{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T15:27:08Z","timestamp":1774452428272,"version":"3.50.1"},"reference-count":76,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T00:00:00Z","timestamp":1695340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.imbio.2023.152750","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T02:00:13Z","timestamp":1695693613000},"page":"152750","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Identification of hub biomarkers and immune-related pathways participating in the progression of Kawasaki disease by integrated bioinformatics analysis"],"prefix":"10.1016","volume":"228","author":[{"given":"Yang","family":"Gao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guanghui","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbiao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nana","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenyu","family":"Zhuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiming","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjie","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiheng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2023.152750_b0005","unstructured":"Aleksander, S.A., Balhoff, J., Carbon, S., Cherry, J.M., Drabkin, H.J., Ebert, D., Feuermann, M., Gaudet, P., Harris, N.L., Hill, D.P., Lee, R., Mi, H., Moxon, S., Mungall, C.J., Muruganugan, A., Mushayahama, T., Sternberg, P.W., Thomas, P.D., Van Auken, K., Ramsey, J., Siegele, D.A., Chisholm, R.L., Fey, P., Aspromonte, M.C., Nugnes, M.V., Quaglia, F., Tosatto, S., Giglio, M., Nadendla, S., Antonazzo, G., Attrill, H., Dos Santos, G., Marygold, S., Strelets, V., Tabone, C.J., Thurmond, J., Zhou, P., Ahmed, S.H., Asanitthong, P., Luna Buitrago, D., Erdol, M.N., Gage, M.C., Ali Kadhum, M., Li, K.Y.C., Long, M., Michalak, A., Pesala, A., Pritazahra, A., Saverimuttu, S.C.C., Su, R., Thurlow, K.E., Lovering, R.C., Logie, C., Oliferenko, S., Blake, J., Christie, K., Corbani, L., Dolan, M.E., Drabkin, H.J., Hill, D.P., Ni, L., Sitnikov, D., Smith, C., Cuzick, A., Seager, J., Cooper, L., Elser, J., Jaiswal, P., Gupta, P., Jaiswal, P., Naithani, S., Lera-Ramirez, M., Rutherford, K., Wood, V., De Pons, J.L., Dwinell, M.R., Hayman, G.T., Kaldunski, M.L., Kwitek, A.E., Laulederkind, S.J.F., Tutaj, M.A., Vedi, M., Wang, S.J., D'Eustachio, P., Aimo, L., Axelsen, K., Bridge, A., Hyka-Nouspikel, N., Morgat, A., Aleksander, S.A., Cherry, J.M., Engel, S.R., Karra, K., Miyasato, S.R., Nash, R.S., Skrzypek, M.S., Weng, S., Wong, E.D., Bakker, E., Berardini, T.Z., Reiser, L., Auchincloss, A., Axelsen, K., Argoud-Puy, G., Blatter, M.C., Boutet, E., Breuza, L., Bridge, A., Casals-Casas, C., Coudert, E., Estreicher, A., Livia Famiglietti, M., Feuermann, M., Gos, A., Gruaz-Gumowski, N., Hulo, C., Hyka-Nouspikel, N., Jungo, F., Le Mercier, P., Lieberherr, D., Masson, P., Morgat, A., Pedruzzi, I., Pourcel, L., Poux, S., Rivoire, C., Sundaram, S., Bateman, A., Bowler-Barnett, E., Bye, A.J.H., Denny, P., Ignatchenko, A., Ishtiaq, R., Lock, A., Lussi, Y., Magrane, M., Martin, M.J., Orchard, S., Raposo, P., Speretta, E., Tyagi, N., Warner, K., Zaru, R., Diehl, A.D., Lee, R., Chan, J., Diamantakis, S., Raciti, D., Zarowiecki, M., Fisher, M., James-Zorn, C., Ponferrada, V., Zorn, A., Ramachandran, S., Ruzicka, L., Westerfield, M., 2023. The Gene Ontology knowledgebase in 2023. Genetics 224(1)."},{"issue":"5","key":"10.1016\/j.imbio.2023.152750_b0010","first-page":"792","article-title":"Monocyte-Derived interleukin-1\u03b2 As the driver of S100A12-induced sterile inflammatory activation of human coronary artery endothelial cells: implications for the pathogenesis of Kawasaki disease","volume":"71","author":"Armaroli","year":"2019","journal-title":"Arth. Rheumatol. (Hoboken N.J.)"},{"issue":"7","key":"10.1016\/j.imbio.2023.152750_b0015","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0020","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.jacc.2006.06.029","article-title":"S100 proteins in the pathogenesis of Kawasaki disease","volume":"48","author":"Burns","year":"2006","journal-title":"J. Am. Coll. Cardiol."