{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:21:12Z","timestamp":1783153272248,"version":"3.54.6"},"reference-count":70,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T00:00:00Z","timestamp":1778457600000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014969","name":"Guilin Medical University","doi-asserted-by":"publisher","award":["GKLBCN-202301-03"],"award-info":[{"award-number":["GKLBCN-202301-03"]}],"id":[{"id":"10.13039\/501100014969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32260166"],"award-info":[{"award-number":["32260166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011161","name":"State Key Laboratory of Cognitive Neuroscience and Learning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011161","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004607","name":"Natural Science Foundation of Guangxi Province","doi-asserted-by":"publisher","award":["2025GXNSFHAO69130\/2024JJH140411"],"award-info":[{"award-number":["2025GXNSFHAO69130\/2024JJH140411"]}],"id":[{"id":"10.13039\/501100004607","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.imbio.2026.153191","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T04:11:45Z","timestamp":1778731905000},"page":"153191","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A novel mitochondrial-related signature to decode tumor immunity and predict survival in chromophobe renal cell carcinoma"],"prefix":"10.1016","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5584-3100","authenticated-orcid":false,"given":"Shuting","family":"Huang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-0055-9804","authenticated-orcid":false,"given":"Congcong","family":"Dai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3295-8338","authenticated-orcid":false,"given":"Xia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0440-9243","authenticated-orcid":false,"given":"Zuosen","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5009-6823","authenticated-orcid":false,"given":"Suwan","family":"Mu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0719-4093","authenticated-orcid":false,"given":"Zhonghua","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0162-3000","authenticated-orcid":false,"given":"Liandong","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-9447-905X","authenticated-orcid":false,"given":"Liang","family":"Zhong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5637-3319","authenticated-orcid":false,"given":"Liuqing","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4647-6238","authenticated-orcid":false,"given":"Miaoling","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5969-1554","authenticated-orcid":false,"given":"Jun","family":"Ou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6438-5955","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2026.153191_bb0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajur.2021.11.010","article-title":"Chromophobe renal cell carcinoma: novel molecular insights and clinicopathologic updates","volume":"9","author":"Alaghehbandan","year":"2022","journal-title":"Asian J. Urol."},{"key":"10.1016\/j.imbio.2026.153191_bb0010","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/nature12477","article-title":"Signatures of mutational processes in human cancer","volume":"500","author":"Alexandrov","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.imbio.2026.153191_bb0015","doi-asserted-by":"crossref","DOI":"10.1007\/s11255-025-04718-5","article-title":"Personalized survival predictions in chromophobe renal cell carcinoma: development of a machine learning-based web tool","author":"Alshwayyat","year":"2025","journal-title":"Int. Urol. Nephrol."},{"key":"10.1016\/j.imbio.2026.153191_bb0020","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1097\/PAS.0b013e3181831e68","article-title":"Chromophobe renal cell carcinoma: histomorphologic characteristics and evaluation of conventional pathologic prognostic parameters in 145 cases","volume":"32","author":"Amin","year":"2008","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.imbio.2026.153191_bb0025","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1158\/1078-0432.CCR-17-3070","article-title":"Oxidative Phosphorylation as an Emerging Target in Cancer Therapy","volume":"24","author":"Ashton","year":"2018","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.imbio.2026.153191_bb0030","first-page":"394","article-title":"Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"68","author":"Bray","year":"2018","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.imbio.2026.153191_bb0035","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1084\/jem.20072378","article-title":"The Death Receptor 3-TNF-like protein 1A pathway drives adverse bone pathology in inflammatory arthritis","volume":"205","author":"Bull","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imbio.2026.153191_bb0040","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1158\/2159-8290.CD-12-0095","article-title":"The cBio cancer genomics portal: an open platform for exploring multidimensional cancer genomics data","volume":"2","author":"Cerami","year":"2012","journal-title":"Cancer Discov."