{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:05:57Z","timestamp":1789635957549,"version":"4.0.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,30]],"date-time":"2026-08-30T00:00:00Z","timestamp":1788048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.imbio.2026.153240","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T15:20:15Z","timestamp":1788276015000},"page":"153240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["m6A writer METTL14 restricts Mycobacterium tuberculosis infection by promoting TAX1BP1-mediated autophagy in macrophages"],"prefix":"10.1016","volume":"231","author":[{"given":"Nueramina","family":"Tieliwaerdi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhen","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigela","family":"Elihamu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Limei","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2026.153240_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.747799","article-title":"Macrophage: a cell with many faces and functions in tuberculosis","volume":"13","author":"Ahmad","year":"2022","journal-title":"Front. Immunol."},{"issue":"23","key":"10.1016\/j.imbio.2026.153240_bb0010","doi-asserted-by":"crossref","first-page":"5910","DOI":"10.1038\/s44318-024-00280-5","article-title":"Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration","volume":"43","author":"Bauer","year":"2024","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.imbio.2026.153240_bb0015","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01871-20","article-title":"Galectin-8 Senses Phagosomal damage and Recruits Selective Autophagy Adapter TAX1BP1 to Control Mycobacterium tuberculosis Infection in Macrophages","volume":"12","author":"Bell","year":"2021","journal-title":"mBio"},{"key":"10.1016\/j.imbio.2026.153240_bb0020","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1062963","article-title":"Mycobacterium tuberculosis-macrophage interaction: molecular updates","volume":"13","author":"Bo","year":"2023","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"2","key":"10.1016\/j.imbio.2026.153240_bb0025","doi-asserted-by":"crossref","first-page":"161","DOI":"10.4049\/jimmunol.2300885","article-title":"Human Alveolar and Monocyte-Derived Human Macrophage responses to Mycobacterium tuberculosis","volume":"213","author":"Campo","year":"2024","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0030","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/annrheumdis-2021-221091","article-title":"METTL3-mediated m(6)a modification of ATG7 regulates autophagy-GATA4 axis to promote cellular senescence and osteoarthritis progression","volume":"81","author":"Chen","year":"2022","journal-title":"Ann. Rheum. Dis."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0035","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/s41392-022-01175-9","article-title":"RNA modifications: importance in immune cell biology and related diseases","volume":"7","author":"Cui","year":"2022","journal-title":"Signal Transduct. Target. Ther."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0040","doi-asserted-by":"crossref","first-page":"29982","DOI":"10.1038\/s41598-024-81790-4","article-title":"Identification of diagnostic biomarkers and molecular subtype analysis associated with m6A in Tuberculosis immunopathology using machine learning","volume":"14","author":"Ding","year":"2024","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.imbio.2026.153240_bb0045","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1038\/s41418-022-01107-8","article-title":"N(6)-methyladenosine-modified USP13 induces pro-survival autophagy and imatinib resistance via regulating the stabilization of autophagy-related protein 5 in gastrointestinal stromal tumors","volume":"30","author":"Gao","year":"2023","journal-title":"Cell Death Differ."},{"issue":"3","key":"10.1016\/j.imbio.2026.153240_bb0050","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1080\/15548627.2021.1938912","article-title":"M. Tuberculosis PknG manipulates host autophagy flux to promote pathogen intracellular survival","volume":"18","author":"Ge","year":"2022","journal-title":"Autophagy"},{"issue":"14","key":"10.1016\/j.imbio.2026.153240_bb0055","doi-asserted-by":"crossref","DOI":"10.1172\/JCI177932","article-title":"Elevated WTAP promotes hyperinflammation by increasing m6A modification in inflammatory disease models","volume":"134","author":"Ge","year":"2024","journal-title":"J. Clin. Invest."