{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T07:04:03Z","timestamp":1793343843831,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T00:00:00Z","timestamp":1781568000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.imbio.2026.153209","type":"journal-article","created":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T16:34:05Z","timestamp":1781800445000},"page":"153209","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Computational identification of natural inhibitors of human neutrophil elastase as potential therapeutics for chronic obstructive pulmonary disease"],"prefix":"10.1016","volume":"231","author":[{"given":"SK Redwan","family":"Zaman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mst. Shahnaj","family":"Parvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masuma","family":"Akter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazi Muhtasim","family":"Fuad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibli","family":"Rubatul Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munna","family":"Mondol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Ekramul","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.imbio.2026.153209_bb0005","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/75556","article-title":"Gene ontology: tool for the unification of biology","volume":"25","author":"Ashburner","year":"2000","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.imbio.2026.153209_bb0010","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1021\/jm901137j","article-title":"New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays","volume":"53","author":"Baell","year":"2010","journal-title":"J. Med. Chem."},{"issue":"6676","key":"10.1016\/j.imbio.2026.153209_bb0015","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/33340","article-title":"Chemokines and leukocyte traffic","volume":"392","author":"Baggiolini","year":"1998","journal-title":"Nature"},{"issue":"3","key":"10.1016\/j.imbio.2026.153209_bb0020","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1038\/nri2254","article-title":"The cytokine network in chronic obstructive pulmonary disease","volume":"8","author":"Barnes","year":"2008","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.imbio.2026.153209_bb0025","first-page":"917","article-title":"Oxidative stress in Chronic Obstructive Pulmonary Disease","volume":"159","author":"Barnes","year":"2021","journal-title":"Chest"},{"key":"10.1016\/j.imbio.2026.153209_bb0030","series-title":"Asthma: Pocketbook: A Practical Guide to the Treatment of Adults and Children","author":"Barnes","year":"2000"},{"key":"10.1016\/j.imbio.2026.153209_bb0035","series-title":"Discovery Studio Visualizer [Software]. Version 21.1","author":"BIOVIA","year":"2021"},{"issue":"5","key":"10.1016\/j.imbio.2026.153209_bb0040","first-page":"324","article-title":"Neutrophils, from marrow to microbes","volume":"10","author":"Borregaard","year":"2010","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2026.153209_bb0045","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.2147\/COPD.S365771","article-title":"New perspectives on chronic obstructive pulmonary disease","author":"Celli","year":"2022","journal-title":"Int. J. Chron. Obstruct. Pulmon. Dis."},{"issue":"5","key":"10.1016\/j.imbio.2026.153209_bb0050","first-page":"L715","article-title":"Proteases and emphysema","volume":"289","author":"Churg","year":"2005","journal-title":"Am. J. Phys. Lung Cell. Mol. Phys."},{"issue":"6","key":"10.1016\/j.imbio.2026.153209_bb0055","first-page":"537","article-title":"Series \u201cmatrix metalloproteinases in lung health and disease\u201d: Matrix metalloproteinases in COPD","volume":"176","author":"Churg","year":"2007","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.imbio.2026.153209_bb0060","doi-asserted-by":"crossref","first-page":"42717","DOI":"10.1038\/srep42717","article-title":"SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules","volume":"7","author":"Daina","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.imbio.2026.153209_bb0065","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/978-1-4939-2269-7_19","article-title":"Small-molecule library screening by docking with PyRx","volume":"1263","author":"Dallakyan","year":"2015","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.imbio.2026.153209_bb0070","first-page":"68","article-title":"Pharmacologic overview of withanolides","volume":"73","author":"Dar","year":"2015","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.imbio.2026.153209_bb0075","article-title":"Integrative approaches to uncover the therapeutic action of Huaiqihuang in myocarditis: network pharmacology, molecular docking, and molecular dynamics","author":"Du","year":"2025","journal-title":"Curr. Pharm. Des."},{"issue":"Database issue","key":"10.1016\/j.imbio.2026.153209_bb0080","first-page":"D808","article-title":"STRING v9.1: protein-protein interaction networks, with increased coverage and integration","volume":"41","author":"Franceschini","year":"2013","journal-title":"Nucleic Acids Res."},{"issue":"59","key":"10.1016\/j.imbio.2026.153209_bb0085","doi-asserted-by":"crossref","first-page":"10952","DOI":"10.1039\/D5CC02904J","article-title":"Recent advances in DNA-encoded libraries","volume":"61","author":"Gao","year":"2025","journal-title":"Chem. Commun."