{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T17:57:09Z","timestamp":1781459829814,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T00:00:00Z","timestamp":1756857600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017691","name":"Guangxi Key Research and Development Program","doi-asserted-by":"publisher","award":["GuikeAB23026020"],"award-info":[{"award-number":["GuikeAB23026020"]}],"id":[{"id":"10.13039\/501100017691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Guangxi Natural Science Foundation","doi-asserted-by":"publisher","award":["2023GXNSFBA026012"],"award-info":[{"award-number":["2023GXNSFBA026012"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.imbio.2025.153114","type":"journal-article","created":{"date-parts":[[2025,9,11]],"date-time":"2025-09-11T16:24:23Z","timestamp":1757607863000},"page":"153114","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pan-cancer analysis of GINS1 identifies its prognostic and immunotherapy predictive value with in vitro experimental validation in nasopharyngeal carcinoma"],"prefix":"10.1016","volume":"230","author":[{"given":"Yang","family":"Xu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanting","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuhan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.imbio.2025.153114_bb0005","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1016\/j.cell.2018.03.059","article-title":"SnapShot: TCGA-Analyzed Tumors","volume":"173","author":"Blum","year":"2018","journal-title":"Cell"},{"issue":"11","key":"10.1016\/j.imbio.2025.153114_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111836","article-title":"Increased replication origin firing links replication stress to whole chromosomal instability in human cancer","volume":"41","author":"B\u00f6hly","year":"2022","journal-title":"Cell Rep."},{"issue":"9","key":"10.1016\/j.imbio.2025.153114_bb0015","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.trecan.2021.04.006","article-title":"Hypertranscription and replication stress in cancer","volume":"7","author":"Bowry","year":"2021","journal-title":"Trends Cancer"},{"issue":"5","key":"10.1016\/j.imbio.2025.153114_bb0020","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"issue":"31","key":"10.1016\/j.imbio.2025.153114_bb0025","doi-asserted-by":"crossref","first-page":"12685","DOI":"10.1073\/pnas.0705558104","article-title":"Crystal structure of the GINS complex and functional insights into its role in DNA replication","volume":"104","author":"Chang","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10192","key":"10.1016\/j.imbio.2025.153114_bb0030","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0140-6736(19)30956-0","article-title":"Nasopharyngeal carcinoma","volume":"394","author":"Chen","year":"2019","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0035","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1038\/s41467-024-46735-5","article-title":"CD276-dependent efferocytosis by tumor-associated macrophages promotes immune evasion in bladder cancer","volume":"15","author":"Cheng","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0040","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41573-022-00558-5","article-title":"Targeting replication stress in cancer therapy","volume":"22","author":"da Costa","year":"2023","journal-title":"Nat. Rev. Drug Discov."},{"issue":"3","key":"10.1016\/j.imbio.2025.153114_bb0045","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.ccell.2023.02.016","article-title":"The evolving tumor microenvironment: from cancer initiation to metastatic outgrowth","volume":"41","author":"de Visser","year":"2023","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0050","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s13073-020-0721-z","article-title":"Large-scale public data reuse to model immunotherapy response and resistance","volume":"12","author":"Fu","year":"2020","journal-title":"Genome Med."},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0055","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13045-021-01103-4","article-title":"Spatial architecture of the immune microenvironment orchestrates tumor immunity and therapeutic response","volume":"14","author":"Fu","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"4","key":"10.1016\/j.imbio.2025.153114_bb0060","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/ncb1382","article-title":"GINS maintains association of Cdc45 with MCM in replisome progression complexes at eukaryotic DNA replication forks","volume":"8","author":"Gambus","year":"2006","journal-title":"Nat. Cell Biol."},{"issue":"9","key":"10.1016\/j.imbio.2025.153114_bb0065","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/s41568-022-00490-1","article-title":"Targeting telomeres: advances in telomere maintenance mechanism-specific cancer therapies","volume":"22","author":"Gao","year":"2022","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0070","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12943-023-01751-9","article-title":"New frontiers in immune checkpoint B7-H3 (CD276) research and drug development","volume":"22","author":"Getu","year":"2023","journal-title":"Mol. Cancer"},{"issue":"6","key":"10.1016\/j.imbio.2025.153114_bb0075","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0080","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.imbio.2025.153114_bb0085","article-title":"Molecular Diagnosis of Nasopharyngeal Carcinoma: past and Future","author":"Hsu","year":"2024","journal-title":"Biom. J."},{"issue":"6235","key":"10.1016\/j.imbio.2025.153114_bb0090","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"Human genomics.","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.imbio.2025.153114_bb0095","doi-asserted-by":"crossref","first-page":"2681","DOI":"10.2147\/CMAR.S341472","article-title":"Advanced Nasopharyngeal Carcinoma: current and emerging Treatment Options","volume":"14","author":"Jiromaru","year":"2022","journal-title":"Cancer Manag. Res."},{"issue":"9","key":"10.1016\/j.imbio.2025.153114_bb0100","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1007\/s11864-023-01101-3","article-title":"Recurrent\/Metastatic Nasopharyngeal Carcinoma Treatment from present to Future: where are we and where are we heading?","volume":"24","author":"Juarez-Vignon Whaley","year":"2023","journal-title":"Curr. Treat. Options in Oncol."