},{"issue":"5","key":"10.1016\/j.imbio.2026.153240_bb0060","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/s41564-023-01354-6","article-title":"Autophagy restricts Mycobacterium tuberculosis during acute infection in mice","volume":"8","author":"Golovkine","year":"2023","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.imbio.2026.153240_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.tube.2024.102502","article-title":"METTL3-deficiency m6A-dependently degrades MALAT1 to suppress NLRP3-mediated pyroptotic cell death and inflammation in Mycobacterium tuberculosis (H37Ra strain)-infected mouse macrophages","volume":"146","author":"Han","year":"2024","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1016\/j.imbio.2026.153240_bb0070","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3389\/fmicb.2016.00328","article-title":"Innate immunity holding the flanks until reinforced by adaptive immunity against Mycobacterium tuberculosis infection","volume":"7","author":"Khan","year":"2016","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0075","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1080\/22221751.2021.2006580","article-title":"Host-cell interactions in HBV infection and pathogenesis: the emerging role of m6A modification","volume":"10","author":"Kostyusheva","year":"2021","journal-title":"Emerg Microbes Infect."},{"issue":"3","key":"10.1016\/j.imbio.2026.153240_bb0080","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1083\/jcb.201603040","article-title":"Mycobacterium tuberculosis replicates within necrotic human macrophages","volume":"216","author":"Lerner","year":"2017","journal-title":"J. Cell Biol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0085","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/s41392-020-00453-8","article-title":"HIF-1\u03b1-induced expression of m6A reader YTHDF1 drives hypoxia-induced autophagy and malignancy of hepatocellular carcinoma by promoting ATG2A and ATG14 translation","volume":"6","author":"Li","year":"2021","journal-title":"Signal Transduct. Target. Ther."},{"issue":"3","key":"10.1016\/j.imbio.2026.153240_bb0090","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jdermsci.2023.02.004","article-title":"Transcriptome-wide assessment of N6-methyladenosine modification identifies different gene expression and infection-associated pathways in Treponema pallidum-infected macrophage","volume":"109","author":"Li","year":"2023","journal-title":"J. Dermatol. Sci."},{"issue":"10","key":"10.1016\/j.imbio.2026.153240_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.116421","article-title":"Mycobacterium bovis induces macrophage mitochondrial release of hexokinase 2 to enhance intracellular survival","volume":"44","author":"Li","year":"2025","journal-title":"Cell Rep."},{"key":"10.1016\/j.imbio.2026.153240_bb0100","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2020.583137","article-title":"Autophagy receptor Tollip facilitates bacterial autophagy by recruiting Galectin-7 in response to Group a Streptococcus infection","volume":"10","author":"Lin","year":"2020","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"2","key":"10.1016\/j.imbio.2026.153240_bb0105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat. Chem. Biol."},{"issue":"7","key":"10.1016\/j.imbio.2026.153240_bb0110","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1080\/15548627.2024.2330105","article-title":"Foot-and-mouth disease virus VP1 degrades YTHDF2 through autophagy to regulate IRF3 activity for viral replication","volume":"20","author":"Liu","year":"2024","journal-title":"Autophagy"},{"key":"10.1016\/j.imbio.2026.153240_bb0115","doi-asserted-by":"crossref","first-page":"1526475","DOI":"10.3389\/fmicb.2025.1526475","article-title":"The role of FTO in m6A RNA methylation and immune regulation in Staphylococcus aureus infection-related osteomyelitis","volume":"16","author":"Liu","year":"2025","journal-title":"Front. Microbiol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41421-024-00653-4","article-title":"Mycobacterium tuberculosis inhibits METTL14-mediated m(6)a methylation of Nox2 mRNA and suppresses anti-TB immunity","volume":"10","author":"Ma","year":"2024","journal-title":"Cell Discov."},{"key":"10.1016\/j.imbio.2026.153240_bb0125","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.tube.2018.10.009","article-title":"The role of epigenetics, bacterial and host factors in progression of Mycobacterium tuberculosis infection","volume":"113","author":"Marimani","year":"2018","journal-title":"Tuberculosis"},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0130","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12866-022-02461-w","article-title":"Impact of pathobiological diversity of Mycobacterium tuberculosis on clinical features and lethal outcome of tuberculosis","volume":"22","author":"Mokrousov","year":"2022","journal-title":"BMC Microbiol."