{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:53:49Z","timestamp":1782464029343,"version":"3.54.5"},"reference-count":57,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472346"],"award-info":[{"award-number":["82472346"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC1540"],"award-info":[{"award-number":["2024NSFSC1540"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["ZYAI24002"],"award-info":[{"award-number":["ZYAI24002"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2406600\/2022YFC2406604"],"award-info":[{"award-number":["2022YFC2406600\/2022YFC2406604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.imbio.2026.153179","type":"journal-article","created":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T15:11:57Z","timestamp":1775315517000},"page":"153179","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Development and preliminary clinical verification of an immune age model based on peripheral immune cells"],"prefix":"10.1016","volume":"231","author":[{"given":"Bin","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erdi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiansen","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.imbio.2026.153179_bb0005","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/s41591-019-0381-y","article-title":"A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring","volume":"25","author":"Alpert","year":"2019","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2026.153179_bb0010","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/8045161","article-title":"The distribution of activation markers and selectins on peripheral t lymphocytes in preeclampsia","volume":"2017","author":"Bajnok","year":"2017","journal-title":"Mediators Inflamm."},{"issue":"5","key":"10.1016\/j.imbio.2026.153179_bb0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1007\/s00281-020-00806-z","article-title":"The interplay between immunosenescence and age-related diseases","volume":"42","author":"Barb\u00e9-Tuana","year":"2020","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.imbio.2026.153179_bb0020","doi-asserted-by":"crossref","unstructured":"Belsky DW, Caspi A, Arseneault L, et al. Quantification of the pace of biological aging in humans through a blood test, the DunedinPoAm DNA methylation algorithm. Elife 2020;9:e54870. doi:10.7554\/eLife.54870. PMID: 32367804; PMCID: PMC7282814.","DOI":"10.7554\/eLife.54870"},{"issue":"6","key":"10.1016\/j.imbio.2026.153179_bb0025","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1378\/chest.101.6.1644","article-title":"Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP\/SCCM consensus conference committee. American college of chest Physicians\/Society of critical care medicine","volume":"101","author":"Bone","year":"1992","journal-title":"Chest"},{"key":"10.1016\/j.imbio.2026.153179_bb0030","doi-asserted-by":"crossref","unstructured":"Brauning A, Rae M, Zhu G, et al. Aging of the immune system: Focus on natural killer cells phenotype and functions. Cells 2022;11(6):1017. doi:10.3390\/cells11061017. PMID: 35326467; PMCID: PMC8947539.","DOI":"10.3390\/cells11061017"},{"key":"10.1016\/j.imbio.2026.153179_bb0035","doi-asserted-by":"crossref","unstructured":"Chang ST, Chuang YF, Li AH, Fan YT, Liao MR, Chen IY, Hung RW, Yang TO, Chiu YL. Age-dependent immune profile in healthy individuals: an original study, systematic review and meta-analysis. Immun. Ageing 2024 21(1):75. doi:https:\/\/doi.org\/10.1186\/s12979-024-00480-x.PMID: 39472926; PMCID: PMC11520839.","DOI":"10.1186\/s12979-024-00480-x"},{"key":"10.1016\/j.imbio.2026.153179_bb0040","doi-asserted-by":"crossref","unstructured":"Chaturvedi V, Mehrotra