{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:46:32Z","timestamp":1792028792359,"version":"4.4.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007509","name":"Spanish Society of Pneumology and Thorax Surgery","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.imbio.2026.153249","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T23:46:06Z","timestamp":1790725566000},"page":"153249","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["GSTP1 homozygous Val105\/Val105 polymorphism is predominant in late vs early onset asthma"],"prefix":"10.1016","volume":"231","author":[{"given":"Maria Auxiliadora","family":"Romero-Falc\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"S\u00e1nchez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Onofrio","family":"Zanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Francisco","family":"Medina-Gallardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rocio Teresa","family":"Martinez-Nunez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Javier","family":"\u00c1lvarez-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.imbio.2026.153249_bb0005","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1093\/emboj\/18.5.1321","article-title":"Regulation of JNK signaling by GSTp","volume":"18","author":"Adler","year":"1999","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.imbio.2026.153249_bb0010","article-title":"The role of glutathione S-transferases in human disease pathogenesis and their current inhibitors","volume":"12","author":"Alnasser","year":"2025","journal-title":"Genes Dis"},{"issue":"1","key":"10.1016\/j.imbio.2026.153249_bb0015","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: a Practical and Powerful Approach to Multiple Testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. R. Stat. Soc. B. Methodol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153249_bb0020","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41467-018-08272-w","article-title":"Patterns of genetic differentiation and the footprints of historical migrations in the Iberian Peninsula","volume":"10","author":"Bycroft","year":"2019","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.imbio.2026.153249_bb0025","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1399-3038.2012.01294.x","article-title":"Oxidative stress in the airways of children with asthma and allergic rhinitis","volume":"23","author":"Celik","year":"2012","journal-title":"Pediatr. Allergy Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153249_bb0030","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1007\/s12016-020-08830-5","article-title":"External Environmental Pollution as a risk factor for Asthma","volume":"62","author":"Chatkin","year":"2022","journal-title":"Clin Rev Allergy Immunol"},{"issue":"3","key":"10.1016\/j.imbio.2026.153249_bb0035","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1586\/ers.12.24","article-title":"Gene-environment interactions in the development of asthma and atopy","volume":"6","author":"Custovic","year":"2012","journal-title":"Expert Rev. Respir. Med."},{"key":"10.1016\/j.imbio.2026.153249_bb0040","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2022.955193","article-title":"Interactions between glutathione S-transferase genes and household air pollution on asthma and lung function","volume":"9","author":"Dai","year":"2022","journal-title":"Front. Mol. Biosci."},{"issue":"12","key":"10.1016\/j.imbio.2026.153249_bb0045","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1164\/rccm.201911-2199OC","article-title":"A Single-Cell Atlas of the Human healthy Airways","volume":"202","author":"Deprez","year":"2020","journal-title":"Am. J. Respir. Crit. Care Med."},{"issue":"1","key":"10.1016\/j.imbio.2026.153249_bb0050","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1111\/cge.13373","article-title":"Association between glutathione S-transferase gene M1 and T1 polymorphisms and chronic obstructive pulmonary disease risk: a meta-analysis","volume":"95","author":"Ding","year":"2019","journal-title":"Clin. Genet."},{"key":"10.1016\/j.imbio.2026.153249_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.compbiomed.2025.110025","article-title":"Toxicogenomics of glutathione S-transferase (GST) gene family members: Chemical-gene interactions and potential implications of gene deletions","volume":"189","author":"Ellwanger","year":"2025","journal-title":"Comput. Biol. Med."