{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T15:40:41Z","timestamp":1783438841865,"version":"3.54.6"},"reference-count":60,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013804","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872959"],"award-info":[{"award-number":["31872959"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102425"],"award-info":[{"award-number":["82102425"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2021SCU12077"],"award-info":[{"award-number":["2021SCU12077"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.imbio.2023.152725","type":"journal-article","created":{"date-parts":[[2023,8,6]],"date-time":"2023-08-06T08:03:32Z","timestamp":1691309012000},"page":"152725","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["TLR-2 agonist Pam3CSK4 has no therapeutic effect on visceral leishmaniasis in BALB\/c mice and may enhance the pathogenesis of the disease"],"prefix":"10.1016","volume":"228","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-7464","authenticated-orcid":false,"given":"Xuechun","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6511-2191","authenticated-orcid":false,"given":"Jinlei","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruanyan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shulan","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuying","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4809-7771","authenticated-orcid":false,"given":"Zheying","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiwan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dali","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2023.152725_b0005","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12910","article-title":"Paradoxical immune response in leishmaniasis: The role of toll-like receptors in disease progression","volume":"44","author":"Bamigbola","year":"2022","journal-title":"Parasite Immunol."},{"issue":"10","key":"10.1016\/j.imbio.2023.152725_b0010","doi-asserted-by":"crossref","first-page":"2963","DOI":"10.1128\/IAI.00528-16","article-title":"Leishmania donovani-Induced Prostaglandin E2 Generation Is Critically Dependent on Host Toll-Like Receptor 2-Cytosolic Phospholipase A2 Signaling","volume":"84","author":"Bhattacharjee","year":"2016","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152725_b0015","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1086\/653210","article-title":"Arabinosylated lipoarabinomannan-mediated protection in visceral leishmaniasis through up-regulation of toll-like receptor 2 signaling: an immunoprophylactic approach","volume":"202","author":"Bhattacharya","year":"2010","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.imbio.2023.152725_b0020","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1016\/j.molimm.2009.06.006","article-title":"Porin of Shigella dysenteriae directly promotes toll-like receptor 2-mediated CD4+ T cell survival and effector function","volume":"46","author":"Biswas","year":"2009","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0025","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1038\/nature04596","article-title":"Toll-dependent selection of microbial antigens for presentation by dendritic cells","volume":"440","author":"Blander","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2023.152725_b0030","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3389\/fcimb.2019.00425","article-title":"The complex interplay of parasites, their hosts, and circadian clocks","volume":"9","author":"Carvalho Cabral","year":"2019","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.imbio.2023.152725_b0035","doi-asserted-by":"crossref","DOI":"10.1111\/pim.12903","article-title":"The involvement of host circadian clocks in the regulation of the immune response to parasitic infections in mammals","volume":"44","author":"Carvalho Cabral","year":"2022","journal-title":"Parasite Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0040","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2249.2008.03741.x","article-title":"Leishmania donovani infection down-regulates TLR2-stimulated IL-12p40 and activates IL-10 in cells of macrophage\/monocytic lineage by modulating MAPK pathways through a contact-dependent mechanism","volume":"154","author":"Chandra","year":"2008","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0045","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/cei.13014","article-title":"Redundant and regulatory roles for Toll-like receptors in Leishmania infection","volume":"190","author":"Chauhan","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0050","doi-asserted-by":"crossref","first-page":"54","DOI":"10.3390\/tropicalmed7040054","article-title":"Immune Responses in Leishmaniasis: An Overview","volume":"7","author":"Costa-da-Silva","year":"2022","journal-title":"Trop. Med. Infect. Dis."