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Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0270","doi-asserted-by":"crossref","unstructured":"Ewer, K.J., Barrett, J.R., Belij-Rammerstorfer, S., Sharpe, H., Makinson, R., Morter, R., Flaxman, A., Wright, D., Bellamy, D., Bittaye, M., Dold, C., Provine, N.M., Aboagye, J., Fowler, J., Silk, S.E., Alderson, J., Aley, P.K., Angus, B., Berrie, E., Bibi, S., Cicconi, P., Clutterbuck, E.A., Chelysheva, I., Folegatti, P.M., Fuskova, M., Green, C.M., Jenkin, D., Kerridge, S., Lawrie, A., Minassian, A.M., Moore, M., Mujadidi, Y., Plested, E., Poulton, I., Ramasamy, M.N., Robinson, H., Song, R., Snape, M.D., Tarrant, R., Voysey, M., Watson, M.E.E., Douglas, A.D., Hill, A.V.S., Gilbert, S.C., Pollard, A.J., Lambe, T., Ali, A., Allen, E., Baker, M., Barnes, E., Borthwick, N., Boyd, A., Brown-O\u2019Sullivan, C., Burgoyne, J., Byard, N., Puig, I.C., Cappuccini, F., Cho, J.S., Cicconi, P., Clark, E., Crocker, W.E.M., Datoo, M.S., Davies, H., Dunachie, S.J., Edwards, N.J., Elias, S.C., Furze, J., Gilbride, C., Harris, S.A., Hodgson, S.H.C., Hou, M.M., Jackson, S., Jones, K., Kailath, R., King, L., Larkworthy, C.W., Li, Y., Lias, A.M., Linder, A., Lipworth, S., Ramon, R.L., Madhavan, M., Marlow, E., Marshall, J.L., Mentzer, A.J., Morrison, H., No\u00e9, A., Pipini, D., Pulido-Gomez, D., Lopez, F.R., Ritchie, A.J., Rudiansyah, I., Sanders, H., Shea, A., Silk, S., Spencer, A.J., Tanner, R., Themistocleous, Y., Thomas, M., Tran, N., Truby, A., Turner, C., Turner, N., Ulaszewska, M., Worth, A.T., Kingham-Page, L., Alvarez, M.P.P., Anslow, R., Bates, L., Beadon, K., Beckley, R., Beveridge, A., Bijker, E.M., Blackwell, L., Burbage, J., Camara, S., Carr, M., Colin-Jones, R., Cooper, R., Cunningham, C.J., Demissie, T., Maso, C. di, Douglas, N., Drake-Brockman, R., Drury, R.E., Emary, K.R.W., Felle, S., Feng, S., Ford, K.J., Francis, E., Gracie, L., Hamlyn, J., Hanumunthadu, B., Harrison, D., Hart, T.C., Hawkins, S., Hill, J., Howe, E., Howell, N., Jones, E., Keen, J., Kelly, S., Kerr, D., Khan, L., Kinch, J., Koleva, S., Lees, E.A., Lelliott, A., Liu, X., Marinou, S., McEwan, J., Morey, E., Morshead, G., Muller, J., Munro, C., Murphy, S., Mweu, P., Nuthall, E., O\u2019Brien, K., O\u2019Connor, D., O\u2019Reilly, P.J., Oguti, B., Osborne, P., Owino, N., Parker, K., Pfafferott, K., Provstgaard-Morys, S., Ratcliffe, H., Rawlinson, T., Rhead, S., Roberts, H., Sanders, K., Silva-Reyes, L., Smith, C.C., Smith, D.J., Szigeti, A., Thomas, T.M., Thompson, A., Tonks, S., Varughes, R., Vichos, I., Walker, L., White, C., White, R., Yao, X.L., Conlon, C.P., Frater, J., Cifuentes, L., Baleanu, I., Bolam, E., Boland, E., Brenner, T., Damratoski, B.E., Datta, C., Muhanna, O. el, Fisher, R., Galian-Rubio, P., Hodges, G., Jackson, F., Liu, S., Loew, L., Morgans, R., Morris, S.J., Olchawski, V., Oliveria, C., Parracho, H., Pabon, E.R., Tahiri-Alaoui, A., Taylor, K., Williams, P., Zizi, D., Arbe-Barnes, E.H., Baker, P., Batten, A., Downing, C., Drake, J., English, M.R., Henry, J.A., Iveson, P., Killen, A., King, T.B., Larwood, J.P.J., Mallett, G., Mansatta, K., Mirtorabi, N., Patrick-Smith, M., Perring, J., Radia, K., Roche, S., Schofield, E., Naude, R. te W., Towner, J., Baker, N., Bewley, K.R., Brunt, E., Buttigieg, K.R., Charlton, S., Coombes, N.S., Elmore, M.J., Godwin, K., Hallis, B., Knott, D., McInroy, L., Shaik, I., Thomas, K., Tree, J.A., Blundell, C.L., Cao, M., Kelly, D., Skelly, D.T., Themistocleous, A., Dong, T., Field, S., Hamilton, E., Kelly, E., Klenerman, P., Knight, J.C., Lie, Y., Petropoulos, C., Sedik, C., Wrin, T., Meddaugh, G., Peng, Y., Screaton, G., Stafford, E., 2020. T cell and antibody responses induced by a single dose of ChAdOx1 nCoV-19 (AZD1222) vaccine in a phase 1\/2 clinical trial. Nature Medicine 2020 27:2 27, 270\u2013278. https:\/\/doi.org\/10.1038\/s41591-020-01194-5.","DOI":"10.1038\/s41591-020-01194-5"},{"key":"10.1016\/j.imbio.2022.152302_b0275","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1007\/978-3-030-63761-3_47","article-title":"Retrieval and Investigation of Data on SARS-CoV-2 and COVID-19 Using Bioinformatics