{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T09:05:57Z","timestamp":1789635957354,"version":"4.0.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017675","name":"William F Vilas Trust Estate","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017675","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG083883"],"award-info":[{"award-number":["R01AG083883"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG062715"],"award-info":[{"award-number":["P30AG062715"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG070973"],"award-info":[{"award-number":["R01AG070973"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.imbio.2026.153241","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T23:44:53Z","timestamp":1788565493000},"page":"153241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The anti-leukemia drug ponatinib attenuates NLRP3 inflammasome activation in macrophages"],"prefix":"10.1016","volume":"231","author":[{"given":"Abigail H.","family":"Evered","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Shippy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaidynne N.","family":"Lash","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia F.","family":"Oliai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tyler K.","family":"Ulland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imbio.2026.153241_bb0005","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.toxlet.2024.08.007","article-title":"Investigation of the role of NLRP3 inflammasome activation in new-generation BCR-ABL1 tyrosine kinase inhibitors-induced hepatotoxicity","volume":"400","author":"Arzuk","year":"2024","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.imbio.2026.153241_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2023.122997","article-title":"Molecular mechanisms underlying NLRP3 inflammasome activation and IL-1\u03b2 production in air pollution fine particulate matter (PM2.5)-primed macrophages","volume":"341","author":"Caceres","year":"2024","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.imbio.2026.153241_bb0015","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2019.01393","article-title":"Ponatinib protects mice from lethal influenza infection by suppressing cytokine storm","volume":"10","author":"Chen","year":"2019","journal-title":"Front. Immunol."},{"issue":"19","key":"10.1016\/j.imbio.2026.153241_bb0020","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1056\/NEJMoa1306494","article-title":"A phase 2 trial of ponatinib in Philadelphia chromosome\u2013positive leukemias","volume":"369","author":"Cortes","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"8","key":"10.1016\/j.imbio.2026.153241_bb0025","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1038\/ni.3503","article-title":"Interleukin 1\u03b1 and the inflammatory process","volume":"17","author":"Di Paolo","year":"2016","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.imbio.2026.153241_bb0030","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abj7293","article-title":"Nonredundancy of IL-1\u03b1 and IL-1\u03b2 is defined by distinct regulation of tissues orchestrating resistance versus tolerance to infection","volume":"8","author":"Eislmayr","year":"2022","journal-title":"Sci. Adv."},{"issue":"13","key":"10.1016\/j.imbio.2026.153241_bb0035","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.imbio.2026.153241_bb0040","doi-asserted-by":"crossref","first-page":"2006","DOI":"10.4049\/jimmunol.1201065","article-title":"NLRP1-dependent pyroptosis leads to acute lung injury and morbidity in mice","volume":"189","author":"Kovarova","year":"2012","journal-title":"J. Immunol."},{"issue":"5206","key":"10.1016\/j.imbio.2026.153241_bb0045","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1126\/science.7535475","article-title":"Altered cytokine export and apoptosis in mice deficient in interleukin-1 beta converting enzyme","volume":"267","author":"Kuida","year":"1995","journal-title":"Science"},{"issue":"5","key":"10.1016\/j.imbio.2026.153241_bb0050","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and Functions of Inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2026.153241_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1040999","article-title":"Ponatinib modulates the metabolic profile of obese mice by inhibiting adipose tissue macrophage inflammation","volume":"13","author":"Lin","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"7","key":"10.1016\/j.imbio.2026.153241_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/molecules24071363","article-title":"Ponatinib inhibits proliferation and induces apoptosis of liver cancer cells, but its efficacy is compromised by its activation on PDK1\/Akt\/mTOR signaling","volume":"24","author":"Liu","year":"2019","journal-title":"Molecules"},{"issue":"9","key":"10.1016\/j.imbio.2026.153241_bb0065","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1038\/s12276-024-01298-9","article-title":"STAT3 promotes NLRP3 inflammasome activation by mediating NLRP3 mitochondrial translocation","volume":"56","author":"Luo","year":"2024","journal-title":"Exp. Mol. Med."