{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:35:04Z","timestamp":1759332904780,"version":"build-2065373602"},"reference-count":45,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81701956","82002097"],"award-info":[{"award-number":["81701956","82002097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.imbio.2023.152374","type":"journal-article","created":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T11:14:22Z","timestamp":1678274062000},"page":"152374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Toll-like receptor 2 deficiency relieves splenic immunosuppression during sepsis"],"prefix":"10.1016","volume":"228","author":[{"given":"Xiaoli","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yi","family":"Qin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaji","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"doi-asserted-by":"crossref","unstructured":"Adib-Conquy, M.and Cavaillon, J. M. 2009. Compensatory anti-inflammatory response syndrome. Thromb Haemost. 101(1): 36-47. doi:09010036 [pii]. PMID: 19132187.","key":"10.1016\/j.imbio.2023.152374_b0005","DOI":"10.1160\/TH08-07-0421"},{"issue":"10","key":"10.1016\/j.imbio.2023.152374_b0010","doi-asserted-by":"crossref","first-page":"4018","DOI":"10.1073\/pnas.0900196106","article-title":"Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis","volume":"106","author":"Alves-Filho","year":"2009","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"21","key":"10.1016\/j.imbio.2023.152374_b0015","first-page":"2063","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N Engl J Med."},{"issue":"23","key":"10.1016\/j.imbio.2023.152374_b0020","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1001\/jama.2011.1829","article-title":"Immunosuppression in patients who die of sepsis and multiple organ failure","volume":"306","author":"Boomer","year":"2011","journal-title":"JAMA."},{"issue":"1","key":"10.1016\/j.imbio.2023.152374_b0025","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4161\/viru.26516","article-title":"The changing immune system in sepsis: is individualized immuno-modulatory therapy the answer?","volume":"5","author":"Boomer","year":"2014","journal-title":"Virulence."},{"issue":"10","key":"10.1016\/j.imbio.2023.152374_b0030","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/s41419-019-2015-1","article-title":"Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis","volume":"10","author":"Cao","year":"2019","journal-title":"Cell Death Dis."},{"issue":"5","key":"10.1016\/j.imbio.2023.152374_b0035","doi-asserted-by":"crossref","first-page":"e37584","DOI":"10.1371\/journal.pone.0037584","article-title":"TLR2, TLR4 and the MYD88 signaling pathway are crucial for neutrophil migration in acute kidney injury induced by sepsis","volume":"7","author":"Castoldi","year":"2012","journal-title":"PLoS One."},{"issue":"6","key":"10.1016\/j.imbio.2023.152374_b0040","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1097\/SHK.0000000000000789","article-title":"The Role of Thioredoxin-1 in Suppression Sepsis Through Inhibiting Mitochondrial-Induced Apoptosis in Spleen","volume":"47","author":"Chen","year":"2017","journal-title":"Shock."},{"issue":"1","key":"10.1016\/j.imbio.2023.152374_b0045","first-page":"443","article-title":"Activation of multiple Toll-like receptors serves different roles in sepsis-induced acute lung injury","volume":"18","author":"Chen","year":"2019","journal-title":"Exp Ther Med."},{"doi-asserted-by":"crossref","unstructured":"Delano, M. J.and Ward, P. A. 2016b. Sepsis-induced immune dysfunction: can immune therapies reduce mortality? J Clin Invest. 