S, Chatterjee S. CD38: T cell immuno-metabolic modulator. Cells 2020;9(7):1716. doi:https:\/\/doi.org\/10.3390\/cells9071716 PMID: 32709019; PMCID: PMC7408359.","DOI":"10.3390\/cells9071716"},{"key":"10.1016\/j.imbio.2026.153179_bb0045","doi-asserted-by":"crossref","unstructured":"Chaturvedi V, Marsh RA, Zoref-Lorenz A, et al. T-cell activation profiles distinguish hemophagocytic lymphohistiocytosis and early sepsis. Blood 2021;137(17):2337\u20132346. doi:https:\/\/doi.org\/10.1182\/blood.2020009499. PMID: 33512385; PMCID: PMC8085480.","DOI":"10.1182\/blood.2020009499"},{"key":"10.1016\/j.imbio.2026.153179_bb0050","doi-asserted-by":"crossref","unstructured":"Sandstedt M, Chung RWS, Skoglund C, et al. Complete fatty degeneration of thymus associates with male sex, obesity and loss of circulating na\u00efve CD8+ t cells in a Swedish middle-aged population. Immun. Ageing 2023;20(1):45. doi:https:\/\/doi.org\/10.1186\/s12979-023-00371-7.PMID: 37653480; PMCID: PMC10470174.","DOI":"10.1186\/s12979-023-00371-7"},{"key":"10.1016\/j.imbio.2026.153179_bb0055","doi-asserted-by":"crossref","unstructured":"Du X, Zhao D, Wang Y, et al. Low serum calcium concentration in patients with systemic lupus erythematosus accompanied by the enhanced peripheral cellular immunity. Front. Immunol. 2022;13:901854. doi:https:\/\/doi.org\/10.3389\/fimmu.2022.901854. PMID: 35757710; PMCID: PMC9226677.","DOI":"10.3389\/fimmu.2022.901854"},{"key":"10.1016\/j.imbio.2026.153179_bb0060","doi-asserted-by":"crossref","unstructured":"Esensten JH, Helou YA, Chopra G, Weiss A, Bluestone JA. CD28 costimulation: from mechanism to therapy. Immunity 2016;44(5):973\u201388. doi:https:\/\/doi.org\/10.1016\/j.immuni.2016.04.020. PMID: 27192564; PMCID: PMC4932896.","DOI":"10.1016\/j.immuni.2016.04.020"},{"key":"10.1016\/j.imbio.2026.153179_bb0065","doi-asserted-by":"crossref","unstructured":"Ferrucci L, Gonzalez-Freire M, Fabbri E, et al. Measuring biological aging in humans: a quest. Aging Cell. 2020;19(2):e13080. doi:https:\/\/doi.org\/10.1111\/acel.13080. Epub 2019 Dec 12. PMID: 31833194; PMCID: PMC6996955.","DOI":"10.1111\/acel.13080"},{"key":"10.1016\/j.imbio.2026.153179_bb0070","doi-asserted-by":"crossref","unstructured":"Frasca D, Diaz A, Romero M, Garcia D, Blomberg BB. B cell immunosenescence. Annu. Rev. Cell Dev. Biol. 2020;36:551\u2013574. doi:https:\/\/doi.org\/10.1146\/annurev-cellbio-011620-034148. PMID: 33021823; PMCID: PMC8060858.","DOI":"10.1146\/annurev-cellbio-011620-034148"},{"key":"10.1016\/j.imbio.2026.153179_bb0075","doi-asserted-by":"crossref","unstructured":"Li J, Xiong M, Fu XH, et al. Determining a multimodal aging clock in a cohort of Chinese women. Med 2023;4(11):825\u2013848.e13. doi:https:\/\/doi.org\/10.1016\/j.medj.2023.06.010. Epub 2023 Jul 28. PMID: 37516104.","DOI":"10.1016\/j.medj.2023.06.010"},{"key":"10.1016\/j.imbio.2026.153179_bb0080","doi-asserted-by":"crossref","unstructured":"Fulop T, Larbi A, Pawelec G, et al. Immunology of aging: the birth of inflammaging. Clin. Rev. Allergy Immunol. 2023;64(2):109\u2013122. doi:https:\/\/doi.org\/10.1007\/s12016-021-08899-6. Epub 2021 Sep 18. PMID: 34536213; PMCID: PMC8449217.","DOI":"10.1007\/s12016-021-08899-6"},{"issue":"12","key":"10.1016\/j.imbio.2026.153179_bb0085","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"issue":"3","key":"10.1016\/j.imbio.2026.153179_bb0090","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00281-023-00990-8","article-title":"Differences in the post-stroke innate immune response between young and old","volume":"45","author":"Gallizioli","year":"2023","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.imbio.2026.153179_bb0095","doi-asserted-by":"crossref","unstructured":"Gao X, Geng T, Jiang M, et al. Accelerated biological aging and risk of depression and anxiety: evidence from 424,299 UK biobank participants. Nat. Commun. 