{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:52:34Z","timestamp":1791582754351,"version":"4.3.4"},"reference-count":44,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002873","name":"Chulalongkorn University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002873","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000836","name":"University of Liverpool","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000836","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.imbio.2026.153220","type":"journal-article","created":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T06:59:07Z","timestamp":1784530747000},"page":"153220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Changes of systemic immune cells subtypes in colorectal carcinoma patients"],"prefix":"10.1016","volume":"231","author":[{"given":"Khin Aye","family":"Thin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phonthep","family":"Angsuwatcharakon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apiwat","family":"Mutirangura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charoenchai","family":"Puttipanyalears","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Pike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Skaife","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Edwards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2026.153220_bb0005","series-title":"Cellular and Molecular Immunology","author":"Abbas","year":"2022"},{"issue":"5","key":"10.1016\/j.imbio.2026.153220_bb0010","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1016\/j.immuni.2017.10.009","article-title":"\u201cCD4(+) T Cell help Confers a Cytotoxic T Cell Effector Program Including Coinhibitory Receptor Downregulation and increased Tissue Invasiveness,\u201d (in eng)","volume":"47","author":"Ahrends","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.imbio.2026.153220_bb0015","doi-asserted-by":"crossref","unstructured":"Y. Cao et al., \"Phenotypic and functional alterations of monocyte subsets with aging,\" Immunity & Ageing, vol. 19, no. 1, p. 63, 2022\/12\/13 2022, doi:https:\/\/doi.org\/10.1186\/s12979-022-00321-9.","DOI":"10.1186\/s12979-022-00321-9"},{"key":"10.1016\/j.imbio.2026.153220_bb0020","doi-asserted-by":"crossref","unstructured":"L. G. Filion, C. A. Izaguirre, G. E. Garber, L. Huebsh, and M. T. Aye, \"Detection of surface and cytoplasmic CD4 on blood monocytes from normal and HIV-1 infected individuals,\" J. Immunol. Methods, vol. 135, no. 1, pp. 59\u201369, 1990\/12\/31\/ 1990, doi:https:\/\/doi.org\/https:\/\/doi.org\/10.1016\/0022-1759(90)90256-U.","DOI":"10.1016\/0022-1759(90)90256-U"},{"issue":"35","key":"10.1016\/j.imbio.2026.153220_bb0025","doi-asserted-by":"crossref","first-page":"12407","DOI":"10.3748\/wjg.v20.i35.12407","article-title":"\u201cImmune reaction and colorectal cancer: friends or foes?,\u201d (in eng)","volume":"20","author":"Formica","year":"2014","journal-title":"World J. Gastroenterol."},{"issue":"11","key":"10.1016\/j.imbio.2026.153220_bb0030","doi-asserted-by":"crossref","first-page":"3864","DOI":"10.18632\/aging.102022","article-title":"\"Immune senescence and immune activation in elderly colorectal cancer patients,\" (in eng)","volume":"11","author":"Giunco","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.imbio.2026.153220_bb0035","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.00618","article-title":"Dual role of CD4 in peripheral T lymphocytes","volume":"10","author":"Glatzov\u00e1","year":"2019","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.imbio.2026.153220_bb0040","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1111\/j.1541-0420.2008.01138_10.x","article-title":"Sample size Calculations in Clinical Research 2nd edition by CHOW, S.