},{"issue":"6","key":"10.1016\/j.imbio.2026.153249_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1008725","article-title":"Age-of-onset information helps identify 76 genetic variants associated with allergic disease","volume":"16","author":"Ferreira","year":"2020","journal-title":"PLoS Genet."},{"issue":"1","key":"10.1016\/j.imbio.2026.153249_bb0065","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.jaci.2012.03.020","article-title":"Genome-wide association study of the age of onset of childhood asthma","volume":"130","author":"Forno","year":"2012","journal-title":"J. Allergy Clin. Immunol."},{"issue":"5","key":"10.1016\/j.imbio.2026.153249_bb0070","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1164\/ajrccm.161.5.9903006","article-title":"Polymorphism at the glutathione S-transferase GSTP1 locus. A new marker for bronchial hyperresponsiveness and asthma","volume":"161","author":"Fryer","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.imbio.2026.153249_bb0075","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.mgene.2015.04.003","article-title":"Genetic model selection for a case-control study and a meta-analysis","volume":"5","author":"Horita","year":"2015","journal-title":"Meta Gene"},{"issue":"4","key":"10.1016\/j.imbio.2026.153249_bb0080","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.iac.2018.06.001","article-title":"Exhaled nitric oxide: an update","volume":"38","author":"Hoyte","year":"2018","journal-title":"Immunol. Allergy Clin. North Am."},{"issue":"8","key":"10.1016\/j.imbio.2026.153249_bb0085","doi-asserted-by":"crossref","DOI":"10.3390\/genes14081644","article-title":"Polymorphisms in Glutathione S-Transferase (GST) Genes Modify the effect of Exposure to Maternal smoking Metabolites in Pregnancy and Offspring DNA Methylation","volume":"14","author":"Kheirkhah Rahimabad","year":"2023","journal-title":"Genes (Basel)"},{"issue":"4","key":"10.1016\/j.imbio.2026.153249_bb0090","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.02079-2019","article-title":"SNPs identified by GWAS affect asthma risk through DNA methylation and expression of cis-genes in airway epithelium","volume":"55","author":"Kim","year":"2020","journal-title":"Eur. Respir. J."},{"issue":"2","key":"10.1016\/j.imbio.2026.153249_bb0095","doi-asserted-by":"crossref","DOI":"10.1136\/bmjdrc-2020-001773","article-title":"Glutathione S-transferases gene polymorphism influence on the age of diabetes type 2 onset","volume":"8","author":"Klusek","year":"2020","journal-title":"BMJ Open Diabetes Res. Care"},{"issue":"W1","key":"10.1016\/j.imbio.2026.153249_bb0100","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"7","key":"10.1016\/j.imbio.2026.153249_bb0105","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2217\/pgs-2022-0017","article-title":"Glutathione S-transferase gene polymorphism and asthma: a case-control study in a pediatric population","volume":"23","author":"Kumar","year":"2022","journal-title":"Pharmacogenomics"},{"key":"10.1016\/j.imbio.2026.153249_bb0110","article-title":"Associations between glutathione-S-transferase genotypes and bronchial hyperreactivity patients with di-isocyanate induced asthma. A follow-up study","volume":"6","author":"Leppilahti","year":"2019","journal-title":"Front Med (Lausanne)"},{"issue":"2","key":"10.1016\/j.imbio.2026.153249_bb0115","doi-asserted-by":"crossref","first-page":"172","DOI":"10.4168\/aair.2018.10.2.172","article-title":"Interactions between Bisphenol a Exposure and GSTP1 Polymorphisms in Childhood Asthma","volume":"10","author":"Lin","year":"2018","journal-title":"Allergy Asthma Immunol Res"},{"issue":"42","key":"10.1016\/j.imbio.2026.153249_bb0120","doi-asserted-by":"crossref","first-page":"72939","DOI":"10.18632\/oncotarget.18513","article-title":"GSTP1 polymorphism predicts treatment outcome and toxicities for breast cancer","volume":"8","author":"Ma","year":"2017","journal-title":"Oncotarget"},{"issue":"8","key":"10.1016\/j.imbio.2026.153249_bb0125","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1111\/j.1365-2222.2007.02704.x","article-title":"Relationship between glutathione S-transferase gene polymorphisms and enzyme activity in Hong Kong Chinese asthmatics","volume":"37","author":"Mak","year":"2007","journal-title":"Clin. Exp. Allergy"},{"issue":"5","key":"10.1016\/j.imbio.2026.153249_bb0130","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1067\/mai.2002.123234","article-title":"Glutathione S-transferase GSTP1 is a susceptibility gene for occupational asthma induced by isocyanates","volume":"109","author":"Mapp","year":"2002","journal-title":"J. Allergy Clin. Immunol."