{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,15]],"date-time":"2026-03-15T08:48:02Z","timestamp":1773564482349,"version":"3.50.1"},"reference-count":59,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006668","name":"FonCyT","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006668","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010677","name":"Instituto Nacional de Tecnolog\u00eda Agropecuaria","doi-asserted-by":"publisher","award":["PNSA 1115052"],"award-info":[{"award-number":["PNSA 1115052"]}],"id":[{"id":"10.13039\/501100010677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["2014-866"],"award-info":[{"award-number":["2014-866"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2013-406"],"award-info":[{"award-number":["PICT 2013-406"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.imbio.2023.152375","type":"journal-article","created":{"date-parts":[[2023,3,9]],"date-time":"2023-03-09T11:25:58Z","timestamp":1678361158000},"page":"152375","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Cytokine expression profile of B. melitensis-infected goat monocyte-derived macrophages"],"prefix":"10.1016","volume":"228","author":[{"given":"Estefan\u00eda","family":"Maurizio","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8401-4658","authenticated-orcid":false,"given":"Ursula A.","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos D.","family":"Trangoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-2521","authenticated-orcid":false,"given":"Carlos A.","family":"Rossetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.imbio.2023.152375_b0005","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1093\/infdis\/173.4.971","article-title":"Differential regulation of inducible nitric oxide synthase production in bovine and caprine macrophages","volume":"173","author":"Adler","year":"1996","journal-title":"J. Inf. Dis."},{"issue":"10","key":"10.1016\/j.imbio.2023.152375_b0010","doi-asserted-by":"crossref","first-page":"e109283","DOI":"10.1371\/journal.pone.0109283","article-title":"The Effect of C. burnetii infection on the cytokine response of PBMCs from pregnant goats","volume":"9","author":"Ammerdorffer","year":"2014","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.imbio.2023.152375_b0015","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1615\/CritRevImmunol.v26.i5.30","article-title":"Host immune responses to the intracellular bacteria Brucella: Does the bacteria instruct the host to facilitate chronic infection?","volume":"26","author":"Baldwin","year":"2006","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0020","doi-asserted-by":"crossref","first-page":"6411","DOI":"10.1128\/IAI.71.11.6411-6419.2003","article-title":"Revaccination of neonatal calves with Mycobacterium bovis BCG reduces the level of protection against bovine tuberculosis induced by a single vaccination","volume":"71","author":"Buddle","year":"2003","journal-title":"Infect Immun."},{"key":"10.1016\/j.imbio.2023.152375_b0025","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2527\/jas1942.12106x","article-title":"Genetic resistance to brucellosis in swine","volume":"1","author":"Cameron","year":"1942","journal-title":"J. Anim. Sci."},{"issue":"7","key":"10.1016\/j.imbio.2023.152375_b0030","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1002\/eji.201848016","article-title":"Brucella abortus nitric oxide metabolite regulates inflammasome activation and IL-1\u03b2 secretion in murine macrophages","volume":"49","author":"Campos","year":"2019","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0035","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.vetmic.2011.02.025","article-title":"Alternative activation modifies macrophage resistance to Mycobacterium bovis","volume":"151","author":"Castillo-Vel\u00e1zquez","year":"2011","journal-title":"Vet Microbiol."},{"issue":"9","key":"10.1016\/j.imbio.2023.152375_b0040","doi-asserted-by":"crossref","first-page":"e74729","DOI":"10.1371\/journal.pone.0074729","article-title":"Lack of endogenous IL-10 enhances production of proinflammatory cytokines and leads to Brucella abortus clearance in Mice","volume":"8","author":"Corsetti","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2023.152375_b0045","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.3181\/0904-RM-124","article-title":"Brucella melitensis, B. neotomae and B. ovis elicit common and distinctive macrophage defense transcriptional responses","volume":"234","author":"Covert","year":"2009","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.imbio.2023.152375_b0050","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1186\/1297-9716-44-83","article-title":"Small ruminant macrophage polarization may play a pivotal role on lentiviral infection","volume":"44","author":"Crespo","year":"2013","journal-title":"Vet. Res."},{"key":"10.1016\/j.imbio.2023.152375_b0055","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.micinf.2009.08.001","article-title":"Transforming growth factor \u03b2 production correlates with depressed lymphocytes function in humans with chronic brucellosis","volume":"11","author":"Elfaki","year":"2009","journal-title":"Microbes Infect."