-C., SHAO, J., and WANG, H","volume":"64","author":"Glueck","year":"2008","journal-title":"Biometrics"},{"key":"10.1016\/j.imbio.2026.153220_bb0045","doi-asserted-by":"crossref","unstructured":"S. S. Gounder et al., \"Effect of aging on NK cell population and their proliferation at ex vivo culture condition,\" (in eng), Anal Cell Pathol (Amst), vol. 2018, p. 7871814, 2018, doi:https:\/\/doi.org\/10.1155\/2018\/7871814.","DOI":"10.1155\/2018\/7871814"},{"issue":"5","key":"10.1016\/j.imbio.2026.153220_bb0050","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1016\/j.cell.2011.02.013","article-title":"\u201cHallmarks of cancer: the next generation,\u201d (in eng)","volume":"144","author":"Hanahan","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2026.153220_bb0055","doi-asserted-by":"crossref","unstructured":"K. J. Hiam-Galvez, B. M. Allen, and M. H. Spitzer, \"Systemic immunity in cancer,\" Nat. Rev. Cancer, vol. 21, no. 6, pp. 345\u2013359, 2021\/06\/01 2021, doi:https:\/\/doi.org\/10.1038\/s41568-021-00347-z.","DOI":"10.1038\/s41568-021-00347-z"},{"issue":"6","key":"10.1016\/j.imbio.2026.153220_bb0060","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.bpg.2009.10.010","article-title":"\u201cColon cancer and the elderly: from screening to treatment in management of GI disease in the elderly,\u201d (in eng)","volume":"23","author":"Holt","year":"2009","journal-title":"Best Pract. Res. Clin. Gastroenterol."},{"key":"10.1016\/j.imbio.2026.153220_bb0065","doi-asserted-by":"crossref","unstructured":"J. Inadomi and B. Jung, \"Colorectal Cancer\u2014recent advances and Future challenges,\" Gastroenterology, vol. 158, no. 2, pp. 289\u2013290, 2020\/01\/01\/ 2020, doi:https:\/\/doi.org\/https:\/\/doi.org\/10.1053\/j.gastro.2019.12.013.","DOI":"10.1053\/j.gastro.2019.12.013"},{"issue":"9","key":"10.1016\/j.imbio.2026.153220_bb0070","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1093\/bjs\/znad097","article-title":"\u201cPINCER (a Platform Study for solId orgaN CancERs): an agile pan-network platform study to deliver high-quality translational research,\u201d (in eng)","volume":"110","author":"Jones","year":"2023","journal-title":"Br. J. Surg."},{"issue":"6","key":"10.1016\/j.imbio.2026.153220_bb0075","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1210\/en.2011-2120","article-title":"\u201cImmune cells have sex and so should journal articles,\u201d (in eng)","volume":"153","author":"Klein","year":"2012","journal-title":"Endocrinology"},{"key":"10.1016\/j.imbio.2026.153220_bb0080","doi-asserted-by":"crossref","unstructured":"E. J. Kuipers et al., \"Colorectal cancer,\" Nat. Rev. Dis. Primers., vol. 1, no. 1, p. 15065, 2015\/11\/05 2015, doi:https:\/\/doi.org\/10.1038\/nrdp.2015.65.","DOI":"10.1038\/nrdp.2015.66"},{"key":"10.1016\/j.imbio.2026.153220_bb0085","doi-asserted-by":"crossref","unstructured":"J. Li, J. Peng, J. Wang, and Z. Chen, \"The dual Role of Exosomes in the Tumor Microenvironment: from Pro-Tumorigenic Signaling to Immune Modulation,\" Med Research, vol. 1, no. 2, pp. 257\u2013284, 2025\/09\/01 2025, doi:https:\/\/doi.org\/https:\/\/doi.org\/10.1002\/mdr2.70022.","DOI":"10.1002\/mdr2.70022"},{"key":"10.1016\/j.imbio.2026.153220_bb0090","doi-asserted-by":"crossref","unstructured":"M. Li et al., \"Age related human T cell subset evolution and senescence,\" Immun. Ageing, vol. 16, no. 1, p. 24, 2019\/09\/11 2019, doi:https:\/\/doi.org\/10.1186\/s12979-019-0165-8.","DOI":"10.1186\/s12979-019-0165-8"},{"issue":"1","key":"10.1016\/j.imbio.2026.153220_bb0095","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2217\/imt-2020-0068","article-title":"Early change in peripheral CD4+ T cells associated with clinical outcomes of immunotherapy in gastrointestinal cancer","volume":"13","author":"Liu","year":"2021","journal-title":"Immunotherapy"},{"key":"10.1016\/j.imbio.2026.153220_bb0100","doi-asserted-by":"crossref","unstructured":"S. Liu et al., \"Monocytic HLA-DR expression in immune responses of acute pancreatitis and COVID-19,\" (in eng), Int. J. Mol. Sci., vol. 24, no. 4, Feb 7 2023, doi:https:\/\/doi.org\/10.3390\/ijms24043246.","DOI":"10.3390\/ijms24043246"},{"key":"10.1016\/j.imbio.2026.153220_bb0105","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mad.2013.12.003","article-title":"\u201cNutrition, diet and immunosenescence,\u201d (in eng)","volume":"136-137","author":"Maij\u00f3","year":"2014","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.imbio.2026.153220_bb0110","doi-asserted-by":"crossref","unstructured":"A. E. Mengos, D. A. Gastineau, and M. P. Gustafson, \"The CD14(+)HLA-DR(lo\/neg) monocyte: an immunosuppressive phenotype that restrains responses to cancer immunotherapy,\" (in