{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:32:44Z","timestamp":1783449164122,"version":"3.55.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T00:00:00Z","timestamp":1747699200000},"content-version":"vor","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Scientific Research Projects of Medical and Health Institutions of Longhua District, Shenzhen","award":["2022046"],"award-info":[{"award-number":["2022046"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.imbio.2025.152916","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T15:53:25Z","timestamp":1747929205000},"page":"152916","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Expression of miR-146a in Th17 cells from rheumatoid arthritis patients and its correlation with inflammatory cytokines"],"prefix":"10.1016","volume":"230","author":[{"given":"Jinhui","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linghua","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2025.152916_bb0005","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1159\/000526937","article-title":"Exploring the Associations and Molecular Impacts of miR-146a\/rs2910164 and miR-196a2\/rs185070757 with Rheumatoid Arthritis in a Pakistani Population","volume":"16","author":"Ali","year":"2023","journal-title":"Lifestyle Genom"},{"key":"10.1016\/j.imbio.2025.152916_bb0010","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3389\/fimmu.2020.00142","article-title":"miR-146a in Myasthenia Gravis Thymus Bridges Innate Immunity with Autoimmunity and is Linked to Therapeutic Effects of Corticosteroids","volume":"11","author":"Bortone","year":"2020","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2025.152916_bb0015","doi-asserted-by":"crossref","first-page":"2338","DOI":"10.1016\/S0140-6736(17)31491-5","article-title":"Novel treatment strategies in rheumatoid arthritis","volume":"389","author":"Burmester","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.imbio.2025.152916_bb0020","doi-asserted-by":"crossref","first-page":"ii90","DOI":"10.1136\/annrheumdis-2012-202203","article-title":"MicroRNA-146a in autoimmunity and innate immune responses","volume":"72 Suppl 2","author":"Chan","year":"2013","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.imbio.2025.152916_bb0025","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0162-3109(00)00200-9","article-title":"Antisense IRAK-1 oligonucleotide blocks activation of NF-kappa B and AP-1 induced by IL-18","volume":"49","author":"Guo","year":"2000","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.imbio.2025.152916_bb0030","doi-asserted-by":"crossref","first-page":"289","DOI":"10.55563\/clinexprheumatol\/urhbn0","article-title":"Iguratimod ameliorates rheumatoid arthritis progression through regulating miR-146a mediated IRAK1 expression and TRAF6\/JNK1 pathway: an in vivo and in vitro study","volume":"39","author":"Kong","year":"2021","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.imbio.2025.152916_bb0035","doi-asserted-by":"crossref","first-page":"11193","DOI":"10.1073\/pnas.1019536108","article-title":"MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis","volume":"108","author":"Kurowska-Stolarska","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.imbio.2025.152916_bb0040","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/BOR.0000000000000594","article-title":"Pathogenesis and treatment of autoimmune rheumatic diseases","volume":"31","author":"Liu","year":"2019","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.imbio.2025.152916_bb0045","doi-asserted-by":"crossref","first-page":"23944","DOI":"10.18632\/oncotarget.24050","article-title":"MicroRNA-146a suppresses rheumatoid arthritis fibroblast-like synoviocytes proliferation and inflammatory responses by inhibiting the TLR4\/NF-kB signaling","volume":"9","author":"Liu","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.imbio.2025.152916_bb0050","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1159\/000525112","article-title":"Upregulated miR-146a Expression in Peripheral Blood Relates to Th17 and Treg Imbalance in Elder Rheumatoid Arthritis patients","volume":"15","author":"Liu","year":"2022","journal-title":"Lifestyle Genom"},{"key":"10.1016\/j.imbio.2025.152916_bb0055","doi-asserted-by":"crossref","first-page":"2205","DOI":"10.1056\/NEJMra1004965","article-title":"The pathogenesis of rheumatoid arthritis","volume":"365","author":"McInnes","year":"2011","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.imbio.2025.152916_bb0060","doi-asserted-by":"crossref","first-page":"1433898","DOI":"10.3389\/fimmu.2024.1433898","article-title":"E3 ubiquitin ligase gene BIRC3 modulates TNF-induced cell death pathways and promotes aberrant proliferation in rheumatoid arthritis fibroblast-like synoviocytes","volume":"15","author":"Meng","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2025.152916_bb0065","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/08923973.2020.1742734","article-title":"The role of \u03b2-d-mannuronic acid, as a new non-steroidal anti-inflammatory drug on expression of miR-146a, IRAK1, TRAF6, NF-\u03baB and pro-inflammatory cytokines following a clinical trial in rheumatoid arthritis patients","volume":"42","author":"Mortazavi-Jahromi","year":"2020","journal-title":"Immunopharmacol. Immunotoxicol."