{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T09:45:43Z","timestamp":1782467143171,"version":"3.54.5"},"reference-count":37,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005946","name":"Hokkaido University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005946","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.imbio.2026.153178","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T17:29:40Z","timestamp":1775755780000},"page":"153178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hyperlipidemia promotes neutrophil extracellular trap-mediated osteonecrosis of the femoral head following methylprednisolone pulse in lupus mice"],"prefix":"10.1016","volume":"231","author":[{"given":"Hodaka","family":"Ogawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naho","family":"Ogawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mizuki","family":"Fukuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shota","family":"Homma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suishin","family":"Arai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Momo","family":"Uchizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riku","family":"Manabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koki","family":"Takai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"China","family":"Washio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuma","family":"Hori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Nishibata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sakiko","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Sakurai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu-Ping","family":"Hui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Watanabe-Kusunoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daigo","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utano","family":"Tomaru","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiro","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norimasa","family":"Iwasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiro","family":"Ishizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2026.153178_bb0005","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1002\/pmic.200800566","article-title":"Proteomic analysis of human low-density lipoprotein reveals the presence of prenylcysteine lyase, a hydrogen peroxide-generating enzyme","volume":"9","author":"Banfi","year":"2009","journal-title":"Proteomics"},{"key":"10.1016\/j.imbio.2026.153178_bb0010","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/s42003-021-02630-z","article-title":"Prenylcysteine oxidase 1, an emerging player in atherosclerosis","volume":"4","author":"Banfi","year":"2021","journal-title":"Commun Biol"},{"key":"10.1016\/j.imbio.2026.153178_bb0015","first-page":"780","article-title":"Longterm beneficial effect of chloroquine diphosphate on lipoprotein profile in lupus patients with and without steroid therapy","volume":"28","author":"Borba","year":"2001","journal-title":"J. Rheumatol."},{"key":"10.1016\/j.imbio.2026.153178_bb0020","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.imbio.2026.153178_bb0025","article-title":"Review: the emerging role of neutrophil extracellular traps in sepsis and Sepsis-Associated thrombosis","volume":"11","author":"Chen","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.imbio.2026.153178_bb0030","doi-asserted-by":"crossref","first-page":"4896","DOI":"10.3390\/ijms24054896","article-title":"Molecular mechanisms of neutrophil extracellular trap (NETs) degradation","volume":"24","author":"Demkow","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.imbio.2026.153178_bb0035","doi-asserted-by":"crossref","first-page":"2598","DOI":"10.1161\/ATVBAHA.120.316389","article-title":"Hypercholesterolemia impairs clearance of neutrophil extracellular traps and promotes inflammation and atherosclerotic plaque progression","volume":"41","author":"Dhawan","year":"2021","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.imbio.2026.153178_bb0040","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.otsr.2010.06.014","article-title":"Early prediction of femoral head avascular necrosis following neck fracture","volume":"97","author":"Ehlinger","year":"2011","journal-title":"Orthop. Traumatol. Surg. Res."