eng), Front. Immunol., vol. 10, p. 1147, 2019, doi:https:\/\/doi.org\/10.3389\/fimmu.2019.01147.","DOI":"10.3389\/fimmu.2019.01147"},{"issue":"3","key":"10.1016\/j.imbio.2026.153220_bb0115","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ni.2523","article-title":"\u201cTranscriptional reprogramming of mature CD4+ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes,\u201d (in eng)","volume":"14","author":"Mucida","year":"2013","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imbio.2026.153220_bb0120","doi-asserted-by":"crossref","unstructured":"A. Mutirangura, \"A Hypothesis to Explain How the DNA of Elderly People Is Prone to Damage: Genome-Wide Hypomethylation Drives Genomic Instability in the Elderly by Reducing Youth-Associated Gnome-Stabilizing DNA Gaps,\" in Epigenetics, R. Meccariello Ed.: IntecOpen, 2019, ch. 5, pp. 65\u201375.","DOI":"10.5772\/intechopen.83372"},{"issue":"3","key":"10.1016\/j.imbio.2026.153220_bb0125","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.4049\/jimmunol.171.3.1266","article-title":"\u201cCD4+ NKT cells, but not conventional CD4+ T cells, are required to generate efferent CD8+ T regulatory cells following antigen inoculation in an immune-privileged site,\u201d (in eng)","volume":"171","author":"Nakamura","year":"2003","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153220_bb0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1189\/jlb.1RU0814-382","article-title":"\u201cCD4+\/CD8+ double-positive T cells: more than just a developmental stage?,\u201d (in eng)","volume":"97","author":"Overgaard","year":"2015","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.imbio.2026.153220_bb0135","doi-asserted-by":"crossref","unstructured":"A. I. Pesce Viglietti et al., \"In-depth analysis of the peripheral immune profile of HER2+ breast cancer patients on neoadjuvant treatment with chemotherapy plus trastuzumab plus pertuzumab,\" (in eng), Int. J. Mol. Sci., vol. 25, no. 17, Aug 27 2024, doi:https:\/\/doi.org\/10.3390\/ijms25179268.","DOI":"10.3390\/ijms25179268"},{"issue":"4","key":"10.1016\/j.imbio.2026.153220_bb0140","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1111\/j.1365-2567.2008.03027.x","article-title":"\u201cCD56bright natural killer (NK) cells: an important NK cell subset,\u201d (in eng)","volume":"126","author":"Poli","year":"2009","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.imbio.2026.153220_bb0145","first-page":"89","article-title":"\"Epidemiology of colorectal cancer: incidence, mortality, survival, and risk factors,\" (in eng)","volume":"14","author":"Rawla","year":"2019","journal-title":"Prz Gastroenterol."},{"key":"10.1016\/j.imbio.2026.153220_bb0150","doi-asserted-by":"crossref","unstructured":"D. Rea et al., \"Natural killer-cell counts are associated with molecular relapse-free survival after imatinib discontinuation in chronic myeloid leukemia: the IMMUNOSTIM study,\" Haematologica, vol. 102, pp. 1368\u20131377, 05\/18 2017, doi:https:\/\/doi.org\/10.3324\/haematol.2017.165001.","DOI":"10.3324\/haematol.2017.165001"},{"key":"10.1016\/j.imbio.2026.153220_bb0155","doi-asserted-by":"crossref","unstructured":"L. Roncucci et al., \"The influence of age on colonic epithelial cell proliferation,\" (in eng), Cancer, vol. 62, no. 11, pp. 2373\u20137, Dec 1 1988, doi:https:\/\/doi.org\/10.1002\/1097-0142(19881201)62:11<2373::aid-cncr2820621120>3.0.co;2-y.","DOI":"10.1002\/1097-0142(19881201)62:11<2373::AID-CNCR2820621120>3.0.CO;2-Y"},{"key":"10.1016\/j.imbio.2026.153220_bb0160","doi-asserted-by":"crossref","unstructured":"S. Roy and B. Bagchi, \"Fluctuation theory of immune response: a statistical mechanical approach to understand pathogen induced T-cell population dynamics,\" J. Chem. Phys., vol. 153, no. 4, p. 045107, 2020\/07\/28 2020, doi:https:\/\/doi.org\/10.1063\/5.0009747.","DOI":"10.1063\/5.0009747"},{"issue":"7","key":"10.1016\/j.imbio.2026.153220_bb0165","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0219214","article-title":"\u201cCD4 and MHCII phenotypic variability of peripheral blood monocytes in dogs,\u201d (in eng)","volume":"14","author":"Rzepecka","year":"2019","journal-title":"PloS One"},{"issue":"9","key":"10.1016\/j.imbio.2026.153220_bb0170","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044450","article-title":"Intermediate Monocytes but not TIE2-Expressing Monocytes are a Sensitive Diagnostic Indicator for Colorectal Cancer","volume":"7","author":"Schauer","year":"2012","journal-title":"PloS One"},{"issue":"3","key":"10.1016\/j.imbio.2026.153220_bb0175","first-page":"145","article-title":"\u201cColorectal cancer statistics, 2020,\u201d (in eng)","volume":"70","author":"Siegel","year":"2020","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.imbio.2026.153220_bb0180","doi-asserted-by":"crossref","unstructured":"Y.