},{"key":"10.1016\/j.imbio.2026.153191_bb0045","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1186\/s12967-023-04033-6","article-title":"Constructing a novel mitochondrial-related gene signature for evaluating the tumor immune microenvironment and predicting survival in stomach adenocarcinoma","volume":"21","author":"Chang","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.imbio.2026.153191_bb0050","first-page":"5419","article-title":"Overexpression of RECQL4 is associated with poor prognosis in patients with gastric cancer","volume":"16","author":"Chen","year":"2018","journal-title":"Oncol. Lett."},{"key":"10.1016\/j.imbio.2026.153191_bb0055","doi-asserted-by":"crossref","first-page":"e238","DOI":"10.1002\/imt2.238","article-title":"Sangerbox 2: enhanced functionalities and update for a comprehensive clinical bioinformatics data analysis platform","volume":"3","author":"Chen","year":"2024","journal-title":"iMeta"},{"key":"10.1016\/j.imbio.2026.153191_bb0060","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1016\/j.biocel.2012.07.016","article-title":"RecQL4 cytoplasmic localization: implications in mitochondrial DNA oxidative damage repair","volume":"44","author":"Chi","year":"2012","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.imbio.2026.153191_bb0065","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1200\/JCO.2007.13.3223","article-title":"Efficacy of sunitinib and sorafenib in metastatic papillary and chromophobe renal cell carcinoma","volume":"26","author":"Choueiri","year":"2008","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.imbio.2026.153191_bb0070","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/j.1474-9726.2012.00803.x","article-title":"RECQL4 localizes to mitochondria and preserves mitochondrial DNA integrity","volume":"11","author":"Croteau","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.imbio.2026.153191_bb0075","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1146\/annurev-biochem-060713-035428","article-title":"Human RecQ helicases in DNA repair, recombination, and replication","volume":"83","author":"Croteau","year":"2014","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.imbio.2026.153191_bb0080","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.ccr.2014.07.014","article-title":"The somatic genomic landscape of chromophobe renal cell carcinoma","volume":"26","author":"Davis","year":"2014","journal-title":"Cancer Cell"},{"key":"10.1016\/j.imbio.2026.153191_bb0085","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14489","article-title":"A TGF -\u03b2 signaling-related lncRNA signature for prediction of glioma prognosis, immune microenvironment, and immunotherapy response","volume":"30","author":"Duan","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.imbio.2026.153191_bb0090","doi-asserted-by":"crossref","first-page":"5130","DOI":"10.1158\/0008-5472.CAN-12-1949","article-title":"Reciprocal Metabolic Reprogramming through Lactate shuttle Coordinately Influences Tumor-Stroma Interplay","volume":"72","author":"Fiaschi","year":"2012","journal-title":"Cancer Res."},{"key":"10.1016\/j.imbio.2026.153191_bb0095","doi-asserted-by":"crossref","first-page":"e678","DOI":"10.1016\/j.clgc.2019.03.018","article-title":"Metastatic Chromophobe Renal Cell Carcinoma: Presence or Absence of Sarcomatoid Differentiation Determines Clinical Course and Treatment Outcomes","volume":"17","author":"Ged","year":"2019","journal-title":"Clin. Genitourin. Cancer"},{"key":"10.1016\/j.imbio.2026.153191_bb0100","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/gb-2014-15-3-r47","article-title":"Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines","volume":"15","author":"Geeleher","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.imbio.2026.153191_bb0105","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1074\/jbc.M111.295063","article-title":"RECQL4, the protein mutated in Rothmund-Thomson syndrome, functions in telomere maintenance","volume":"287","author":"Ghosh","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imbio.2026.153191_bb0110","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/s41587-020-0546-8","article-title":"Visualizing and interpreting cancer genomics data via the Xena platform","volume":"38","author":"Goldman","year":"2020","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.imbio.2026.153191_bb0115","doi-asserted-by":"crossref","first-page":"142","DOI":"10.3892\/etm.2025.12892","article-title":"Analysis of a pan-cancer panel reveals the amino acid metabolism-related gene MTHFD1 as a potential prognostic and immunotherapeutic biomarker","volume":"30","author":"Gong","year":"2025","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.imbio.2026.153191_bb0120","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1158\/2159-8290.CD-21-1059","article-title":"Hallmarks of Cancer: New Dimensions","volume":"12","author":"Hanahan","year":"2022","journal-title":"Cancer Discov."