{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:01:24Z","timestamp":1773813684618,"version":"3.50.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T00:00:00Z","timestamp":1768780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017959","name":"Hebei Province Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017959","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.imbio.2026.153161","type":"journal-article","created":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T16:11:16Z","timestamp":1769271076000},"page":"153161","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Clinical value of CTCs combined with serum tumor markers\/inflammatory cytokines for the early diagnosis of non-small cell lung cancer"],"prefix":"10.1016","volume":"231","author":[{"given":"Xiuxue","family":"Gu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingling","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.imbio.2026.153161_bb0005","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1186\/s12885-020-07338-7","article-title":"Racial differences in 5-year relative survival rates of cervical cancer by stage at diagnosis, between African American (black) and white women, living in the state of Alabama, USA","volume":"20","author":"Abdalla","year":"2020","journal-title":"BMC Cancer"},{"issue":"5","key":"10.1016\/j.imbio.2026.153161_bb0010","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1056\/NEJMoa1102873","article-title":"Reduced lung-cancer mortality with low-dose computed tomographic screening","volume":"365","author":"Aberle","year":"2011","journal-title":"N. Engl. J. Med."},{"issue":"10374","key":"10.1016\/j.imbio.2026.153161_bb0015","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/S0140-6736(22)01694-4","article-title":"Lung cancer screening","volume":"401","author":"Adams","year":"2023","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.imbio.2026.153161_bb0020","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"issue":"10","key":"10.1016\/j.imbio.2026.153161_bb0025","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1038\/s41591-019-0593-1","article-title":"Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse","volume":"25","author":"Chemi","year":"2019","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.imbio.2026.153161_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0299447","article-title":"Meta-analysis of the accuracy for RASSF1A methylation in bronchial aspirates for the diagnosis of lung cancer","volume":"19","author":"Chen","year":"2024","journal-title":"PLoS One"},{"issue":"6586","key":"10.1016\/j.imbio.2026.153161_bb0035","doi-asserted-by":"crossref","DOI":"10.1126\/science.aay9040","article-title":"Early detection of cancer","volume":"375","author":"Crosby","year":"2022","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.imbio.2026.153161_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1391","article-title":"TIMP1 is an early biomarker for detection and prognosis of lung cancer","volume":"13","author":"Dantas","year":"2023","journal-title":"Clin. Transl. Med."},{"issue":"2","key":"10.1016\/j.imbio.2026.153161_bb0045","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00432-023-05588-z","article-title":"Detection of the DNA methylation of seven genes contribute to the early diagnosis of lung cancer","volume":"150","author":"Du","year":"2024","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"25","key":"10.1016\/j.imbio.2026.153161_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/smll.202207324","article-title":"Promising Mass-Productive 4-Inch Commercial SERS Sensor with Particle in Micro-Nano Porous Ag\/Si\/Ag Structure using in Auxiliary Diagnosis of early Lung Cancer","volume":"19","author":"Gao","year":"2023","journal-title":"Small"},{"issue":"5","key":"10.1016\/j.imbio.2026.153161_bb0055","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/ijc.33295","article-title":"Overdiagnosis in lung cancer screening: estimates from the German Lung Cancer Screening intervention Trial","volume":"148","author":"Gonzalez","year":"2021","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.imbio.2026.153161_bb0060","doi-asserted-by":"crossref","first-page":"841","DOI":"10.2147\/CMAR.S240773","article-title":"Circulating Tumor Cells as a Biomarker to Assist Molecular Diagnosis for early Stage Non-Small Cell Lung Cancer","volume":"12","author":"He","year":"2020","journal-title":"Cancer Manag. Res."},{"issue":"10","key":"10.1016\/j.imbio.2026.153161_bb0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0111597","article-title":"\u201cSentinel\u201d circulating tumor cells allow early diagnosis of lung cancer in patients with chronic obstructive pulmonary disease","volume":"9","author":"Ilie","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.imbio.2026.153161_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041565","article-title":"The Role of Tumor Microenvironment Cells in Colorectal Cancer (CRC) Cachexia","volume":"22","author":"Kasprzak","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.imbio.2026.153161_bb0075","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1177\/1758834010378414","article-title":"Circulating tumour cells: their utility in cancer management and predicting outcomes","volume":"2","author":"Krebs","year":"2010","journal-title":"Ther. Adv. Med. Oncol."},{"issue":"2","key":"10.1016\/j.imbio.2026.153161_bb0080","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.imlet.2012.10.011","article-title":"IL-17 promoted metastasis of non-small-cell lung cancer cells","volume":"148","author":"Li","year":"2012","journal-title":"Immunol. Lett."},{"issue":"8","key":"10.1016\/j.imbio.2026.153161_bb0085","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1002\/cam4.2286","article-title":"Clinical significance of circulating tumor cells and tumor markers in the diagnosis of lung cancer","volume":"8","author":"Li","year":"2019","journal-title":"Cancer Med."