Approach","volume":"1318","author":"Fahmi","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.imbio.2022.152302_b0280","doi-asserted-by":"crossref","unstructured":"Fan, X., Cao, D., Kong, L., Zhang, X., 2020. Cryo-EM analysis of the post-fusion structure of the SARS-CoV spike glycoprotein. Nature Communications 2020 11:1 11, 1\u201310. https:\/\/doi.org\/10.1038\/s41467-020-17371-6.","DOI":"10.1038\/s41467-020-17371-6"},{"key":"10.1016\/j.imbio.2022.152302_b0285","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1128\/JVI.02596-14","article-title":"The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced Encephalitis","volume":"89","author":"Fehr","year":"2015","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0290","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/mBio.01721-16","article-title":"The conserved coronavirus macrodomain promotes virulence and suppresses the innate immune response during severe acute respiratory syndrome coronavirus infection","volume":"7","author":"Fehr","year":"2016","journal-title":"mBio"},{"key":"10.1016\/j.imbio.2022.152302_b0295","first-page":"E162","article-title":"Structural and molecular basis of mismatch correction and ribavirin excision from coronavirus RNA","volume":"115","author":"Ferron","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.imbio.2022.152302_b0300","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1128\/JVI.02220-08","article-title":"Severe Acute Respiratory Syndrome Coronavirus Papain-Like Protease Ubiquitin-Like Domain and Catalytic Domain Regulate Antagonism of IRF3 and NF-\u03baB Signaling","volume":"83","author":"Frieman","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0730","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1128\/JVI.02220-08","article-title":"Severe acute respiratory syndrome coronavirus papain-like protease ubiquitin-like domain and catalytic domain regulate antagonism of IRF3 and NF-kappaB signaling","volume":"83","author":"Frieman","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0305","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-020-20718-8","article-title":"The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery","volume":"12","author":"Fu","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imbio.2022.152302_b0310","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1128\/JVI.01772-09","article-title":"Murine Hepatitis Virus Nonstructural Protein 4 Regulates Virus-Induced Membrane Modifications and Replication Complex Function","volume":"84","author":"Gadlage","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0315","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1056\/NEJMoa1208953","article-title":"Nucleotide Polymerase Inhibitor Sofosbuvir plus Ribavirin for Hepatitis C","volume":"368","author":"Gane","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"368","key":"10.1016\/j.imbio.2022.152302_b0320","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1126\/science.abb7498","article-title":"Structure of the RNA-dependent RNA polymerase from COVID-19 virus","volume":"1979","author":"Gao","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.imbio.2022.152302_b0325","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/0014-5793(91)81034-6","article-title":"Putative papain-related thiol proteases of positive-strand RNA viruses Identification of rubi- and aphthovirus proteases and delineation of a novel conserved domain associated with proteases of rubi-, \u03b1- and coronaviruses","volume":"288","author":"Gorbalenya","year":"1991","journal-title":"FEBS Lett."},{"key":"10.1016\/j.imbio.2022.152302_b0330","doi-asserted-by":"crossref","unstructured":"Gordon, D.E., Jang, G.M., Bouhaddou, M., Xu, J., Obernier, K., White, K.M., O\u2019Meara, M.J., Rezelj, V. v., Guo, J.Z., Swaney, D.L., Tummino, T.A., H\u00fcttenhain, R., Kaake, R.M., Richards, A.L., Tutuncuoglu, B., Foussard, H., Batra, J., Haas, K., Modak, M., Kim, M., Haas, P., Polacco, B.J., Braberg, H., Fabius, J.M., Eckhardt, M., Soucheray, M., Bennett, M.J., Cakir, M., McGregor, M.J., Li, Q., Meyer, B., Roesch, F., Vallet, T., mac