{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T06:38:05Z","timestamp":1784097485585,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T00:00:00Z","timestamp":1776902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"publisher","award":["APQ-00720-23"],"award-info":[{"award-number":["APQ-00720-23"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100020670","name":"Cancer Council Australia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100020670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009730","name":"Universidade Federal de Ouro Preto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006506","name":"Minist\u00e9rio da Sa\u00fade","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006506","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.imbio.2026.153182","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T22:52:54Z","timestamp":1777762374000},"page":"153182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Blue light-emitting diode phototherapy reduces cerebral parasitic load and inflammation in murine congenital toxoplasmosis model"],"prefix":"10.1016","volume":"231","author":[{"given":"D\u00e9bora Nonato Miranda","family":"Toledo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natiele","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia Caroline","family":"Dantas-Vieira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Monteiro de Castro","family":"Burle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lauro de Assis","family":"Duarte-Junior","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Laura","family":"Cruz Castro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita Rodrigues","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guilherme Paula","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiano Schetini","family":"de Azevedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela Caldeira","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lida Mara Leite","family":"Rabelo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Fernando","family":"Bianchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9rica Santos","family":"Martins-Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Talvani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2026.153182_bb0005","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1074\/jbc.M406367200","article-title":"Peroxiredoxin-linked detoxification of hydroperoxides in toxoplasma gondii","volume":"280","author":"Akerman","year":"2005","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2026.153182_bb0010","doi-asserted-by":"crossref","DOI":"10.4103\/jmau.jmau_122_20","article-title":"Placental dysfunction and acute toxoplasmosis: the role of melatonin in relation to inflammatory cytokines interleukin-10 and interleukin-12","volume":"11","author":"Al-Kuraishi","year":"2023","journal-title":"J. Microsc. Ultrastruct."},{"key":"10.1016\/j.imbio.2026.153182_bb0015","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1111\/j.1473-2165.2008.00386.x","article-title":"An assessment of the efficacy of blue light phototherapy in the treatment of acne vulgaris","volume":"7","author":"Ammad","year":"2008","journal-title":"J. Cosmet. Dermatol."},{"key":"10.1016\/j.imbio.2026.153182_bb0020","first-page":"41","article-title":"Low-level laser (light) therapy (LLLT) in skin: Stimulating, healing, restoring","volume":"32","author":"Avci","year":"2013","journal-title":"Semin. Cutan. Med. Surg."},{"key":"10.1016\/j.imbio.2026.153182_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2025.104685","article-title":"Blue light-emitting diode: a new adjuvant approach to conventional treatment of recurrent vulvovaginal candidiasis","volume":"54","author":"Bastiani Biondo","year":"2025","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.imbio.2026.153182_bb0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008499","article-title":"Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection","volume":"16","author":"Bergmann","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.imbio.2026.153182_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fped.2022.894573","article-title":"Congenital toxoplasmosis: the state of the art","volume":"10","author":"Bollani","year":"2022","journal-title":"Front. Pediatr."},{"key":"10.1016\/j.imbio.2026.153182_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/admt.202100395","article-title":"Organic light-emitting diodes as an innovative approach for treating cutaneous leishmaniasis","volume":"6","author":"Cabral","year":"2021","journal-title":"Adv. Mater. Technol."