{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T23:06:48Z","timestamp":1792364808569,"version":"4.4.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,20]],"date-time":"2023-07-20T00:00:00Z","timestamp":1689811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.imbio.2023.152708","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T22:08:42Z","timestamp":1689804522000},"page":"152708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["PD1 is transcriptionally regulated by LEF1 in mature T cells"],"prefix":"10.1016","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8113-7137","authenticated-orcid":false,"given":"Pin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lanming","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samiullah","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2023.152708_b0005","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.4049\/jimmunol.167.3.1245","article-title":"CD4+CD25high regulatory cells in human peripheral blood","volume":"167","author":"Baecher-Allan","year":"2001","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0010","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.addr.2003.10.030","article-title":"Lectin-mediated drug targeting: history and applications","volume":"56","author":"Bies","year":"2004","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.imbio.2023.152708_b0015","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1002\/hep.21509","article-title":"Concanavalin A induces autophagy in hepatoma cells and has a therapeutic effect in a murine in situ hepatoma model","volume":"45","author":"Chang","year":"2007","journal-title":"Hepatology"},{"issue":"9","key":"10.1016\/j.imbio.2023.152708_b0020","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1002\/eji.201344423","article-title":"PD-1 regulates extrathymic regulatory T-cell differentiation","volume":"44","author":"Chen","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0025","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1038\/ni.3226","article-title":"LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6","volume":"16","author":"Choi","year":"2015","journal-title":"Nat Immunol"},{"key":"10.1016\/j.imbio.2023.152708_b0030","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1002\/eji.201444688","article-title":"PD-1 is not required for natural or peripherally induced regulatory T cells: Severe autoimmunity despite normal production of regulatory T cells","volume":"44","author":"Ellestad","year":"2014","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0035","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/hep.21498","article-title":"IL-10, regulatory T cells, and Kupffer cells mediate tolerance in concanavalin A\u2013induced liver injury in mice","volume":"45","author":"Erhardt","year":"2007","journal-title":"Hepatology"},{"issue":"7","key":"10.1016\/j.imbio.2023.152708_b0040","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1084\/jem.192.7.1027","article-title":"Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation","volume":"192","author":"Freeman","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.imbio.2023.152708_b0045","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1177\/0023677215572841","article-title":"The concanavalin A model of acute hepatitis in mice","volume":"49","author":"Heymann","year":"2015","journal-title":"Lab. Anim"},{"key":"10.1016\/j.imbio.2023.152708_b0050","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2567.2008.02854.x","article-title":"Lymphoid enhancer factor interacts with GATA-3 and controls its function in T helper type 2 cells","volume":"125","author":"Hossain","year":"2008","journal-title":"Immunology"},{"key":"10.1016\/j.imbio.2023.152708_b0055","first-page":"291","article-title":"Molecular cloning and expression analysis of bovine programmed death-1","volume":"54","author":"Ikebuchi","year":"2010","journal-title":"Microbiol. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0060","doi-asserted-by":"crossref","first-page":"3887","DOI":"10.1002\/j.1460-2075.1992.tb05481.x","article-title":"Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death","volume":"11","author":"Ishida","year":"1992","journal-title":"EMBO J."},{"key":"10.1016\/j.imbio.2023.152708_b0065","doi-asserted-by":"crossref","first-page":"14733","DOI":"10.1073\/pnas.1009731107","article-title":"Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection","volume":"107","author":"Jin","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imbio.2023.152708_b0070","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/0165-2478(91)90198-J","article-title":"Mechanisms of T lymphocyte activation","volume":"29","author":"Kay","year":"1991","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imbio.2023.152708_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.849922","article-title":"Transcriptome profiling of porcine na\u00efve, intermediate and terminally differentiated CD8(+) T cells","volume":"13","author":"Lagumdzic","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0080","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1002\/eji.201242445","article-title":"The Wnt inhibitor secreted Frizzled-Related Protein 1 (sFRP1) promotes human Th17 differentiation","volume":"42","author":"Lee","year":"2012","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0085","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/925135","article-title":"CD4T cells: differentiation and functions","volume":"2012","author":"Luckheeram","year":"2012","journal-title":"Clin Dev Immunol"},{"key":"10.1016\/j.imbio.2023.152708_b0090","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0968-0004(03)00091-4","article-title":"The \u2018Shp'ing news: SH2 domain-containing tyrosine phosphatases in cell signaling","volume":"28","author":"Neel","year":"2003","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.imbio.2023.152708_b0095","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1038\/s41590-021-00987-1","article-title":"TCF-1 controls T(reg) cell functions that regulate inflammation, CD8(+) T cell cytotoxicity and severity of colon cancer","volume":"22","author":"Osman","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0100","doi-asserted-by":"crossref","DOI":"10.1126\/scisignal.2002796","article-title":"Selective effects of PD-1 on Akt and Ras pathways regulate molecular components of the cell cycle and inhibit T cell proliferation","volume":"5","author":"Patsoukis","year":"2012","journal-title":"Sci. Signal."