126(1): 23-31. doi:82224 [pii] 10.1172\/JCI82224. PMID: 26727230.","key":"10.1016\/j.imbio.2023.152374_b0050","DOI":"10.1172\/JCI82224"},{"issue":"1","key":"10.1016\/j.imbio.2023.152374_b0055","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/imr.12499","article-title":"The immune system's role in sepsis progression, resolution, and long-term outcome","volume":"274","author":"Delano","year":"2016","journal-title":"Immunol Rev."},{"issue":"2","key":"10.1016\/j.imbio.2023.152374_b0060","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/17471060500435662","article-title":"Inflammatory mediators in sepsis: Cytokines, chemokines, adhesion molecules and gases","volume":"2","author":"Devi Ramnath","year":"2006","journal-title":"J Organ Dysfunct."},{"doi-asserted-by":"crossref","unstructured":"Ding, Y., Chung, C. S., Newton, S., Chen, Y., Carlton, S., Albina, J. E. et al. 2004. Polymicrobial sepsis induces divergent effects on splenic and peritoneal dendritic cell function in mice. Shock. 22(2): 137-144. doi:00024382-200408000-00007 [pii]. PMID: 15257086.","key":"10.1016\/j.imbio.2023.152374_b0065","DOI":"10.1097\/01.shk.0000131194.80038.3f"},{"key":"10.1016\/j.imbio.2023.152374_b0070","article-title":"Inflammatory mediators of cytokines and chemokines in sepsis: From bench to bedside","volume":"41(9603271221078871","author":"Doganyigit","year":"2022","journal-title":"Hum Exp Toxicol."},{"issue":"1","key":"10.1016\/j.imbio.2023.152374_b0075","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3109\/10408363.2013.764490","article-title":"Biomarkers of sepsis","volume":"50","author":"Faix","year":"2013","journal-title":"Crit Rev Clin Lab Sci."},{"issue":"4","key":"10.1016\/j.imbio.2023.152374_b0080","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.mcna.2020.02.011","article-title":"Sepsis and Septic Shock - Basics of diagnosis, pathophysiology and clinical decision making","volume":"104","author":"Font","year":"2020","journal-title":"Med Clin North Am."},{"issue":"6","key":"10.1016\/j.imbio.2023.152374_b0085","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1097\/ALN.0000000000000470","article-title":"Importance of Toll-like receptor 2 in mitochondrial dysfunction during polymicrobial sepsis","volume":"121","author":"Gong","year":"2014","journal-title":"Anesthesiology."},{"issue":"6","key":"10.1016\/j.imbio.2023.152374_b0090","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1007\/s10753-016-0428-x","article-title":"Reduced Expression of SARM in Mouse Spleen during Polymicrobial Sepsis","volume":"39","author":"Gong","year":"2016","journal-title":"Inflammation."},{"key":"10.1016\/j.imbio.2023.152374_b0095","article-title":"Sepsis: pathophysiology and clinical management","volume":"353(i1585","author":"Gotts","year":"2016","journal-title":"BMJ."},{"key":"10.1016\/j.imbio.2023.152374_b0100","doi-asserted-by":"crossref","first-page":"106359","DOI":"10.1016\/j.intimp.2020.106359","article-title":"Cholinergic leukocytes in sepsis and at the neuroimmune junction in the spleen","volume":"81","author":"Hoover","year":"2020","journal-title":"Int Immunopharmacol."},{"doi-asserted-by":"crossref","unstructured":"Huston, J. M., Wang, H., Ochani, M., Ochani, K., Rosas-Ballina, M., Gallowitsch-Puerta, M. et al. 2008. Splenectomy protects against sepsis lethality and reduces serum HMGB1 levels. J Immunol. 181(5): 3535-3539. doi:10.4049\/jimmunol.181.5.3535. PMID: 18714026.","key":"10.1016\/j.imbio.2023.152374_b0105","DOI":"10.4049\/jimmunol.181.5.3535"},{"issue":"15","key":"10.1016\/j.imbio.2023.152374_b0110","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1001\/archinte.167.15.1655","article-title":"Understanding the inflammatory cytokine response in pneumonia and sepsis: results of the Genetic and Inflammatory Markers of Sepsis (GenIMS) Study","volume":"167","author":"Kellum","year":"2007","journal-title":"Arch Intern Med."