2023;14(1):2277. doi:https:\/\/doi.org\/10.1038\/s41467-023-38013-7. Erratum in: Nat. Commun. 2023 Sep 25;14(1):5970. PMID: 37080981; PMCID: PMC10119095.","DOI":"10.1038\/s41467-023-38013-7"},{"issue":"4","key":"10.1016\/j.imbio.2026.153179_bb0100","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.jphys.2022.05.017","article-title":"Clinimetrics: Modified Rankin scale (mRS)","volume":"68","author":"Haggag","year":"2022","journal-title":"J. Physiother."},{"key":"10.1016\/j.imbio.2026.153179_bb0105","doi-asserted-by":"crossref","unstructured":"Huang C, Xiong H, Li W, et al. T cell activation profiles can distinguish gram negative\/positive bacterial sepsis and are associated with ICU discharge. Front. Immunol. 2023;13:1058606. doi:10.3389\/fimmu.2022.1058606. PMID: 36703970; PMCID: PMC9871918.","DOI":"10.3389\/fimmu.2022.1058606"},{"issue":"3","key":"10.1016\/j.imbio.2026.153179_bb0110","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1097\/TP.0000000000004715","article-title":"The impact of t-cell aging on alloimmunity and inflammaging","volume":"108","author":"Iske","year":"2024","journal-title":"Transplantation"},{"key":"10.1016\/j.imbio.2026.153179_bb0115","doi-asserted-by":"crossref","unstructured":"Jang IH, Niedernhofer LJ, Robbins PD, Camell CD. The ageing immune system as a driver of systemic ageing. Nat. Rev. Immunol. 2026 Feb 13. doi:10.1038\/s41577-026-01269-3. Epub ahead of print. PMID: 41688787.","DOI":"10.1038\/s41577-026-01269-3"},{"key":"10.1016\/j.imbio.2026.153179_bb0120","doi-asserted-by":"crossref","unstructured":"Jian B, Hu M, Cai W, Zhang B, Lu Z. Update of immunosenescence in cerebral small vessel disease. Front. Immunol. 2020 11:585655. doi:https:\/\/doi.org\/10.3389\/fimmu.2020.585655. PMID: 33362768; PMCID: PMC7756147.","DOI":"10.3389\/fimmu.2020.585655"},{"key":"10.1016\/j.imbio.2026.153179_bb0125","article-title":"Early markers of systemic inflammation are not related to pain burden after aneurysmal subarachnoid hemorrhage: a multicenter observational study","author":"Kardon","year":"2025","journal-title":"Neurocrit. Care"},{"key":"10.1016\/j.imbio.2026.153179_bb0130","doi-asserted-by":"crossref","unstructured":"Kverneland AH, Streitz M, Geissler E, et al. Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol. Cytometry A 2016;89(6):543\u201364. doi:https:\/\/doi.org\/10.1002\/cyto.a.22855. Epub 2016 May 3. PMID: 27144459.","DOI":"10.1002\/cyto.a.22855"},{"key":"10.1016\/j.imbio.2026.153179_bb0135","doi-asserted-by":"crossref","unstructured":"Li F, Xing X, Jin Q, et al. Sex differences orchestrated by androgens at single-cell resolution. Nature 2024;629(8010):193\u2013200. doi:https:\/\/doi.org\/10.1038\/s41586-024-07291-6. Epub 2024 Apr 10. PMID: 38600383.","DOI":"10.1038\/s41586-024-07291-6"},{"key":"10.1016\/j.imbio.2026.153179_bb0140","doi-asserted-by":"crossref","unstructured":"Li J, Farzaneh F, Candore G, et al. Immunosenescence and its hallmarks: how to oppose aging strategically? A review of potential options for therapeutic intervention. Front. Immunol. 2019;10:2247. doi:10.3389\/fimmu.2019.02247. PMID: 31608061; PMCID: PMC6773825.","DOI":"10.3389\/fimmu.2019.02247"},{"key":"10.1016\/j.imbio.2026.153179_bb0145","doi-asserted-by":"crossref","unstructured":"Li YF, Feng GQ, Ao YP, Gu B, Wang J, Xiao AF, You JQ. Impact of timeline-based management on treatment efficiency and outcomes in acute ischemic stroke: a quasi-experimental study. Ann. Med. 2025 57(1):2561793. doi:https:\/\/doi.org\/10.1080\/07853890.2025.2561793. Epub 2025 Sep 22. PMID: 40982725; PMCID: PMC12456036.","DOI":"10.1080\/07853890.2025.2561793"},{"key":"10.1016\/j.imbio.2026.153179_bb0150","doi-asserted-by":"crossref","unstructured":"Lian J, Yue Y, Yu W, Zhang Y. Immunosenescence: a key player in cancer development. J. Hematol. Oncol. 