{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T19:23:09Z","timestamp":1779391389856,"version":"3.53.1"},"reference-count":50,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,3,1]],"date-time":"2023-03-01T00:00:00Z","timestamp":1677628800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2023,3]]},"DOI":"10.1016\/j.imbio.2023.152349","type":"journal-article","created":{"date-parts":[[2023,2,15]],"date-time":"2023-02-15T03:30:00Z","timestamp":1676431800000},"page":"152349","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["l-ficolin-MASP arm of the complement system in schizophrenia"],"prefix":"10.1016","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9712-4939","authenticated-orcid":false,"given":"Karine R.","family":"Mayilyan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Krarup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armen F.","family":"Soghoyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens C.","family":"Jensenius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Sim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.imbio.2023.152349_b0005","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1038\/s41588-022-01158-0","article-title":"Gene\u2013environment correlations across geographic regions affect genome-wide association studies","volume":"54","author":"Abdellaoui","year":"2022","journal-title":"Nature Genetics"},{"issue":"5","key":"10.1016\/j.imbio.2023.152349_b0010","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1001\/archpsyc.1996.01830050061010","article-title":"Maldistribution of interstitial neurons in prefrontal white matter of the brains of schizophrenic patients","volume":"53","author":"Akbarian","year":"1996","journal-title":"Archives of General Psychiatry"},{"issue":"8","key":"10.1016\/j.imbio.2023.152349_b0015","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0006-3223(97)00142-X","article-title":"Further Evidence of Abnormal Cytoarchitecture of the Entorhinal Cortex in Schizophrenia Using Spatial Point Pattern Analyses","volume":"42","author":"Arnold","year":"1997","journal-title":"Biological Psychiatry"},{"issue":"4","key":"10.1016\/j.imbio.2023.152349_bib249","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1134\/S002689331304002X","article-title":"Markers of apoptotic dysfunctions in schizophrenia","volume":"47","author":"Boyajyan","year":"2013","journal-title":"Molecular Biology"},{"issue":"1","key":"10.1016\/j.imbio.2023.152349_b0025","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1128\/CVI.00607-13","article-title":"Blood collection tubes influence serum ficolin-1 and ficolin-2 levels","volume":"21","author":"Brady","year":"2014","journal-title":"Clinical and Vaccine Immunology"},{"issue":"5","key":"10.1016\/j.imbio.2023.152349_b0030","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1073\/pnas.052023499","article-title":"Cortex mapping reveals regionally specific patterns of genetic and disease-specific gray-matter deficits in twins discordant for schizophrenia","volume":"99","author":"Cannon","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"issue":"2","key":"10.1016\/j.imbio.2023.152349_b0035","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.biopsych.2014.05.023","article-title":"Progressive reduction in cortical thickness as psychosis develops: A multisite longitudinal neuroimaging study of youth at elevated clinical risk","volume":"77","author":"Cannon","year":"2015","journal-title":"Biological Psychiatry"},{"issue":"2","key":"10.1016\/j.imbio.2023.152349_b0040","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/j.1365-2249.2004.02690.x","article-title":"Deficiency of the mannan-binding lectin pathway of complement and poor outcome in cystic fibrosis: Bacterial colonization may be decisive for a relationship","volume":"139","author":"Carlsson","year":"2005","journal-title":"Clinical and Experimental Immunology"},{"issue":"2","key":"10.1016\/j.imbio.2023.152349_b0045","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/j.1365-2249.2004.02453.x","article-title":"Mannan-binding lectin insufficiency in children with recurrent infections of the respiratory system","volume":"136","author":"Cedzynski","year":"2004","journal-title":"Clinical and Experimental