},{"key":"10.1016\/j.imbio.2023.152375_b0060","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1128\/IAI.71.3.1125-1133.2003","article-title":"Microarray analysis of mRNA levels from RAW264.7 macrophages infected with Brucella abortus","volume":"71","author":"Eskra","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152375_b0065","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1574-695X.1996.tb00136.x","article-title":"Comparison of T cell cytokines in resistant and susceptible mice infected with virulent Brucella abortus strain 2308","volume":"16","author":"Fernandes","year":"1996","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.imbio.2023.152375_b0070","doi-asserted-by":"crossref","unstructured":"Giambartolomei, G.H., Zwerdling, A., Cassataro, J., Bruno, L., Fossati, C.A., Philipp, M.T., 2004. Lipoproteins, not lipopolysaccharide, are the key mediators of the proinflammatory response elicited by heat-killed Brucella abortus. J. Immunol. 173, 4635-4642. doi:10.4049\/jimmunol.173.7.4635.","DOI":"10.4049\/jimmunol.173.7.4635"},{"key":"10.1016\/j.imbio.2023.152375_b0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1093\/infdis\/jis310","article-title":"B lymphocytes provide an infection niche for intracellular bacterium Brucella abortus","volume":"206","author":"Goenka","year":"2012","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.imbio.2023.152375_b0080","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1128\/IAI.66.4.1309-1316.1998","article-title":"Expression and bactericidal activity of nitric oxide synthase in Brucella suis-infected murine macrophages","volume":"66","author":"Gross","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152375_b0085","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1172\/JCI119598","article-title":"Interferon gamma and interleukin 4 stimulate prolonged expression of inducible nitric oxide synthase in human airway epithelium through synthesis of soluble mediators","volume":"100","author":"Guo","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"6","key":"10.1016\/j.imbio.2023.152375_b0090","doi-asserted-by":"crossref","first-page":"3925","DOI":"10.1016\/j.ygeno.2020.06.050","article-title":"Association of TNF rs668920841 and INRA111 polymorphisms with caprine brucellosis: A case-control study of candidate genes involved in innate immunity","volume":"112","author":"Hasenauer","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.imbio.2023.152375_b0095","doi-asserted-by":"crossref","first-page":"5035","DOI":"10.1128\/IAI.01998-05","article-title":"Brucella melitensis triggers time-dependent modulation of apoptosis and down-regulation of mitochondrion-associated gene expression in mouse macrophages","volume":"74","author":"He","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152375_b0100","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.vetmic.2019.04.019","article-title":"Interleukin 1 alpha (IL-1\u03b1) restricts Brucella abortus 544 survival through promoting lysosomal-mediated killing and NO production in macrophages","volume":"232","author":"Hop","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.imbio.2023.152375_b0105","article-title":"Peculiarities of the prevalence of polymorphism (C-589T) of the IL-4 gene and its relationship with serum IL-4 level in patients with acute brucellosis in the Republic of Azerbaijan","author":"Huseynov","year":"2019","journal-title":"Georgian Med. News"},{"key":"10.1016\/j.imbio.2023.152375_b0110","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.vetimm.2014.05.007","article-title":"Polymorphisms at the 3\u2019 untranslated region of SLC11A1 gene are associated with protection to Brucella infection in goats","volume":"160","author":"Iacoboni","year":"2014","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.imbio.2023.152375_b0115","first-page":"2063","article-title":"Brucella phage lysate bacterin induces elevated TLRs and cytokines response in murine model","volume":"10","author":"Jain","year":"2016","journal-title":"J. Pure Appl. Microbiol."},{"key":"10.1016\/j.imbio.2023.152375_b0120","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.clim.2004.07.010","article-title":"Cellular bioterrorism: How Brucella corrupts macrophage physiology to promote invasion and proliferation","volume":"114","author":"Jimenez De Bagues","year":"2005","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0125","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2017.02013","article-title":"Brucella downregulates tumor necrosis factor-\u03b1 to promote intracellular survival via Omp25 regulation of different microRNAs in porcine and murine macrophages","volume":"8","author":"Luo","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0130","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.vetimm.2012.12.001","article-title":"Monocyte-derived macrophages from Zebu (Bos taurus indicus) are more efficient to control Brucella abortus intracellular survival than macrophages from European cattle (Bos taurus taurus)","volume":"151","author":"Macedo","year":"2013","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.imbio.2023.152375_b0135","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s00281-016-0581-1","article-title":"The role of NLRP3 and AIM2 in inflammasome activation during Brucella abortus infection","volume":"39","author":"Marim","year":"2017","journal-title":"Semin. Immunopathol."