},{"key":"10.1016\/j.imbio.2023.152725_b0055","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1002\/eji.200636181","article-title":"TLR2 engagement on CD8 T cells lowers the threshold for optimal antigen-induced T cell activation","volume":"36","author":"Cottalorda","year":"2006","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0060","doi-asserted-by":"crossref","first-page":"2061","DOI":"10.1084\/jem.185.12.2061","article-title":"Inhibition of phagolysosomal biogenesis by the Leishmania lipophosphoglycan","volume":"185","author":"Desjardins","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2023.152725_b0065","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.812774","article-title":"Toll-Like receptor signaling and its role in cell-mediated immunity","volume":"13","author":"Duan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0070","doi-asserted-by":"crossref","first-page":"4241","DOI":"10.1128\/IAI.01714-07","article-title":"The absence of cutaneous lymph nodes results in a Th2 response and increased susceptibility to Leishmania major infection in mice","volume":"76","author":"Ehrchen","year":"2008","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152725_b0075","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/930257","article-title":"Toll-like receptors in leishmania infections: guardians or promoters?","volume":"2012","author":"Faria","year":"2012","journal-title":"J. Parasitol. Res."},{"issue":"3","key":"10.1016\/j.imbio.2023.152725_b0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004570","article-title":"Down-Regulation of TLR and JAK\/STAT Pathway Genes Is Associated with Diffuse Cutaneous Leishmaniasis: A Gene Expression Analysis in NK Cells from Patients Infected with Leishmania mexicana","volume":"10","author":"Fern\u00e1ndez-Figueroa","year":"2016","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"Suppl","key":"10.1016\/j.imbio.2023.152725_b0085","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1017\/S0031182005008139","article-title":"Subversion of host cell signalling by the protozoan parasite Leishmania","volume":"130","author":"Gregory","year":"2005","journal-title":"Parasitology"},{"key":"10.1016\/j.imbio.2023.152725_b0090","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1111\/cmi.12484","article-title":"Innate immunity against Leishmania infections","volume":"17","author":"Gurung","year":"2015","journal-title":"Cell. Microbiol."},{"issue":"6","key":"10.1016\/j.imbio.2023.152725_b0095","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00019-18","article-title":"PDL-1 Blockade Prevents T Cell Exhaustion, Inhibits Autophagy, and Promotes Clearance of Leishmania donovani","volume":"86","author":"Habib","year":"2018","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152725_b0100","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13071-016-1381-0","article-title":"The TLR2\/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models","volume":"9","author":"Halliday","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.imbio.2023.152725_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.actatropica.2023.106921","article-title":"TLR9 agonist CpG ODN 2395 promotes the immune response against Leishmania donovani in obesity and undernutrition mice","volume":"242","author":"He","year":"2023","journal-title":"Acta Trop."},{"key":"10.1016\/j.imbio.2023.152725_b0110","doi-asserted-by":"crossref","first-page":"570","DOI":"10.4049\/jimmunol.135.1.570","article-title":"Complement-mediated serum cytotoxicity for Leishmania major amastigotes: killing by serum deficient in early components of the membrane attack complex","volume":"135","author":"Hoover","year":"1985","journal-title":"J. Immunol."},{"issue":"Suppl 2","key":"10.1016\/j.imbio.2023.152725_b0115","article-title":"Calcium signalling and related ion channels in neutrophil recruitment and function","volume":"48","author":"Immler","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"issue":"1","key":"10.1016\/j.imbio.2023.152725_b0120","doi-asserted-by":"crossref","first-page":"e3321","DOI":"10.1371\/journal.pntd.0003321","article-title":"Th1-biased immunomodulation and therapeutic potential of Artemisia annua in murine visceral leishmaniasis","volume":"9","author":"Islamuddin","year":"2015","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"6","key":"10.1016\/j.imbio.2023.152725_b0125","doi-asserted-by":"crossref","first-page":"e1204","DOI":"10.1371\/journal.pntd.0001204","article-title":"TLR1\/2 activation during heterologous prime-boost vaccination (DNA-MVA) enhances CD8+ T Cell responses providing protection against Leishmania (Viannia)","volume":"5","author":"Jayakumar","year":"2011","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.imbio.2023.152725_b0130","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/836485","article-title":"The effects of TLR activation on T-cell development and differentiation","volume":"2012","author":"Jin","year":"2012","journal-title":"Clin. Dev. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0135","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1002\/eji.201646846","article-title":"Toll like Receptor 2 engagement on CD4(+) T cells promotes TH9 differentiation and function","volume":"47","author":"Karim","year":"2017","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0140","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/1471-2172-14-52","article-title":"Analysis of localized immune responses reveals presence of Th17 and Treg cells in cutaneous leishmaniasis due to Leishmania tropica","volume":"14","author":"Katara","year":"2013","journal-title":"BMC Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0145","doi-asserted-by":"crossref","first-page":"10892","DOI":"10.1038\/s41598-017-11297-8","article-title":"The circadian clock in immune cells controls the magnitude of Leishmania parasite infection","volume":"7","author":"Kiessling","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.imbio.2023.152725_b0150","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/164_2021_568","article-title":"Toll-Like receptors (TLRs) in health and disease: an overview","volume":"276","author":"Kumar","year":"2022","journal-title":"Handb. Exp. Pharmacol."},{"key":"10.1016\/j.imbio.2023.152725_b0155","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1365-2567.2009.03223.x","article-title":"Evaluation of localized and systemic immune responses in cutaneous leishmaniasis caused by Leishmania tropica: interleukin-8, monocyte chemotactic protein-1 and nitric oxide are major regulatory factors","volume":"130","author":"Kumar","year":"2010","journal-title":"Immunology"},{"key":"10.1016\/j.imbio.2023.152725_b0160","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/jpi.12279","article-title":"Melatonin attenuates Leishmania (L.) amazonensis infection by modulating arginine metabolism","volume":"59","author":"Laranjeira-Silva","year":"2015","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.imbio.2023.152725_b0165","doi-asserted-by":"crossref","first-page":"127","DOI":"10.4110\/in.2009.9.4.127","article-title":"Expression and function of TLR2 on CD4 versus CD8 T Cells","volume":"9","author":"Lee","year":"2009","journal-title":"Immune Netw."},{"key":"10.1016\/j.imbio.2023.152725_b0170","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1111\/j.1462-5822.2006.00758.x","article-title":"Leishmania donovani lipophosphoglycan blocks NADPH oxidase assembly at the phagosome membrane","volume":"8","author":"Lodge","year":"2006","journal-title":"Cell. Microbiol."},{"key":"10.1016\/j.imbio.2023.152725_b0175","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1126\/science.aah4966","article-title":"Immunity around the clock","volume":"354","author":"Man","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.imbio.2023.152725_b0180","doi-asserted-by":"crossref","unstructured":"Mercier , B.C. , Cottalorda , A. , Coupet , C.A. , Marvel , J. , Bonnefoy-Berard , N. , 2009 . TLR2 engagement on CD8 T cells enables generation of functional memory cells in response to a suboptimal TCR signal . J. Immunol. 182 , 1860 \u2013 7 . doi: 10.4049\/jimmunol.0801167 .","DOI":"10.4049\/jimmunol.0801167"},{"key":"10.1016\/j.imbio.2023.152725_b0185","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1101\/gad.873501","article-title":"Antagonistic role of E4BP4 and PAR proteins in the circadian oscillatory mechanism","volume":"15","author":"Mitsui","year":"2001","journal-title":"Genes Dev."},{"issue":"7","key":"10.1016\/j.imbio.2023.152725_b0190","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1128\/IAI.01468-12","article-title":"Regulatory actions of Toll-like receptor 2 (TLR2) and TLR4 in Leishmania donovani infection in the liver","volume":"81","author":"Murray","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152725_b0195","doi-asserted-by":"crossref","first-page":"957","DOI":"10.4049\/jimmunol.1800062","article-title":"Leishmania donovani Exploits Tollip, a Multitasking Protein, To Impair TLR\/IL-1R Signaling for Its Survival in the Host","volume":"201","author":"Parmar","year":"2018","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0200","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0092-8674(02)00825-5","article-title":"The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator","volume":"110","author":"Preitner","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2023.152725_b0205","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0169-4758(00)01692-6","article-title":"Leishmania-host-cell interaction: complexities and alternative views","volume":"16","author":"Rittig","year":"2000","journal-title":"Parasitol. Today"},{"key":"10.1016\/j.imbio.2023.152725_b0210","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13071-016-1412-x","article-title":"Regulation of immunity during visceral Leishmania infection","volume":"9","author":"Rodrigues","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.imbio.2023.152725_b0215","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.1002\/eji.200323163","article-title":"Development of protective immunity against cutaneous leishmaniasis is dependent on STAT1-mediated IFN signaling pathway","volume":"33","author":"Rosas","year":"2003","journal-title":"Eur. J. Immunol."