{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:52:53Z","timestamp":1791582773680,"version":"4.3.4"},"reference-count":38,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T00:00:00Z","timestamp":1783641600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.imbio.2026.153218","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T04:52:28Z","timestamp":1783918348000},"page":"153218","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exogenous recombinant complement proteins C3a and C5a regulate osteogenic differentiation of P-PDLSCs: a process associated with the Wnt\/beta-catenin axis"],"prefix":"10.1016","volume":"231","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-9220-4271","authenticated-orcid":false,"given":"Lingyan","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-6942-3250","authenticated-orcid":false,"given":"Yong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-0529-9082","authenticated-orcid":false,"given":"Xiaohui","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7325-2923","authenticated-orcid":false,"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1912-9733","authenticated-orcid":false,"given":"Jing","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"8","key":"10.1016\/j.imbio.2026.153218_bb0005","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/cbin.10779","article-title":"Runx2 alleviates high glucose-suppressed osteogenic differentiation via PI3K\/AKT\/GSK3\u03b2\/\u03b2-catenin pathway","volume":"41","author":"Chen","year":"2017","journal-title":"Cell Biol. Int."},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0010","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1186\/s12903-023-03026-7","article-title":"Graphene quantum dots enhance the osteogenic differentiation of PDLSCs in the inflammatory microenvironment","volume":"23","author":"Gao","year":"2023","journal-title":"BMC Oral Health"},{"issue":"Suppl. 3","key":"10.1016\/j.imbio.2026.153218_bb0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1034\/j.1600-051X.29.s3.5.x","article-title":"A systematic review of the effect of surgical debridement vs non-surgical debridement for the treatment of chronic periodontitis","volume":"29","author":"Heitz-Mayfield","year":"2002","journal-title":"J. Clin. Periodontol."},{"issue":"3","key":"10.1016\/j.imbio.2026.153218_bb0020","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s10047-013-0711-7","article-title":"Bone tissue engineering with bone marrow-derived stromal cells integrated with concentrated growth factor in Rattus norvegicus calvaria defect model","volume":"16","author":"Honda","year":"2013","journal-title":"J. Artif. Organs"},{"issue":"5","key":"10.1016\/j.imbio.2026.153218_bb0025","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/iej.13045","article-title":"The potential application of concentrated growth factor in regenerative endodontics","volume":"52","author":"Hong","year":"2019","journal-title":"Int. Endod. J."},{"issue":"9","key":"10.1016\/j.imbio.2026.153218_bb0030","doi-asserted-by":"crossref","first-page":"2594","DOI":"10.1002\/jcb.23186","article-title":"Complement C3a and C5a modulate osteoclast formation and inflammatory response of osteoblasts in synergism with IL-1\u03b2","volume":"112","author":"Ignatius","year":"2011","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.imbio.2026.153218_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1469414","article-title":"Periodontitis: etiology, conventional treatments, and emerging bacteriophage and predatory bacteria therapies","volume":"15","author":"\u0141asica","year":"2024","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0040","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00441-014-1831-y","article-title":"Combined effects of dentin sialoprotein and bone morphogenetic protein-2 on differentiation in human cementoblasts","volume":"357","author":"Lee","year":"2014","journal-title":"Cell Tissue Res."},{"issue":"5","key":"10.1016\/j.imbio.2026.153218_bb0045","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/j.metabol.2015.01.014","article-title":"C3a and C5a receptor antagonists ameliorate endothelial-myofibroblast transition via the Wnt\/\u03b2-catenin signaling pathway in diabetic kidney disease","volume":"64","author":"Li","year":"2015","journal-title":"Metabolism"},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0050","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1186\/s12967-025-06925-1","article-title":"Multi-omics data reveal that SAA1+fibroblasts exacerbate periodontitis by regulating macrophage inflammation and chemotaxis","volume":"23","author":"Li","year":"2025","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0055","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1186\/s13287-025-04399-y","article-title":"Ubiquitin C-terminal hydrolase L1 promoted pro-angiogenic capacity of periodontal ligament stem cells via HIF-1\u03b1\/YAP signaling in periodontitis","volume":"16","author":"Lin","year":"2025","journal-title":"Stem Cell Res. Ther."