},{"issue":"5","key":"10.1016\/j.imbio.2026.153209_bb0090","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities","volume":"10","author":"Genheden","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"issue":"5","key":"10.1016\/j.imbio.2026.153209_bb0095","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/17460441.2015.1032936","article-title":"The MM\/PBSA and MM\/GBSA methods to estimate ligand-binding affinities","volume":"10","author":"Genheden","year":"2015","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.imbio.2026.153209_bb0100","author":"Global Initiative for Chronic Obstructive Lung Disease"},{"issue":"12","key":"10.1016\/j.imbio.2026.153209_bb0105","doi-asserted-by":"crossref","first-page":"4501","DOI":"10.1021\/cr000033x","article-title":"Serine protease mechanism and specificity","volume":"102","author":"Hedstrom","year":"2002","journal-title":"Chem. Rev."},{"issue":"6","key":"10.1016\/j.imbio.2026.153209_bb0110","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.neuron.2018.08.011","article-title":"Molecular dynamics simulation for all","volume":"99","author":"Hollingsworth","year":"2018","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.imbio.2026.153209_bb0115","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1016\/j.neuron.2018.08.011","article-title":"Molecular dynamics simulation for all","volume":"99","author":"Hollingsworth","year":"2018","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.imbio.2026.153209_bb0120","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/minf.201100135","article-title":"Free energy calculations by the molecular mechanics Poisson\u2013Boltzmann surface area method","volume":"31","author":"Homeyer","year":"2012","journal-title":"Mol. Inform."},{"issue":"11","key":"10.1016\/j.imbio.2026.153209_bb0125","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1038\/nchembio.118","article-title":"Network pharmacology: the next paradigm in drug discovery","volume":"4","author":"Hopkins","year":"2008","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.imbio.2026.153209_bb0130","author":"IMPAAT"},{"issue":"10","key":"10.1016\/j.imbio.2026.153209_bb0135","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1016\/j.ajpath.2025.06.005","article-title":"The substructure of the endothelial glycocalyx in rat aorta and its interaction with the low-density lipoproteins (LDL)","volume":"195","author":"Kang","year":"2025","journal-title":"Am. J. Pathol."},{"issue":"9","key":"10.1016\/j.imbio.2026.153209_bb0140","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/nsb0902-646","article-title":"Molecular dynamics simulations of biomolecules","volume":"9","author":"Karplus","year":"2002","journal-title":"Nat. Struct. Biol."},{"issue":"2","key":"10.1016\/j.imbio.2026.153209_bb0145","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1164\/ajrccm.153.2.8564092","article-title":"Differences in interleukin-8 and tumor necrosis factor-\u03b1 in induced sputum from patients with chronic obstructive pulmonary disease or asthma","volume":"153","author":"Keatings","year":"1996","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"D1","key":"10.1016\/j.imbio.2026.153209_bb0150","doi-asserted-by":"crossref","first-page":"D1373","DOI":"10.1093\/nar\/gkac956","article-title":"PubChem 2023 update","volume":"51","author":"Kim","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"W1","key":"10.1016\/j.imbio.2026.153209_bb0155","doi-asserted-by":"crossref","first-page":"W207","DOI":"10.1093\/nar\/gkad347","article-title":"G:Profiler-interoperable web service for functional enrichment analysis and gene identifier mapping (2023 update)","volume":"51","author":"Kolberg","year":"2023","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.imbio.2026.153209_bb0160","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1124\/pr.110.002733","article-title":"Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases","volume":"62","author":"Korkmaz","year":"2010","journal-title":"Pharmacol. Rev."},{"issue":"4","key":"10.1016\/j.imbio.2026.153209_bb0165","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1124\/pr.110.002733","article-title":"Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases","volume":"62","author":"Korkmaz","year":"2010","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.imbio.2026.153209_bb0170","article-title":"Recent advances in the development of human neutrophil elastase inhibitors for the treatment of inflammatory diseases","volume":"223","author":"Kumar","year":"2021","journal-title":"Eur. J. Med. Chem."},{"issue":"10","key":"10.1016\/j.imbio.2026.153209_bb0175","doi-asserted-by":"crossref","first-page":"3664","DOI":"10.1021\/acsinfecdis.4c00531","article-title":"Enzyme dynamics determine the potency and selectivity of inhibitors targeting disease-transmitting mosquitoes","volume":"10","author":"Kumari","year":"2024","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.imbio.2026.153209_bb0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14740338.2024.2430302","article-title":"Clinical features, treatment, and prognosis of SGLT2 inhibitors induced acute pancreatitis","author":"Li","year":"2024","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.imbio.2026.153209_bb0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/14740338.2024.2430302","article-title":"Clinical features, treatment, and prognosis of SGLT2 inhibitors induced acute pancreatitis","author":"Li","year":"2024","journal-title":"Expert Opin. Drug Saf."