},{"issue":"5","key":"10.1016\/j.imbio.2026.153241_bb0070","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.ccr.2009.09.028","article-title":"AP24534, a Pan-BCR-ABL inhibitor for chronic myeloid leukemia, potently inhibits the T315I mutant and overcomes mutation-based resistance","volume":"16","author":"O\u2019Hare","year":"2009","journal-title":"Cancer Cell"},{"key":"10.1016\/j.imbio.2026.153241_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2024.578364","article-title":"Mitigation of CXCL10 secretion by metabolic disorder drugs in microglial-mediated neuroinflammation","volume":"391","author":"Oliai","year":"2024","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"10.1016\/j.imbio.2026.153241_bb0080","first-page":"1281","article-title":"NF-kappa B as inducible transcriptional activator of the granulocyte-macrophage colony-stimulating factor gene","volume":"10","author":"Schreck","year":"1990","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.imbio.2026.153241_bb0085","doi-asserted-by":"crossref","DOI":"10.1186\/s12950-025-00455-9","article-title":"Verteporfin attenuates NLRP3 inflammasome activation to alleviate gout arthritis flares","volume":"22","author":"Shippy","year":"2025","journal-title":"J. Inflamm."},{"issue":"1","key":"10.1016\/j.imbio.2026.153241_bb0090","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-020-01948-5","article-title":"\u03b2-Hydroxybutyrate inhibits inflammasome activation to attenuate Alzheimer\u2019s disease pathology","volume":"17","author":"Shippy","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.imbio.2026.153241_bb0095","doi-asserted-by":"crossref","DOI":"10.1186\/s12864-022-08417-8","article-title":"Transcriptional response of murine microglia in Alzheimer\u2019s disease and inflammation","volume":"23","author":"Shippy","year":"2022","journal-title":"BMC Genomics"},{"key":"10.1016\/j.imbio.2026.153241_bb0100","doi-asserted-by":"crossref","DOI":"10.1186\/s12950-026-00487-9","article-title":"Montelukast suppresses NLRP3 inflammasome activation as a potential prophylactic agent against gout arthritis flares","author":"Shippy","year":"2026","journal-title":"J. Inflamm."},{"issue":"8","key":"10.1016\/j.imbio.2026.153241_bb0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.imbio.2026.153241_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/cancers10120526","article-title":"Ponatinib inhibits multiple signaling pathways involved in STAT3 signaling and attenuates colorectal tumor growth","volume":"10","author":"Tan","year":"2018","journal-title":"Cancers"},{"issue":"3","key":"10.1016\/j.imbio.2026.153241_bb0115","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1161\/CIRCRESAHA.122.321504","article-title":"Ponatinib drives cardiotoxicity by S100A8\/A9-NLRP3-IL-1\u03b2 mediated inflammation","volume":"132","author":"Tousif","year":"2023","journal-title":"Circ. Res."},{"issue":"2","key":"10.1016\/j.imbio.2026.153241_bb0120","doi-asserted-by":"crossref","DOI":"10.3390\/cells11020267","article-title":"Selective interactions of mouse melanocortin receptor accessory proteins with somatostatin receptors","volume":"11","author":"Wang","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.imbio.2026.153241_bb0125","doi-asserted-by":"crossref","first-page":"56","DOI":"10.4161\/cbt.22628","article-title":"Small molecule kinase inhibitors block the ZAK-dependent inflammatory effects of doxorubicin","volume":"14","author":"Wong","year":"2013","journal-title":"Cancer Biol. Ther."},{"issue":"10","key":"10.1016\/j.imbio.2026.153241_bb0130","doi-asserted-by":"crossref","first-page":"1395","DOI":"10.4161\/cbt.29922","article-title":"Production of IL-1\u03b2 by bone marrow-derived macrophages in response to chemotherapeutic drugs","volume":"15","author":"Wong","year":"2014","journal-title":"Cancer Biol. Ther."},{"key":"10.1016\/j.imbio.2026.153241_bb0135","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.714943","article-title":"Janus kinase inhibition ameliorates ischemic stroke injury and neuroinflammation through reducing NLRP3 inflammasome activation via JAK2\/STAT3 pathway inhibition","volume":"12","author":"Zhu","year":"2021","journal-title":"Front. Immunol."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000872?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000872?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T08:49:06Z","timestamp":1789634946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S0171298526000872"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153241","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The anti-leukemia drug ponatinib attenuates NLRP3 inflammasome activation in macrophages","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153241","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153241"}}