},{"issue":"4","key":"10.1016\/j.imbio.2026.153161_bb0090","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.21037\/tcr-21-527","article-title":"The value of combined detection of CEA, CYFRA21-1, SCC-Ag, and pro-GRP in the differential diagnosis of lung cancer","volume":"10","author":"Li","year":"2021","journal-title":"Transl. Cancer Res."},{"key":"10.1016\/j.imbio.2026.153161_bb0095","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/7841279","article-title":"IL-17A Promotes the Migration, Invasion and the EMT Process of Lung Cancer Accompanied by NLRP3 Activation","volume":"2022","author":"Liu","year":"2022","journal-title":"Biomed. Res. Int."},{"issue":"23","key":"10.1016\/j.imbio.2026.153161_bb0100","doi-asserted-by":"crossref","first-page":"3393","DOI":"10.1111\/1759-7714.14702","article-title":"Combined measurement of circulating tumor cell counts and serum tumor marker levels enhances the screening efficiency for malignant versus benign pulmonary nodules","volume":"13","author":"Ma","year":"2022","journal-title":"Thorac Cancer"},{"issue":"7203","key":"10.1016\/j.imbio.2026.153161_bb0105","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1038\/nature07205","article-title":"Cancer-related inflammation","volume":"454","author":"Mantovani","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.imbio.2026.153161_bb0110","doi-asserted-by":"crossref","first-page":"287","DOI":"10.2174\/1745017902117010287","article-title":"Clinical Implications of Cancer Related Inflammation and Depression: a critical Review","volume":"17","author":"McFarland","year":"2021","journal-title":"Clin. Pract. Epidemiol. Ment. Health"},{"issue":"12","key":"10.1016\/j.imbio.2026.153161_bb0115","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1038\/sj.bjc.6602248","article-title":"The relationship between circulating concentrations of C-reactive protein, inflammatory cytokines and cytokine receptors in patients with non-small-cell lung cancer","volume":"91","author":"McKeown","year":"2004","journal-title":"Br. J. Cancer"},{"issue":"11","key":"10.1016\/j.imbio.2026.153161_bb0120","first-page":"934","article-title":"Diagnostic values of conventional tumor markers and their combination with chest CT for patients with stageIA lung cancer","volume":"45","author":"Peng","year":"2023","journal-title":"Chin. J. Oncol."},{"issue":"5","key":"10.1016\/j.imbio.2026.153161_bb0125","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11748-007-0101-2","article-title":"Circulating tumor cells in peripheral blood caused by surgical manipulation of non-small-cell lung cancer: pilot study using an immunocytology method","volume":"55","author":"Sawabata","year":"2007","journal-title":"Gen. Thorac. Cardiovasc. Surg."},{"issue":"11","key":"10.1016\/j.imbio.2026.153161_bb0130","first-page":"863","article-title":"Exoression changes and clinical significance of cytokines and inflammatory cells in peripheral blood of lung cancer patients","volume":"40","author":"Shi","year":"2022","journal-title":"Chin. J. Clin. Lab. Sci."},{"issue":"1","key":"10.1016\/j.imbio.2026.153161_bb0135","first-page":"7","article-title":"Cancer Statistics, 2021","volume":"71","author":"Siegel","year":"2021","journal-title":"CA Cancer J. Clin."},{"issue":"7","key":"10.1016\/j.imbio.2026.153161_bb0140","doi-asserted-by":"crossref","first-page":"1656","DOI":"10.1158\/1078-0432.CCR-19-2541","article-title":"Analysis of Released Circulating Tumor Cells during Surgery for Non-Small Cell Lung Cancer","volume":"26","author":"Tamminga","year":"2020","journal-title":"Clin. Cancer Res."},{"issue":"10","key":"10.1016\/j.imbio.2026.153161_bb0145","first-page":"1540","article-title":"NSCLC patients serum cytokine levels and the influence factors of its variation","volume":"26","author":"Wang","year":"2018","journal-title":"J. Modern Oncol."},{"issue":"20","key":"10.1016\/j.imbio.2026.153161_bb0150","doi-asserted-by":"crossref","DOI":"10.1002\/pmic.202300140","article-title":"Comprehensive serum N-glycan profiling identifies a biomarker panel for early diagnosis of non-small-cell lung cancer","volume":"23","author":"Wang","year":"2023","journal-title":"Proteomics"},{"issue":"15","key":"10.1016\/j.imbio.2026.153161_bb0155","doi-asserted-by":"crossref","first-page":"67","DOI":"10.14715\/cmb\/2017.64.15.11","article-title":"Combined detection of CEA and CA125 for the diagnosis for lung cancer: a meta-analysis","volume":"64","author":"Wu","year":"2018","journal-title":"Cell. Mol. Biol. (Noisy-le-Grand)"},{"issue":"1","key":"10.1016\/j.imbio.2026.153161_bb0160","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1186\/s12885-022-09728-5","article-title":"Development and validation of reassigned CEA, CYFRA21-1 and NSE-based models for lung cancer diagnosis and prognosis prediction","volume":"22","author":"Yuan","year":"2022","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.imbio.2026.153161_bb0165","first-page":"10515","article-title":"Prognostic significance of interleukin-17 in solid tumors: a meta-analysis","volume":"8","author":"Zeng","year":"2015","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"Suppl. 7","key":"10.1016\/j.imbio.2026.153161_bb0170","doi-asserted-by":"crossref","first-page":"S830","DOI":"10.21037\/jtd.2017.12.125","article-title":"Performance evaluation of detecting circulating tumor cells and tumor cells in bronchoalveolar lavage fluid in diagnosis of peripheral lung cancer","volume":"10","author":"Zhong","year":"2018","journal-title":"J. Thorac. Dis."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000070?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000070?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T05:03:53Z","timestamp":1773810233000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000070"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":34,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S0171298526000070"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153161","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical value of CTCs combined with serum tumor markers\/inflammatory cytokines for the early diagnosis of non-small cell lung cancer","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153161","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153161"}}