},{"issue":"29","key":"10.1016\/j.imbio.2026.153218_bb0060","doi-asserted-by":"crossref","first-page":"47642","DOI":"10.18632\/oncotarget.17465","article-title":"\u03b1MSH inhibits adipose inflammation via reducing FoxOs transcription and blocking Akt\/JNK pathway in mice","volume":"8","author":"Liu","year":"2017","journal-title":"Oncotarget"},{"issue":"9","key":"10.1016\/j.imbio.2026.153218_bb0065","doi-asserted-by":"crossref","first-page":"2082","DOI":"10.1002\/jbmr.440","article-title":"High levels of \u03b2-catenin signaling reduce osteogenic differentiation of stem cells in inflammatory microenvironments through inhibition of the noncanonical Wnt pathway","volume":"26","author":"Liu","year":"2011","journal-title":"J. Bone Miner. Res."},{"issue":"3","key":"10.1016\/j.imbio.2026.153218_bb0070","first-page":"420","article-title":"Human bone marrow mesenchymal stem cell exosome-derived miR-335-5p promotes osteogenic differentiation of human periodontal ligament stem cells to alleviate periodontitis by downregulating DKK1","volume":"43","author":"Liu","year":"2023","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.imbio.2026.153218_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fgene.2021.750990","article-title":"Translational and clinical applications of dental stem cell-derived exosomes","volume":"12","author":"Mai","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.imbio.2026.153218_bb0080","article-title":"Effect of micro-nano-hybrid structured hydroxyapatite bioceramics on osteogenic and cementogenic differentiation of human periodontal ligament stem cell via Wnt signaling pathway","volume":"10","author":"Mao","year":"2015","journal-title":"Int. J. Nanomedicine"},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0085","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12104","article-title":"Molecular aspects of the pathogenesis of periodontitis","volume":"69","author":"Meyle","year":"2015","journal-title":"Periodontol 2000"},{"issue":"2","key":"10.1016\/j.imbio.2026.153218_bb0090","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/jre.12294","article-title":"Wnt3a signaling induces murine dental follicle cells to differentiate into cementoblastic\/osteoblastic cells via an osterix-dependent pathway","volume":"51","author":"Nemoto","year":"2016","journal-title":"J. Periodontal Res."},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0095","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1111\/prd.12250","article-title":"Cellular therapy in periodontal regeneration","volume":"79","author":"Nu\u00f1ez","year":"2019","journal-title":"Periodontol 2000"},{"issue":"Suppl. 1","key":"10.1016\/j.imbio.2026.153218_bb0100","first-page":"S173","article-title":"Periodontitis: consensus report of workgroup 2 of the 2017 World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions","volume":"89","author":"Papapanou","year":"2018","journal-title":"J. Periodontol."},{"issue":"3","key":"10.1016\/j.imbio.2026.153218_bb0105","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/09537104.2016.1213381","article-title":"Effect of concentrated growth factors on function and Wnt3a expression of human periodontal ligament cells in vitro","volume":"28","author":"Qiao","year":"2017","journal-title":"Platelets"},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0110","doi-asserted-by":"crossref","first-page":"9656","DOI":"10.1038\/s41598-025-93519-y","article-title":"PNO1 enhances ovarian cancer cell growth, invasion, and stemness via activating the AKT\/Wnt\/\u03b2-catenin pathway","volume":"15","author":"Qin","year":"2025","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.imbio.2026.153218_bb0115","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1002\/jemt.20968","article-title":"Growth factors, CD34 positive cells, and fibrin network analysis in concentrated growth factors fraction","volume":"74","author":"Rodella","year":"2011","journal-title":"Microsc. Res. Tech."},{"issue":"9429","key":"10.1016\/j.imbio.2026.153218_bb0120","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S0140-6736(04)16627-0","article-title":"Investigation of multipotent postnatal stem cells from human periodontal ligament","volume":"364","author":"Seo","year":"2004","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0125","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/prd.12221","article-title":"Periodontitis: facts, fallacies and the future","volume":"75","author":"Slots","year":"2000","journal-title":"Periodontol"},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0130","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/jcpe.12501","article-title":"Stem cells derived from \u201cinflamed\u201d and healthy periodontal ligament tissues and their sheet functionalities: a patient-matched comparison","volume":"43","author":"Tang","year":"2016","journal-title":"J. Clin. Periodontol."