2020;13(1):151. doi:https:\/\/doi.org\/10.1186\/s13045-020-00986-z. PMID: 33168037; PMCID: PMC7653700.","DOI":"10.1186\/s13045-020-00986-z"},{"key":"10.1016\/j.imbio.2026.153179_bb0155","doi-asserted-by":"crossref","unstructured":"Liu W, Xu J, Pu Q, et al. The reference ranges and characteristics of lymphocyte parameters and the correlation between lymphocyte parameters and routine health indicators in adults from China. Immun. Ageing 2022;19(1):42. doi:10.1186\/s12979-022-00298-5. PMID: 36167546; PMCID: PMC9513899.","DOI":"10.1186\/s12979-022-00298-5"},{"key":"10.1016\/j.imbio.2026.153179_bb0160","doi-asserted-by":"crossref","unstructured":"Liu Z, Liang Q, Ren Y, et al. Immunosenescence: Molecular mechanisms and diseases. Signal Transduct. Target. Ther. 2023;8(1):200. doi:10.1038\/s41392-023-01451-2. PMID: 37179335; PMCID: PMC10182360.","DOI":"10.1038\/s41392-023-01451-2"},{"issue":"1","key":"10.1016\/j.imbio.2026.153179_bb0165","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.cmet.2022.11.001","article-title":"Meta-hallmarks of aging and cancer","volume":"35","author":"L\u00f3pez-Ot\u00edn","year":"2023","journal-title":"Cell Metab."},{"key":"10.1016\/j.imbio.2026.153179_bb0170","doi-asserted-by":"crossref","unstructured":"Lu J, Li H, Zhang G, et al. Age-related alterations in peripheral immune landscape with magnified impact on post-stroke brain. Research (Wash D C). 2023;6:0287. doi:10.34133\/research.0287. PMID: 38090608; PMCID: PMC10712880.","DOI":"10.34133\/research.0287"},{"key":"10.1016\/j.imbio.2026.153179_bb0175","doi-asserted-by":"crossref","unstructured":"Hu L, Zhu T, Long J, Luo Q, Lyu X. From infection to immune exhaustion: the Epstein-Barr virus and its contribution to immunosenescence. Biochim. Biophys. Acta Rev. Cancer 2025 1880(5):189421. doi:https:\/\/doi.org\/10.1016\/j.bbcan.2025.189421. Epub 2025 Aug 13. PMID: 40816546.","DOI":"10.1016\/j.bbcan.2025.189421"},{"issue":"4","key":"10.1016\/j.imbio.2026.153179_bb0180","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1038\/s41569-021-00624-2","article-title":"The role of cellular senescence in cardiac disease: basic biology and clinical relevance","volume":"19","author":"Mehdizadeh","year":"2022","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.imbio.2026.153179_bb0185","doi-asserted-by":"crossref","unstructured":"Minhas PS, Liu L, Moon PK, et al. Macrophage de novo NAD+ synthesis specifies immune function in aging and inflammation. Nat. Immunol. 2019;20(1):50\u201363. doi:https:\/\/doi.org\/10.1038\/s41590-018-0255-3. Epub 2018 Nov 26. PMID: 30478397; PMCID: PMC6768398.","DOI":"10.1038\/s41590-018-0255-3"},{"key":"10.1016\/j.imbio.2026.153179_bb0190","doi-asserted-by":"crossref","unstructured":"Mittelbrunn M, Kroemer G. Hallmarks of t cell aging. Nat. Immunol. 2021;22(6):687\u2013698. doi:https:\/\/doi.org\/10.1038\/s41590-021-00927-z. Epub 2021 May 13. PMID: 33986548.","DOI":"10.1038\/s41590-021-00927-z"},{"issue":"5","key":"10.1016\/j.imbio.2026.153179_bb0195","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.1038\/s41591-023-02338-z","article-title":"Organ-specific aging and the risk of chronic diseases","volume":"29","author":"Moqri","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2026.153179_bb0200","doi-asserted-by":"crossref","unstructured":"Mutke MA, Madai VI, Hilbert A, Zihni E, Potreck A, Weyland CS, M\u00f6hlenbruch MA, Heiland S, Ringleb PA, Nagel S, Bendszus M, Frey D. Comparing poor and favorable outcome prediction with machine learning after mechanical thrombectomy in acute ischemic stroke. Front. Neurol. 