Kain, A., Miorin, L., Moreno, E., Naing, Z.Z.C., Zhou, Y., Peng, S., Shi, Y., Zhang, Z., Shen, W., Kirby, I.T., Melnyk, J.E., Chorba, J.S., Lou, K., Dai, S.A., Barrio-Hernandez, I., Memon, D., Hernandez-Armenta, C., Lyu, J., Mathy, C.J.P., Perica, T., Pilla, K.B., Ganesan, S.J., Saltzberg, D.J., Rakesh, R., Liu, X., Rosenthal, S.B., Calviello, L., Venkataramanan, S., Liboy-Lugo, J., Lin, Y., Huang, X.P., Liu, Y.F., Wankowicz, S.A., Bohn, M., Safari, M., Ugur, F.S., Koh, C., Savar, N.S., Tran, Q.D., Shengjuler, D., Fletcher, S.J., O\u2019Neal, M.C., Cai, Y., Chang, J.C.J., Broadhurst, D.J., Klippsten, S., Sharp, P.P., Wenzell, N.A., Kuzuoglu-Ozturk, D., Wang, H.Y., Trenker, R., Young, J.M., Cavero, D.A., Hiatt, J., Roth, T.L., Rathore, U., Subramanian, A., Noack, J., Hubert, M., Stroud, R.M., Frankel, A.D., Rosenberg, O.S., Verba, K.A., Agard, D.A., Ott, M., Emerman, M., Jura, N., von Zastrow, M., Verdin, E., Ashworth, A., Schwartz, O., d\u2019Enfert, C., Mukherjee, S., Jacobson, M., Malik, H.S., Fujimori, D.G., Ideker, T., Craik, C.S., Floor, S.N., Fraser, J.S., Gross, J.D., Sali, A., Roth, B.L., Ruggero, D., Taunton, J., Kortemme, T., Beltrao, P., Vignuzzi, M., Garc\u00eda-Sastre, A., Shokat, K.M., Shoichet, B.K., Krogan, N.J., 2020. A SARS-CoV-2 protein interaction map reveals targets for drug repurposing. Nature 2020 583:7816 583, 459\u2013468. https:\/\/doi.org\/10.1038\/s41586-020-2286-9.","DOI":"10.1038\/s41586-020-2286-9"},{"key":"10.1016\/j.imbio.2022.152302_b0335","doi-asserted-by":"crossref","unstructured":"Gorgulla, C., Das, K.M.P., Leigh, K.E., Cespugli, M., Fischer, P.D., Wang, Z.-F., Tesseyre, G., Pandita, S., Shnapir, A., Calderaio, A., Gechev, M., Rose, A., Lewis, N., Hutcheson, C., Yaffe, E., Luxenburg, R., Herce, H.D., Durmaz, V., Halazonetis, T.D., Fackeldey, K., Patten, J.J., Chuprina, A., Dziuba, I., Plekhova, A., Moroz, Y., Radchenko, D., Tarkhanova, O., Yavnyuk, I., Gruber, C., Yust, R., Payne, D., N\u00e4\u00e4r, A.M., Namchuk, M.N., Davey, R.A., Wagner, G., Kinney, J., Arthanari, H., 2021. A multi-pronged approach targeting SARS-CoV-2 proteins using ultra-large virtual screening. iScience 24. https:\/\/doi.org\/10.1016\/J.ISCI.2020.102021.","DOI":"10.1016\/j.isci.2020.102021"},{"key":"10.1016\/j.imbio.2022.152302_b0340","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.virusres.2007.02.017","article-title":"SARS coronavirus replicase proteins in pathogenesis","volume":"133","author":"Graham","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.imbio.2022.152302_b0345","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1038\/nm.2972","article-title":"A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease","volume":"18","author":"Graham","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2022.152302_b0350","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1016\/j.cell.2020.05.015","article-title":"Targets of T Cell Responses to SARS-CoV-2 Coronavirus in Humans with COVID-19 Disease and Unexposed Individuals","volume":"181","author":"Grifoni","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2022.152302_b0355","doi-asserted-by":"crossref","unstructured":"Guo, G., Gao, M., Gao, X., Zhu, B., Huang, J., Luo, K., Zhang, Y., Sun, J., Deng, M., Lou, Z., 2021. SARS-CoV-2 non-structural protein 13 (nsp13) hijacks host deubiquitinase USP13 and counteracts host antiviral immune response. Signal Transduction and Targeted Therapy 2021 6:1 6, 1\u20133. https:\/\/doi.org\/10.1038\/s41392-021-00509-3.","DOI":"10.1038\/s41392-021-00509-3"},{"key":"10.1016\/j.imbio.2022.152302_b0360","doi-asserted-by":"crossref","first-page":"9552","DOI":"10.1039\/C7OB02094E","article-title":"Synthesis and biological applications of fluoro-modified nucleic acids","volume":"15","author":"Guo","year":"2017","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.imbio.2022.152302_b0365","doi-asserted-by":"crossref","unstructured":"Gupta, M., Azumaya, C.M., Moritz, M., Pourmal, S., Diallo, A., Merz, G.E., Jang, G., Bouhaddou, M., Fossati, A., Brilot, A.F., Diwanji, D., Hernandez, E., Herrera, N., Kratochvil, H.T., Lam, V.L., Li, F., Li, Y., Nguyen, H.C., Nowotny, C., Owens, T.W., Peters, J.K., Rizo, A.N., Schulze-Gahmen, U., Smith, A.M., Young, I.D., Yu, Z., Asarnow, D., Billesb\u00f8lle, C., Campbell, M.G., Chen, J., Chen, K.-H., Chio, U.S., Dickinson, M.S., Doan, L., Jin, M., Kim, K., Li, J., Li, Y.