},{"key":"10.1016\/j.imbio.2023.152708_b0105","doi-asserted-by":"crossref","first-page":"4305","DOI":"10.4161\/cc.22135","article-title":"PD-1 inhibits T cell proliferation by upregulating p27 and p15 and suppressing Cdc25A","volume":"11","author":"Patsoukis","year":"2012","journal-title":"Cell Cycle"},{"key":"10.1016\/j.imbio.2023.152708_b0110","doi-asserted-by":"crossref","first-page":"3091","DOI":"10.1128\/MCB.00319-13","article-title":"PD-1 increases PTEN phosphatase activity while decreasing PTEN protein stability by inhibiting casein kinase 2","volume":"33","author":"Patsoukis","year":"2013","journal-title":"Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.imbio.2023.152708_b0115","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1038\/s41590-022-01170-w","article-title":"PD-L1\u2013PD-1 interactions limit effector regulatory T cell populations at homeostasis and during infection","volume":"23","author":"Perry","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0120","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.it.2019.10.006","article-title":"Control of lymphocyte fate, infection, and tumor immunity by TCF-1","volume":"40","author":"Raghu","year":"2019","journal-title":"Trends Immunol."},{"issue":"7","key":"10.1016\/j.imbio.2023.152708_b0125","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/ni.2897","article-title":"TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4(+) T cell fate and interact with Runx3 to silence Cd4 in CD8(+) T cells","volume":"15","author":"Steinke","year":"2014","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0130","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1074\/jbc.M009134200","article-title":"The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus: implications for PTEN stability to proteasome-mediated degradation","volume":"276","author":"Torres","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2023.152708_b0135","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/stem.5530130305","article-title":"Life span of naive and memory t cells","volume":"13","author":"Tough","year":"1995","journal-title":"Stem Cells"},{"issue":"1-2","key":"10.1016\/j.imbio.2023.152708_b0140","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0022-1759(03)00010-3","article-title":"T cell stimulation and expansion using anti-CD3\/CD28 beads","volume":"275","author":"Trickett","year":"2003","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.imbio.2023.152708_b0145","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.immuni.2013.07.019","article-title":"Canonical Wnt signaling negatively modulates regulatory T cell function","volume":"39","author":"Van Loosdregt","year":"2013","journal-title":"Immunity"},{"key":"10.1016\/j.imbio.2023.152708_b0150","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1007\/s00018-009-0026-2","article-title":"The development and function of regulatory T cells","volume":"66","author":"Workman","year":"2009","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.imbio.2023.152708_b0155","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1038\/ni.3456","article-title":"Tcf1 and Lef1 transcription factors establish CD8(+) T cell identity through intrinsic HDAC activity","volume":"17","author":"Xing","year":"2016","journal-title":"Nat Immunol"},{"issue":"4","key":"10.1016\/j.imbio.2023.152708_b0160","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1084\/jem.20182010","article-title":"Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells","volume":"216","author":"Xing","year":"2019","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2023.152708_b0165","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1111\/j.1749-6632.2011.06302.x","article-title":"Regulation of mature T cell responses by the Wnt signaling pathway","volume":"1247","author":"Xue","year":"2012","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.imbio.2023.152708_b0170","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1016\/j.celrep.2019.05.061","article-title":"TCF1 and LEF1 control Treg competitive survival and Tfr development to prevent autoimmune diseases","volume":"27","author":"Yang","year":"2019","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.imbio.2023.152708_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.110079","article-title":"CD19-CAR T cells undergo exhaustion DNA methylation programming in patients with acute lymphoblastic leukemia","volume":"37","author":"Zebley","year":"2021","journal-title":"Cell Rep."},{"key":"10.1016\/j.imbio.2023.152708_b0180","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41577-021-00563-6","article-title":"TCF1 in T cell immunity: a broadened frontier","volume":"22","author":"Zhao","year":"2022","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2023.152708_b0185","doi-asserted-by":"crossref","first-page":"3566","DOI":"10.1039\/C6FO00667A","article-title":"Immunostimulatory activity of glycopeptides from Paecilomyces sinensis under normal and cyclophosphamide induced immunosuppressive conditions in mice models","volume":"7","author":"Zhu","year":"2016","journal-title":"Food Funct."},{"issue":"4","key":"10.1016\/j.imbio.2023.152708_b0190","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1084\/jem.20121416","article-title":"PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis","volume":"210","author":"Zinselmeyer","year":"2013","journal-title":"J. Exp. Med."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523045102?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523045102?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:51:51Z","timestamp":1759251111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298523045102"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0171298523045102"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152708","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.03.01.530714","asserted-by":"object"}]},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PD1 is transcriptionally regulated by LEF1 in mature T cells","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"152708"}}