2022 May 27;13:737667. doi:https:\/\/doi.org\/10.3389\/fneur.2022.737667. MID: 35693017; PMCID: PMC9184444.","DOI":"10.3389\/fneur.2022.737667"},{"issue":"5","key":"10.1016\/j.imbio.2026.153179_bb0205","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.imbio.2026.153179_bb0210","doi-asserted-by":"crossref","unstructured":"Ross JB, Myers LM, Noh JJ, et al. Depleting myeloid-biased haematopoietic stem cells rejuvenates aged immunity. Nature 2024;628(8006):162\u2013170. doi:https:\/\/doi.org\/10.1038\/s41586-024-07238-x. Epub 2024 Mar 27. PMID: 38538791.","DOI":"10.1038\/s41586-024-07238-x"},{"key":"10.1016\/j.imbio.2026.153179_bb0215","doi-asserted-by":"crossref","unstructured":"Salinas GF, Braza F, Brouard S, Tak PP, Baeten D. The role of b lymphocytes in the progression from autoimmunity to autoimmune disease. Clin. Immunol. 2013;146(1):34\u201345. doi:https:\/\/doi.org\/10.1016\/j.clim.2012.10.005. Epub 2012 Oct 22. PMID: 23202542.","DOI":"10.1016\/j.clim.2012.10.005"},{"key":"10.1016\/j.imbio.2026.153179_bb0220","doi-asserted-by":"crossref","unstructured":"Salminen A. Role of indoleamine 2,3-dioxygenase 1 (IDO1) and kynurenine pathway in the regulation of the aging process. Ageing Res. Rev. 2022;75:101573. doi:https:\/\/doi.org\/10.1016\/j.arr.2022.101573. Epub 2022 Jan 24. PMID: 35085834.","DOI":"10.1016\/j.arr.2022.101573"},{"key":"10.1016\/j.imbio.2026.153179_bb0225","doi-asserted-by":"crossref","unstructured":"Santoro A, Bientinesi E, Monti D. Immunosenescence and inflammaging in the aging process: Age-related diseases or longevity? Ageing Res. Rev. 2021; 71: 101422. doi:https:\/\/doi.org\/10.1016\/j.arr.2021.101422. Epub 2021 Aug 13. PMID: 34391943.","DOI":"10.1016\/j.arr.2021.101422"},{"key":"10.1016\/j.imbio.2026.153179_bb0230","doi-asserted-by":"crossref","unstructured":"Swain AC, Borghans JAM, de Boer RJ. Effect of cellular aging on memory t-cell homeostasis. Front. Immunol. 2022;13:947242. doi:https:\/\/doi.org\/10.3389\/fimmu.2022.947242. PMID: 36059495; PMCID: PMC9429809.","DOI":"10.3389\/fimmu.2022.947242"},{"key":"10.1016\/j.imbio.2026.153179_bb0235","doi-asserted-by":"crossref","unstructured":"Sykes GP, Kamtchum-Tatuene J, Falcione S, Zehnder S, Munsterman D, Stamova B, Ander BP, Sharp FR, Jickling G. Aging immune system in acute ischemic stroke: a transcriptomic analysis. Stroke 2021 Apr;52(4):1355\u20131361. doi:https:\/\/doi.org\/10.1161\/STROKEAHA.120.032040. Epub 2021 Mar 1. PMID: 33641386; PMCID: PMC8011932.","DOI":"10.1161\/STROKEAHA.120.032040"},{"key":"10.1016\/j.imbio.2026.153179_bb0240","doi-asserted-by":"crossref","unstructured":"Tedeschi V, Paldino G, Kunkl M, et al. CD8+ t cell senescence: Lights and shadows in viral infections, autoimmune disorders and cancer. Int. J. Mol. Sci. 2022;23(6):3374. doi:https:\/\/doi.org\/10.3390\/ijms23063374. PMID: 35328795; PMCID: PMC8955595.","DOI":"10.3390\/ijms23063374"},{"key":"10.1016\/j.imbio.2026.153179_bb0245","doi-asserted-by":"crossref","unstructured":"Terekhova M, Swain A, Bohacova P, et al. 2023 Single-cell atlas of healthy human blood unveils age-related loss of NKG2C+GZMB-CD8+ memory t cells and accumulation of type 2 memory t cells. Immunity :S1074-7613(23)00453\u20133. doi:https:\/\/doi.org\/10.1016\/j.immuni.2023.10.013. (Epub ahead of print. PMID: 37963457).","DOI":"10.1016\/j.immuni.2023.10.013"},{"key":"10.1016\/j.imbio.2026.153179_bb0250","doi-asserted-by":"crossref","unstructured":"Tian YE, Cropley V, Maier AB, Lautenschlager NT, Breakspear M, Zalesky A. Heterogeneous aging across