-L., Linossi, E., Liu, Y., Lo, M., Lopez, J., Lopez, K.E., Mancino, A., Moss, F.R., Paul, M.D., Pawar, K.I., Pelin, A., Pospiech, T.H., Puchades, C., Remesh, S.G., Safari, M., Schaefer, K., Sun, M., Tabios, M.C., Thwin, A.C., Titus, E.W., Trenker, R., Tse, E., Tsui, T.K.M., Wang, F., Zhang, K., Zhang, Y., Zhao, J., Zhou, F., Zhou, Y., Zuliani-Alvarez, L., QCRG Structural Biology Consortium, Agard, D.A., Cheng, Y., Fraser, J.S., Jura, N., Kortemme, T., Manglik, A., Southworth, D.R., Stroud, R.M., Swaney, D.L., Krogan, N.J., Frost, A., Rosenberg, O.S., Verba, K.A., 2021. CryoEM and AI reveal a structure of SARS-CoV-2 Nsp2, a multifunctional protein involved in key host processes. bioRxiv. https:\/\/doi.org\/10.1101\/2021.05.10.443524.","DOI":"10.1101\/2021.05.10.443524"},{"key":"10.1016\/j.imbio.2022.152302_b0370","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/s41590-020-0773-7","article-title":"ORF8 and ORF3b antibodies are accurate serological markers of early and late SARS-CoV-2 infection","volume":"21","author":"Hachim","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2022.152302_b0375","doi-asserted-by":"crossref","first-page":"8094","DOI":"10.1073\/pnas.1921485117","article-title":"Coronavirus endoribonuclease targets viral polyuridine sequences to evade activating host sensors","volume":"117","author":"Hackbart","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.imbio.2022.152302_b0380","doi-asserted-by":"crossref","first-page":"4572","DOI":"10.1128\/JVI.00042-11","article-title":"Mobility and Interactions of Coronavirus Nonstructural Protein 4","volume":"85","author":"Hagemeijer","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0385","doi-asserted-by":"crossref","first-page":"3245","DOI":"10.3390\/v4113245","article-title":"Biogenesis and Dynamics of the Coronavirus Replicative Structures","volume":"4","author":"Hagemeijer","year":"2012","journal-title":"Viruses"},{"key":"10.1016\/j.imbio.2022.152302_b0390","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.virol.2014.04.027","article-title":"Membrane rearrangements mediated by coronavirus nonstructural proteins 3 and 4","volume":"458\u2013459","author":"Hagemeijer","year":"2014","journal-title":"Virology"},{"key":"10.1016\/j.imbio.2022.152302_b0395","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40709-021-00149-2","article-title":"Predicted antiviral drugs Darunavir, Amprenavir, Rimantadine and Saquinavir can potentially bind to neutralize SARS-CoV-2 conserved proteins","volume":"28","author":"Halder","year":"2021","journal-title":"J. Biol. Res. Thessaloniki"},{"key":"10.1016\/j.imbio.2022.152302_b0400","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23937","article-title":"Analysis of COVID-19 vaccines: Types, thoughts, and application","volume":"35","author":"Han","year":"2021","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.imbio.2022.152302_b0405","doi-asserted-by":"crossref","first-page":"13600","DOI":"10.1128\/JVI.78.24.13600-13612.2004","article-title":"Identification of Severe Acute Respiratory Syndrome Coronavirus Replicase Products and Characterization of Papain-Like Protease Activity","volume":"78","author":"Harcourt","year":"2004","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0975","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104380","article-title":"A unique view of SARS-CoV-2 through the lens of ORF8 protein","volume":"133","author":"Hassan","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.imbio.2022.152302_b0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2021.104380","article-title":"A unique view of SARS-CoV-2 through the lens of ORF8 protein","volume":"133","author":"Hassan","year":"2021","journal-title":"Comput. Biol. Med."},{"key":"10.1016\/j.imbio.2022.152302_b0415","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1126\/science.abh2315","article-title":"Defining variant-resistant epitopes targeted by SARS-CoV-2 antibodies: A global consortium study","volume":"374","author":"Hastie","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.imbio.2022.152302_b0420","doi-asserted-by":"crossref","first-page":"D482","DOI":"10.1093\/nar\/gkw1065","article-title":"Virus Variation Resource - improved response to emergent viral outbreaks","volume":"45","author":"Hatcher","year":"2017","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.imbio.2022.152302_b0425","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.bbrc.2004.06.076","article-title":"Potent