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Immunol."},{"key":"10.1016\/j.imbio.2021.152057_b0325","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1126\/science.3107127","article-title":"Interferon-\u03b3 and B cell stimulatory factor-1 reciprocally regulate Ig isotype production","volume":"236","author":"Snapper","year":"1987","journal-title":"Science (80-.)"},{"key":"10.1016\/j.imbio.2021.152057_b0330","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.parint.2014.10.003","article-title":"Evaluation of the immunoprophylactic potential of a killed vaccine candidate in combination with different adjuvants against murine visceral leishmaniasis","volume":"64","author":"Thakur","year":"2015","journal-title":"Parasitol. 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