},{"issue":"9433","key":"10.1016\/j.imbio.2023.152750_b0025","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/S0140-6736(04)16814-1","article-title":"Kawasaki syndrome","volume":"364","author":"Burns","year":"2004","journal-title":"Lancet (london, England)"},{"issue":"D1","key":"10.1016\/j.imbio.2023.152750_b0030","doi-asserted-by":"crossref","first-page":"D325","DOI":"10.1093\/nar\/gkaa1113","article-title":"The Gene Ontology resource: enriching a GOld mine","volume":"49","author":"Consortium","year":"2021","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.imbio.2023.152750_b0035","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1016\/j.jpeds.2015.02.003","article-title":"Diagnosis of systemic-onset juvenile idiopathic arthritis after treatment for presumed Kawasaki disease","volume":"166","author":"Dong","year":"2015","journal-title":"J. Pediatr."},{"key":"10.1016\/j.imbio.2023.152750_b0040","first-page":"108375","article-title":"Differential analysis of serum and urine S100 proteins in juvenile-onset systemic lupus erythematosus (jSLE). Clinical immunology (Orlando","volume":"214","author":"Donohue","year":"2020","journal-title":"Fla.)"},{"issue":"9","key":"10.1016\/j.imbio.2023.152750_b0045","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1161\/CIRCRESAHA.120.315931","article-title":"Neutrophil extracellular traps participate in cardiovascular diseases: recent experimental and clinical insights","volume":"126","author":"D\u00f6ring","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.imbio.2023.152750_b0050","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.sigpro.2016.03.001","article-title":"Generalized LASSO with under-determined regularization matrices","volume":"127","author":"Duan","year":"2016","journal-title":"Signal Process."},{"issue":"9365","key":"10.1016\/j.imbio.2023.152750_b0055","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1016\/S0140-6736(03)12986-8","article-title":"S100A12 (EN-RAGE) in monitoring Kawasaki disease","volume":"361","author":"Foell","year":"2003","journal-title":"Lancet (london, England)"},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v033.i01","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J. Stat. Softw."},{"key":"10.1016\/j.imbio.2023.152750_b0065","doi-asserted-by":"crossref","unstructured":"G, S.C., van Waarde, A., I, F.A., D\u00f6mling, A., P, H.E., 2020. Arginase as a Potential Biomarker of Disease Progression: A Molecular Imaging Perspective. International journal of molecular sciences 21(15).","DOI":"10.3390\/ijms21155291"},{"issue":"4","key":"10.1016\/j.imbio.2023.152750_b0070","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1161\/01.ATV.0000065385.47152.FD","article-title":"Systemic arterial expression of matrix metalloproteinases 2 and 9 in acute Kawasaki disease","volume":"23","author":"Gavin","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.imbio.2023.152750_b0075","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cytogfr.2017.05.004","article-title":"Amino-acid sensing and degrading pathways in immune regulation","volume":"35","author":"Grohmann","year":"2017","journal-title":"Cytokine Growth Factor Rev."},{"key":"10.1016\/j.imbio.2023.152750_b0080","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3389\/fped.2020.00129","article-title":"Epigenetic regulation of macrophage marker expression profiles in Kawasaki disease","volume":"8","author":"Guo","year":"2020","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.imbio.2023.152750_b0085","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinf."},{"issue":"11","key":"10.1016\/j.imbio.2023.152750_b0090","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1186\/s13073-014-0102-6","article-title":"Global gene expression profiling identifies new therapeutic targets in acute Kawasaki disease","volume":"6","author":"Hoang","year":"2014","journal-title":"Genome Med."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0095","doi-asserted-by":"crossref","first-page":"e286","DOI":"10.1097\/PCC.0000000000001496","article-title":"Neutrophil extracellular traps in children with meningococcal sepsis","volume":"19","author":"Hoppenbrouwers","year":"2018","journal-title":"Pediatr. Crit. Care Med."},{"issue":"27","key":"10.1016\/j.imbio.2023.152750_b0100","doi-asserted-by":"crossref","first-page":"18939","DOI":"10.18632\/oncotarget.24851","article-title":"Epigenetic hypomethylation and upregulation of NLRC4 and NLRP12 in Kawasaki disease","volume":"9","author":"Huang","year":"2018","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.imbio.2023.152750_b0105","first-page":"315","article-title":"Expression of Toll-like Receptor-2 on the peripheral blood monocytes in Kawasaki disease patients","volume":"48","author":"Hwang","year":"2005","journal-title":"Clin. Exp. Pediatr."