},{"issue":"1","key":"10.1016\/j.imbio.2023.152375_b0140","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1111\/j.1600-065X.2010.00982.x","article-title":"An evolutionary strategy for a stealthy intracellular Brucella pathogen","volume":"240","author":"Martirosyan","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.imbio.2023.152375_b0145","doi-asserted-by":"crossref","first-page":"110223","DOI":"10.1016\/j.vetimm.2021.110223","article-title":"Characterization of innate immune response to Brucella melitensis infection in goats with permissive or restrictive phenotype for Brucella intramacrophagic growth","volume":"234","author":"Maurizio","year":"2021","journal-title":"Veterinary Immunol. Immunopathol."},{"key":"10.1016\/j.imbio.2023.152375_b0150","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.3389\/fimmu.2019.02181","article-title":"Bacterial RNA contributes to the down-modulation of MHC-II expression on monocytes\/macrophages diminishing CD4+ T Cell responses","volume":"10","author":"Milillo","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0155","doi-asserted-by":"crossref","unstructured":"Mills, C.D., Kincaid, K., Alt, J.M., Heilman, M.J., Hill, A.M., 2000. M-1\/M-2 Macrophages and the Th1\/Th2 paradigm. J. Immunol. 164, 6166-6173. doi:10.4049\/jimmunol.164.12.6166.","DOI":"10.4049\/jimmunol.164.12.6166"},{"key":"10.1016\/j.imbio.2023.152375_b0160","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1146\/annurev.immunol.19.1.683","article-title":"Interleukin-10 and the interleukin-10 receptor","volume":"19","author":"Moore","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0165","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3389\/fimmu.2014.00603","article-title":"TH1\/TH2 paradigm extended: macrophage polarization as an unappreciated pathogen-driven escape mechanism?","volume":"5","author":"Muraille","year":"2014","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0170","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1046\/j.1365-2567.2001.01258.x","article-title":"Interferon-\u03b3 is crucial for surviving a Brucella abortus infection in both resistant C57BL\/6 and susceptible BALB\/c mice","volume":"103","author":"Murphy","year":"2001","journal-title":"Immunology"},{"key":"10.1016\/j.imbio.2023.152375_b0180","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1128\/CDLI.9.2.491-492.2002","article-title":"Effect of Exogenous interleukin-18 (IL-18) and IL-12 in the course of Brucella abortus 2308 infection in mice","volume":"9","author":"Pasquali","year":"2002","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0185","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.cytogfr.2016.07.003","article-title":"Opposing roles of IL-10 in acute bacterial infection","volume":"32","author":"Pe\u00f1aloza","year":"2016","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.imbio.2023.152375_b0190","doi-asserted-by":"crossref","first-page":"45e","DOI":"10.1093\/nar\/29.9.e45","article-title":"A new mathematical model for relative quantification in real-time RT-PCR","volume":"29","author":"Pfaffl","year":"2001","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.imbio.2023.152375_b0195","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.imbio.2023.152375_b0200","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0304-3940(02)01423-4","article-title":"Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data","volume":"339","author":"Ramakers","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.imbio.2023.152375_b0205","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.it.2004.06.005","article-title":"IL-4 in tuberculosis: implications for vaccine design","volume":"25","author":"Rook","year":"2004","journal-title":"Trends Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0210","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.rvsc.2010.09.002","article-title":"Comparative analysis of the early transcriptome of Brucella abortus - Infected monocyte-derived macrophages from cattle naturally resistant or susceptible to brucellosis","volume":"91","author":"Rossetti","year":"2011","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.imbio.2023.152375_b0225","series-title":"Brucellosis International Research Conference","article-title":"TIRAP exon 5 polymorphisms influence the outcome of B. melitensis infection in goats (Abstract)","author":"Rossi","year":"2022"},{"key":"10.1016\/j.imbio.2023.152375_b0215","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.vetmic.2017.06.001","article-title":"A haplotype at intron 8 of PTPRT gene is associated with resistance to Brucella infection in Argentinian creole goats","volume":"207","author":"Rossi","year":"2017","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.imbio.2023.152375_b0220","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cyto.2018.11.024","article-title":"Association of an IRF3 putative functional uORF variant with resistance to Brucella infection: a candidate gene based analysis of InDel polymorphisms in goats","volume":"115","author":"Rossi","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.imbio.2023.152375_b0230","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nri2711","article-title":"The regulation of IL-10 production by immune cells","volume":"10","author":"Saraiva","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0235","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1016\/j.celrep.2016.04.001","article-title":"TNF-mediated restriction of Arginase 1 expression in myeloid cells triggers Type 2 NO Synthase activity at the site of infection","volume":"15","author":"Schleicher","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.imbio.2023.152375_b0240","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.2147\/IDR.S341331","article-title":"Serum levels of seven general cytokines in acute brucellosis before and after treatment","volume":"14","author":"Tang","year":"2021","journal-title":"Infect. Drug Resist."