and selective inhibition of SARS coronavirus replication by aurintricarboxylic acid","volume":"320","author":"He","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.imbio.2022.152302_b0430","doi-asserted-by":"crossref","unstructured":"Heo, L., Feig, M., 2020. Modeling of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Proteins by Machine Learning and Physics-Based Refinement. bioRxiv. https:\/\/doi.org\/10.1101\/2020.03.25.008904.","DOI":"10.1101\/2020.03.25.008904"},{"key":"10.1016\/j.imbio.2022.152302_b0435","doi-asserted-by":"crossref","DOI":"10.1038\/sj.onc.1209941","article-title":"Manipulation of the nuclear factor-\u03baB pathway and the innate immune response by viruses","author":"Hiscott","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.imbio.2022.152302_b0440","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1002\/pro.3150","article-title":"Structural basis for dimerization and RNA binding of avian infectious bronchitis virus nsp9","volume":"26","author":"Hu","year":"2017","journal-title":"Protein Sci."},{"key":"10.1016\/j.imbio.2022.152302_b0445","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/S1672-0229(03)01016-7","article-title":"The M protein of SARS-CoV: basic structural and immunological properties","volume":"1","author":"Hu","year":"2003","journal-title":"Genomics Proteom. Bioinform. Beijing Genomics Institute"},{"key":"10.1016\/j.imbio.2022.152302_b0450","doi-asserted-by":"crossref","first-page":"7287","DOI":"10.1128\/JVI.00414-06","article-title":"Severe Acute Respiratory Syndrome Coronavirus 7a Accessory Protein Is a Viral Structural Protein","volume":"80","author":"Huang","year":"2006","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0455","doi-asserted-by":"crossref","first-page":"10276","DOI":"10.1128\/JVI.01287-10","article-title":"An Interaction between the Nucleocapsid Protein and a Component of the Replicase-Transcriptase Complex Is Crucial for the Infectivity of Coronavirus Genomic RNA","volume":"84","author":"Hurst","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0460","doi-asserted-by":"crossref","first-page":"9159","DOI":"10.1128\/JVI.01275-13","article-title":"Characterization of a Critical Interaction between the Coronavirus Nucleocapsid Protein and Nonstructural Protein 3 of the Viral Replicase-Transcriptase Complex","volume":"87","author":"Hurst","year":"2013","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0465","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.virusres.2007.11.017","article-title":"The SARS-Coronavirus PLnc domain of nsp3 as a replication\/transcription scaffolding protein","volume":"133","author":"Imbert","year":"2008","journal-title":"Virus Res."},{"key":"10.1016\/j.imbio.2022.152302_b0470","doi-asserted-by":"crossref","unstructured":"Issa, E., Merhi, G., Panossian, B., Salloum, T., Tokajian, S., 2020. 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Rep."},{"key":"10.1016\/j.imbio.2022.152302_b0510","doi-asserted-by":"crossref","first-page":"6700","DOI":"10.1128\/JVI.02817-06","article-title":"Crystal Structure of a Monomeric Form of Severe Acute Respiratory Syndrome Coronavirus Endonuclease nsp15 Suggests a Role for Hexamerization as an Allosteric Switch","volume":"81","author":"Joseph","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0515","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-23036-9","article-title":"A SARS-CoV-2 antibody curbs viral nucleocapsid protein-induced complement hyperactivation","volume":"12","author":"Kang","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imbio.2022.152302_b0520","doi-asserted-by":"crossref","first-page":"757","DOI":"10.22207\/JPAM.14.SPL1.13","article-title":"Molecular Characterization and Amino Acid Homology of Nucleocapsid (N) Protein in SARS-CoV-1, SARSCoV-2, MERS-CoV, and Bat Coronavirus","volume":"14","author":"Kannan","year":"2020","journal-title":"J Pure Appl Microbiol"},{"key":"10.1016\/j.imbio.2022.152302_b0525","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2020.198114","article-title":"COVID-19 Vaccine: A comprehensive status report","volume":"288","author":"Kaur","year":"2020","journal-title":"Virus Res."