},{"issue":"10","key":"10.1016\/j.imbio.2023.152750_b0110","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/s41419-019-2021-3","article-title":"Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1\/RAGE\/cathespin B signaling pathway and NLRP3 inflammasome activation","volume":"10","author":"Jia","year":"2019","journal-title":"Cell Death Dis."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0115","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1038\/s41419-021-03852-z","article-title":"IL-37b alleviates endothelial cell apoptosis and inflammation in Kawasaki disease through IL-1R8 pathway","volume":"12","author":"Jia","year":"2021","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.imbio.2023.152750_b0120","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1136\/ard.2009.114363","article-title":"Neutrophil-derived S100A12 as novel biomarker of inflammation in familial Mediterranean fever","volume":"69","author":"Kallinich","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0125","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/nar\/28.1.27","article-title":"KEGG: kyoto encyclopedia of genes and genomes","volume":"28","author":"Kanehisa","year":"2000","journal-title":"Nucleic Acids Res."},{"issue":"D1","key":"10.1016\/j.imbio.2023.152750_b0130","doi-asserted-by":"crossref","first-page":"D457","DOI":"10.1093\/nar\/gkv1070","article-title":"KEGG as a reference resource for gene and protein annotation","volume":"44","author":"Kanehisa","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"3","key":"10.1016\/j.imbio.2023.152750_b0135","first-page":"178","article-title":"Acute febrile mucocutaneous syndrome with lymphoid involvement with specific desquamation of the fingers and toes in children","volume":"16","author":"Kawasaki","year":"1967","journal-title":"Arerugi = [allergy]"},{"key":"10.1016\/j.imbio.2023.152750_b0140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1186\/1471-2105-9-559","article-title":"WGCNA: an R package for weighted correlation network analysis","volume":"9","author":"Langfelder","year":"2008","journal-title":"BMC Bioinf."},{"issue":"11","key":"10.1016\/j.imbio.2023.152750_b0145","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v046.i11","article-title":"Fast R functions for robust correlations and hierarchical clustering","volume":"46","author":"Langfelder","year":"2012","journal-title":"J. Stat. Softw."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0150","doi-asserted-by":"crossref","first-page":"516","DOI":"10.4070\/kcj.2015.45.6.516","article-title":"T-Helper cytokine profiles in patients with Kawasaki disease","volume":"45","author":"Lee","year":"2015","journal-title":"Korean Circulation Journal"},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0155","doi-asserted-by":"crossref","first-page":"15645","DOI":"10.1038\/s41598-020-72695-z","article-title":"Serum proteins may facilitate the identification of Kawasaki disease and promote in vitro neutrophil infiltration","volume":"10","author":"Li","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0160","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0038635","article-title":"Augmented TLR2 expression on monocytes in both human Kawasaki disease and a mouse model of coronary arteritis","volume":"7","author":"Lin","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2023.152750_b0165","article-title":"Establishment of a Risk Score Model for Early Prediction of Severe H1N1 Influenza","volume":"11","author":"Lin","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.imbio.2023.152750_b0170","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2021.774755","article-title":"Identification of CALU and PALLD as potential biomarkers associated with immune infiltration in heart failure","volume":"8","author":"Liu","year":"2021","journal-title":"Front. Cardiovasc. Med."},{"key":"10.1016\/j.imbio.2023.152750_b0175","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.585058","article-title":"In silico identification of 10 hub genes and an miRNA-mRNA regulatory network in acute Kawasaki disease","volume":"12","author":"Ma","year":"2021","journal-title":"Front. Genet."