},{"key":"10.1016\/j.imbio.2026.153191_bb0125","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.ccell.2023.07.006","article-title":"Chromophobe renal cell carcinoma","volume":"41","author":"Henske","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.imbio.2026.153191_bb0130","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1038\/nrc.2016.73","article-title":"The biology and function of fibroblasts in cancer","volume":"16","author":"Kalluri","year":"2016","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.imbio.2026.153191_bb0135","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/path.1711670303","article-title":"Mitochondrial and chromosomal DNA alterations in human chromophobe renal cell carcinomas","volume":"167","author":"Kovacs","year":"1992","journal-title":"J. Pathol."},{"key":"10.1016\/j.imbio.2026.153191_bb0140","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1200\/JCO-25-00234","article-title":"Tumor-intrinsic and microenvironmental determinants of impaired antitumor immunity in chromophobe renal cell carcinoma","volume":"43","author":"Labaki","year":"2025","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.imbio.2026.153191_bb0145","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/s41420-024-01926-3","article-title":"Mitochondria transcription and cancer","volume":"10","author":"Lei","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.imbio.2026.153191_bb0150","doi-asserted-by":"crossref","first-page":"8322","DOI":"10.7150\/thno.62378","article-title":"Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming","volume":"11","author":"Li","year":"2021","journal-title":"Theranostics"},{"key":"10.1016\/j.imbio.2026.153191_bb0155","doi-asserted-by":"crossref","first-page":"113043","DOI":"10.1016\/j.intimp.2024.113043","article-title":"DUS4L suppresses invasion and metastasis in LUAD via modulation of PI3K\/AKT and ERK\/MAPK signaling through GRB2","volume":"142","author":"Li","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.imbio.2026.153191_bb0160","doi-asserted-by":"crossref","first-page":"12354","DOI":"10.3390\/ijms232012354","article-title":"Modulating p-AMPK\/mTOR Pathway of Mitochondrial Dysfunction Caused by MTERF1 Abnormal Expression in Colorectal Cancer Cells","volume":"23","author":"Liu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.imbio.2026.153191_bb0165","article-title":"Genetic expression in cancer research: challenges and complexity","volume":"37","author":"Liu","year":"2024","journal-title":"Gene Rep."},{"key":"10.1016\/j.imbio.2026.153191_bb0170","doi-asserted-by":"crossref","first-page":"34","DOI":"10.7150\/jca.100922","article-title":"Technical and Biological Biases in Bulk Transcriptomic Data Mining for Cancer Research","volume":"16","author":"Liu","year":"2025","journal-title":"J. Cancer"},{"key":"10.1016\/j.imbio.2026.153191_bb0175","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3390\/biom12121760","article-title":"Evolutionary Diversity of Dus2 Enzymes reveals Novel Structural and Functional Features among members of the RNA Dihydrouridine Synthases Family","volume":"12","author":"Lombard","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.imbio.2026.153191_bb0180","doi-asserted-by":"crossref","first-page":"1747","DOI":"10.1101\/gr.239244.118","article-title":"Maftools: efficient and comprehensive analysis of somatic variants in cancer","volume":"28","author":"Mayakonda","year":"2018","journal-title":"Genome Res."},{"key":"10.1016\/j.imbio.2026.153191_bb0185","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1158\/2326-6066.CIR-17-0475","article-title":"The clinical activity of PD-1\/PD-L1 inhibitors in metastatic non-clear cell renal cell carcinoma","volume":"6","author":"McKay","year":"2018","journal-title":"Cancer Immunol. Res."},{"key":"10.1016\/j.imbio.2026.153191_bb0190","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.immuni.2008.04.021","article-title":"The TNF-family receptor DR3 is essential for diverse T cell-mediated inflammatory diseases","volume":"29","author":"Meylan","year":"2008","journal-title":"Immunity"},{"key":"10.1016\/j.imbio.2026.153191_bb0195","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.eururo.2016.02.029","article-title":"The 2016 WHO Classification of Tumours of the Urinary System and Male Genital Organs-Part A: Renal, Penile, and Testicular Tumours","volume":"70","author":"Moch","year":"2016","journal-title":"Eur. Urol."},{"key":"10.1016\/j.imbio.2026.153191_bb0200","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1038\/s41591-018-0052-4","article-title":"An inhibitor of oxidative phosphorylation exploits cancer vulnerability","volume":"24","author":"Molina","year":"2018","journal-title":"Nat. Med."