},{"issue":"1","key":"10.1016\/j.imbio.2023.152374_b0115","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/138945006775270169","article-title":"Bacterial sepsis and chemokines","volume":"7","author":"Kobayashi","year":"2006","journal-title":"Curr Drug Targets."},{"issue":"Pt B","key":"10.1016\/j.imbio.2023.152374_b0120","article-title":"Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets","volume":"89","author":"Kumar","year":"2020","journal-title":"Int Immunopharmacol."},{"issue":"5","key":"10.1016\/j.imbio.2023.152374_b0125","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/j.clinthera.2016.04.002","article-title":"Purinergic Signaling and the Immune Response in Sepsis: A Review","volume":"38","author":"Ledderose","year":"2016","journal-title":"Clin Ther."},{"issue":"4","key":"10.1016\/j.imbio.2023.152374_b0130","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods."},{"doi-asserted-by":"crossref","unstructured":"Lomas-Neira, J. L., Chung, C. S., Grutkoski, P. S., Miller, E. J.and Ayala, A. 2004. CXCR2 inhibition suppresses hemorrhage-induced priming for acute lung injury in mice. J Leukoc Biol. 76(1): 58-64. doi:10.1189\/jlb.1103541 jlb.1103541 [pii]. PMID: 15123771.","key":"10.1016\/j.imbio.2023.152374_b0135","DOI":"10.1189\/jlb.1103541"},{"issue":"2","key":"10.1016\/j.imbio.2023.152374_b0140","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1006\/exmp.1999.2296","article-title":"Endogenous MCP-1 influences systemic cytokine balance in a murine model of acute septic peritonitis","volume":"68","author":"Matsukawa","year":"2000","journal-title":"Exp Mol Pathol."},{"issue":"12","key":"10.1016\/j.imbio.2023.152374_b0145","doi-asserted-by":"crossref","first-page":"5651","DOI":"10.1128\/IAI.00238-09","article-title":"Toll-like receptors 2 and 4 contribute to sepsis-induced depletion of spleen dendritic cells","volume":"77","author":"P\u00e8ne","year":"2009","journal-title":"Infect Immun."},{"doi-asserted-by":"crossref","unstructured":"Pene, F., Grimaldi, D., Zuber, B., Sauneuf, B., Rousseau, C., El Hachem, C. et al. 2012. Toll-like receptor 2 deficiency increases resistance to Pseudomonas aeruginosa pneumonia in the setting of sepsis-induced immune dysfunction. J Infect Dis. 206(6): 932-942. doi:10.1093\/infdis\/jis438. PMID: 22782952.","key":"10.1016\/j.imbio.2023.152374_b0150","DOI":"10.1093\/infdis\/jis438"},{"doi-asserted-by":"crossref","unstructured":"Rittirsch, D., Flierl, M. A.and Ward, P. A. 2008. Harmful molecular mechanisms in sepsis. Nat Rev Immunol. 8(10): 776-787. doi:nri2402 [pii] 10.1038\/nri2402. PMID: 18802444.","key":"10.1016\/j.imbio.2023.152374_b0155","DOI":"10.1038\/nri2402"},{"issue":"6","key":"10.1016\/j.imbio.2023.152374_b0160","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat Protoc."},{"issue":"8","key":"10.1016\/j.imbio.2023.152374_b0165","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3)","volume":"315","author":"Singer","year":"2016","journal-title":"JAMA."},{"issue":"4","key":"10.1016\/j.imbio.2023.152374_b0170","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/S1074-7613(00)80119-3","article-title":"Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components","volume":"11","author":"Takeuchi","year":"1999","journal-title":"Immunity."},{"issue":"7","key":"10.1016\/j.imbio.2023.152374_b0175","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat Rev Immunol."},{"issue":"2","key":"10.1016\/j.imbio.2023.152374_b0180","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrneph.2017.165","article-title":"Advances in the understanding and treatment of sepsis-induced immunosuppression","volume":"14","author":"Venet","year":"2018","journal-title":"Nat Rev Nephrol."