{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T02:25:27Z","timestamp":1777861527240,"version":"3.51.4"},"reference-count":31,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["038\/2010-CEP\/NMT"],"award-info":[{"award-number":["038\/2010-CEP\/NMT"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.imbio.2020.152050","type":"journal-article","created":{"date-parts":[[2020,12,2]],"date-time":"2020-12-02T21:08:13Z","timestamp":1606943293000},"page":"152050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Decrease in na\u00efve T cell production due to HTLV-1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) development"],"prefix":"10.1016","volume":"226","author":[{"given":"J\u00e9ssica Antonia Nunes","family":"Gomes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George Alberto","family":"da Silva Dias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satomi","family":"Fujihara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gilberto Toshimitsu","family":"Yoshikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta Vilela Lopes","family":"Koyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita Catarina Medeiros","family":"Sousa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juarez Ant\u00f4nio Sim\u00f5es","family":"Quaresma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hellen Thais","family":"Fuzii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2020.152050_b0005","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1002\/jemt.20588","article-title":"Age-related changes in the human thymus studied with scanning electron microscopy","volume":"71","author":"Cavallotti","year":"2008","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.imbio.2020.152050_b0010","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1038\/25374","article-title":"Changes in thymic function with age and during the treatment of HIV infection","volume":"396","author":"Douek","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2020.152050_b0015","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.70.6.4038-4044.1996","article-title":"Human T-Cell Leukemia Virus Infection of Human Hematopoietic Progenitor Cells: Maintenance of Virus Infection during Differentiation In Vitro and In Vivo","author":"Feuer","year":"1996","journal-title":"JOURNAL OF VIROLOGY."},{"key":"10.1016\/j.imbio.2020.152050_b0020","doi-asserted-by":"crossref","unstructured":"Furtado, K.C.Y.O., da Costa, C.A., Ferreira, L. de S.C., Martins, L.C., Linhares, A. da C., Ishikawa, E.A.Y., Batista, E. de J.O., Sousa, M.S. de S., 2013. Occurrence of strongyloidiasis among patients with HTLV-1\/2 seen at the outpatient clinic of the N\u00facleo de medicina Tropical, Bel\u00e9m, state of Par\u00e1, Brazil. Rev. Soc. Bras. Med. Trop. 46, 241\u2013243. doi: 10.1590\/0037-8682-981-2013.","DOI":"10.1590\/0037-8682-981-2013"},{"key":"10.1016\/j.imbio.2020.152050_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/v10120691","article-title":"Cytokine networks dysregulation during htlv-1 infection and associated diseases","volume":"10","author":"Futsch","year":"2018","journal-title":"Viruses"},{"key":"10.1016\/j.imbio.2020.152050_b0030","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.lfs.2014.03.025","article-title":"Immunopathogenesis of HTLV-1-assoaciated myelopathy\/tropical spastic paraparesis (HAM\/TSP)","volume":"104","author":"Fuzii","year":"2014","journal-title":"Life Sci."},{"key":"10.1016\/j.imbio.2020.152050_b0035","first-page":"866","article-title":"Affected and non-affected skin fibroblasts from systemic sclerosis patients share a gene expression profile deviated from the one observed in healthy individuals","volume":"26","author":"Fuzii","year":"2008","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.imbio.2020.152050_b0040","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(85)92734-5","article-title":"Antibodies to Human T-lymphotropic virus type-I in patients with tropical spastic paraparesis","volume":"326","author":"Gessain","year":"1985","journal-title":"Lancet"},{"key":"10.1016\/j.imbio.2020.152050_b0045","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/ni.2588","article-title":"Understanding immunosenescence to improve responses to vaccines","volume":"14","author":"Goronzy","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2020.152050_b0050","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1111\/sji.12096","article-title":"Impaired thymic output in patients with chronic hepatitis c virus infection","volume":"78","author":"Hartling","year":"2013","journal-title":"Scand. J. Immunol."},{"key":"10.1016\/j.imbio.2020.152050_b0055","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.1002\/(SICI)1521-4141(199810)28:10<3057::AID-IMMU3057>3.0.CO;2-Z","article-title":"IL-7 promotes the survival and maturation but not differentiation of human post-thymic CD4+ T cells","volume":"28","author":"Hassan","year":"1998","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2020.152050_b0060","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1146\/annurev.immunol.18.1.529","article-title":"The Role of the Thymus in Immune Reconstitution in Aging, Bone Marrow Transplantation, and HIV-1 Infection","volume":"18","author":"Haynes","year":"2002","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imbio.2020.152050_b0065","doi-asserted-by":"crossref","first-page":"566","DOI":"10.2340\/00015555-0550","article-title":"T-cell receptor excision circles (TREC) in CD4+ and CD8 + T-cell subpopulations in atopic dermatitis and psoriasis show major differences in the emission of recent thymic emigrants","volume":"88","author":"Just","year":"2008","journal-title":"Acta Derm. Venereol."