},{"issue":"12","key":"10.1016\/j.imbio.2023.152725_b0220","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1128\/IAI.00975-15","article-title":"Toll-like receptor 9 signaling in dendritic cells regulates neutrophil recruitment to inflammatory foci following Leishmania infantum infection","volume":"83","author":"Sacramento","year":"2015","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imbio.2023.152725_b0225","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.micinf.2019.02.005","article-title":"Pam3CSK4 adjuvant given intranasally boosts anti-Leishmania immunogenicity but not protective immune responses conferred by LaAg vaccine against visceral leishmaniasis","volume":"21","author":"Salgado","year":"2019","journal-title":"Microb. Infect."},{"key":"10.1016\/j.imbio.2023.152725_b0230","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0001-706X(97)00104-6","article-title":"Diurnal periodicity of Leishmania amastigotes in peripheral blood of Indian Kala-azar patients","volume":"68","author":"Saran","year":"1997","journal-title":"Acta Trop."},{"key":"10.1016\/j.imbio.2023.152725_b0235","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/j.neuron.2004.07.018","article-title":"A functional genomics strategy reveals Rora as a component of the mammalian circadian clock","volume":"43","author":"Sato","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.imbio.2023.152725_b0240","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1084\/jem.20061293","article-title":"NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs","volume":"204","author":"Schleicher","year":"2007","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2023.152725_b0245","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.1016\/j.peptides.2011.09.014","article-title":"Effect of Pam3Cys induced protection on the therapeutic efficacy of miltefosine against experimental visceral leishmaniasis","volume":"32","author":"Shakya","year":"2011","journal-title":"Peptides"},{"key":"10.1016\/j.imbio.2023.152725_b0250","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/imm.13364","article-title":"Interdependencies between Toll-like receptors in Leishmania infection","volume":"164","author":"Shukla","year":"2021","journal-title":"Immunology"},{"key":"10.1016\/j.imbio.2023.152725_b0255","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2217\/fmb-2021-0101","article-title":"Phagosome maturation and modulation of macrophage effector function by intracellular pathogens: target for therapeutics","volume":"17","author":"Sontyana","year":"2022","journal-title":"Future Microbiol."},{"key":"10.1016\/j.imbio.2023.152725_b0260","doi-asserted-by":"crossref","first-page":"270","DOI":"10.2119\/molmed.2011.00201","article-title":"Natural killer (NK) cells in antibacterial innate immunity: angels or devils?","volume":"18","author":"Souza-Fonseca-Guimaraes","year":"2012","journal-title":"Mol. Med."},{"key":"10.1016\/j.imbio.2023.152725_b0265","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.imbio.2023.152725_b0270","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0275","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.862104","article-title":"Mass spectrometry imaging identifies altered hepatic lipid signatures during experimental Leishmania donovani infection","volume":"13","author":"Tans","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0280","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.rvsc.2020.02.004","article-title":"The balancing act: Immunology of leishmaniosis","volume":"130","author":"Toepp","year":"2020","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.imbio.2023.152725_b0285","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1007\/s11882-020-0896-9","article-title":"Circadian rhythms in immunity","volume":"20","author":"Waggoner","year":"2020","journal-title":"Curr. Allergy Asthma Rep."},{"key":"10.1016\/j.imbio.2023.152725_b0290","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2023.152725_b0295","unstructured":"WHO, Leishmaniasis. https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/leishmaniasis, (8 January)."},{"key":"10.1016\/j.imbio.2023.152725_b0300","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/nature13992","article-title":"A comparative encyclopedia of DNA elements in the mouse genome","volume":"515","author":"Yue","year":"2014","journal-title":"Nature"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523045278?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523045278?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:52:39Z","timestamp":1759251159000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298523045278"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":60,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S0171298523045278"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152725","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TLR-2 agonist Pam3CSK4 has no therapeutic effect on visceral leishmaniasis in BALB\/c mice and may enhance the pathogenesis of the disease","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152725","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier GmbH. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"152725"}}