},{"issue":"9","key":"10.1016\/j.imbio.2026.153218_bb0135","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1177\/0022034515590349","article-title":"Effects of TNF-\u03b1 on Cementoblast Differentiation, Mineralization, and Apoptosis","volume":"94","author":"Wang","year":"2015","journal-title":"J. Dent. Res."},{"issue":"10424","key":"10.1016\/j.imbio.2026.153218_bb0140","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0140-6736(23)01524-6","article-title":"Complement in human disease: approved and up-and-coming therapeutics","volume":"403","author":"West","year":"2024","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0145","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s13287-019-1247-4","article-title":"The potential application of concentrated growth factor in pulp regeneration: an in vitro and in vivo study","volume":"10","author":"Xu","year":"2019","journal-title":"Stem Cell Res. Ther."},{"issue":"4","key":"10.1016\/j.imbio.2026.153218_bb0150","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1002\/sctm.18-0181","article-title":"Concise review: periodontal tissue regeneration using stem cells: strategies and translational considerations","volume":"8","author":"Xu","year":"2019","journal-title":"Stem Cells Transl. Med."},{"issue":"3","key":"10.1016\/j.imbio.2026.153218_bb0155","doi-asserted-by":"crossref","first-page":"2330","DOI":"10.1111\/jcmm.14915","article-title":"Imperatorin promotes osteogenesis and suppresses osteoclast by activating AKT\/GSK3 \u03b2\/\u03b2-catenin pathways","volume":"24","author":"Yan","year":"2020","journal-title":"J. Cell. Mol. Med."},{"key":"10.1016\/j.imbio.2026.153218_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2019.117184","article-title":"Periostin reverses high glucose-inhibited osteogenesis of periodontal ligament stem cells via AKT pathway","volume":"242","author":"Yan","year":"2020","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.imbio.2026.153218_bb0165","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1007\/s00784-018-2582-z","article-title":"Cytokine release kinetics of concentrated growth factors in different scaffolds","volume":"23","author":"Yu","year":"2019","journal-title":"Clin. Oral Investig."},{"issue":"3","key":"10.1016\/j.imbio.2026.153218_bb0170","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1111\/jre.13109","article-title":"Thyrotropin inhibits osteogenic differentiation of human periodontal ligament stem cells","volume":"58","author":"Zeng","year":"2023","journal-title":"J. Periodontal Res."},{"issue":"2 Pt B","key":"10.1016\/j.imbio.2026.153218_bb0175","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.canlet.2014.10.016","article-title":"Proton pump inhibitor pantoprazole abrogates adriamycin-resistant gastric cancer cell invasiveness via suppression of Akt\/GSK-\u03b2\/\u03b2-catenin signaling and epithelial-mesenchymal transition","volume":"356","author":"Zhang","year":"2015","journal-title":"Cancer Lett."},{"issue":"1","key":"10.1016\/j.imbio.2026.153218_bb0180","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1186\/s13287-022-03093-7","article-title":"Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543\/PTEN\/PI3K\/AKT\/mTOR signaling pathway in the inflammatory microenvironment","volume":"13","author":"Zhao","year":"2022","journal-title":"Stem Cell Res. Ther."},{"issue":"5","key":"10.1016\/j.imbio.2026.153218_bb0185","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1631\/jzus.B2200576","article-title":"Overview of the main biological mechanisms linked to changes in periodontal ligament stem cells and the inflammatory microenvironment","volume":"24","author":"Zhao","year":"2023","journal-title":"J. Zhejiang Univ. Sci. B"},{"key":"10.1016\/j.imbio.2026.153218_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114517","article-title":"Rapamycin ameliorates senescence of periodontal ligament stem cells and promotes their osteogenesis via the PI3K\/AKT pathway","volume":"153","author":"Zheng","year":"2025","journal-title":"Int. Immunopharmacol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:07:40Z","timestamp":1791580060000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":38,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0171298526000641"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153218","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exogenous recombinant complement proteins C3a and C5a regulate osteogenic differentiation of P-PDLSCs: a process associated with the Wnt\/beta-catenin axis","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153218","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153218"}}