{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T11:22:28Z","timestamp":1783164148760,"version":"3.54.6"},"reference-count":31,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T00:00:00Z","timestamp":1778025600000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012228","name":"Development and Reform Commission of Shenzhen Municipality","doi-asserted-by":"publisher","award":["XMHT20230108023"],"award-info":[{"award-number":["XMHT20230108023"]}],"id":[{"id":"10.13039\/501100012228","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202111006"],"award-info":[{"award-number":["SZSM202111006"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["GJHZ20220913142614027"],"award-info":[{"award-number":["GJHZ20220913142614027"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.imbio.2026.153188","type":"journal-article","created":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T15:55:29Z","timestamp":1778601329000},"page":"153188","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Low-abundance plasma proteomics reveals NET-associated molecular signatures in rheumatoid arthritis"],"prefix":"10.1016","volume":"231","author":[{"given":"Feng","family":"Zhu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejia","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongzhou","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhipeng","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huihui","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yurong","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donge","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.imbio.2026.153188_bb0005","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1038\/s41584-018-0039-z","article-title":"The role of neutrophil extracellular traps in rheumatic diseases","volume":"14","author":"Apel","year":"2018","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.imbio.2026.153188_bb0010","doi-asserted-by":"crossref","unstructured":"Apweiler R, Bairoch A, Wu CH, Barker WC, Boeckmann B, Ferro S, Gasteiger E, Huang H, Lopez R, Magrane M, Martin MJ, Natale DA, O'Donovan C, Redaschi N, Yeh LS. UniProt: the universal protein knowledgebase. Nucleic Acids Res. 2004;32(Database issue):D115\u2013D119. doi:https:\/\/doi.org\/10.1093\/nar\/gkh131.","DOI":"10.1093\/nar\/gkh131"},{"issue":"1","key":"10.1016\/j.imbio.2026.153188_bb0015","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/s41420-021-00491-3","article-title":"ROS induces NETosis by oxidizing DNA and initiating DNA repair","volume":"7","author":"Azzouz","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.imbio.2026.153188_bb0020","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/bs.enz.2017.08.004","article-title":"Strategies for characterization of low-abundant intact or truncated low-molecular-weight proteins from human plasma","volume":"42","author":"Cai","year":"2017","journal-title":"Enzymes"},{"issue":"1","key":"10.1016\/j.imbio.2026.153188_bb0025","doi-asserted-by":"crossref","first-page":"14248","DOI":"10.1038\/s41598-017-14755-5","article-title":"Assessment of variability in the SOMAscan assay","volume":"7","author":"Candia","year":"2017","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.imbio.2026.153188_bb0030","doi-asserted-by":"crossref","first-page":"5531","DOI":"10.1021\/acs.jproteome.4c00667","article-title":"Variability of 7K and 11K SomaScan plasma proteomics assays","volume":"23","author":"Candia","year":"2024","journal-title":"J. Proteome Res."},{"issue":"10391","key":"10.1016\/j.imbio.2026.153188_bb0035","doi-asserted-by":"crossref","first-page":"1878","DOI":"10.1016\/S0140-6736(23)00457-9","article-title":"Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK","volume":"401","author":"Conrad","year":"2023","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.imbio.2026.153188_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102776","article-title":"Rheumatoid arthritis: extra-articular manifestations and comorbidities","volume":"20","author":"Figus","year":"2021","journal-title":"Autoimmun. Rev."},{"issue":"10","key":"10.1016\/j.imbio.2026.153188_bb0045","first-page":"591","article-title":"Global epidemiology of rheumatoid arthritis","volume":"18","author":"Finckh","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"issue":"3","key":"10.1016\/j.imbio.2026.153188_bb0050","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.cels.2016.02.015","article-title":"Plasma proteome profiling to assess human health and disease","volume":"2","author":"Geyer","year":"2016","journal-title":"Cell Syst."},{"issue":"1_Supplement","key":"10.1016\/j.imbio.2026.153188_bb0055","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.212.supp.0271.6286","article-title":"Quantitative immunology protein panel built on the SomaScan assay platform","volume":"212","author":"Katilius","year":"2024","journal-title":"J. Immunol."},{"issue":"Suppl. 6","key":"10.1016\/j.imbio.2026.153188_bb0060","first-page":"vi5","article-title":"ACR\/EULAR 2010 rheumatoid arthritis classification criteria","volume":"51","author":"Kay","year":"2012","journal-title":"Rheumatology (Oxford)."},{"issue":"178","key":"10.1016\/j.imbio.2026.153188_bb0065","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3005580","article-title":"NETs are a source of citrullinated autoantigens and stimulate inflammatory responses in rheumatoid arthritis","volume":"5","author":"Khandpur","year":"2013","journal-title":"Sci. Transl. Med."},{"issue":"2","key":"10.1016\/j.imbio.2026.153188_bb0070","doi-asserted-by":"crossref","first-page":"R7","DOI":"10.1186\/gb-2004-5-2-r7","article-title":"A comprehensive evolutionary classification of proteins encoded in complete eukaryotic genomes","volume":"5","author":"Koonin","year":"2004","journal-title":"Genome Biol."