{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T04:17:37Z","timestamp":1751948257918,"version":"3.41.2"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,3]],"date-time":"2025-04-03T00:00:00Z","timestamp":1743638400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22YF1407900"],"award-info":[{"award-number":["22YF1407900"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373383","82372332","82072876","32200741"],"award-info":[{"award-number":["82373383","82372332","82072876","32200741"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.imbio.2025.152899","type":"journal-article","created":{"date-parts":[[2025,4,6]],"date-time":"2025-04-06T17:38:00Z","timestamp":1743961080000},"page":"152899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Circulating Tfh cells and Tfr cells in papillary thyroid carcinoma and their diagnostic potential"],"prefix":"10.1016","volume":"230","author":[{"given":"Heng","family":"Zhang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Minglei","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renquan","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2025.152899_bb0005","doi-asserted-by":"crossref","first-page":"1125503","DOI":"10.3389\/fimmu.2023.1125503","article-title":"The transcriptional program during germinal center reaction - a close view at GC B cells, Tfh cells and Tfr cells","volume":"14","author":"Betzler","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2025.152899_bb0010","doi-asserted-by":"crossref","first-page":"4075522","DOI":"10.1155\/2022\/4075522","article-title":"The Frequency of Intrathyroidal Follicular Helper T Cells Varies with the Progression of Graves\u2019 Disease and Hashimoto\u2019s Thyroiditis","volume":"2022","author":"Cai","year":"2022","journal-title":"J Immunol Res"},{"issue":"6","key":"10.1016\/j.imbio.2025.152899_bb0015","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1089\/thy.2021.0666","article-title":"Serum Thyroglobulin Measurement following Surgery without Radioactive Iodine for Differentiated Thyroid Cancer: a Systematic Review","volume":"32","author":"Chou","year":"2022","journal-title":"Thyroid\u202f: official journal of the American Thyroid Association"},{"issue":"8","key":"10.1016\/j.imbio.2025.152899_bb0020","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/nm.2426","article-title":"Follicular regulatory T cells expressing Foxp3 and Bcl-6 suppress germinal center reactions","volume":"17","author":"Chung","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2025.152899_bb0025","doi-asserted-by":"crossref","unstructured":"Crotty S. Follicular helper CD4 T cells (TFH). Annu. Rev. Immunol. 2011;29:621\u201363. https:\/\/doi.org\/10.1146\/annurev-immunol-031210-101400.","DOI":"10.1146\/annurev-immunol-031210-101400"},{"issue":"4","key":"10.1016\/j.imbio.2025.152899_bb0030","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/j.immuni.2014.10.004","article-title":"T follicular helper cell differentiation, function, and roles in disease","volume":"41","author":"Crotty","year":"2014","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.imbio.2025.152899_bb0035","doi-asserted-by":"crossref","first-page":"832","DOI":"10.4049\/jimmunol.1500759","article-title":"Circulating Follicular Regulatory T Cells are Defective in Multiple Sclerosis","volume":"195","author":"Dhaeze","year":"2015","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2025.152899_bb0040","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.semcancer.2019.05.019","article-title":"Thyroid autoimmune disorders and cancer","volume":"64","author":"Ferrari","year":"2020","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.imbio.2025.152899_bb0045","first-page":"12","article-title":"T follicular helper 17 (Tfh17) cells are superior for immunological memory maintenance","author":"Gao","year":"2023","journal-title":"eLife"},{"key":"10.1016\/j.imbio.2025.152899_bb0050","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.3389\/fimmu.2017.01790","article-title":"Are Follicular Regulatory T Cells involved in Autoimmune Diseases?","volume":"8","author":"Gong","year":"2017","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2025.152899_bb0055","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.imlet.2018.03.001","article-title":"Circulating CXCR5(+)CD4(+) T cells participate in the IgE accumulation in allergic asthma","volume":"197","author":"Gong","year":"2018","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imbio.2025.152899_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.jncc.2024.01.006","article-title":"Cancer incidence and mortality in China, 2022","author":"Han","year":"2024","journal-title":"Journal of the National Cancer Center"},{"key":"10.1016\/j.imbio.2025.152899_bb0065","doi-asserted-by":"crossref","first-page":"452","DOI":"10.3389\/fendo.2020.00452","article-title":"Clinical Analysis of Preoperative Anti-thyroglobulin Antibody in Papillary Thyroid Cancer between 2011 and 2015 in Beijing, China: a Retrospective Study","volume":"11","author":"Jia","year":"2020","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.imbio.2025.152899_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.canep.2024.102636","article-title":"Clinical value of complete blood count ratio in benign and malignant thyroid diseases","volume":"92","author":"Jiang","year":"2024","journal-title":"Cancer Epidemiol."