{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:36:22Z","timestamp":1783017382385,"version":"3.54.6"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T00:00:00Z","timestamp":1752537600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["202140142"],"award-info":[{"award-number":["202140142"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.imbio.2025.153103","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T00:33:30Z","timestamp":1752712410000},"page":"153103","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exosomes derived from baicalin-pretreated bone marrow mesenchymal stem cells inactivate the TLR4\/MyD88\/NF-kB pathway to improve asthma"],"prefix":"10.1016","volume":"230","author":[{"given":"Wenbo","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisheng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.imbio.2025.153103_bb0005","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.bbadis.2016.11.005","article-title":"Nrf2 signaling pathway: Pivotal roles in inflammation","volume":"1863","author":"Ahmed","year":"2017","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0010","doi-asserted-by":"crossref","first-page":"12","DOI":"10.2174\/1570164620666230220112500","article-title":"Pilot Study of the Ex Vivo Blood Leukocytes\u2019 Proteomic Response to Prednisone Stimulation in Corticosteroid-responsive Asthma","volume":"20","author":"Aleksandra","year":"2023","journal-title":"Curr. Proteomics"},{"issue":"12","key":"10.1016\/j.imbio.2025.153103_bb0015","doi-asserted-by":"crossref","first-page":"2104","DOI":"10.1080\/02770903.2023.2228911","article-title":"An update on asthma diagnosis","volume":"60","author":"Armeftis","year":"2023","journal-title":"J. Asthma"},{"key":"10.1016\/j.imbio.2025.153103_bb0020","article-title":"Role for the metalloproteinase ADAM28 in the control of airway inflammation, remodelling and responsiveness in asthma","volume":"13","author":"Bendavid","year":"2022","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.imbio.2025.153103_bb0025","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1164\/rccm.201904-0903SO","article-title":"Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management","volume":"201","author":"Bleecker","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0030","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12931-022-02112-8","article-title":"Behavioural side effects of inhaled corticosteroids among children and adolescents with asthma","volume":"23","author":"Bodum","year":"2022","journal-title":"Respir. Res."},{"issue":"10","key":"10.1016\/j.imbio.2025.153103_bb0035","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","article-title":"Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.imbio.2025.153103_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2023.152361","article-title":"Immune response modulation by allergen loaded into mesenchymal stem cell-derived exosomes as an effective carrier through sublingual immunotherapy","volume":"228","author":"Dehnavi","year":"2023","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0045","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.yexcr.2017.12.021","article-title":"Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma","volume":"363","author":"Du","year":"2018","journal-title":"Exp. Cell Res."},{"issue":"9","key":"10.1016\/j.imbio.2025.153103_bb0055","first-page":"1407","article-title":"Primary study on mechanism of baicalin on the Th1\/Th2 response in murine model of asthma","volume":"32","author":"Huang","year":"2009","journal-title":"Zhong Yao Cai"},{"key":"10.1016\/j.imbio.2025.153103_bb0060","doi-asserted-by":"crossref","DOI":"10.1177\/15347354221144312","article-title":"Traditional herbal medicine: a potential therapeutic approach for adjuvant treatment of non-small cell lung cancer in the future","volume":"21","author":"Huang","year":"2022","journal-title":"Integr. Cancer Ther."},{"issue":"6478","key":"10.1016\/j.imbio.2025.153103_bb0065","doi-asserted-by":"crossref","DOI":"10.1126\/science.aau6977","article-title":"The biology, function, and biomedical applications of exosomes","volume":"367","author":"Kalluri","year":"2020","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.imbio.2025.153103_bb0070","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.3390\/ijms24021337","article-title":"The machinery of exosomes: biogenesis, release, and uptake","volume":"24","author":"Krylova","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.imbio.2025.153103_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jconrel.2023.04.014","article-title":"Tanshinone IIA enhances the therapeutic efficacy of mesenchymal stem cells derived exosomes in myocardial ischemia\/reperfusion injury via up-regulating miR-223-5p","volume":"358","author":"Li","year":"2023","journal-title":"J. Control. Release"},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0080","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1186\/s13287-022-02985-y","article-title":"Mesenchymal