},{"key":"10.1016\/j.imbio.2023.152375_b0245","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.iy.13.040195.001343","article-title":"Interleukin-12: a proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity","volume":"13","author":"Trinchieri","year":"1995","journal-title":"Annu. Rev. Immunol."},{"issue":"9","key":"10.1016\/j.imbio.2023.152375_b0250","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.3389\/fimmu.2018.01000","article-title":"Platelets promote brucella abortus monocyte invasion by establishing complexes with monocytes","volume":"7","author":"Trotta","year":"2018","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.imbio.2023.152375_b0255","doi-asserted-by":"crossref","first-page":"4271","DOI":"10.1128\/IAI.00761-12","article-title":"Crucial role of gamma Interferon-producing CD4+Th1 cells but dispensable function of CD8+T cell, B cell, Th2, and Th17 responses in the control of Brucella melitensis infection in mice","volume":"80","author":"Vitry","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152375_b0260","doi-asserted-by":"crossref","unstructured":"Wahl, L.M., Wahl, S.M., Smythies, L.E., Smith, P.D., 2006. Isolation of Human Monocyte Populations, in: Current Protocols in Immunology. John Wiley & Sons, Inc. doi:10.1002\/0471142735.im0706as70.","DOI":"10.1002\/0471142735.im0706as70"},{"key":"10.1016\/j.imbio.2023.152375_b0265","article-title":"The molecular basis of IL-10 function: From receptor structure to the onset of signaling","author":"Walter","year":"2014","journal-title":"Curr. Top. Microbiol. Immunol."},{"key":"10.1016\/j.imbio.2023.152375_b0270","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.rvsc.2022.02.006","article-title":"Brucella induces M1 to M2 polarization of macrophages through STAT6 signaling pathway to promote bacterial intracellular survival","volume":"145","author":"Wang","year":"2022","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.imbio.2023.152375_b0275","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S1472-9792(03)00055-6","article-title":"Vaccination with DNA vaccines encoding MPB70 or MPB83 or a MPB70 DNA prime-protein boost does not protect cattle against bovine tuberculosis","volume":"83","author":"Wedlock","year":"2003","journal-title":"Tuberculosis"},{"key":"10.1016\/j.imbio.2023.152375_b0280","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.chom.2013.07.009","article-title":"PPAR\u03b3-mediated increase in glucose availability sustains chronic Brucella abortus infection in alternatively activated macrophages","volume":"14","author":"Xavier","year":"2013","journal-title":"Cell Host Microbe"},{"issue":"6","key":"10.1016\/j.imbio.2023.152375_b0285","doi-asserted-by":"crossref","first-page":"e1003454","DOI":"10.1371\/journal.ppat.1003454","article-title":"CD4+ T cell-derived IL-10 promotes Brucella abortus persistence via modulation of macrophage function","volume":"9","author":"Xavier","year":"2013","journal-title":"PLoS Pathog."},{"issue":"4","key":"10.1016\/j.imbio.2023.152375_b0290","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1128\/iai.63.4.1387-1390.1995","article-title":"Endogenous interleukin-12 is involved in resistance to Brucella abortus infection","volume":"63","author":"Zhan","year":"1995","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152375_b0295","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1128\/iai.64.7.2782-2786.1996","article-title":"Tumor necrosis factor alpha and interleukin-12 contribute to resistance to the intracellular bacterium Brucella abortus by different mechanisms","volume":"64","author":"Zhan","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152375_b0300","doi-asserted-by":"crossref","first-page":"52294","DOI":"10.18632\/oncotarget.10561","article-title":"TGF-\u03b2 induces M2-like macrophage polarization via SNAIL mediated suppression of a pro-inflammatory phenotype","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523000438?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523000438?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:51:11Z","timestamp":1759251071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298523000438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":59,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["S0171298523000438"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152375","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytokine expression profile of B. melitensis-infected goat monocyte-derived macrophages","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152375","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152375"}}