},{"issue":"W1","key":"10.1016\/j.imbio.2025.153114_bb0105","doi-asserted-by":"crossref","first-page":"W509","DOI":"10.1093\/nar\/gkaa407","article-title":"TIMER2.0 for analysis of tumor-infiltrating immune cells","volume":"48","author":"Li","year":"2020","journal-title":"Nucleic Acids Res."},{"issue":"22","key":"10.1016\/j.imbio.2025.153114_bb0110","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1038\/s41388-021-01816-3","article-title":"MALAT1 modulated FOXP3 ubiquitination then affected GINS1 transcription and drived NSCLC proliferation","volume":"40","author":"Li","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.imbio.2025.153114_bb0115","article-title":"GINS1 Induced Sorafenib Resistance by Promoting Cancer Stem Properties in Human Hepatocellular Cancer Cells","volume":"9","author":"Li","year":"2021","journal-title":"Front. Cell Dev. Biol."},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0120","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13045-022-01360-x","article-title":"The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment","volume":"15","author":"Li","year":"2022","journal-title":"J. Hematol. Oncol."},{"issue":"5","key":"10.1016\/j.imbio.2025.153114_bb0125","doi-asserted-by":"crossref","first-page":"e387","DOI":"10.1002\/mco2.387","article-title":"Progresses in biomarkers for cancer immunotherapy","volume":"4","author":"Lin","year":"2020","journal-title":"MedComm"},{"key":"10.1016\/j.imbio.2025.153114_bb0130","article-title":"Immunotherapy: Reshape the Tumor Immune Microenvironment","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.imbio.2025.153114_bb0135","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1016\/j.immuni.2021.01.012","article-title":"Chemokines and the immune response to cancer","volume":"54","author":"Ozga","year":"2021","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2021.100336","article-title":"Real-world application of tumor mutational burden-high (TMB-high) and microsatellite instability (MSI) confirms their utility as immunotherapy biomarkers","volume":"7","author":"Palmeri","year":"2022","journal-title":"ESMO Open"},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0145","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.immuni.2022.12.008","article-title":"Microenvironment-driven metabolic adaptations guiding CD8(+) T cell anti-tumor immunity","volume":"56","author":"Park","year":"2023","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.imbio.2025.153114_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/imt2.36","article-title":"Sangerbox: a comprehensive, interaction-friendly clinical bioinformatics analysis platform","volume":"1","author":"Shen","year":"2022","journal-title":"Imeta"},{"key":"10.1016\/j.imbio.2025.153114_bb0155","doi-asserted-by":"crossref","first-page":"1116143","DOI":"10.3389\/fmicb.2023.1116143","article-title":"The role of Epstein-Barr virus in nasopharyngeal carcinoma","volume":"14","author":"Su","year":"2023","journal-title":"Front. Microbiol."},{"issue":"3","key":"10.1016\/j.imbio.2025.153114_bb0160","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"12","key":"10.1016\/j.imbio.2025.153114_bb0165","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1007\/s12094-019-02090-2","article-title":"Anlotinib inhibits synovial sarcoma by targeting GINS1: a novel downstream target oncogene in progression of synovial sarcoma","volume":"21","author":"Tang","year":"2019","journal-title":"Clin. Transl. Oncol."},{"issue":"W1","key":"10.1016\/j.imbio.2025.153114_bb0170","doi-asserted-by":"crossref","first-page":"W556","DOI":"10.1093\/nar\/gkz430","article-title":"GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis","volume":"47","author":"Tang","year":"2019","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.imbio.2025.153114_bb0175","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/s41568-022-00544-4","article-title":"Mechanisms driving the immunoregulatory function of cancer cells","volume":"23","author":"van Weverwijk","year":"2023","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0180","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s12943-021-01316-8","article-title":"The cancer metabolic reprogramming and immune response","volume":"20","author":"Xia","year":"2021","journal-title":"Mol. Cancer"},{"issue":"1","key":"10.1016\/j.imbio.2025.153114_bb0185","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s12943-020-01278-3","article-title":"Exosome-based immunotherapy: a promising approach for cancer treatment","volume":"19","author":"Xu","year":"2020","journal-title":"Mol. Cancer"},{"key":"10.1016\/j.imbio.2025.153114_bb0190","doi-asserted-by":"crossref","DOI":"10.1177\/17588359221096214","article-title":"Current status and advances of immunotherapy in nasopharyngeal carcinoma","volume":"14","author":"Xu","year":"2022","journal-title":"Ther Adv Med Oncol"},{"issue":"9","key":"10.1016\/j.imbio.2025.153114_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104952","article-title":"GINS1 promotes the proliferation and migration of glioma cells through USP15-mediated deubiquitination of TOP2A","volume":"25","author":"Yang","year":"2022","journal-title":"iScience"},{"issue":"D1","key":"10.1016\/j.imbio.2025.153114_bb0200","doi-asserted-by":"crossref","first-page":"D1391","DOI":"10.1093\/nar\/gkab804","article-title":"TISMO: syngeneic mouse tumor database to model tumor immunity and immunotherapy response","volume":"50","author":"Zeng","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"5","key":"10.1016\/j.imbio.2025.153114_bb0205","first-page":"4149","article-title":"Complementary biomarkers of computed tomography for diagnostic grading of gastric cancer: DSCC1 and GINS1","volume":"16","author":"Zhu","year":"2024","journal-title":"Aging (Albany NY)"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298525002487?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298525002487?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,14]],"date-time":"2026-06-14T17:09:29Z","timestamp":1781456969000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298525002487"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":41,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0171298525002487"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2025.153114","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pan-cancer analysis of GINS1 identifies its prognostic and immunotherapy predictive value with in vitro experimental validation in nasopharyngeal carcinoma","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2025.153114","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153114"}}