},{"issue":"19","key":"10.1016\/j.imbio.2026.153188_bb0075","doi-asserted-by":"crossref","first-page":"1799","DOI":"10.4155\/bio-2019-0145","article-title":"Plasma\/serum proteomics: depletion strategies for reducing high-abundance proteins for biomarker discovery","volume":"11","author":"Lee","year":"2019","journal-title":"Bioanalysis"},{"key":"10.1016\/j.imbio.2026.153188_bb0080","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.3389\/fimmu.2020.01749","article-title":"The emerging role of neutrophil extracellular traps (NETs) in tumor progression and metastasis","volume":"11","author":"Masucci","year":"2020","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.imbio.2026.153188_bb0085","first-page":"947","article-title":"Novel insights into the management of rheumatoid arthritis: one year in review 2024","volume":"42","author":"Molteni","year":"2024","journal-title":"Clin. Exp. Rheumatol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153188_bb0090","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s42003-023-05051-2","article-title":"Alpha 7 nicotinic acetylcholine receptor signaling boosts cell-cell interactions in macrophages, effecting anti-inflammatory and organ protection","volume":"6","author":"Nakamura","year":"2023","journal-title":"Commun Biol."},{"key":"10.1016\/j.imbio.2026.153188_bb0095","doi-asserted-by":"crossref","first-page":"373","DOI":"10.3389\/fcimb.2017.00373","article-title":"Neutrophils to the ROScue: mechanisms of NADPH oxidase activation and bacterial resistance","volume":"7","author":"Nguyen","year":"2017","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"4","key":"10.1016\/j.imbio.2026.153188_bb0100","doi-asserted-by":"crossref","first-page":"337","DOI":"10.3899\/jrheum.2023-0334","article-title":"Rheumatoid arthritis: the continuum of disease and strategies for prediction, early intervention, and prevention","volume":"51","author":"O\u2019Neil","year":"2024","journal-title":"J. Rheumatol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153188_bb0105","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1038\/s41467-019-09160-7","article-title":"Neutrophil activation and NETosis are the major drivers of thrombosis in heparin-induced thrombocytopenia","volume":"10","author":"Perdomo","year":"2019","journal-title":"Nat. Commun."},{"issue":"11","key":"10.1016\/j.imbio.2026.153188_bb0110","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.molmed.2020.06.005","article-title":"Inflammasomes and cell death: common pathways in microparticle diseases","volume":"26","author":"Rashidi","year":"2020","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.imbio.2026.153188_bb0115","doi-asserted-by":"crossref","unstructured":"Rooney MR, Chen J, Ballantyne CM, Hoogeveen RC, Boerwinkle E, Yu B, Walker KA, Schlosser P, Selvin E, Chatterjee N, Couper D, Grams ME, Coresh J. Plasma proteomic comparisons change as coverage expands for SomaLogic and Olink. medRxiv [preprint]. 2024. doi:https:\/\/doi.org\/10.1101\/2024.07.11.24310161.","DOI":"10.1101\/2024.07.11.24310161"},{"key":"10.1016\/j.imbio.2026.153188_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2025.117593","article-title":"Large-scale proteomics analysis identifies plasma protein biomarkers and potential therapeutic targets for rheumatoid arthritis: a prospective study in UK Biobank","volume":"200","author":"Ruan","year":"2025","journal-title":"Bone"},{"issue":"7","key":"10.1016\/j.imbio.2026.153188_bb0125","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.it.2011.04.001","article-title":"Histone deacetylases as regulators of inflammation and immunity","volume":"32","author":"Shakespear","year":"2011","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153188_bb0130","doi-asserted-by":"crossref","first-page":"30","DOI":"10.2478\/jtim-2022-0028","article-title":"Mesenchymal stem cells and connective tissue diseases: from bench to bedside","volume":"11","author":"Shi","year":"2023","journal-title":"J. Transl. Int. Med."},{"issue":"37","key":"10.1016\/j.imbio.2026.153188_bb0135","doi-asserted-by":"crossref","first-page":"42507","DOI":"10.1021\/acsomega.5c03776","article-title":"Enrichment of low-abundance and low-molecular-weight proteins in human milk using mass spectrometry-based proteomics","volume":"10","author":"Singh","year":"2025","journal-title":"ACS Omega"},{"issue":"4","key":"10.1016\/j.imbio.2026.153188_bb0140","doi-asserted-by":"crossref","first-page":"404","DOI":"10.31138\/mjr.301223.eaf","article-title":"Epidemiology and risk factors for rheumatoid arthritis development","volume":"34","author":"Venetsanopoulou","year":"2023","journal-title":"Mediterr J Rheumatol."},{"issue":"6","key":"10.1016\/j.imbio.2026.153188_bb0145","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.3390\/antiox11061153","article-title":"The role of reactive oxygen species in the rheumatoid arthritis-associated synovial microenvironment","volume":"11","author":"Wang","year":"2022","journal-title":"Antioxidants"},{"key":"10.1016\/j.imbio.2026.153188_bb0150","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1051082","article-title":"Systemic complications of rheumatoid arthritis: focus on pathogenesis and treatment","volume":"13","author":"Wu","year":"2022","journal-title":"Front. Immunol."},{"issue":"18","key":"10.1016\/j.imbio.2026.153188_bb0155","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1093\/bioinformatics\/btv313","article-title":"DSigDB: drug signatures database for gene set analysis","volume":"31","author":"Yoo","year":"2015","journal-title":"Bioinformatics"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T10:57:29Z","timestamp":1783162649000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":31,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0171298526000343"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153188","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low-abundance plasma proteomics reveals NET-associated molecular signatures in rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153188","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153188"}}