},{"key":"10.1016\/j.imbio.2022.152302_b0530","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.virusres.2012.05.017","article-title":"Short peptides derived from the interaction domain of SARS coronavirus nonstructural protein nsp10 can suppress the 2\u2019-O-methyltransferase activity of nsp10\/nsp16 complex","volume":"167","author":"Ke","year":"2012","journal-title":"Virus Res."},{"key":"10.1016\/j.imbio.2022.152302_b0535","doi-asserted-by":"crossref","unstructured":"Kern, D.M., Sorum, B., Mali, S.S., Hoel, C.M., Sridharan, S., Remis, J.P., Toso, D.B., Kotecha, A., Bautista, D.M., Brohawn, S.G., 2021. Cryo-EM structure of SARS-CoV-2 ORF3a in lipid nanodiscs. Nature Structural & Molecular Biology 2021 28:7 28, 573\u2013582. https:\/\/doi.org\/10.1038\/s41594-021-00619-0.","DOI":"10.1038\/s41594-021-00619-0"},{"key":"10.1016\/j.imbio.2022.152302_b0540","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1159\/000513686","article-title":"Structures of SARS-CoV-2 RNA-Binding Proteins and Therapeutic Targets","volume":"64","author":"Khan","year":"2021","journal-title":"Intervirology"},{"key":"10.1016\/j.imbio.2022.152302_b0545","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.710778","article-title":"Remdesivir Strongly Binds to RNA-Dependent RNA Polymerase, Membrane Protein, and Main Protease of SARS-CoV-2: Indication From Molecular Modeling and Simulations","volume":"12","author":"Khan","year":"2021","journal-title":"Front. 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Biol. Chem."},{"key":"10.1016\/j.imbio.2022.152302_b0575","doi-asserted-by":"crossref","DOI":"10.1016\/j.jsb.2020.107548","article-title":"Structural analysis of the putative SARS-CoV-2 primase complex","volume":"211","author":"Konkolova","year":"2020","journal-title":"J. Struct. Biol."},{"key":"10.1016\/j.imbio.2022.152302_b0580","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1128\/JVI.01782-06","article-title":"Severe Acute Respiratory Syndrome Coronavirus Open Reading Frame (ORF) 3b, ORF 6, and Nucleocapsid Proteins Function as Interferon Antagonists","volume":"81","author":"Kopecky-Bromberg","year":"2007","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0585","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1016\/0092-8674(94)90014-0","article-title":"Crystal structure of the eukaryotic DNA polymerase processivity factor PCNA","volume":"79","author":"Krishna","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2022.152302_b0590","doi-asserted-by":"crossref","first-page":"1899","DOI":"10.1099\/vir.0.031856-0","article-title":"The ADP-ribose-1\u2033-monophosphatase domains of severe acute respiratory syndrome coronavirus and human coronavirus 229E mediate resistance to antiviral interferon responses","volume":"92","author":"Kuri","year":"2011","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0595","doi-asserted-by":"crossref","DOI":"10.1038\/s41541-021-00292-w","article-title":"SARS-CoV-2 vaccines strategies: a comprehensive review of phase 3 candidates","volume":"6","author":"Kyriakidis","year":"2021","journal-title":"npj Vaccines"},{"key":"10.1016\/j.imbio.2022.152302_b0605","doi-asserted-by":"crossref","unstructured":"Lam, S.D., Bordin, N., Waman, V.P., Scholes, H.M., Ashford, P., Sen, N., Dorp, L. van, Rauer, C., Dawson, N.L., Pang, C.S.M., Abbasian, M., Sillitoe, I., Edwards, S.J.L., Fraternali, F., Lees, J.G., Santini, J.M., Orengo, C.A., 2020. SARS-CoV-2 spike protein predicted to form complexes with host receptor protein orthologues from a broad range of mammals. Scientific Reports 2020 10:1 10, 1\u201314. https:\/\/doi.org\/10.1038\/s41598-020-71936-5.","DOI":"10.1038\/s41598-020-71936-5"},{"key":"10.1016\/j.imbio.2022.152302_b0610","doi-asserted-by":"crossref","unstructured":"Lam, T.T.-Y., Jia, N., Zhang, Y.-W., Shum, M.H.-H., Jiang, J.-F., Zhu, H.-C., Tong, Y.-G., Shi, Y.-X., Ni, X.-B., Liao, Y.-S., Li, W.-J., Jiang, B.-G., Wei, W., Yuan, T.-T., Zheng, K., Cui, X.-M., Li, J., Pei, G.-Q., Qiang, X., Cheung, W.Y.-M., Li, L.-F., Sun, F.-F., Qin, S., Huang, J.-C., Leung, G.M., Holmes, E.C., Hu, Y.-L., Guan, Y., Cao, W.