Immunology"},{"issue":"2","key":"10.1016\/j.imbio.2023.152349_b0050","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.neuron.2019.05.013","article-title":"Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia","volume":"103","author":"Collado-Torres","year":"2019","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.imbio.2023.152349_b0055","doi-asserted-by":"crossref","first-page":"5735","DOI":"10.4049\/jimmunol.169.10.5735","article-title":"Characterization of the Interaction Between L-Ficolin\/P35 and Mannan-Binding Lectin-Associated Serine Proteases-1 and -2","volume":"169","author":"Cseh","year":"2002","journal-title":"The Journal of Immunology"},{"issue":"C","key":"10.1016\/j.imbio.2023.152349_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/0076-6879(93)23037-N","article-title":"Small-Scale Preparation of Complement Components C3and C4","volume":"223","author":"Dodds","year":"1993","journal-title":"Methods in Enzymology"},{"key":"10.1016\/j.imbio.2023.152349_b0065","series-title":"Complement: A PrActicAl ApproAch","author":"Dodds","year":"1997"},{"issue":"2","key":"10.1016\/j.imbio.2023.152349_b0070","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2249.2007.03538.x","article-title":"L-Ficolin binding and lectin pathway activation by acetylated low-density lipoprotein","volume":"151","author":"Faro","year":"2008","journal-title":"Clinical and Experimental Immunology"},{"issue":"4","key":"10.1016\/j.imbio.2023.152349_b0075","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1601-5215.2011.00618.x","article-title":"MBL and MASP-2 concentrations in serum and MBL2 promoter polymorphisms are associated to schizophrenia","volume":"24","author":"Foldager","year":"2012","journal-title":"Acta Neuropsychiatrica"},{"key":"10.1016\/j.imbio.2023.152349_b0080","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15096","article-title":"Developmental activities of the complement pathway in migrating neurons","volume":"8","author":"Gorelik","year":"2017","journal-title":"Nature Communications"},{"issue":"4","key":"10.1016\/j.imbio.2023.152349_b0085","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.molimm.2013.05.233","article-title":"Ficolin-2 reveals different analytical and biological properties dependent on different sample handling procedures","volume":"56","author":"Hein","year":"2013","journal-title":"Molecular Immunology"},{"issue":"12","key":"10.1016\/j.imbio.2023.152349_b0090","doi-asserted-by":"crossref","first-page":"6117","DOI":"10.4049\/jimmunol.1302121","article-title":"Heteromeric Complexes of Native Collectin Kidney 1 and Collectin Liver 1 Are Found in the Circulation with MASPs and Activate the Complement System","volume":"191","author":"Henriksen","year":"2013","journal-title":"The Journal of Immunology"},{"key":"10.1016\/j.imbio.2023.152349_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.00201","article-title":"Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D","volume":"11","author":"Holers","year":"2020","journal-title":"Frontiers in Immunology"},{"issue":"5","key":"10.1016\/j.imbio.2023.152349_b0100","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.molimm.2006.04.002","article-title":"Ficolin-2 recognizes DNA and participates in the clearance of dying host cells","volume":"44","author":"Jensen","year":"2007","journal-title":"Molecular Immunology"},{"key":"10.1016\/j.imbio.2023.152349_b0105","series-title":"Collagen-Related Lectins in Innate Immunity","author":"Kilpatrick","year":"2007"},{"issue":"2","key":"10.1016\/j.imbio.2023.152349_b0110","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1128\/IAI.73.2.1052-1060.2005","article-title":"Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules Mannan-binding lectin, L-ficolin, and H-ficolin","volume":"73","author":"Krarup","year":"2005","journal-title":"Infection and Immunity"},{"issue":"1","key":"10.1016\/j.imbio.2023.152349_b0115","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4049\/jimmunol.182.1.456","article-title":"Residue Lys 57 in the Collagen-Like Region of Human L-Ficolin and Its Counterpart Lys 47 in H-Ficolin Play a Key Role in the Interaction with the Mannan-Binding Lectin-Associated Serine Proteases and the Collectin Receptor Calreticulin 1","volume":"182","author":"Lacroix","year":"2009","journal-title":"The Journal of Immunology"},{"issue":"2","key":"10.1016\/j.imbio.2023.152349_b0120","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.4049\/jimmunol.172.2.1198","article-title":"L-Ficolin Specifically Binds to Lipoteichoic Acid, a Cell Wall Constituent of Gram-Positive Bacteria, and Activates the Lectin Pathway of Complement","volume":"172","author":"Lynch","year":"2004","journal-title":"The Journal of