},{"key":"10.1016\/j.imbio.2026.153178_bb0045","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1136\/annrheumdis-2020-218272","article-title":"Update on the diagnosis and management of systemic lupus erythematosus","volume":"80","author":"Fanouriakis","year":"2021","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.imbio.2026.153178_bb0050","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.5114\/amsad\/150872","article-title":"An insertion mutation in the apoe gene associated with spontaneous hyperlipidemia in mice","volume":"7","author":"Hatakeyama","year":"2022","journal-title":"Arch Med Sci Atheroscler Dis"},{"key":"10.1016\/j.imbio.2026.153178_bb0055","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.2741\/4631","article-title":"Prenylcysteine oxidase 1, a pro-oxidant enzyme of low density lipoproteins","volume":"23","author":"Herrera-Marcos","year":"2018","journal-title":"Front. Biosci. (Landmark Ed)"},{"key":"10.1016\/j.imbio.2026.153178_bb0060","doi-asserted-by":"crossref","DOI":"10.3346\/jkms.2021.36.e177","article-title":"Osteonecrosis of the femoral head: an updated review of ARCO on pathogenesis, staging and treatment","volume":"36","author":"Hines","year":"2021","journal-title":"J. Korean Med. Sci."},{"key":"10.1016\/j.imbio.2026.153178_bb0065","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cca.2019.02.020","article-title":"Composition of plasmalogens in serum lipoproteins from patients with non-alcoholic steatohepatitis and their susceptibility to oxidation","volume":"493","author":"Ikuta","year":"2019","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.imbio.2026.153178_bb0070","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1111\/jth.12796","article-title":"Impaired DNase1-mediated degradation of neutrophil extracellular traps is associated with acute thrombotic microangiopathies","volume":"13","author":"Jim\u00e9nez-Alc\u00e1zar","year":"2015","journal-title":"J. Thromb. Haemost."},{"key":"10.1016\/j.imbio.2026.153178_bb0075","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/art.43019","article-title":"Exploring the role of neutrophil extracellular traps in systemic lupus erythematosus: a clinical case study and comprehensive review","volume":"77","author":"Kaplan","year":"2025","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imbio.2026.153178_bb0080","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/nm.1959","article-title":"Netting neutrophils in autoimmune small-vessel vasculitis","volume":"15","author":"Kessenbrock","year":"2009","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2026.153178_bb0085","doi-asserted-by":"crossref","first-page":"3413","DOI":"10.1073\/pnas.90.8.3413","article-title":"Genetic selection for crescent formation yields mouse strain with rapidly progressive glomerulonephritis and small vessel vasculitis","volume":"90","author":"Kinjoh","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.imbio.2026.153178_bb0090","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1007\/s10067-015-3075-y","article-title":"High triglyceride is a risk factor for silent osteonecrosis of the femoral head in systemic lupus erythematosus","volume":"34","author":"Kuroda","year":"2015","journal-title":"Clin. Rheumatol."},{"key":"10.1016\/j.imbio.2026.153178_bb0095","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1055\/s-0038-1677040","article-title":"Neutrophil extracellular traps in arterial and venous thrombosis","volume":"45","author":"Laridan","year":"2019","journal-title":"Semin. Thromb. Hemost."},{"key":"10.1016\/j.imbio.2026.153178_bb0100","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1002\/art.34451","article-title":"Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia","volume":"64","author":"Lewis","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imbio.2026.153178_bb0105","doi-asserted-by":"crossref","first-page":"2416070","DOI":"10.1080\/07853890.2024.2416070","article-title":"Pathological mechanisms and related markers of steroid-induced osteonecrosis of the femoral head","volume":"56","author":"Li","year":"2024","journal-title":"Ann. Med."},{"key":"10.1016\/j.imbio.2026.153178_bb0110","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1186\/s12967-016-0901-1","article-title":"The apoe\u2212\/\u2212 mouse model: a suitable model to study cardiovascular and respiratory diseases in the context of cigarette smoke exposure and harm reduction","volume":"14","author":"Lo Sasso","year":"2016","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.imbio.2026.153178_bb0115","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/cyto.a.23169","article-title":"Measurement of NET formation in vitro and in vivo by flow cytometry","volume":"91","author":"Masuda","year":"2017","journal-title":"Cytometry A"},{"key":"10.1016\/j.imbio.2026.153178_bb0120","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0140-6736(82)91513-6","article-title":"Lipid nephrotoxicity in chronic progressive glomerular and tubulo-interstitial disease","volume":"2","author":"Moorhead","year":"1982","journal-title":"Lancet"},{"key":"10.1016\/j.imbio.2026.153178_bb0125","first-page":"609","article-title":"Hypercholesterolemia: an association with osteonecrosis of the femoral head","volume":"26","author":"Moskal","year":"1997","journal-title":"Am. J. Orthop. (Belle Mead N.J.)"