-p. Tang, M.-z. Xie, K.-z. Li, J.-l. Li, Z.-m. Cai, and B.-l. Hu, \"Prognostic value of peripheral blood natural killer cells in colorectal cancer,\" BMC Gastroenterol., vol. 20, no. 1, p. 31, 2020\/02\/07 2020, doi:https:\/\/doi.org\/10.1186\/s12876-020-1177-8.","DOI":"10.1186\/s12876-020-1177-8"},{"key":"10.1016\/j.imbio.2026.153220_bb0185","doi-asserted-by":"crossref","unstructured":"K. A. Thin, A. Cross, P. Angsuwatcharakon, A. Mutirangura, C. Puttipanyalears, and S. W. Edwards, \"Changes in immune cell subtypes during ageing,\" Arch. Gerontol. Geriatr., vol. 122, p. 105376, 2024\/07\/01\/ 2024, doi:https:\/\/doi.org\/https:\/\/doi.org\/10.1016\/j.archger.2024.105376.","DOI":"10.1016\/j.archger.2024.105376"},{"key":"10.1016\/j.imbio.2026.153220_bb0190","doi-asserted-by":"crossref","unstructured":"C. Wang et al., \"CD8+NKT-like cells regulate the immune response by killing antigen-bearing DCs,\" Sci. Rep., vol. 5, no. 1, p. 14124, 2015\/09\/15 2015, doi:https:\/\/doi.org\/10.1038\/srep14124.","DOI":"10.1038\/srep14124"},{"key":"10.1016\/j.imbio.2026.153220_bb0195","doi-asserted-by":"crossref","unstructured":"Y. Xiong, Y. Wang, and K. Tiruthani, \"Tumor immune microenvironment and nano-immunotherapeutics in colorectal cancer,\" Nanomedicine, vol. 21, p. 102034, 2019\/10\/01\/ 2019, doi:https:\/\/doi.org\/https:\/\/doi.org\/10.1016\/j.nano.2019.102034.","DOI":"10.1016\/j.nano.2019.102034"},{"issue":"9","key":"10.1016\/j.imbio.2026.153220_bb0200","doi-asserted-by":"crossref","DOI":"10.1177\/03000605221122742","article-title":"Potential diagnostic value of the hematological parameters lymphocyte\u2013monocyte ratio and hemoglobin\u2013platelet ratio for detecting colon cancer","volume":"50","author":"Yu","year":"2022","journal-title":"J. Int. Med. Res."},{"issue":"5","key":"10.1016\/j.imbio.2026.153220_bb0205","first-page":"1294","article-title":"Chronic stress-induced immune dysregulation in cancer: implications for initiation, progression, metastasis, and treatment","volume":"10","author":"Zhang","year":"2020","journal-title":"Am. J. Cancer Res."},{"issue":"12","key":"10.1016\/j.imbio.2026.153220_bb0210","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12123850","article-title":"Mechanisms of immunosuppression in colorectal cancer","volume":"12","author":"Zhang","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"17","key":"10.1016\/j.imbio.2026.153220_bb0215","doi-asserted-by":"crossref","first-page":"9934","DOI":"10.1128\/JVI.00616-14","article-title":"\u201cCD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection,\u201d (in eng)","volume":"88","author":"Zhen","year":"2014","journal-title":"J. Virol."},{"issue":"17","key":"10.1016\/j.imbio.2026.153220_bb0220","doi-asserted-by":"crossref","first-page":"9934","DOI":"10.1128\/JVI.00616-14","article-title":"\u201cCD4 ligation on human blood monocytes triggers macrophage differentiation and enhances HIV infection,\u201d (in eng)","volume":"88","author":"Zhen","year":"2014","journal-title":"J. Virol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000665?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000665?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:08:03Z","timestamp":1791580083000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000665"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":44,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S0171298526000665"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153220","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Changes of systemic immune cells subtypes in colorectal carcinoma patients","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153220"}}