{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T02:46:21Z","timestamp":1791081981063,"version":"4.1.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100014857","name":"National Natural Science Foundation of China-Guangdong Joint Fund","doi-asserted-by":"publisher","award":["81860119"],"award-info":[{"award-number":["81860119"]}],"id":[{"id":"10.13039\/501100014857","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260131"],"award-info":[{"award-number":["82260131"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009102","name":"Education Department of Jiangxi Province","doi-asserted-by":"publisher","award":["GJJ200193"],"award-info":[{"award-number":["GJJ200193"]}],"id":[{"id":"10.13039\/501100009102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20212ACB206017"],"award-info":[{"award-number":["20212ACB206017"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.imbio.2022.152323","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T11:22:23Z","timestamp":1672312943000},"page":"152323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["SIRT7 affects autophagy and activation of hepatic stellate cells by regulating the acetylation level of high mobility group protein 1"],"prefix":"10.1016","volume":"228","author":[{"given":"Zhi-Hua","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng-Yuan","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heng-Wei","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.imbio.2022.152323_b0005","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/jth.14425","article-title":"Activated proteinC inhibits lipopolysaccharide-mediated acetylation and secretion of high-mobility group box1 in endothelial cells","volume":"17","author":"Cai","year":"2019","journal-title":"J. Thromb. Haemost."},{"issue":"8","key":"10.1016\/j.imbio.2022.152323_b0010","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.4161\/auto.25063","article-title":"Functions of autophagy in normal and diseased liver","volume":"9","author":"Czaja","year":"2013","journal-title":"Autophagy"},{"issue":"6","key":"10.1016\/j.imbio.2022.152323_b0015","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/nsmb.1842","article-title":"Post-translational modifications in signal integration","volume":"17","author":"Deribe","year":"2010","journal-title":"Nat. Struct. Mol. Biol."},{"issue":"3","key":"10.1016\/j.imbio.2022.152323_b0020","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.cell.2013.03.028","article-title":"A vitamin D receptor\/SMAD genomic circuit gates hepatic fibrotic response","volume":"153","author":"Ding","year":"2013","journal-title":"Cell"},{"issue":"36","key":"10.1016\/j.imbio.2022.152323_b0025","doi-asserted-by":"crossref","first-page":"4090","DOI":"10.3748\/wjg.v17.i36.4090","article-title":"Inhibition of high-mobility group box 1 expression by siRNA in rat hepatic stellate cells","volume":"17","author":"Ge","year":"2011","journal-title":"World J. Gastroenterol."},{"issue":"2","key":"10.1016\/j.imbio.2022.152323_b0030","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.yexcr.2017.02.038","article-title":"Modulation of hepatic stellate cells and reversibility of hepatic fibrosis","volume":"352","author":"Huang","year":"2017","journal-title":"Exp. Cell Res."},{"issue":"5","key":"10.1016\/j.imbio.2022.152323_b0035","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/hep.26976","article-title":"Hepatocyte-specific high-mobility group box 1 deletion worsens the injury in liver ischemia\/reperfusion: a role for intracellular high-mobility group box 1 in cellular protection","volume":"59","author":"Huang","year":"2014","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.imbio.2022.152323_b0040","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1016\/j.transproceed.2008.07.055","article-title":"High-mobility group box 1 protein activates hepatic stellate cells in vitro","volume":"40","author":"Kao","year":"2008","journal-title":"Transpl. Proc."},{"issue":"9","key":"10.1016\/j.imbio.2022.152323_b0045","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.bbadis.2014.06.017","article-title":"Involvement of the nuclear high mobility group B1 peptides released from injured hepatocytes in murine hepatic fibrogenesis","volume":"1842","author":"Kao","year":"2014","journal-title":"BBA-Mol. Basis Dis."},{"issue":"14","key":"10.1016\/j.imbio.2022.152323_b0050","doi-asserted-by":"crossref","first-page":"3451","DOI":"10.1111\/febs.12346","article-title":"Intracellular distribution of human SIRT7 and mapping of the nuclear\/nucleolar localization signal","volume":"280","author":"Kiran","year":"2013","journal-title":"FEBS J."},{"issue":"11","key":"10.1016\/j.imbio.2022.152323_b0055","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1136\/gutjnl-2017-314098","article-title":"Regulatory NK cells mediated between immunosuppressive monocytes and dysfunctional T cells in chronic HBV infection","volume":"67","author":"Li","year":"2018","journal-title":"Gut"},{"issue":"6080","key":"10.1016\/j.imbio.2022.152323_b0060","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1126\/science.1217032","article-title":"GSK3-TIP60-ULK1 signaling pathway links growth factor deprivation to autophagy","volume":"336","author":"Lin","year":"2012","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.imbio.2022.152323_b0065","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1038\/s42255-019-0136-6","article-title":"SIRT7 couples light-driven body temperature cues to hepatic circadian phase coherence and gluconeogenesis","volume":"1","author":"Liu","year":"2019","journal-title":"Nat. Metab."