},{"issue":"2","key":"10.1016\/j.imbio.2023.152750_b0180","first-page":"188","article-title":"Down-regulation of TLR2, 3, 9 and signaling mediators, MyD88 and TRIF, gene transcript levels in patients with Kawasaki disease treated with IVIG, Iran","volume":"14","author":"Mortazavi","year":"2015","journal-title":"J. Allergy Asthma Immunol."},{"issue":"23","key":"10.1016\/j.imbio.2023.152750_b0185","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1056\/NEJM199106063242305","article-title":"A single intravenous infusion of gamma globulin as compared with four infusions in the treatment of acute Kawasaki syndrome","volume":"324","author":"Newburger","year":"1991","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0190","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1002\/iid3.373","article-title":"Five immune-gene-signatures participate in the development and pathogenesis of Kawasaki disease","volume":"9","author":"Nie","year":"2021","journal-title":"Immun. Inflammation Dis."},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0195","doi-asserted-by":"crossref","first-page":"1","DOI":"10.7150\/ijms.5.1","article-title":"Differential constitutive and cytokine-modulated expression of human Toll-like receptors in primary neutrophils, monocytes, and macrophages","volume":"5","author":"O'Mahony","year":"2008","journal-title":"Int. J. Med. Sci."},{"issue":"2","key":"10.1016\/j.imbio.2023.152750_b0200","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0205","doi-asserted-by":"crossref","DOI":"10.1186\/ar4094","article-title":"Reverse regulation of soluble receptor for advanced glycation end products and proinflammatory factor resistin and S100A12 in Kawasaki disease","volume":"14","author":"Qi","year":"2012","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.imbio.2023.152750_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jprot.2021.104183","article-title":"Leukocyte proteomics coupled with serum metabolomics identifies novel biomarkers and abnormal amino acid metabolism in Kawasaki disease","volume":"239","author":"Qian","year":"2021","journal-title":"J. Proteomics"},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0215","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1186\/s12887-021-03003-5","article-title":"CASP5 and CR1 as potential biomarkers for Kawasaki disease: an integrated bioinformatics-experimental study","volume":"21","author":"Rahmati","year":"2021","journal-title":"BMC Pediatr."},{"issue":"19","key":"10.1016\/j.imbio.2023.152750_b0220","doi-asserted-by":"crossref","first-page":"2966","DOI":"10.1161\/CIRCULATIONAHA.105.537530","article-title":"TLR2 and MyD88 contribute to Lactobacillus casei extract-induced focal coronary arteritis in a mouse model of Kawasaki disease","volume":"112","author":"Rosenkranz","year":"2005","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0225","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1146\/annurev-med-042409-151944","article-title":"Kawasaki disease: novel insights into etiology and genetic susceptibility","volume":"62","author":"Rowley","year":"2011","journal-title":"Annu. Rev. Med."},{"issue":"3","key":"10.1016\/j.imbio.2023.152750_b0230","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/CIRCULATIONAHA.120.046657","article-title":"Medium- and large-vessel vasculitis","volume":"143","author":"Saadoun","year":"2021","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.imbio.2023.152750_b0235","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000000086","article-title":"Intravenous immunoglobulin in the therapeutic armamentarium of systemic lupus erythematosus: a systematic review and meta-analysis","volume":"93","author":"Sakthiswary","year":"2014","journal-title":"Medicine"},{"issue":"10197","key":"10.1016\/j.imbio.2023.152750_b0240","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0140-6736(19)30769-X","article-title":"Association between urinary dickkopf-3, acute kidney injury, and subsequent loss of kidney function in patients undergoing cardiac surgery: an observational cohort study","volume":"394","author":"Schunk","year":"2019","journal-title":"Lancet (london, England)"},{"issue":"10","key":"10.1016\/j.imbio.2023.152750_b0245","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1136\/adc.2005.087437","article-title":"The pathophysiology of coronary artery aneurysms in Kawasaki disease: role of matrix metalloproteinases","volume":"91","author":"Senzaki","year":"2006","journal-title":"Arch. Dis. Child."