the role and consequences","volume":"79","author":"Lyman","year":"2014","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.imbio.2019.05.010_bib0085","doi-asserted-by":"crossref","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2019.05.010_bib0090","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/S0091-6749(99)70316-7","article-title":"Mast cell-T cell interactions","volume":"104","author":"Mekori","year":"1999","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0095","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.molimm.2014.02.016","article-title":"Mast cells, basophils and B cell connection network","volume":"63","author":"Merluzzi","year":"2014","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/srep20531","article-title":"Activated mast cells promote differentiation of B cells into effector cells","volume":"6","author":"Palm","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.imbio.2019.05.010_bib0105","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/jnr.20488","article-title":"Microglial cell activation and proliferation precedes the onset of CNS autoimmunity","volume":"81","author":"Ponomarev","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.imbio.2019.05.010_bib0110","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.jaci.2006.04.015","article-title":"Molecular regulation of mast cell activation","volume":"117","author":"Rivera","year":"2006","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0115","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/jcmm.13401","article-title":"Supramolecular aggregation of aquaporin-4 is different in muscle and brain: correlation with tissue susceptibility in neuromyelitis optica","volume":"22","author":"Rosito","year":"2018","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.imbio.2019.05.010_bib0120","first-page":"1","article-title":"Induction of paralysis and visual system injury in mice by T cells specific for neuromyelitis optica autoantigen aquaporin-4","author":"Sagan","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.imbio.2019.05.010_bib0125","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1167\/iovs.17-23398","article-title":"Mast cells initiate the recruitment of neutrophils following ocular surface injury","volume":"59","author":"Sahu","year":"2018","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"10.1016\/j.imbio.2019.05.010_bib0130","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1111\/imm.12170","article-title":"Mast cells, glia and neuroinflammation: partners in crime?","volume":"141","author":"Skaper","year":"2014","journal-title":"Immunology"},{"issue":"Nov\u2013Dec (6)","key":"10.1016\/j.imbio.2019.05.010_bib0135","first-page":"1345","article-title":"Stress, inflammation and natural treatments","volume":"32","author":"Theoharides","year":"2018","journal-title":"J. Biol. Regul. Homeost. Agents"},{"key":"10.1016\/j.imbio.2019.05.010_bib0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fimmu.2017.01785","article-title":"Immunopathogenesis in myasthenia gravis and neuromyelitis optica","volume":"8","author":"Wang","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2019.05.010_bib0145","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.53.5.1107","article-title":"The clinical course of neuromyelitis optica (Devic\u2019s syndrome)","volume":"53","author":"Wingerchuk","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.imbio.2019.05.010_bib0150","article-title":"Revised diagnostic criteria for neuromyelitis optica","author":"Wingerchuk","year":"2007","journal-title":"Neurology"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298519300890?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298519300890?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:46:01Z","timestamp":1759250761000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298519300890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,9]]}},"alternative-id":["S0171298519300890"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2019.05.010","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mast cells: A key component in the pathogenesis of Neuromyelitis Optica Spectrum Disorder?","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2019.05.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}]}}