-C., 2020. Identifying SARS-CoV-2-related coronaviruses in Malayan pangolins. Nature 2020 583:7815 583, 282\u2013285. https:\/\/doi.org\/10.1038\/s41586-020-2169-0.","DOI":"10.1038\/s41586-020-2169-0"},{"key":"10.1016\/j.imbio.2022.152302_b0615","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/s41586-020-2180-5","article-title":"Structure of the SARS-CoV-2 spike receptor-binding domain bound to the ACE2 receptor","volume":"581","author":"Lan","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2022.152302_b0620","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/d41586-021-03074-5","article-title":"COVID antiviral pills: what scientists still want to know","volume":"599","author":"Ledford","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2022.152302_b0625","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/nm0302-240","article-title":"Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice","volume":"8","author":"Lee","year":"2002","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2022.152302_b0630","doi-asserted-by":"crossref","unstructured":"Lee, J.-G., Huang, W., Lee, H., van de Leemput, J., Kane, M.A., Han, Z., 2021. Characterization of SARS-CoV-2 proteins reveals Orf6 pathogenicity, subcellular localization, host interactions and attenuation by Selinexor. Cell & Bioscience 2021 11:1 11, 1\u201312. https:\/\/doi.org\/10.1186\/S13578-021-00568-7.","DOI":"10.1186\/s13578-021-00568-7"},{"key":"10.1016\/j.imbio.2022.152302_b0635","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-19662-4","article-title":"Crystallographic structure of wild-type SARS-CoV-2 main protease acyl-enzyme intermediate with physiological C-terminal autoprocessing site","volume":"11","author":"Lee","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.imbio.2022.152302_b0640","doi-asserted-by":"crossref","first-page":"3190","DOI":"10.1002\/1873-3468.12827","article-title":"RNA-virus proteases counteracting host innate immunity","volume":"591","author":"Lei","year":"2017","journal-title":"FEBS Lett."},{"key":"10.1016\/j.imbio.2022.152302_b0645","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.antiviral.2014.06.011","article-title":"Crystal structure of the papain-like protease of MERS coronavirus reveals unusual, potentially druggable active-site features","volume":"109","author":"Lei","year":"2014","journal-title":"Antiviral Res."},{"key":"10.1016\/j.imbio.2022.152302_b0650","doi-asserted-by":"crossref","DOI":"10.1016\/j.antiviral.2017.11.001","article-title":"Nsp3 of coronaviruses: Structures and functions of a large multi-domain protein","author":"Lei","year":"2018","journal-title":"Antiviral Res."},{"key":"10.1016\/j.imbio.2022.152302_b0655","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1021\/acscentsci.1c00120","article-title":"A Comprehensive Review of the Global Efforts on COVID-19 Vaccine Development","volume":"7","author":"Li","year":"2021","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.imbio.2022.152302_b0660","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3389\/fmolb.2021.813248","article-title":"Molecular Mechanism of SARS-CoVs Orf6 Targeting the Rae1\u2013Nup98 Complex to Compete With mRNA Nuclear Export","volume":"8","author":"Li","year":"2022","journal-title":"Front Mol Biosci"},{"key":"10.1016\/j.imbio.2022.152302_b0665","article-title":"Crystal structure of SARS-CoV-2 nsp10\/nsp16 2\u2032-O-methylase and its implication on antiviral drug design","volume":"5","author":"Lin","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.imbio.2022.152302_b0670","doi-asserted-by":"crossref","first-page":"5382","DOI":"10.1093\/nar\/gkab320","article-title":"Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity","volume":"49","author":"Lin","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.imbio.2022.152302_b0675","article-title":"In silico design of antiviral peptides targeting the spike protein of SARS-CoV-2","volume":"N.Y.) 130","author":"Ling","year":"2020","journal-title":"Peptides"},{"key":"10.1016\/j.imbio.2022.152302_b0680","volume":"iScience 23","author":"Littler","year":"2020","journal-title":"Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9."