},{"key":"10.1016\/j.imbio.2026.153178_bb0130","first-page":"655","article-title":"Class II lupus nephritis with podocyte injury in imiquimod-induced lupus-prone mice","volume":"37","author":"Murai","year":"2022","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.imbio.2026.153178_bb0135","first-page":"700","article-title":"A meta-analysis of avascular necrosis in systemic lupus erythematosus: Prevalence and risk factors","volume":"35","author":"Nevskaya","year":"2017","journal-title":"Clin. Exp. Rheumatol."},{"key":"10.1016\/j.imbio.2026.153178_bb0140","doi-asserted-by":"crossref","first-page":"2282","DOI":"10.1016\/j.ajpath.2020.07.008","article-title":"Association of neutrophil extracellular traps with the development of idiopathic osteonecrosis of the femoral head","volume":"190","author":"Nonokawa","year":"2020","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.imbio.2026.153178_bb0145","doi-asserted-by":"crossref","DOI":"10.1136\/lupus-2023-001042","article-title":"Methylprednisolone pulse-enhanced neutrophil extracellular trap formation in mice with imiquimod-induced lupus-like disease, resulting in ischaemia of the femoral head cartilage","volume":"10","author":"Ogawa","year":"2023","journal-title":"Lupus Sci Med"},{"key":"10.1016\/j.imbio.2026.153178_bb0150","doi-asserted-by":"crossref","first-page":"161","DOI":"10.2119\/molmed.2013.00010","article-title":"Lupus nephritis: Enigmas, conflicting models and an emerging concept","volume":"19","author":"Seredkina","year":"2013","journal-title":"Mol. Med."},{"key":"10.1016\/j.imbio.2026.153178_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0172223","article-title":"Streptococcus sanguinis induces neutrophil cell death by production of hydrogen peroxide","volume":"12","author":"Sumioka","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.imbio.2026.153178_bb0160","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1161\/CIRCRESAHA.123.321750","article-title":"NETs-Induced thrombosis impacts on cardiovascular and chronic kidney disease","volume":"132","author":"Thakur","year":"2023","journal-title":"Circ. Res."},{"key":"10.1016\/j.imbio.2026.153178_bb0165","doi-asserted-by":"crossref","first-page":"538","DOI":"10.4049\/jimmunol.1100450","article-title":"Netting neutrophils induce endothelial damage, infiltrate tissues, and expose immunostimulatory molecules in systemic lupus erythematosus","volume":"187","author":"Villanueva","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2026.153178_bb0170","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jot.2014.12.002","article-title":"Steroid-associated osteonecrosis: Epidemiology, pathophysiology, animal model, prevention, and potential treatments (an overview)","volume":"3","author":"Xie","year":"2015","journal-title":"J Orthop Translat"},{"key":"10.1016\/j.imbio.2026.153178_bb0175","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1002\/jor.25006","article-title":"Development of a murine model of ischemic osteonecrosis to study the effects of aging on bone repair","volume":"39","author":"Yamaguchi","year":"2021","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.imbio.2026.153178_bb0180","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1097\/00003086-199507000-00033","article-title":"Corticosteroid enhances the experimental induction of osteonecrosis in rabbits with shwartzman reaction","volume":"316","author":"Yamamoto","year":"1995","journal-title":"Clin. Orthop. Relat. Res."},{"key":"10.1016\/j.imbio.2026.153178_bb0185","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1002\/art.38298","article-title":"Epicutaneous application of toll-like receptor 7 agonists leads to systemic autoimmunity in wild-type mice: a new model of systemic lupus erythematosus","volume":"66","author":"Yokogawa","year":"2014","journal-title":"Arthritis Rheum."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000240?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000240?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:47:14Z","timestamp":1782463634000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0171298526000240"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153178","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Hyperlipidemia promotes neutrophil extracellular trap-mediated osteonecrosis of the femoral head following methylprednisolone pulse in lupus mice","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153178"}}