{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:45:14Z","timestamp":1791488714103,"version":"4.3.4"},"reference-count":13,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004505","name":"Universit\u00e0 di Catania","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004505","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.imbio.2019.12.006","type":"journal-article","created":{"date-parts":[[2019,12,14]],"date-time":"2019-12-14T20:41:42Z","timestamp":1576356102000},"page":"151897","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Titration of Igs contained in an intravenous IgM-enriched preparation against selected pathogens involved in sepsis"],"prefix":"10.1016","volume":"225","author":[{"given":"Stefano","family":"Stracquadanio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavia","family":"Lo Verde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessio","family":"Cialfi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Zega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefania","family":"Stefani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viviana","family":"Cafiso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2019.12.006_bib0005","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1128\/AAC.39.9.1965","article-title":"Bactericidal properties of Campylobacter jejuni-specific immunoglobulin M antibodies in commercial immunoglobulin preparations","volume":"39","author":"Autenrieth","year":"1995","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.imbio.2019.12.006_bib0010","first-page":"28","article-title":"Role of immunoglobulins in neonatal sepsis","volume":"11","author":"Capasso","year":"2015","journal-title":"Transl. Med. UniSa"},{"issue":"1","key":"10.1016\/j.imbio.2019.12.006_bib0015","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13613-019-0501-3","article-title":"The clinical efficacy of intravenous IgM-enriched immunoglobulin (pentaglobin) in sepsis or septic shock: a meta-analysis with trial sequential analysis","volume":"6","author":"Cui","year":"2019","journal-title":"Ann. Intensive Care"},{"issue":"3","key":"10.1016\/j.imbio.2019.12.006_bib0020","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1574-6968.1984.tb00724.x","article-title":"Analysis of electrophoretically heterogeneous lipopolysaccharides of Escherichia coli by immunoblotting","volume":"22","author":"Karch","year":"1984","journal-title":"FEMS Microbiol. Lett."},{"issue":"9","key":"10.1016\/j.imbio.2019.12.006_bib0025","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1093\/cid\/ciy401","article-title":"Polyspecific intravenous immunoglobulin in clindamycin-treated patients with streptococcal toxic shock syndrome: a systematic review and meta-analysis","volume":"15","author":"Parks","year":"2018","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.imbio.2019.12.006_bib0030","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1172\/JCI108971","article-title":"The key role of peptidoglycan in the opsonization of Staphylococcus aureus","volume":"61","author":"Peterson","year":"1978","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.imbio.2019.12.006_bib0035","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1007\/s15010-014-0706-1","article-title":"In vitro and in vivo activity of hyperimmune globulin preparations against multiresistant nosocomial pathogens","volume":"43","author":"Rossmann","year":"2015","journal-title":"Infection."},{"issue":"11","key":"10.1016\/j.imbio.2019.12.006_bib0040","first-page":"1353","article-title":"Pentaglobin as an adjunct therapy in very low birthweight neonates with nosocomial sepsis","volume":"63","author":"Salihoglu","year":"2013","journal-title":"J. Pak. Med. Assoc."},{"issue":"3","key":"10.1016\/j.imbio.2019.12.006_bib0045","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1128\/iai.61.3.975-980.1993","article-title":"Estimation of protective levels of anti-O-specific lipopolysaccharide immunoglobulin G antibody against experimental Escherichia coli infection","volume":"61","author":"Schiff","year":"1993","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2019.12.006_bib0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/infdis\/144.1.1","article-title":"Antibodies to cell wall peptidoglycan of Staphylococcus aureus in patients with serious staphylococcal infections","volume":"144","author":"Verbrugh","year":"1981","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.imbio.2019.12.006_bib0055","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/mpat.1993.1054","article-title":"Role of plasmid-encoded antigens of Yersinia enterocolitica in humoral immunity against secondary Y.eNterocolitica infection in mice","volume":"15","author":"Vogel","year":"1993","journal-title":"Microb. Pathog."},{"issue":"8","key":"10.1016\/j.imbio.2019.12.006_bib0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160907","article-title":"IgM-enriched immunoglobulin attenuates systemic endotoxin activity in early severe Sepsis: a before-after cohort study","volume":"9","author":"Wand","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2019.12.006_bib0065","first-page":"83","article-title":"Bacterial lipopolysaccharides extraction with phenol-water and further applications of the procedure","volume":"5","author":"Westphal","year":"1965","journal-title":"Methods in Carbohydrate Chemistry"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298519303730?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298519303730?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:46:57Z","timestamp":1759250817000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298519303730"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0171298519303730"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2019.12.006","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Titration of Igs contained in an intravenous IgM-enriched preparation against selected pathogens involved in sepsis","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2019.12.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"151897"}}