},{"key":"10.1016\/j.imbio.2026.153182_bb0045","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.1006031","article-title":"Photobiomodulation for the treatment of neuroinflammation: a systematic review of controlled laboratory animal studies","volume":"16","author":"Cardoso","year":"2022","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.imbio.2026.153182_bb0050","series-title":"Mechanisms for Low-Light Therapy IV","first-page":"9","article-title":"Role of reactive oxygen species in low level light therapy","author":"Chen","year":"2009"},{"key":"10.1016\/j.imbio.2026.153182_bb0055","doi-asserted-by":"crossref","first-page":"771","DOI":"10.4049\/jimmunol.180.9.5771","article-title":"IL-10: the master regulator of immunity to infection","volume":"180","author":"Couper","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2026.153182_bb0060","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1177\/0394632016638668","article-title":"Role of oxidative stress in the pathophysiology of toxoplasma gondii infection","volume":"29","author":"Dincel","year":"2016","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.imbio.2026.153182_bb0065","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00057-17","article-title":"Treatment of toxoplasmosis: Historical perspective, animal models, and current clinical practice","volume":"31","author":"Dunay","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.imbio.2026.153182_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens11070798","article-title":"Ginger is a potential therapeutic for chronic toxoplasmosis","volume":"11","author":"El-kady","year":"2022","journal-title":"Pathogens"},{"key":"10.1016\/j.imbio.2026.153182_bb0080","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1073\/pnas.90.13.6115","article-title":"Interleukin 12 is required for the t-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in t-cell-deficient hosts","volume":"90","author":"Gazzinelli","year":"1993","journal-title":"PNAS"},{"key":"10.1016\/j.imbio.2026.153182_bb0085","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.bbi.2008.09.002","article-title":"Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1\u03b2 and anti-inflammatory IL-10 cytokines","volume":"23","author":"Henry","year":"2009","journal-title":"Brain Behav.Immun."},{"key":"10.1016\/j.imbio.2026.153182_bb0090","doi-asserted-by":"crossref","first-page":"5554","DOI":"10.3390\/ijms26125554","article-title":"Effects of long-term blue light exposure on body fat synthesis and body weight gain in mice and the inhibitory effect of tranexamic acid","volume":"26","author":"Hiramoto","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.imbio.2026.153182_bb0095","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.673070","article-title":"New insights into blue light phototherapy in experimental trypanosoma cruzi infection","volume":"11","author":"Ivanova","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.imbio.2026.153182_bb0105","doi-asserted-by":"crossref","first-page":"2872","DOI":"10.3390\/ijms24032872","article-title":"Regulatory mechanism between ferritin and mitochondrial reactive oxygen species in spinal ligament-derived cells from ossification of posterior longitudinal ligament patient","volume":"24","author":"Kim","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.imbio.2026.153182_bb0110","doi-asserted-by":"crossref","first-page":"R770","DOI":"10.1016\/j.cub.2018.05.035","article-title":"Toxoplasma gondii","volume":"28","author":"Kochanowsky","year":"2018","journal-title":"Curr. Biol."},{"key":"10.1016\/j.imbio.2026.153182_bb0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003088","article-title":"Make it, take it, or leave it: Heme metabolism of parasites","volume":"9","author":"Ko\u0159en\u00fd","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.imbio.2026.153182_bb0120","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3390\/cosmetics12010030","article-title":"Blue light therapy in dermatological practice: a review","volume":"12","author":"Lodi","year":"2025","journal-title":"Cosmetics"},{"key":"10.1016\/j.imbio.2026.153182_bb0125","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s00436-024-08155-8","article-title":"Molecular effects of photodynamic therapy with curcumin on leishmania major promastigotes","volume":"123","author":"Marcolino","year":"2024","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.imbio.2026.153182_bb0130","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.exppara.2009.12.011","article-title":"Toxoplasma gondii: Fluconazole and itraconazole activity against toxoplasmosis in a murine model","volume":"124","author":"Martins-Duarte","year":"2010","journal-title":"Exp. Parasitol."},{"key":"10.1016\/j.imbio.2026.153182_bb0135","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1007\/s40124-014-0055-7","article-title":"Management of congenital toxoplasmosis","volume":"2","author":"McLeod","year":"2014","journal-title":"Curr. Pediatr. Rep."},{"key":"10.1016\/j.imbio.2026.153182_bb0140","doi-asserted-by":"crossref","first-page":"52","DOI":"10.36468\/pharmaceutical-sciences.1475","article-title":"Latent toxoplasmosis and the involvement in traffic accidents among drivers","volume":"87","author":"Mohamed","year":"2025","journal-title":"Indian J. Pharm. Sci."},{"issue":"Suppl. 1","key":"10.1016\/j.imbio.2026.153182_bb0145","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.15171\/jlms.2017.s5","article-title":"The effect of combination of red, infrared and blue wavelengths of low-level laser on reduction of abdominal girth: a before-after case series","volume":"8","author":"Montazeri","year":"2017","journal-title":"J Lasers Med Sci."