},{"issue":"8","key":"10.1016\/j.imbio.2025.152899_bb0075","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1089\/thy.2009.0384","article-title":"Thyroglobulin antibody is associated with increased cancer risk in thyroid nodules","volume":"20","author":"Kim","year":"2010","journal-title":"Thyroid\u202f: official journal of the American Thyroid Association"},{"issue":"6","key":"10.1016\/j.imbio.2025.152899_bb0080","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/j.immuni.2018.10.012","article-title":"The Transcription factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus","volume":"49","author":"Kim","year":"2018","journal-title":"Immunity"},{"issue":"4","key":"10.1016\/j.imbio.2025.152899_bb0085","doi-asserted-by":"crossref","DOI":"10.4110\/in.2019.19.e26","article-title":"Circulating CCR7loPD-1hi Follicular Helper T Cells Indicate disease activity and Glandular Inflammation in patients with primary Sj\u00f6gren\u2019s Syndrome","volume":"19","author":"Kim","year":"2019","journal-title":"Immune Netw."},{"issue":"3","key":"10.1016\/j.imbio.2025.152899_bb0090","doi-asserted-by":"crossref","DOI":"10.1530\/ERC-23-0240","article-title":"Immunophenotyping with high-dimensional flow cytometry identifies Treg cell subsets associated with recurrence in papillary thyroid carcinoma","volume":"31","author":"Li","year":"2024","journal-title":"Endocr. Relat. Cancer"},{"year":"2024","series-title":"Papillary Thyroid Carcinoma","author":"Limaiem","key":"10.1016\/j.imbio.2025.152899_bb0095"},{"key":"10.1016\/j.imbio.2025.152899_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.smim.2023.101801","article-title":"Age-dependent changes in T follicular helper cells shape the humoral immune response to vaccination","volume":"69","author":"Linterman","year":"2023","journal-title":"Semin. Immunol."},{"issue":"8","key":"10.1016\/j.imbio.2025.152899_bb0105","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm.2425","article-title":"Foxp3+ follicular regulatory T cells control the germinal center response","volume":"17","author":"Linterman","year":"2011","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2025.152899_bb0110","doi-asserted-by":"crossref","first-page":"8972572","DOI":"10.1155\/2018\/8972572","article-title":"Constitutive changes in Circulating Follicular Helper T Cells and their Subsets in patients with Graves\u2019 Disease","volume":"2018","author":"Liu","year":"2018","journal-title":"J Immunol Res"},{"issue":"1","key":"10.1016\/j.imbio.2025.152899_bb0115","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/icb.2013.55","article-title":"Human T follicular helper (Tfh) cells and disease","volume":"92","author":"Ma","year":"2014","journal-title":"Immunol. Cell Biol."},{"key":"10.1016\/j.imbio.2025.152899_bb0120","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.intimp.2017.09.024","article-title":"Upregulation of bacterial-specific Th1 and Th17 responses that are enriched in CXCR5(+)CD4(+) T cells in non-small cell lung cancer","volume":"52","author":"Ma","year":"2017","journal-title":"Int. Immunopharmacol."},{"issue":"8","key":"10.1016\/j.imbio.2025.152899_bb0125","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.humimm.2020.05.008","article-title":"T follicular helper cell-mediated IL-21 production suppresses FOXP3 expression of T follicular regulatory-like cells in diffuse large B cell lymphoma patients","volume":"81","author":"Ma","year":"2020","journal-title":"Hum. Immunol."},{"issue":"3","key":"10.1016\/j.imbio.2025.152899_bb0130","first-page":"3917","article-title":"Distribution of circulating follicular helper T cells and expression of interleukin-21 and chemokine C-X-C ligand 13 in gastric cancer","volume":"16","author":"Meng","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.imbio.2025.152899_bb0135","doi-asserted-by":"crossref","first-page":"1287632","DOI":"10.3389\/fimmu.2024.1287632","article-title":"Increased circulating regulatory T cells and decreased follicular T helper cells are associated with colorectal carcinogenesis","volume":"15","author":"Meng","year":"2024","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2025.152899_bb0140","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.immuni.2010.12.012","article-title":"Human Blood CXCR5+CD4+ T Cells are Counterparts of T Follicular Cells and Contain specific Subsets that Differentially support Antibody Secretion","volume":"34","author":"Morita","year":"2011","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.imbio.2025.152899_bb0145","doi-asserted-by":"crossref","first-page":"1791","DOI":"10.1111\/jdv.13027","article-title":"Increased circulating follicular helper T cells and activated B cells correlate with disease severity in patients with psoriasis","volume":"29","author":"Niu","year":"2015","journal-title":"Journal of the European Academy of Dermatology and Venereology\u202f: JEADV"},{"issue":"8","key":"10.1016\/j.imbio.2025.152899_bb0150","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1111\/apm.13062","article-title":"Thyroid cancer metastasis is associated with an overabundance of defective follicular helper T cells","volume":"128","author":"Qian","year":"2020","journal-title":"APMIS\u202f: acta pathologica, microbiologica, et immunologica Scandinavica"},{"key":"10.1016\/j.imbio.2025.152899_bb0155","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2022.02.008","article-title":"T follicular cells: the regulators of germinal center homeostasis","volume":"244","author":"Ribeiro","year":"2022","journal-title":"Immunol. Lett."