},{"key":"10.1016\/j.imbio.2026.153191_bb0205","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.3389\/fimmu.2019.01835","article-title":"The Dark Side of Fibroblasts: Cancer-Associated Fibroblasts as Mediators of Immunosuppression in the Tumor Microenvironment","volume":"10","author":"Monteran","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2026.153191_bb0210","doi-asserted-by":"crossref","first-page":"4346","DOI":"10.36922\/td.4346","article-title":"Hypoxia-inducible factor-1\u03b1 inhibition in renal cell carcinoma","volume":"3","author":"Morey","year":"2024","journal-title":"Tumor Discov."},{"key":"10.1016\/j.imbio.2026.153191_bb0215","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1056\/NEJMoa1816047","article-title":"Avelumab plus Axitinib versus Sunitinib for Advanced Renal-Cell Carcinoma","volume":"380","author":"Motzer","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.imbio.2026.153191_bb0220","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nmeth.3337","article-title":"Robust enumeration of cell subsets from tissue expression profiles","volume":"12","author":"Newman","year":"2015","journal-title":"Nat. Methods"},{"key":"10.1016\/j.imbio.2026.153191_bb0225","doi-asserted-by":"crossref","first-page":"79","DOI":"10.14740\/wjon1279","article-title":"Epidemiology of renal cell carcinoma","volume":"11","author":"Padala","year":"2020","journal-title":"World. J. Oncol."},{"key":"10.1016\/j.imbio.2026.153191_bb0230","doi-asserted-by":"crossref","first-page":"3984","DOI":"10.4161\/cc.8.23.10238","article-title":"The reverse Warburg effect: aerobic glycolysis in cancer associated fibroblasts and the tumor stroma","volume":"8","author":"Pavlides","year":"2009","journal-title":"Cell Cycle"},{"key":"10.1016\/j.imbio.2026.153191_bb0235","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cmet.2015.12.006","article-title":"The emerging Hallmarks of Cancer Metabolism","volume":"23","author":"Pavlova","year":"2016","journal-title":"Cell Metab."},{"key":"10.1016\/j.imbio.2026.153191_bb0240","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1097\/PAS.0b013e31821a455d","article-title":"Chromophobe renal cell carcinoma: a clinicopathologic study of 203 tumors in 200 patients with primary resection at a single institution","volume":"35","author":"Przybycin","year":"2011","journal-title":"Am. J. Surg. Pathol."},{"key":"10.1016\/j.imbio.2026.153191_bb0245","doi-asserted-by":"crossref","first-page":"D1541","DOI":"10.1093\/nar\/gkaa1011","article-title":"MitoCarta3.0: an updated mitochondrial proteome now with sub-organelle localization and pathway annotations","volume":"49","author":"Rath","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.imbio.2026.153191_bb0250","doi-asserted-by":"crossref","first-page":"e10769","DOI":"10.7554\/eLife.10769","article-title":"Mitochondrial DNA copy number variation across human cancers","volume":"5","author":"Reznik","year":"2016","journal-title":"eLife"},{"key":"10.1016\/j.imbio.2026.153191_bb0255","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1038\/s41379-020-0607-z","article-title":"Molecular characterization of chromophobe renal cell carcinoma reveals mTOR pathway alterations in patients with poor outcome","volume":"33","author":"Roldan-Romero","year":"2020","journal-title":"Mod. Pathol."},{"key":"10.1016\/j.imbio.2026.153191_bb0260","first-page":"1","article-title":"Prognosis prediction and drug guidance of ovarian serous cystadenocarcinoma through mitochondria gene-based model","volume":"292\u2013293","author":"Shen","year":"2025","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.imbio.2026.153191_bb0265","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.eururo.2020.03.003","article-title":"Next-generation RNA Sequencing\u2013based Biomarker Characterization of Chromophobe Renal Cell Carcinoma and Related Oncocytic Neoplasms","volume":"78","author":"Skala","year":"2020","journal-title":"Eur. Urol."},{"key":"10.1016\/j.imbio.2026.153191_bb0270","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cancergen.2024.06.002","article-title":"Cancer treatments: past, present, and future","volume":"286\u2013287","author":"Sonkin","year":"2024","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.imbio.2026.153191_bb0275","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1038\/nrg3966","article-title":"The dynamics of mitochondrial DNA heteroplasmy: implications for human health and disease","volume":"16","author":"Stewart","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.imbio.2026.153191_bb0280","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.imbio.2026.153191_bb0285","doi-asserted-by":"crossref","first-page":"109","DOI":"10.56434\/j.arch.esp.urol.20257801.14","article-title":"Intrarenal ectopic adrenal tissue mimics renal cell carcinoma in the kidney: a clinicopathological diagnostic challenge","volume":"78","author":"Telli\u02d9","year":"2025","journal-title":"Arch. Esp. Urol."