},{"key":"10.1016\/j.imbio.2022.152302_b0685","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101018","article-title":"Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9","volume":"297","author":"Littler","year":"2021","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2022.152302_b0690","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.101018","article-title":"Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9","volume":"297","author":"Littler","year":"2021","journal-title":"J. Biol. 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Dis."},{"key":"10.1016\/j.imbio.2022.152302_b0705","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00447-20","article-title":"Porcine Epidemic Diarrhea Virus Deficient in RNA Cap Guanine-N-7 Methylation Is Attenuated and Induces Higher Type I and III Interferon Responses","volume":"94","author":"Lu","year":"2020","journal-title":"J. Virol."},{"key":"10.1016\/j.imbio.2022.152302_b0710","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11262-010-0544-x","article-title":"SARS-CoV nucleocapsid protein antagonizes IFN-\u03b2 response by targeting initial step of IFN-\u03b2 induction pathway, and its C-terminal region is critical for the antagonism","volume":"42","author":"Lu","year":"2011","journal-title":"Virus Genes"},{"key":"10.1016\/j.imbio.2022.152302_b0715","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0140-6736(20)30251-8","article-title":"Genomic characterisation and epidemiology of 2019 novel coronavirus: implications for virus origins and receptor binding","volume":"395","author":"Lu","year":"2020","journal-title":"The Lancet"},{"key":"10.1016\/j.imbio.2022.152302_b0720","doi-asserted-by":"crossref","first-page":"12540","DOI":"10.1073\/pnas.0605402103","article-title":"Severe acute respiratory syndrome-associated coronavirus 3a protein forms an ion channel and modulates virus release","volume":"103","author":"Lu","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.imbio.2022.152302_b0725","doi-asserted-by":"crossref","first-page":"18454","DOI":"10.1074\/jbc.RA118.004950","article-title":"Heme oxygenase-1 protects airway epithelium against apoptosis by targeting the proinflammatory NLRP3-RXR axis in asthma","volume":"293","author":"Lv","year":"2018","journal-title":"J. Biol. Chem."},{"issue":"5","key":"10.1016\/j.imbio.2022.152302_b0480","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1007\/s12250-021-00431-6","article-title":"Structure and Function of N-Terminal Zinc Finger Domain of SARS-CoV-2 NSP2","volume":"36","author":"Ma","year":"2021","journal-title":"Virol Sin"},{"key":"10.1016\/j.imbio.2022.152302_b0735","doi-asserted-by":"crossref","first-page":"9436","DOI":"10.1073\/pnas.1508686112","article-title":"Structural basis and functional analysis of the SARS coronavirus nsp14\u2013nsp10 complex","volume":"112","author":"Ma","year":"2015","journal-title":"Proc. Natl. Acad. 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Virtual screening, molecular dynamics and structure\u2013activity relationship studies to identify potent approved drugs for Covid-19 treatment. https:\/\/doi.org\/10.1080\/07391102.2020.1794974 1\u201311. https:\/\/doi.org\/10.1080\/07391102.2020.1794974.","DOI":"10.1080\/07391102.2020.1794974"},{"key":"10.1016\/j.imbio.2022.152302_b0870","doi-asserted-by":"crossref","unstructured":"Ren, Y., Shu, T., Wu, D., Mu, J., Wang, C., Huang, M., Han, Y., Zhang, X.-Y., Zhou, W., Qiu, Y., Zhou, X., 2020. The ORF3a protein of SARS-CoV-2 induces apoptosis in cells. 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Inhibition of SARS-CoV-2 (previously 2019-nCoV)infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion. Cell Research 2020 30:4 30, 343\u2013355. https:\/\/doi.org\/10.1038\/s41422-020-0305-x.","DOI":"10.1038\/s41422-020-0305-x"},{"key":"10.1016\/j.imbio.2022.152302_b1105","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/med.21783","article-title":"What coronavirus 3C-like protease tells us: From structure, substrate selectivity, to inhibitor design","volume":"41","author":"Xiong","year":"2021","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.imbio.2022.152302_b1110","doi-asserted-by":"crossref","first-page":"7909","DOI":"10.1128\/JVI.00525-06","article-title":"New Antiviral Target Revealed by the Hexameric Structure of Mouse Hepatitis Virus Nonstructural Protein nsp15","volume":"80","author":"Xu","year":"2006","journal-title":"J. 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