},{"issue":"12","key":"10.1016\/j.imbio.2025.152899_bb0160","doi-asserted-by":"crossref","first-page":"5191","DOI":"10.1172\/JCI76861","article-title":"Circulating T follicular regulatory and helper cells have memory-like properties","volume":"124","author":"Sage","year":"2014","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.imbio.2025.152899_bb0165","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1056\/NEJM199801293380506","article-title":"Papillary and follicular thyroid carcinoma","volume":"338","author":"Schlumberger","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.imbio.2025.152899_bb0170","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.imlet.2017.04.010","article-title":"Expansion of circulating follicular T helper cells associates with disease severity in childhood atopic dermatitis","volume":"189","author":"Szab\u00f3","year":"2017","journal-title":"Immunol. Lett."},{"issue":"9","key":"10.1016\/j.imbio.2025.152899_bb0175","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1038\/s41577-022-00693-5","article-title":"The link between circulating follicular helper T cells and autoimmunity","volume":"22","author":"Walker","year":"2022","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.imbio.2025.152899_bb0180","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1089\/thy.2014.0173","article-title":"Multi-organ distant metastases confer worse disease-specific survival in differentiated thyroid cancer","volume":"24","author":"Wang","year":"2014","journal-title":"Thyroid\u202f: official journal of the American Thyroid Association"},{"issue":"8","key":"10.1016\/j.imbio.2025.152899_bb0185","doi-asserted-by":"crossref","first-page":"2754","DOI":"10.1210\/jc.2012-1533","article-title":"The utility of serum thyroglobulin measurement at the time of remnant ablation for predicting disease-free status in patients with differentiated thyroid cancer: a meta-analysis involving 3947 patients","volume":"97","author":"Webb","year":"2012","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.imbio.2025.152899_bb0190","doi-asserted-by":"crossref","first-page":"4553","DOI":"10.4049\/jimmunol.1101328","article-title":"Regulation of the germinal center reaction by Foxp3+ follicular regulatory T cells","volume":"187","author":"Wollenberg","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2025.152899_bb0195","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.clim.2017.07.004","article-title":"The ratio of circulating follicular T helper cell to follicular T regulatory cell is correlated with disease activity in systemic lupus erythematosus","volume":"183","author":"Xu","year":"2017","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.imbio.2025.152899_bb0200","doi-asserted-by":"crossref","first-page":"9003902","DOI":"10.1155\/2022\/9003902","article-title":"The Regulation between CD4(+)CXCR5(+) Follicular Helper T (Tfh) Cells and CD19(+)CD24(hi)CD38(hi) Regulatory B (Breg) Cells in Gastric Cancer","volume":"2022","author":"Zhang","year":"2022","journal-title":"J Immunol Res"},{"issue":"7","key":"10.1016\/j.imbio.2025.152899_bb0205","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/08916934.2018.1516759","article-title":"Increased circulating follicular regulatory T cells in Hashimoto\u2019s thyroiditis","volume":"51","author":"Zhao","year":"2018","journal-title":"Autoimmunity"},{"key":"10.1016\/j.imbio.2025.152899_bb0210","doi-asserted-by":"crossref","first-page":"3724033","DOI":"10.1155\/2022\/3724033","article-title":"Abnormal Function of Circulating Follicular Helper T Cells leads to Different Manifestations of B Cell Maturation and Differentiation in patients with Osteosarcoma","volume":"2022","author":"Zhao","year":"2022","journal-title":"Journal of healthcare engineering"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298525000336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298525000336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T20:09:12Z","timestamp":1751918952000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298525000336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0171298525000336"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2025.152899","relation":{},"ISSN":["0171-2985"],"issn-type":[{"type":"print","value":"0171-2985"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Circulating Tfh cells and Tfr cells in papillary thyroid carcinoma and their diagnostic potential","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2025.152899","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"152899"}}