},{"key":"10.1016\/j.imbio.2026.153191_bb0290","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1080\/21681805.2022.2119273","article-title":"(99m)Tc-Sestamibi SPECT\/CT and histopathological features of oncocytic renal neoplasia","volume":"56","author":"Tzortzakakis","year":"2022","journal-title":"Scand. J. Urol."},{"key":"10.1016\/j.imbio.2026.153191_bb0295","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/0168-9525(93)90209-Z","article-title":"The multistep nature of cancer","volume":"9","author":"Vogelstein","year":"1993","journal-title":"Trends Genet."},{"key":"10.1016\/j.imbio.2026.153191_bb0300","doi-asserted-by":"crossref","first-page":"18374","DOI":"10.1038\/s41598-025-03331-x","article-title":"The oncogenic role of TIMM8A in cancer and the mechanistic insights into the function in breast cancer cells","volume":"15","author":"Wang","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.imbio.2026.153191_bb0305","doi-asserted-by":"crossref","first-page":"4413","DOI":"10.1038\/s41388-021-01853-y","article-title":"A risk model developed based on tumor microenvironment predicts overall survival and associates with tumor immunity of patients with lung adenocarcinoma","volume":"40","author":"Wu","year":"2021","journal-title":"Oncogene"},{"key":"10.1016\/j.imbio.2026.153191_bb0310","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cancergen.2025.10.101","article-title":"YME1L facilitates the development of non-small cell lung cancer by promoting activation of mitochondria-G\u03b1i1-Akt pathway","volume":"298\u2013299","author":"Wu","year":"2025","journal-title":"Cancer Gene Ther."},{"key":"10.1016\/j.imbio.2026.153191_bb0315","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1097\/CM9.0000000000002108","article-title":"Cancer statistics in China and United States, 2022: profiles, trends, and determinants","volume":"135","author":"Xia","year":"2022","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.imbio.2026.153191_bb0320","doi-asserted-by":"crossref","first-page":"149097","DOI":"10.1016\/j.gene.2024.149097","article-title":"Identification and validation of biomarkers related to mitochondria during ex vivo lung perfusion for lung transplants based on machine learning algorithm","volume":"936","author":"Yang","year":"2025","journal-title":"Gene"},{"key":"10.1016\/j.imbio.2026.153191_bb0325","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1038\/s41420-024-02097-x","article-title":"Dysregulation of tRNA methylation in cancer: Mechanisms and targeting therapeutic strategies","volume":"10","author":"Yuan","year":"2024","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.imbio.2026.153191_bb0330","doi-asserted-by":"crossref","first-page":"1623588","DOI":"10.3389\/fimmu.2025.1623588","article-title":"Multimodal therapeutic strategies against gastric cancer: from conventional treatments to tumor microenvironment targeting","volume":"16","author":"Yuan","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2026.153191_bb0335","doi-asserted-by":"crossref","first-page":"213","DOI":"10.7150\/ijbs.6.213","article-title":"Analysis of differentially expressed mitochondrial proteins in chromophobe renal cell carcinomas and renal oncocytomas by 2-D gel electrophoresis","volume":"6","author":"Yusenko","year":"2010","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.imbio.2026.153191_bb0340","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.810572","article-title":"A novel inflammation-related lncRNAs prognostic signature identifies LINC00346 in promoting proliferation, migration, and immune infiltration of glioma","volume":"13","author":"Zeng","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2026.153191_bb0345","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1186\/s12957-022-02736-6","article-title":"TIMM8A is associated with dysfunction of immune cell in BRCA and UCEC for predicting anti-PD-L1 therapy efficacy","volume":"20","author":"Zhu","year":"2022","journal-title":"World J. Surg. Oncol."},{"key":"10.1016\/j.imbio.2026.153191_bb0350","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.molcel.2016.02.011","article-title":"Mitochondria and Cancer","volume":"61","author":"Zong","year":"2016","journal-title":"Mol. Cell"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T08:08:53Z","timestamp":1783152533000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":70,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0171298526000379"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153191","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel mitochondrial-related signature to decode tumor immunity and predict survival in chromophobe renal cell carcinoma","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153191","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153191"}}