},{"issue":"8","key":"10.1016\/j.imbio.2023.152750_b0250","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nrrheum.2015.54","article-title":"Kawasaki disease: insights into pathogenesis and approaches to treatment","volume":"11","author":"Shulman","year":"2015","journal-title":"Nat. Rev. Rheumatol."},{"issue":"20","key":"10.1016\/j.imbio.2023.152750_b0255","doi-asserted-by":"crossref","first-page":"3940","DOI":"10.1093\/bioinformatics\/bti623","article-title":"ROCR: visualizing classifier performance in R","volume":"21","author":"Sing","year":"2005","journal-title":"Bioinformatics (oxford, England)"},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0260","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.116.005378","article-title":"Predicting coronary artery aneurysms in Kawasaki disease at a North American Center: an assessment of baseline z scores","volume":"6","author":"Son","year":"2017","journal-title":"J. Am. Heart Assoc."},{"issue":"2","key":"10.1016\/j.imbio.2023.152750_b0265","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s11926-020-0882-1","article-title":"A comprehensive update on kawasaki disease vasculitis and myocarditis","volume":"22","author":"Soni","year":"2020","journal-title":"Curr. Rheumatol. Rep."},{"issue":"Supplement_1","key":"10.1016\/j.imbio.2023.152750_b0270","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1365-2249.2011.04361.x","article-title":"Pathogenesis of Kawasaki disease","volume":"164","author":"Takahashi","year":"2011","journal-title":"Clin. Exp. Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0275","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.smim.2003.10.003","article-title":"TLR signaling pathways","volume":"16","author":"Takeda","year":"2004","journal-title":"Semin. Immunol."},{"issue":"2","key":"10.1016\/j.imbio.2023.152750_b0280","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1046\/j.1365-2249.2001.01608.x","article-title":"Elevated serum levels of matrix metalloproteinase-9 (MMP-9) in Kawasaki disease","volume":"125","author":"Takeshita","year":"2001","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imbio.2023.152750_b0285","doi-asserted-by":"crossref","first-page":"102615","DOI":"10.1016\/j.jaut.2021.102615","article-title":"Clinical disease activity and flare in SLE: current concepts and novel biomarkers","volume":"119","author":"Thanou","year":"2021","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0290","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41387-021-00164-1","article-title":"Amino acid metabolism and signalling pathways: potential targets in the control of infection and immunity","volume":"11","author":"Tom\u00e9","year":"2021","journal-title":"Nutr. Diabetes"},{"issue":"12","key":"10.1016\/j.imbio.2023.152750_b0295","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/nrrheum.2016.186","article-title":"New insights into the immunopathogenesis of systemic lupus erythematosus","volume":"12","author":"Tsokos","year":"2016","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0300","doi-asserted-by":"crossref","first-page":"E78","DOI":"10.1542\/peds.105.6.e78","article-title":"Initial intravenous gammaglobulin treatment failure in Kawasaki disease","volume":"105","author":"Wallace","year":"2000","journal-title":"Pediatrics"},{"key":"10.1016\/j.imbio.2023.152750_b0305","article-title":"Intravenous Immunoglobulin Therapy Restores the Quantity and Phenotype of Circulating Dendritic Cells and CD4(+) T Cells in Children With Acute Kawasaki Disease","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0310","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1038\/s41467-021-25771-5","article-title":"Single-cell RNA sequencing of peripheral blood mononuclear cells from acute Kawasaki disease patients","volume":"12","author":"Wang","year":"2021","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.imbio.2023.152750_b0315","first-page":"576","article-title":"Prediction model for diagnosis of kawasaki disease using iTRAQ-based analysis","volume":"8","author":"Weng","year":"2021","journal-title":"Children (basel, Switzerland)"},{"issue":"10","key":"10.1016\/j.imbio.2023.152750_b0320","doi-asserted-by":"crossref","DOI":"10.1001\/jamapediatrics.2018.2293","article-title":"Diagnosis of Kawasaki disease using a minimal whole-blood gene expression signature","volume":"172","author":"Wright","year":"2018","journal-title":"JAMA Pediatr."