},{"key":"10.1016\/j.imbio.2025.152916_bb0070","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1002\/art.30321","article-title":"The inhibitory effect of microRNA-146a expression on bone destruction in collagen-induced arthritis","volume":"63","author":"Nakasa","year":"2011","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imbio.2025.152916_bb0075","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/nri2708","article-title":"Physiological and pathological roles for microRNAs in the immune system","volume":"10","author":"O\u2019Connell","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2025.152916_bb0080","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1016\/S0140-6736(16)30173-8","article-title":"Rheumatoid arthritis","volume":"388","author":"Smolen","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.imbio.2025.152916_bb0085","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.jaci.2016.07.025","article-title":"MicroRNA-146a suppresses IL-17-mediated skin inflammation and is genetically associated with psoriasis","volume":"139","author":"Srivastava","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"10.1016\/j.imbio.2025.152916_bb0090","doi-asserted-by":"crossref","first-page":"12481","DOI":"10.1073\/pnas.0605298103","article-title":"NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses","volume":"103","author":"Taganov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.imbio.2025.152916_bb0095","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1002\/art.24436","article-title":"MicroRNA-146A contributes to abnormal activation of the type I interferon pathway in human lupus by targeting the key signaling proteins","volume":"60","author":"Tang","year":"2009","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imbio.2025.152916_bb0100","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2174\/1566523220666200916120708","article-title":"miRNA-146a Improves Immunomodulatory Effects of MSC-derived Exosomes in Rheumatoid Arthritis","volume":"20","author":"Tavasolian","year":"2020","journal-title":"Curr. Gene Ther."},{"key":"10.1016\/j.imbio.2025.152916_bb0105","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s10238-022-00916-y","article-title":"Association analysis of miRNA-146a and miRNA-499 polymorphisms with rheumatoid arthritis: a case-control and trio-family study","volume":"23","author":"Ul Islam","year":"2023","journal-title":"Clin. Exp. Med."},{"key":"10.1016\/j.imbio.2025.152916_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115338","article-title":"Toll-like receptor 4: a potential therapeutic target for multiple human diseases","volume":"166","author":"Wei","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.imbio.2025.152916_bb0115","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1080\/08820139.2020.1864397","article-title":"Association of Toll-like Receptor 4 Rs7873784 G\/C Polymorphism with Rheumatoid Arthritis Risk in a Chinese Population","volume":"51","author":"Yang","year":"2022","journal-title":"Immunol. Investig."},{"key":"10.1016\/j.imbio.2025.152916_bb0120","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s11914-018-0473-5","article-title":"Mechanisms for Joint Pain in Rheumatoid Arthritis (RA): from Cytokines to Central Sensitization","volume":"16","author":"Zhang","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.imbio.2025.152916_bb0125","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.nbd.2019.01.019","article-title":"MiR-146a promotes oligodendrocyte progenitor cell differentiation and enhances remyelination in a model of experimental autoimmune encephalomyelitis","volume":"125","author":"Zhang","year":"2019","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.imbio.2025.152916_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.virusres.2019.197671","article-title":"miR-146a promotes Borna disease virus 1 replication through IRAK1\/TRAF6\/NF-\u03baB signaling pathway","volume":"271","author":"Zhang","year":"2019","journal-title":"Virus Res."},{"key":"10.1016\/j.imbio.2025.152916_bb0135","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1080\/07853890.2021.1933163","article-title":"Genetic variant in microRNA-146a gene is associated with risk of rheumatoid arthritis","volume":"53","author":"Zhang","year":"2021","journal-title":"Ann. Med."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298525000506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298525000506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T20:10:58Z","timestamp":1751919058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298525000506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S0171298525000506"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2025.152916","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Expression of miR-146a in Th17 cells from rheumatoid arthritis patients and its correlation with inflammatory cytokines","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2025.152916","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"152916"}}