Immunology"},{"issue":"46","key":"10.1016\/j.imbio.2023.152349_bib247","doi-asserted-by":"crossref","first-page":"47513","DOI":"10.1074\/jbc.M407161200","article-title":"L-ficolin is a pattern recognition molecule specific for acetyl groups","volume":"279","author":"Krarup","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"24","key":"10.1016\/j.imbio.2023.152349_b0125","doi-asserted-by":"crossref","first-page":"25307","DOI":"10.1074\/jbc.M400701200","article-title":"Human mannose-binding lectin and L-ficolin function as specific pattern recognition proteins in the lectin activation pathway of complement","volume":"279","author":"Ma","year":"2004","journal-title":"Journal of Biological Chemistry"},{"issue":"4","key":"10.1016\/j.imbio.2023.152349_b0130","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s10266-020-00486-z","article-title":"Acute cytotoxic effects of silica microparticles used for coating of plastic blood-collection tubes on human periosteal cells","volume":"108","author":"Masuki","year":"2020","journal-title":"Odontology"},{"issue":"5","key":"10.1016\/j.imbio.2023.152349_b0135","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1074\/jbc.271.5.2448","article-title":"A Novel Human Serum Lectin with Collagen-and Fibrinogen-like Domains That Functions as an Opsonin","volume":"271","author":"Matsushita","year":"1996","journal-title":"Journal of Biological Chemistry"},{"issue":"3","key":"10.1016\/j.imbio.2023.152349_b0140","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.neulet.2006.06.051","article-title":"Increased complement classical and mannan-binding lectin pathway activities in schizophrenia","volume":"404","author":"Mayilyan","year":"2006","journal-title":"Neuroscience Letters"},{"issue":"8","key":"10.1016\/j.imbio.2023.152349_b0145","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.molimm.2005.07.011","article-title":"Heterogeneity of MBL-MASP complexes","volume":"43","author":"Mayilyan","year":"2006","journal-title":"Molecular Immunology"},{"issue":"3","key":"10.1016\/j.imbio.2023.152349_b0150","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1177\/039463200601900313","article-title":"Discrete MBL-MASP complexes show wide inter-individual variability in concentration: data from UK vs Armenian populations","volume":"19","author":"Mayilyan","year":"2006","journal-title":"International Journal of Immunopathology and Pharmacology"},{"issue":"1","key":"10.1016\/j.imbio.2023.152349_b0155","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s12903-021-01497-0","article-title":"A technical note on contamination from PRF tubes containing silica and silicone","volume":"21","author":"Miron","year":"2021","journal-title":"BMC Oral Health"},{"issue":"1\u20132","key":"10.1016\/j.imbio.2023.152349_b0160","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.jim.2003.08.012","article-title":"Levels of mannan-binding lectin-associated serine protease-2 in healthy individuals","volume":"282","author":"M\u00f8ller-Kristensen","year":"2003","journal-title":"Journal of Immunological Methods"},{"issue":"3","key":"10.1016\/j.imbio.2023.152349_b0165","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0920-9964(94)00045-A","article-title":"Immunoglobulin and albumin content of cerebrospinal fluid in schizophrenic patients: relationship to negative symptomatology","volume":"14","author":"Muller","year":"1995","journal-title":"Schizophrenia Research"},{"issue":"3","key":"10.1016\/j.imbio.2023.152349_b0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1006679","article-title":"COLEC10 is mutated in 3MC patients and regulates early craniofacial development","volume":"13","author":"Munye","year":"2017","journal-title":"PLoS Genetics"},{"issue":"9","key":"10.1016\/j.imbio.2023.152349_b0175","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1007\/s00251-006-0142-1","article-title":"Genomic view of the evolution of the complement system","volume":"58","author":"Nonaka","year":"2006","journal-title":"Immunogenetics"},{"issue":"2","key":"10.1016\/j.imbio.2023.152349_b0180","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/jnen\/59.2.137","article-title":"Increase in HLA-DR Immunoreactive Microglia in Frontal and Temporal Cortex of Chronic Schizophrenics","volume":"59","author":"Radewicz","year":"2000","journal-title":"Journal of Neuropathology and Experimental