},{"issue":"3","key":"10.1016\/j.imbio.2023.152750_b0325","first-page":"100141","article-title":"clusterProfiler 4.0: A universal enrichment tool for interpreting omics data","volume":"2","author":"Wu","year":"2021","journal-title":"Innovation (Cambridge (Mass.))"},{"key":"10.1016\/j.imbio.2023.152750_b0330","article-title":"Identification of hub biomarkers and immune-related pathways participating in the progression of antineutrophil cytoplasmic antibody-associated glomerulonephritis","volume":"12","author":"Xia","year":"2021","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.imbio.2023.152750_b0335","doi-asserted-by":"crossref","first-page":"152261","DOI":"10.1016\/j.imbio.2022.152261","article-title":"Exploring the relationship between pyroptosis, infiltrating immune cells and Kawasaki disease with resistance to intravenous immunoglobulin (IVIG) via bioinformatic analysis","volume":"227","author":"Xie","year":"2022","journal-title":"Immunobiology"},{"key":"10.1016\/j.imbio.2023.152750_b0340","doi-asserted-by":"crossref","first-page":"108396","DOI":"10.1016\/j.intimp.2021.108396","article-title":"Atlas of circulating immune cells in Kawasaki disease","volume":"102","author":"Xie","year":"2022","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0345","first-page":"391","article-title":"Matrix metalloproteinase-9: Many shades of function in cardiovascular disease","volume":"28","author":"Yabluchanskiy","year":"2013","journal-title":"Physiology (Bethesda)"},{"key":"10.1016\/j.imbio.2023.152750_b0350","first-page":"1","article-title":"The predictive values of MMP-9, PLTs, ESR, and CRP levels in Kawasaki disease with cardiovascular injury","volume":"2022","author":"Yang","year":"2022","journal-title":"Evid. Based Complement. Alternat. Med."},{"key":"10.1016\/j.imbio.2023.152750_b0355","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.896645","article-title":"Neutrophil Infiltration Characterized by Upregulation of S100A8, S100A9, S100A12 and CXCR2 Is Associated With the Co-Occurrence of Crohn's Disease and Peripheral Artery Disease","volume":"13","author":"Yao","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0360","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.amjcard.2004.05.076","article-title":"Neutrophil-derived S100A12 is profoundly upregulated in the early stage of acute Kawasaki disease","volume":"94","author":"Ye","year":"2004","journal-title":"Am. J. Cardiol."},{"issue":"6","key":"10.1016\/j.imbio.2023.152750_b0365","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/s41390-019-0710-3","article-title":"Enhanced formation of neutrophil extracellular traps in Kawasaki disease","volume":"87","author":"Yoshida","year":"2020","journal-title":"Pediatr. Res."},{"issue":"5","key":"10.1016\/j.imbio.2023.152750_b0370","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"OMICS"},{"key":"10.1016\/j.imbio.2023.152750_b0375","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.molimm.2020.03.022","article-title":"S100A12 promotes inflammation and cell apoptosis in sepsis-induced ARDS via activation of NLRP3 inflammasome signaling","volume":"122","author":"Zhang","year":"2020","journal-title":"Mol. Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2023.152750_b0380","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12967-020-02698-x","article-title":"Identification of key biomarkers and immune infiltration in systemic lupus erythematosus by integrated bioinformatics analysis","volume":"19","author":"Zhao","year":"2021","journal-title":"J. Transl. Med."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523045527?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298523045527?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T16:52:55Z","timestamp":1759251175000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298523045527"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":76,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11]]}},"alternative-id":["S0171298523045527"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152750","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of hub biomarkers and immune-related pathways participating in the progression of Kawasaki disease by integrated bioinformatics analysis","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2023.152750","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"152750"}}