},{"issue":"6746","key":"10.1016\/j.imbio.2026.153209_bb0190","doi-asserted-by":"crossref","DOI":"10.1126\/science.ado4188","article-title":"Metabolic signaling of ceramides through the FPR2 receptor inhibits adipocyte thermogenesis","volume":"388","author":"Lin","year":"2025","journal-title":"Science"},{"issue":"16","key":"10.1016\/j.imbio.2026.153209_bb0195","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2174\/1568026614666140929124445","article-title":"Structure-based virtual screening for drug discovery: principles, applications and recent advances","volume":"14","author":"Lionta","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"issue":"16","key":"10.1016\/j.imbio.2026.153209_bb0200","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.2174\/1568026614666140929124445","article-title":"Structure-based virtual screening for drug discovery: principles, applications and recent advances","volume":"14","author":"Lionta","year":"2014","journal-title":"Curr. Top. Med. Chem."},{"issue":"1\u20133","key":"10.1016\/j.imbio.2026.153209_bb0205","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0169-409X(00)00129-0","article-title":"Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings","volume":"46","author":"Lipinski","year":"2001","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.imbio.2026.153209_bb0210","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"issue":"7","key":"10.1016\/j.imbio.2026.153209_bb0215","first-page":"637","article-title":"Alpha1-antitrypsin polymerization and the serpinopathies: pathobiology and prospects for therapy","volume":"57","author":"Lomas","year":"2002","journal-title":"Thorax"},{"issue":"6","key":"10.1016\/j.imbio.2026.153209_bb0220","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1038\/s12276-025-01465-6","article-title":"Extracellular vesicles derived from lung M2 macrophages enhance group 2 innate lymphoid cells function in allergic airway inflammation","volume":"57","author":"Lv","year":"2025","journal-title":"Exp. Mol. Med."},{"issue":"18","key":"10.1016\/j.imbio.2026.153209_bb0225","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1021\/jm020881f","article-title":"Discovery of further pyrrolidine trans-lactams as inhibitors of human neutrophil elastase (HNE) with potential as development candidates and the crystal structure of HNE complexed with an inhibitor (GW475151)","volume":"45","author":"Macdonald","year":"2002","journal-title":"J. Med. Chem."},{"issue":"12","key":"10.1016\/j.imbio.2026.153209_bb0230","first-page":"735","article-title":"The IL-17 family of cytokines in health and disease","volume":"19","author":"McGeachy","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imbio.2026.153209_bb0235","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/978-1-59745-177-2_19","article-title":"Molecular docking","volume":"443","author":"Morris","year":"2008","journal-title":"Methods Mol. Biol."},{"issue":"16","key":"10.1016\/j.imbio.2026.153209_bb0240","doi-asserted-by":"crossref","first-page":"2785","DOI":"10.1002\/jcc.21256","article-title":"AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility","volume":"30","author":"Morris","year":"2009","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.imbio.2026.153209_bb0245","series-title":"Oxidative Stress in Lung Diseases: Volume 1","first-page":"429","article-title":"Therapeutic targeting of oxidative stress and inflammation in asthma and COPD and pharmacological interventions with phytochemicals","author":"Nalban","year":"2019"},{"key":"10.1016\/j.imbio.2026.153209_bb0250","first-page":"33","article-title":"Open Babel: an open chemical toolbox","volume":"3","author":"O\u2019Boyle","year":"2011","journal-title":"Aust. J. Chem."},{"issue":"9","key":"10.1016\/j.imbio.2026.153209_bb0255","first-page":"3028","article-title":"Roles for proteinases in the pathogenesis of chronic obstructive pulmonary disease","volume":"118","author":"Owen","year":"2008","journal-title":"J. Clin. Invest."},{"issue":"4","key":"10.1016\/j.imbio.2026.153209_bb0260","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1142\/S2737416523500205","article-title":"In Silico Identification of Triclosan Derivatives as potential Inhibitors of Mutant Mycobacterium tuberculosis InhA","volume":"22","author":"Panahi","year":"2023","journal-title":"J. Computat. Biophys. Chem."},{"key":"10.1016\/j.imbio.2026.153209_bb0265","doi-asserted-by":"crossref","DOI":"10.1017\/jns.2016.41","article-title":"Flavonoids: an overview","volume":"5","author":"Panche","year":"2016","journal-title":"J Nutr Sci."},{"key":"10.1016\/j.imbio.2026.153209_bb0270","author":"PDBID"},{"issue":"12","key":"10.1016\/j.imbio.2026.153209_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/molecules28124860","article-title":"A comprehensive update of various attempts by medicinal chemists to combat COVID-19 through natural products","volume":"28","author":"Rafiq","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.imbio.2026.153209_bb0280","article-title":"Therapeutic potential of natural compounds for treatment of chronic obstructive pulmonary disease: current status and future perspective","volume":"11","author":"Sahu","year":"2024","journal-title":"Europ. J. Med. Chem. Rep."