},{"doi-asserted-by":"crossref","unstructured":"Wesche, D. E., Lomas-Neira, J. L., Perl, M., Chung, C. S.and Ayala, A. 2005. Leukocyte apoptosis and its significance in sepsis and shock. J Leukoc Biol. 78(2): 325-337. doi:jlb.0105017 [pii] 10.1189\/jlb.0105017. PMID: 15817707.","key":"10.1016\/j.imbio.2023.152374_b0185","DOI":"10.1189\/jlb.0105017"},{"doi-asserted-by":"crossref","unstructured":"Wesche-Soldato, D. E., Chung, C. S., Lomas-Neira, J., Doughty, L. A., Gregory, S. H.and Ayala, A. 2005. In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood. 106(7): 2295-2301. doi:2004-10-4086 [pii] 10.1182\/blood-2004-10-4086. PMID: 15941915.","key":"10.1016\/j.imbio.2023.152374_b0190","DOI":"10.1182\/blood-2004-10-4086"},{"issue":"4","key":"10.1016\/j.imbio.2023.152374_b0195","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2174\/138945007780362764","article-title":"The apoptotic pathway as a therapeutic target in sepsis","volume":"8","author":"Wesche-Soldato","year":"2007","journal-title":"Curr Drug Targets."},{"doi-asserted-by":"crossref","unstructured":"Wichterman, K. A., Baue, A. E.and Chaudry, I. H. 1980. Sepsis and septic shock--a review of laboratory models and a proposal. J Surg Res. 29(2): 189-201. doi:0022-4804(80)90037-2 [pii]. PMID: 6997619.","key":"10.1016\/j.imbio.2023.152374_b0200","DOI":"10.1016\/0022-4804(80)90037-2"},{"issue":"1","key":"10.1016\/j.imbio.2023.152374_b0205","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1055\/s-0035-1570356","article-title":"Balance between Hyperinflammation and Immunosuppression in Sepsis","volume":"37","author":"Yadav","year":"2016","journal-title":"Semin Respir Crit Care Med."},{"doi-asserted-by":"crossref","unstructured":"Zou, L., Feng, Y., Li, Y., Zhang, M., Chen, C., Cai, J. et al. 2013. Complement factor B is the downstream effector of TLRs and plays an important role in a mouse model of severe sepsis. J Immunol. 191(11): 5625-5635. doi:10.4049\/jimmunol.1301903. PMID: 24154627.","key":"10.1016\/j.imbio.2023.152374_b0210","DOI":"10.4049\/jimmunol.1301903"},{"issue":"5","key":"10.1016\/j.imbio.2023.152374_b0215","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1097\/CCM.0b013e3181d99e67","article-title":"Toll-like receptor 2 plays a critical role in cardiac dysfunction during polymicrobial sepsis","volume":"38","author":"Zou","year":"2010","journal-title":"Crit Care Med."},{"issue":"4","key":"10.1016\/j.imbio.2023.152374_b0220","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/SHK.0b013e3182279868","article-title":"Nonhematopoietic toll-like receptor 2 contributes to neutrophil and cardiac function impairment during polymicrobial sepsis","volume":"36","author":"Zou","year":"2011","journal-title":"Shock."},{"issue":"11","key":"10.1016\/j.imbio.2023.152374_b0225","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1097\/CCM.0000000000001254","article-title":"Imaging Lymphoid Cell Death In Vivo During Polymicrobial Sepsis","volume":"43","author":"Zou","year":"2015","journal-title":"Crit Care Med."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523000426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523000426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:51:04Z","timestamp":1759251064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298523000426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":45,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0171298523000426"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152374","relation":{},"ISSN":["0171-2985"],"issn-type":[{"type":"print","value":"0171-2985"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Toll-like receptor 2 deficiency relieves splenic immunosuppression during sepsis","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152374","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152374"}}