stem cells and their microenvironment","volume":"13","author":"Liu","year":"2022","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.imbio.2025.153103_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102389","article-title":"Signal amplification in the KEAP1-NRF2-ARE antioxidant response pathway","volume":"54","author":"Liu","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.imbio.2025.153103_bib222","doi-asserted-by":"crossref","first-page":"113558","DOI":"10.1016\/j.jep.2020.113558","article-title":"The treatment of asthma using the Chinese Materia Medica","volume":"269","author":"Liu","year":"2021","journal-title":"J Ethnopharmacol"},{"issue":"25","key":"10.1016\/j.imbio.2025.153103_bb0090","first-page":"434","article-title":"The Treatment of Mild and Moderate Asthma in adults","volume":"117","author":"Lommatzsch","year":"2020","journal-title":"Dtsch. Arztebl. Int."},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bib221","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13287-023-03287-7","article-title":"Mesenchymal stromal\/stem cell (MSC)-derived exosomes in clinical trials","volume":"14","author":"Lotfy","year":"2023","journal-title":"Stem Cell. Res. Ther."},{"issue":"15","key":"10.1016\/j.imbio.2025.153103_bb0095","doi-asserted-by":"crossref","first-page":"931","DOI":"10.21037\/atm-20-4233","article-title":"Ligustilide modulates oxidative stress, apoptosis, and immunity to avoid pathological damages in bleomycin induced pulmonary fibrosis rats via inactivating TLR4\/MyD88\/NF-KB P65","volume":"8","author":"Luo","year":"2020","journal-title":"Ann. Transl. Med."},{"issue":"4","key":"10.1016\/j.imbio.2025.153103_bb0100","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1111\/cns.14063","article-title":"Artemisinin exerts a protective effect in the MPTP mouse model of Parkinson\u2019s disease by inhibiting microglial activation via the TLR4\/Myd88\/NF-KB pathway","volume":"29","author":"Lv","year":"2023","journal-title":"CNS Neurosci. Ther."},{"issue":"9","key":"10.1016\/j.imbio.2025.153103_bb0105","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.2174\/1570180819666220422114450","article-title":"Computational drug shifting towards drug-drug conjugates and monoclonal antibody conjugates in the contradictory excursion of asthma","volume":"20","author":"Muhammad","year":"2023","journal-title":"Lett Drug Design Discov"},{"issue":"176","key":"10.1016\/j.imbio.2025.153103_bb0110","doi-asserted-by":"crossref","first-page":"372","DOI":"10.24976\/Discov.Med.202335176.38","article-title":"Baicalin Reduces Renal Inflammation in Mesangial Proliferative Glomerulonephritis through Activation of Nrf2\/ARE and PI3K\/AKT Pathways","volume":"35","author":"Ning","year":"2023","journal-title":"Discov. Med."},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/ncb2000","article-title":"Rab27a and Rab27b control different steps of the exosome secretion pathway","volume":"12","author":"Ostrowski","year":"2010","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.imbio.2025.153103_bb0120","doi-asserted-by":"crossref","first-page":"193","DOI":"10.2147\/JAA.S176026","article-title":"Adverse outcomes from initiation of systemic corticosteroids for asthma: long-term observational study","volume":"11","author":"Price","year":"2018","journal-title":"J. Asthma Allergy"},{"key":"10.1016\/j.imbio.2025.153103_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107288","article-title":"Intranasal delivery of MSC-derived exosomes attenuates allergic asthma via expanding IL-10 producing lung interstitial macrophages in mice","volume":"91","author":"Ren","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"4","key":"10.1016\/j.imbio.2025.153103_bb0130","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/aps.2018.19","article-title":"Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro","volume":"39","author":"Ruan","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"issue":"3","key":"10.1016\/j.imbio.2025.153103_bb0135","doi-asserted-by":"crossref","first-page":"5305","DOI":"10.1080\/21655979.2022.2032939","article-title":"MicroRNA-885-3p alleviates bronchial epithelial cell injury induced by lipopolysaccharide via toll-like receptor 4","volume":"13","author":"Shen","year":"2022","journal-title":"Bioengineered"},{"issue":"Pt 2","key":"10.1016\/j.imbio.2025.153103_bb0140","article-title":"Exosome-mediated delivery and regulation in neurological disease progression","volume":"264","author":"Singh","year":"2024","journal-title":"Int. J. Biol. Macromol."