Neurology"},{"issue":"3","key":"10.1016\/j.imbio.2023.152349_b0185","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/ng.757","article-title":"Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome","volume":"43","author":"Rooryck","year":"2011","journal-title":"Nature Genetics"},{"key":"10.1016\/j.imbio.2023.152349_b0190","series-title":"Psychoneuroimmunology","first-page":"563","article-title":"Schizophrenia and Immunity","author":"Rothermundt","year":"2007"},{"issue":"4","key":"10.1016\/j.imbio.2023.152349_b0195","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1006\/brbi.2001.0648","article-title":"Review of immunological and immunopathological findings in schizophrenia","volume":"15","author":"Rothermundt","year":"2001","journal-title":"Brain, Behavior, and Immunity"},{"issue":"3","key":"10.1016\/j.imbio.2023.152349_b0200","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0304-3940(98)00655-7","article-title":"Blood-cerebrospinal fluid barrier impairment as indicator for an immune process in schizophrenia","volume":"253","author":"Schwarz","year":"1998","journal-title":"Neuroscience Letters"},{"issue":"1","key":"10.1016\/j.imbio.2023.152349_b0205","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0006-3223(98)00281-9","article-title":"The Reduced Neuropil Hypothesis: A Circuit Based Model of Schizophrenia","volume":"45","author":"Selemon","year":"1999","journal-title":"Biological Psychiatry"},{"issue":"5","key":"10.1016\/j.imbio.2023.152349_b0210","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ajhg.2010.09.018","article-title":"MASP1 mutations in patients with facial, umbilical, coccygeal, and auditory findings of carnevale, malpuech, OSA, and michels syndromes","volume":"87","author":"Sirmaci","year":"2010","journal-title":"American Journal of Human Genetics"},{"issue":"2","key":"10.1016\/j.imbio.2023.152349_b0215","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1038\/sj.gene.6364373","article-title":"Deficiency of mannan-binding lectin associated serine protease-2 due to missense polymorphisms","volume":"8","author":"Thiel","year":"2007","journal-title":"Genes and Immunity"},{"issue":"3","key":"10.1016\/j.imbio.2023.152349_b0220","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1002\/ajmg.a.30878","article-title":"Michels syndrome, Carnevale syndrome, OSA syndrome, and Malpuech syndrome: Variable expression of a single disorder (3MC syndrome)?","volume":"137A","author":"Titomanlio","year":"2005","journal-title":"American Journal of Medical Genetics"},{"issue":"1","key":"10.1016\/j.imbio.2023.152349_b0225","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/cei.12909","article-title":"Lectin complement pathway proteins in healthy individuals","volume":"188","author":"Troldborg","year":"2017","journal-title":"Clinical and Experimental Immunology"},{"key":"10.1016\/j.imbio.2023.152349_b0230","doi-asserted-by":"crossref","unstructured":"Weinberger, D., Levitt, P., 2011. The neurodevelopmental origins of schizophrenia. In: Weinberger, DR, Harrison, PJ (Eds.), Schizophrenia, 3rd Ed Wiley-Blackwell, pp. 393\u2013412. https:\/\/doi.org\/10.1002\/9781444327298.ch19.","DOI":"10.1002\/9781444327298.ch19"},{"key":"10.1016\/j.imbio.2023.152349_b0235","unstructured":"World Health Organization. (1992). Schedule for Clinical Assessment in Neuropsychiatry. WHO."},{"key":"10.1016\/j.imbio.2023.152349_b0240","unstructured":"World Health Organization. (1997). The Composite International Diagnostic Interview: Core Version 2.1. WHO."},{"issue":"1","key":"10.1016\/j.imbio.2023.152349_b0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000282","article-title":"Local inflammation induces complement crosstalk which amplifies the antimicrobial response","volume":"5","author":"Zhang","year":"2009","journal-title":"PLoS Pathogens"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523000177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523000177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:53:26Z","timestamp":1759251206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298523000177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3]]},"references-count":50,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,3]]}},"alternative-id":["S0171298523000177"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152349","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2023,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"l-ficolin-MASP arm of the complement system in schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152349","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152349"}}