},{"key":"10.1016\/j.imbio.2026.153182_bb0150","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(04)16412-X","article-title":"Toxoplasmosis","volume":"363","author":"Montoya","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.imbio.2026.153182_bb0155","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/phpp.12841","article-title":"Utilization of light-emitting diodes for skin therapy: Systematic review and meta-analysis","volume":"39","author":"Ngoc","year":"2023","journal-title":"Photodermatol. Photoimmunol. Photomed."},{"key":"10.1016\/j.imbio.2026.153182_bb0160","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/bj3570241","article-title":"Ferritin and the response to oxidative stress","volume":"357","author":"Orino","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.imbio.2026.153182_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.parint.2022.102645","article-title":"Comparative study of oxidative stress and antioxidative markers in patients infected with toxoplasma gondii","volume":"91","author":"Paraboni","year":"2022","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.imbio.2026.153182_bb0170","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1007\/s10103-018-2678-3","article-title":"Blue light-emitting diode in healthy vaginal mucosa - a new therapeutic possibility","volume":"34","author":"Pavie","year":"2019","journal-title":"Lasers Med. Sci."},{"key":"10.1016\/j.imbio.2026.153182_bb0175","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3390\/pathogens8010024","article-title":"Maternal and congenital toxoplasmosis: Diagnosis and treatment recommendations of a french multidisciplinary working group","volume":"8","author":"Peyron","year":"2019","journal-title":"Pathogens"},{"key":"10.1016\/j.imbio.2026.153182_bb0180","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1554051","article-title":"Blue light-emitting diode phototherapy presents in vitro efficacy against distinct Leishmania species and is therapeutic against tegumentary leishmaniasis in BALB\/c mice","volume":"16","author":"Pimenta","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2026.153182_bb0185","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.856953","article-title":"The influence of blue light and the BlsA photoreceptor on the oxidative stress resistance mechanisms of acinetobacter baumannii","volume":"12","author":"Squire","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.imbio.2026.153182_bb0190","doi-asserted-by":"crossref","first-page":"5705","DOI":"10.3390\/ijms22115705","article-title":"Oxidative stress as a possible target in the treatment of toxoplasmosis: Perspectives and smbiguities","volume":"22","author":"Szewczyk-Golec","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.imbio.2026.153182_bb0195","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nri1001","article-title":"Interleukin-12 and the regulation of innate resistance and adaptive immunity","volume":"3","author":"Trinchieri","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2026.153182_bb0200","doi-asserted-by":"crossref","first-page":"7743","DOI":"10.2147\/IDR.S443047","article-title":"Potential anti-toxoplasmosis efficiency of phoenix dactylifera extracts loaded on selenium nanoparticles","volume":"16","author":"Wakid","year":"2023","journal-title":"Infec. Drug Resist."},{"key":"10.1016\/j.imbio.2026.153182_bb0205","doi-asserted-by":"crossref","first-page":"4447","DOI":"10.1096\/fj.201700008R","article-title":"Thioredoxin reductase from toxoplasma gondii: an essential virulence effector with antioxidant function","volume":"31","author":"Xue","year":"2017","journal-title":"FASEB J."},{"key":"10.1016\/j.imbio.2026.153182_bb0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2024.112908","article-title":"Blue light induced ferroptosis via STAT3\/GPX4\/SLC7A11\/FTH1 in conjunctiva epithelium in vivo and in vitro","volume":"255","author":"Yang","year":"2024","journal-title":"J. Photochem. Photobiol. B"},{"key":"10.1016\/j.imbio.2026.153182_bb0215","first-page":"717","article-title":"Blue light irradiation induces human keratinocyte cell damage via transient receptor potential vanilloid 1 (TRPV1) regulation","volume":"15","author":"Yoo","year":"2020","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.imbio.2026.153182_bb0220","doi-asserted-by":"crossref","first-page":"15549","DOI":"10.2147\/IJN.S557723","article-title":"Advances in Nano-Phototherapy for targeted fat reduction: from mechanisms to clinical translation in obesity","volume":"20","author":"Zhang","year":"2025","journal-title":"Int. J. Nanomedicine"},{"key":"10.1016\/j.imbio.2026.153182_bb0225","first-page":"4007","article-title":"Analysis of therapeutic effect of intermittent and continuous phototherapy on neonatal hemolytic jaundice","volume":"17","author":"Zhou","year":"2019","journal-title":"Exp. Ther. Med."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:57:21Z","timestamp":1783162641000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":43,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0171298526000288"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153182","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Blue light-emitting diode phototherapy reduces cerebral parasitic load and inflammation in murine congenital toxoplasmosis model","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153182"}}