},{"issue":"11","key":"10.1016\/j.imbio.2026.153209_bb0285","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res."},{"issue":"7","key":"10.1016\/j.imbio.2026.153209_bb0290","first-page":"2990","article-title":"IMN4NPD: an integrated molecular networking workflow for natural product dereplication","volume":"96","author":"Sheng","year":"2024","journal-title":"Anal. Chem."},{"issue":"W1","key":"10.1016\/j.imbio.2026.153209_bb0295","doi-asserted-by":"crossref","first-page":"W216","DOI":"10.1093\/nar\/gkac194","article-title":"DAVID: a web server for functional enrichment analysis and functional annotation of gene lists (2021 update)","volume":"50","author":"Sherman","year":"2022","journal-title":"Nucleic Acids Res."},{"issue":"10","key":"10.1016\/j.imbio.2026.153209_bb0300","first-page":"891","article-title":"Neutrophils and the pathogenesis of COPD","volume":"57","author":"Stockley","year":"2002","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.imbio.2026.153209_bb0305","first-page":"636","article-title":"Neutrophils and the pathogenesis of COPD","volume":"57","author":"Stockley","year":"2002","journal-title":"Thorax"},{"key":"10.1016\/j.imbio.2026.153209_bb0310","series-title":"Encyclopedia of Cancer","article-title":"Neutrophil Elastase","author":"Sun","year":"2017"},{"issue":"7","key":"10.1016\/j.imbio.2026.153209_bb0315","first-page":"1051","article-title":"Neutrophil-dependent goblet cell degranulation: role of membrane-bound elastase and adhesion molecules","volume":"108","author":"Takeyama","year":"2001","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.imbio.2026.153209_bb0320","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"issue":"9869","key":"10.1016\/j.imbio.2026.153209_bb0325","first-page":"669","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary","volume":"381","author":"Vestbo","year":"2013","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.imbio.2026.153209_bb0330","first-page":"1721","article-title":"Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2021 report: a critique","volume":"159","author":"Vogelmeier","year":"2021","journal-title":"Chest"},{"issue":"7","key":"10.1016\/j.imbio.2026.153209_bb0335","first-page":"1163","article-title":"Freezing the dynamic gap: discovery and optimization of selective inhibitors of human neutrophil elastase","volume":"10","author":"Von Nussbaum","year":"2015","journal-title":"ChemMedChem"},{"issue":"7","key":"10.1016\/j.imbio.2026.153209_bb0340","first-page":"1163","article-title":"Freezing the dynamic gap: discovery and optimization of selective inhibitors of human neutrophil elastase","volume":"10","author":"Von Nussbaum","year":"2015","journal-title":"ChemMedChem"},{"issue":"2","key":"10.1016\/j.imbio.2026.153209_bb0345","doi-asserted-by":"crossref","DOI":"10.4110\/in.2024.24.e3","article-title":"Cigarette smoke extract-treated mouse airway epithelial cells-derived exosomal LncRNA MEG3 promotes M1 macrophage polarization and pyroptosis in chronic obstructive pulmonary disease by upregulating TREM-1 via m6A methylation","volume":"24","author":"Wang","year":"2024","journal-title":"Immune Netw."},{"issue":"14","key":"10.1016\/j.imbio.2026.153209_bb0350","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.3390\/ijms26146799","article-title":"LSA-DDI: Learning stereochemistry-aware drug interactions via 3D feature fusion and contrastive cross-attention","volume":"26","author":"Wang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.imbio.2026.153209_bb0355","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.cell.2024.12.001","article-title":"Evolutionary study and structural basis of proton sensing by Mus GPR4 and Xenopus GPR4","volume":"188","author":"Wen","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2026.153209_bb0360","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.2174\/1568026617666161116143440","article-title":"Bioinformatics and drug discovery","volume":"17","author":"Xia","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.imbio.2026.153209_bb0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/13813455.2026.2628187","article-title":"Protein tyrosine phosphatase 1B protein macromolecule combined with aerobic exercise intervention on lipid metabolism in type II diabetes patients","author":"Xujiu","year":"2026","journal-title":"Arch. Physiol. Biochem."},{"key":"10.1016\/j.imbio.2026.153209_bb0370","first-page":"1","article-title":"Identification of potential neutrophil elastase inhibitors from Inulae Flos through integrated pharmacophore screening, virtual screening and molecular dynamics simulation study","author":"Zhang","year":"2024","journal-title":"J. Biomol. Struct. Dyn."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000550?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000550?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:07:25Z","timestamp":1791580045000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0171298526000550"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153209","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational identification of natural inhibitors of human neutrophil elastase as potential therapeutics for chronic obstructive pulmonary disease","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153209","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153209"}}