},{"key":"10.1016\/j.imbio.2020.152050_b0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0058764","article-title":"Decreased IL-7 responsiveness is related to oxidative stress in HIV disease","volume":"8","author":"Kalinowska","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2020.152050_b0075","doi-asserted-by":"crossref","first-page":"S72","DOI":"10.1038\/jp.2010.187","article-title":"Protein tyrosine kinase 7: a novel surface marker for human recent thymic emigrants with potential clinical utility","volume":"31","author":"Lewis","year":"2011","journal-title":"J. Perinatol."},{"key":"10.1016\/j.imbio.2020.152050_b0080","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/S0140-6736(86)91298-5","article-title":"HTLV-I associated myelopathy, a new clinical entity","volume":"327","author":"Osame","year":"1986","journal-title":"Lancet"},{"key":"10.1016\/j.imbio.2020.152050_b0085","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.scr.2018.01.014","article-title":"A2E-associated cell death and inflammation in retinal pigmented epithelial cells from human induced pluripotent stem cells","volume":"27","author":"Parmar","year":"2018","journal-title":"Stem Cell Res."},{"key":"10.1016\/j.imbio.2020.152050_b0090","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.ijgo.2005.06.004","article-title":"Human papillomavirus (HPV) DNA detection in self-collected urine","volume":"90","author":"Prusty","year":"2005","journal-title":"Int. J. Gynecol. Obstet."},{"key":"10.1016\/j.imbio.2020.152050_b0095","doi-asserted-by":"crossref","first-page":"5682","DOI":"10.1128\/jvi.64.11.5682-5687.1990","article-title":"In vivo cellular tropism of human T-cell leukemia virus type 1","volume":"64","author":"Richardson","year":"1990","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2020.152050_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3960\/jslrt.50.1","article-title":"HTLV-1 and the host immune system: how the virus disrupts immune regulation, leading to HTLV-1 associated diseases","volume":"50","author":"Satou","year":"2010","journal-title":"J. Clin. Exp. Hematop."},{"key":"10.1016\/j.imbio.2020.152050_b0105","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/j.coi.2011.05.001","article-title":"Altered thymic activity in early life: how does it affect the immune system in young adults?","volume":"23","author":"Sauce","year":"2011","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.imbio.2020.152050_b0110","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/ACI.0b013e32834c233a","article-title":"T-cell receptor excision circles in primary immunodeficiencies and other T-cell immune disorders","volume":"11","author":"Somech","year":"2011","journal-title":"Curr. Opin. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2020.152050_b0115","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1038\/nri913","article-title":"Development of \u03b1\u03b2 T cells in the human thymus","volume":"2","author":"Spits","year":"2002","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2020.152050_b0120","first-page":"1066","article-title":"HTLV-1 infection is frequent among out-patients with pulmonary tuberculosis in northern Lima, Peru","volume":"11","author":"Verdonck","year":"2007","journal-title":"Int J Tuberc Lung Dis"},{"key":"10.1016\/j.imbio.2020.152050_b0125","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.humimm.2006.10.019","article-title":"Healthy aging and latent infection with CMV lead to distinct changes in CD8+ and CD4+ T-cell subsets in the elderly","volume":"68","author":"Weinberger","year":"2007","journal-title":"Hum. Immunol."},{"key":"10.1016\/j.imbio.2020.152050_b0130","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1128\/JVI.00766-06","article-title":"Human T-cell leukemia virus type 1 tax protein down-regulates pre-T-cell receptor alpha gene transcription in human immature thymocytes","volume":"81","author":"Wencker","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2020.152050_b0135","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1097\/BOR.0000000000000011","article-title":"T-cell aging in rheumatoid arthritis","volume":"26","author":"Weyand","year":"2014","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.imbio.2020.152050_b0140","unstructured":"World Health Organization, 1988. Scientific Group on HTLV-I Infections and Associated Diseases, Kagoshima, Japan, 10-15 December 1988: report."},{"key":"10.1016\/j.imbio.2020.152050_b0145","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jneuroim.2016.08.012","article-title":"HTLV-1 induces a Th1-like state in CD4+ CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM\/TSP","volume":"304","author":"Yamano","year":"2017","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.imbio.2020.152050_b0150","doi-asserted-by":"crossref","first-page":"3177","DOI":"10.1182\/blood.V97.10.3177","article-title":"Impaired production of naive T lymphocytes in human T-cell leukemia virus type I-infected individuals: Its implications in the immunodeficient state","volume":"97","author":"Yasunaga","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.imbio.2020.152050_b0155","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1073\/pnas.79.6.2031","article-title":"Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease","volume":"79","author":"Yoshida","year":"1982","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298520305726?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298520305726?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T04:22:17Z","timestamp":1777522937000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298520305726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":31,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["S0171298520305726"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2020.152050","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Decrease in na\u00efve T cell production due to HTLV-1-associated myelopathy\/tropical spastic paraparesis (HAM\/TSP) development","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2020.152050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152050"}}