},{"key":"10.1016\/j.imbio.2025.153103_bb0145","article-title":"The protective effects of baicalin for respiratory diseases: an update and future perspectives","volume":"14","author":"Song","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0150","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s41387-023-00238-2","article-title":"Vitamin D deficiency contributes to the diabetic kidney disease progression via increase ZEB1\/ZEB2 expressions","volume":"13","author":"Souza","year":"2023","journal-title":"Nutr. Diabetes"},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0155","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00281-020-00785-1","article-title":"Asthma epidemiology and risk factors","volume":"42","author":"Stern","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.imbio.2025.153103_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107272","article-title":"Effect of gut microbiota on LPS-induced acute lung injury by regulating the TLR4\/NF-kB signaling pathway","volume":"91","author":"Tang","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.imbio.2025.153103_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104717","article-title":"Cellular senescence in asthma: from pathogenesis to therapeutic challenges","volume":"94","author":"Wan","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.imbio.2025.153103_bb0170","article-title":"Pharmacological effects of baicalin in lung diseases","volume":"14","author":"Wang","year":"2023","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0175","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1186\/s12890-021-01698-x","article-title":"Interleukin-22 attenuates allergic airway inflammation in ovalbumin-induced asthma mouse model","volume":"21","author":"Wang","year":"2021","journal-title":"BMC Pulm. Med."},{"issue":"2","key":"10.1016\/j.imbio.2025.153103_bb0185","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41422-020-00409-1","article-title":"RAB31 marks and controls an ESCRT-independent exosome pathway","volume":"31","author":"Wei","year":"2021","journal-title":"Cell Res."},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0190","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1186\/s12967-022-03337-3","article-title":"Study effect of probiotics and prebiotics on treatment of OVA-LPS-induced of allergic asthma inflammation and pneumonia by regulating the TLR4\/NF-kB signaling pathway","volume":"20","author":"Wu","year":"2022","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.imbio.2025.153103_bb0195","article-title":"Zhuifeng tougu capsules inhibit the TLR4\/MyD88\/NF-\u03baB signaling pathway and alleviate knee osteoarthritis: in vitro and in vivo experiments","volume":"13","author":"Xu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.imbio.2025.153103_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2024.155850","article-title":"Involucrasin B suppresses airway inflammation in obese asthma by inhibiting the TLR4-NF-\u03baB-NLRP3 pathway","volume":"132","author":"Yang","year":"2024","journal-title":"Phytomedicine"},{"issue":"3","key":"10.1016\/j.imbio.2025.153103_bb0205","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/10799893.2021.1900865","article-title":"Baicalin regulates the development of pediatric asthma via upregulating microRNA-103 and mediating the TLR4\/NF-\u03baB pathway","volume":"42","author":"Zhai","year":"2022","journal-title":"J. Recept. Signal Transduct. Res."},{"issue":"11","key":"10.1016\/j.imbio.2025.153103_bb0210","doi-asserted-by":"crossref","first-page":"2359","DOI":"10.1002\/ar.24782","article-title":"An introduction to traditional Chinese medicine, including acupuncture","volume":"304","author":"Zhang","year":"2021","journal-title":"Anat Rec (Hoboken)"},{"issue":"1","key":"10.1016\/j.imbio.2025.153103_bb0215","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1186\/s13223-022-00724-9","article-title":"Anti-asthmatic miR-224-5p inhibits the FHL1\/MAPK pathway to repress airway smooth muscle cell proliferation in a murine model of asthma-like airway inflammation","volume":"18","author":"Zhuang","year":"2022","journal-title":"Allergy, Asthma Clin. Immunol."},{"issue":"7","key":"10.1016\/j.imbio.2025.153103_bb0220","doi-asserted-by":"crossref","first-page":"838","DOI":"10.2174\/1570180819666220429100342","article-title":"Asiaticoside enhances the osteoblast potential of LPS-induced periodontal ligament stem cells through TLR4\/NF-KB Pathway","volume":"20","author":"Zou","year":"2023","journal-title":"Lett Drug Design Discov"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298525002372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298525002372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T13:04:27Z","timestamp":1762261467000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298525002372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S0171298525002372"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2025.153103","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomes derived from baicalin-pretreated bone marrow mesenchymal stem cells inactivate the TLR4\/MyD88\/NF-kB pathway to improve asthma","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2025.153103","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153103"}}