},{"issue":"4","key":"10.1016\/j.imbio.2026.153240_bb0135","first-page":"001041","article-title":"From infection niche to therapeutic target: the intracellular lifestyle of","volume":"167","author":"Rankine-Wilson","year":"2021","journal-title":"Mycobacterium tuberculosis. Microbiology (Reading)"},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0140","doi-asserted-by":"crossref","first-page":"9368","DOI":"10.1038\/s41467-025-64404-z","article-title":"Fundamental role of spatial positioning of Mycobacterium tuberculosis in mycobacterial survival in macrophages","volume":"16","author":"Sahu","year":"2025","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0145","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1080\/15548627.2021.2021495","article-title":"The exploitation of host autophagy and ubiquitin machinery by Mycobacterium tuberculosis in shaping immune responses and host defense during infection","volume":"19","author":"Shariq","year":"2023","journal-title":"Autophagy"},{"issue":"21","key":"10.1016\/j.imbio.2026.153240_bb0150","doi-asserted-by":"crossref","first-page":"11801","DOI":"10.3390\/ijms252111801","article-title":"Epigenetic Mechanisms Induced by Mycobacterium tuberculosis to Promote its Survival in the host","volume":"25","author":"Thomas","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"10","key":"10.1016\/j.imbio.2026.153240_bb0155","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005174","article-title":"The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI are Required for Clearance of Salmonella Typhimurium by Autophagy","volume":"11","author":"Tumbarello","year":"2015","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.imbio.2026.153240_bb0160","doi-asserted-by":"crossref","first-page":"73628","DOI":"10.7554\/eLife.73628","article-title":"m6A modifications regulate intestinal immunity and rotavirus infection","volume":"11","author":"Wang","year":"2022","journal-title":"Elife"},{"issue":"5","key":"10.1016\/j.imbio.2026.153240_bb0165","doi-asserted-by":"crossref","first-page":"1949","DOI":"10.7150\/thno.102682","article-title":"Betaine inhibits the stem cell-like properties of hepatocellular carcinoma by activating autophagy via SAM\/m(6)a\/YTHDF1-mediated enhancement on ATG3 stability","volume":"15","author":"Wang","year":"2025","journal-title":"Theranostics"},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0170","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1080\/15548627.2022.2070331","article-title":"Multifaceted roles of TAX1BP1 in autophagy","volume":"19","author":"White","year":"2023","journal-title":"Autophagy"},{"key":"10.1016\/j.imbio.2026.153240_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.tube.2023.102337","article-title":"Identification of N6-methylandenosine-related lncRNA for tuberculosis diagnosis in person living with human immunodeficiency virus","volume":"140","author":"Xu","year":"2023","journal-title":"Tuberculosis (Edinb.)"},{"key":"10.1016\/j.imbio.2026.153240_bb0180","article-title":"Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis","volume":"13","author":"Zhang","year":"2022","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0185","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/s12931-025-03210-z","article-title":"Early secretory antigen target of 6-kDa of Mycobacterium tuberculosis inhibits macrophage apoptosis and host defense via TLR2","volume":"26","author":"Zhang","year":"2025","journal-title":"Respir. Res."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0190","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1080\/22221751.2021.1899771","article-title":"Trained immunity contributes to the prevention of Mycobacterium tuberculosis infection, a novel role of autophagy","volume":"10","author":"Zhou","year":"2021","journal-title":"Emerg Microbes Infect."},{"issue":"1","key":"10.1016\/j.imbio.2026.153240_bb0195","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1038\/s42003-025-08897-w","article-title":"CAPRIN1 specifically mediates m(6)a modification of RIG-I RNA to inhibit Mycobacterium Tuberculosis infection","volume":"8","author":"Zhou","year":"2025","journal-title":"Commun. Biol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000860?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000860?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:49:10Z","timestamp":1789634950000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000860"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0171298526000860"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153240","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"m6A writer METTL14 restricts Mycobacterium tuberculosis infection by promoting TAX1BP1-mediated autophagy in macrophages","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153240","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153240"}}