multiple organ systems and prediction of chronic disease and mortality. Nat. Med. 2023;29(5):1221\u20131231. doi:https:\/\/doi.org\/10.1038\/s41591-023-02296-6. Epub 2023 Apr 6. PMID: 37024597.","DOI":"10.1038\/s41591-023-02296-6"},{"key":"10.1016\/j.imbio.2026.153179_bb0255","doi-asserted-by":"crossref","unstructured":"Wang M, Zhai J, Liao L, Cui C, Zhu L, Wu Q. A comparative analysis of outcomes in patients with aneurysmal subarachnoid hemorrhage based on surgical timing. Front. Surg. 2025 ;12:1682278. doi:https:\/\/doi.org\/10.3389\/fsurg.2025.1682278. PMID: 41356170; PMCID: PMC12678366.","DOI":"10.3389\/fsurg.2025.1682278"},{"key":"10.1016\/j.imbio.2026.153179_bb0260","doi-asserted-by":"crossref","unstructured":"Wu TD, Madireddi S, de Almeida PE, et al. Peripheral t cell expansion predicts tumour infiltration and clinical response. Nature 2020;579(7798):274\u2013278. doi:https:\/\/doi.org\/10.1038\/s41586-020-2056-8. Epub 2020 Feb 26. PMID: 32103181.","DOI":"10.1038\/s41586-020-2056-8"},{"key":"10.1016\/j.imbio.2026.153179_bb0265","doi-asserted-by":"crossref","unstructured":"Yu T, Shi G, Ye Z, Jiang X, Jia W, Wang Y, Wang Y, Xu J. Rationale and design of a PROBE trial comparing continuous enteral nutrition to time-restricted enteral nutrition in severe stroke. Stroke Vasc Neurol. 2025 Dec 3:svn-2025-004382. doi:https:\/\/doi.org\/10.1136\/svn-2025-004382. (Epub ahead of print. PMID: 41339081).","DOI":"10.1136\/svn-2025-004382"},{"key":"10.1016\/j.imbio.2026.153179_bb0270","doi-asserted-by":"crossref","unstructured":"Zhang A, Zhu Y, Liao J, Wu D, Yan X, Chen J, He Q, Song F, Li L, Li Y, Chen Z, Li W, Yang Q, Fang Z, Wu M. The association of systemic inflammatory response index and neutrophil-to-high-density lipoprotein ratio mediated by fasting blood glucose with 90-day prognosis in acute ischemic stroke patients Neuroepidemiology 2025;59(1):31\u201342. doi:https:\/\/doi.org\/10.1159\/000539132. Epub 2024 May 15. PMID: 38749405; PMCID: PMC11797957.","DOI":"10.1159\/000539132"},{"key":"10.1016\/j.imbio.2026.153179_bb0275","doi-asserted-by":"crossref","unstructured":"Zhou W, Li W, Wang S, et al. An optogenetic-phosphoproteomic study reveals dynamic akt1 signaling profiles in endothelial cells. Nat. Commun. 2023;14(1):3803. doi:https:\/\/doi.org\/10.1038\/s41467-023-39514-1. PMID: 37365174; PMCID: PMC10293293.","DOI":"10.1038\/s41467-023-39514-1"},{"key":"10.1016\/j.imbio.2026.153179_bb0280","doi-asserted-by":"crossref","unstructured":"Zhu H, Lin Y, Lu D, et al. Proteomics of adjacent-to-tumor samples uncovers clinically relevant biological events in hepatocellular carcinoma. Natl. Sci. Rev. 2023;10(8):nwad167. doi:https:\/\/doi.org\/10.1093\/nsr\/nwad167. (PMID: 37575948; PMCID: PMC10416816).","DOI":"10.1093\/nsr\/nwad167"},{"key":"10.1016\/j.imbio.2026.153179_bb0285","doi-asserted-by":"crossref","unstructured":"Zinatizadeh MR, Zarandi PK, Ghiasi M, et al. Immunosenescence and inflamm-ageing in COVID-19. Ageing Res. Rev. 2023;84:101818. doi:https:\/\/doi.org\/10.1016\/j.arr.2022.101818. Epub 2022 Dec 11. PMID: 36516928; PMCID: PMC9741765.","DOI":"10.1016\/j.arr.2022.101818"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T08:44:51Z","timestamp":1782463491000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":57,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0171298526000252"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153179","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Development and preliminary clinical verification of an immune age model based on peripheral immune cells","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153179","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153179"}}