},{"issue":"8","key":"10.1016\/j.imbio.2022.152323_b0070","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1158\/0008-5472.CAN-11-2291","article-title":"p53\/HMGB1 complexes regulate autophagy and apoptosis","volume":"72","author":"Livesey","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.imbio.2022.152323_b0075","first-page":"2014","article-title":"Autophagy: A multifaceted partner in liver fibrosis","author":"Mallat","year":"2014","journal-title":"Biomed Res. Int."},{"issue":"1","key":"10.1016\/j.imbio.2022.152323_b0080","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jcmgh.2018.09.005","article-title":"Enhancer of zeste homologue 2 inhibition attenuates TGF-beta dependent hepatic stellate cell activation and liver fibrosis","volume":"7","author":"Martin-Mateos","year":"2019","journal-title":"Cell. Mol. Gastroenterol. Hepatol."},{"key":"10.1016\/j.imbio.2022.152323_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.118201","article-title":"Sirtuins as endogenous regulators of lung fibrosis: A current perspective","volume":"258","author":"Mazumder","year":"2020","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.imbio.2022.152323_b0090","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.cell.2011.10.026","article-title":"Autophagy: renovation of cells and tissues","volume":"147","author":"Mizushima","year":"2011","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.imbio.2022.152323_b0095","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1002\/JLB.3MR0121-277R","article-title":"HMGB1: An overview of its roles in the pathogenesis of liver disease","volume":"110","author":"Ni","year":"2021","journal-title":"J. Leukoc. Biol."},{"issue":"7","key":"10.1016\/j.imbio.2022.152323_b0100","first-page":"e256","article-title":"Regulation of ER stress-induced autophagy by GSK3\u03b2-TIP60-ULK1 pathway","volume":"29","author":"Nie","year":"2016","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.imbio.2022.152323_b0105","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mam.2018.09.002","article-title":"Liver fibrosis: Pathophysiology, pathogenetic targets and clinical issues","volume":"65","author":"Parola","year":"2019","journal-title":"Mol. Aspects Med."},{"issue":"10","key":"10.1016\/j.imbio.2022.152323_b0115","doi-asserted-by":"crossref","first-page":"6244","DOI":"10.4049\/jimmunol.0900390","article-title":"HMGB1 enhances the proinflammatory activity of lipopolysaccharide by promoting the phosphorylation of MAPK p38 through receptor for advanced glycation end products","volume":"183","author":"Qin","year":"2009","journal-title":"J. Immunol."},{"issue":"4","key":"10.1016\/j.imbio.2022.152323_b0120","doi-asserted-by":"crossref","first-page":"203","DOI":"10.31491\/APT.2020.12.041","article-title":"Y: Thioredoxin down-regulation in the cytosol in thioredoxin 2 transgenic mice did not have beneficial effects to extend lifespan in male C57BL\/6 mice","volume":"2","author":"Roman","year":"2020","journal-title":"Aging Pathobiol. Therap."},{"issue":"4","key":"10.1016\/j.imbio.2022.152323_bib141","doi-asserted-by":"crossref","first-page":"95","DOI":"10.31491\/APT.2021.12.072","article-title":"Mechanisms of autophagy regulation by adiponectin[J]","volume":"3","author":"Rong","year":"2021","journal-title":"Aging Pathobiol. Therap."},{"issue":"3","key":"10.1016\/j.imbio.2022.152323_b0125","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.celrep.2013.10.007","article-title":"SIRT7 represses myc activity to suppress ER stress and prevent fatty liver disease","volume":"5","author":"Shin","year":"2013","journal-title":"Cell Rep."},{"key":"10.1016\/j.imbio.2022.152323_b0130","first-page":"2014","article-title":"Autophagy in hepatic fibrosis","author":"Song","year":"2014","journal-title":"Biomed Res. Int."},{"issue":"2","key":"10.1016\/j.imbio.2022.152323_b0135","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1002\/hep.29138","article-title":"Substance P increases liver fibrosis by differential changes in senescence of cholangiocytes and hepatic stellate cells","volume":"66","author":"Wan","year":"2017","journal-title":"Hepatology"},{"issue":"6","key":"10.1016\/j.imbio.2022.152323_b0140","doi-asserted-by":"crossref","first-page":"L945","DOI":"10.1152\/ajplung.00473.2016","article-title":"Sirtuin 7 is decreased in pulmonary fibrosis and regulates the fibrotic phenotype of lung fibroblasts","volume":"312","author":"Wyman","year":"2017","journal-title":"Am. J. Physiol. Lung Cell. Mol. Physiol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298522001498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298522001498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T00:36:48Z","timestamp":1778632608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298522001498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":28,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0171298522001498"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2022.152323","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SIRT7 affects autophagy and activation of hepatic stellate cells by regulating the acetylation level of high mobility group protein 1","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2022.152323","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152323"}}