},{"issue":"4","key":"10.1016\/j.imbio.2026.153249_bb0135","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1007\/s12291-010-0047-5","article-title":"Age-dependent changes in glutathione-s-transferase: correlation with total plasma antioxidant potential and red cell intracellular glutathione","volume":"25","author":"Maurya","year":"2010","journal-title":"Indian J. Clin. Biochem."},{"issue":"D1","key":"10.1016\/j.imbio.2026.153249_bb0140","doi-asserted-by":"crossref","first-page":"D672","DOI":"10.1093\/nar\/gkad1025","article-title":"The Reactome Pathway Knowledgebase 2024","volume":"52","author":"Milacic","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"6","key":"10.1016\/j.imbio.2026.153249_bb0145","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1080\/02770903.2021.1910295","article-title":"Analysis of the GSTP1 rs1695 polymorphism association with the development of asthma and phenotypic manifestations","volume":"59","author":"Mukhammadiyeva","year":"2022","journal-title":"J. Asthma"},{"issue":"6","key":"10.1016\/j.imbio.2026.153249_bb0150","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1111\/j.1399-3038.2005.00307.x","article-title":"Association study of glutathione S-transferase P1 (GSTP1) with asthma and bronchial hyper-responsiveness in two German pediatric populations","volume":"16","author":"Nickel","year":"2005","journal-title":"Pediatr. Allergy Immunol."},{"issue":"10","key":"10.1016\/j.imbio.2026.153249_bb0155","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1164\/rccm.202008-3198OC","article-title":"Secretory Cells Dominate Airway CFTR Expression and Function in Human Airway Superficial Epithelia","volume":"203","author":"Okuda","year":"2021","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.imbio.2026.153249_bb0160","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.851940","article-title":"Interleukins 4 and 13 in asthma: key pathophysiologic cytokines and druggable molecular targets","volume":"13","author":"Pelaia","year":"2022","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.imbio.2026.153249_bb0165","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00453-2019","article-title":"Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux","volume":"53","author":"Perotin","year":"2019","journal-title":"Eur. Respir. J."},{"issue":"D1","key":"10.1016\/j.imbio.2026.153249_bb0170","doi-asserted-by":"crossref","first-page":"D925","DOI":"10.1093\/nar\/gkae977","article-title":"The evolution of dbSNP: 25 years of impact in genomic research","volume":"53","author":"Phan","year":"2025","journal-title":"Nucleic Acids Res."},{"issue":"4","key":"10.1016\/j.imbio.2026.153249_bb0175","first-page":"252","article-title":"Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, Central Italy","volume":"22","author":"Piacentini","year":"2012","journal-title":"J. Invest. Allergol. Clin. Immunol."},{"issue":"4","key":"10.1016\/j.imbio.2026.153249_bb0180","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1007\/s11033-012-2405-2","article-title":"Glutathione S-transferase polymorphisms, asthma susceptibility and confounding variables: a meta-analysis","volume":"40","author":"Piacentini","year":"2013","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.imbio.2026.153249_bb0185","doi-asserted-by":"crossref","unstructured":"Resende, E.P., et al., Asthma and rhinitis have different genetic profiles for IL13, IL17A and GSTP1 polymorphisms. Rev. Port. Pneumol. (2006), 2017. 23(1): p. 10\u201316.","DOI":"10.1016\/j.rppnen.2016.06.009"},{"issue":"3","key":"10.1016\/j.imbio.2026.153249_bb0190","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.jaci.2011.04.018","article-title":"Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress","volume":"128","author":"Schroer","year":"2011","journal-title":"J. Allergy Clin. Immunol."},{"issue":"23","key":"10.1016\/j.imbio.2026.153249_bb0195","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1093\/bioinformatics\/btab503","article-title":"UCSC Cell Browser: visualize your single-cell data","volume":"37","author":"Speir","year":"2021","journal-title":"Bioinformatics"},{"issue":"4","key":"10.1016\/j.imbio.2026.153249_bb0200","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1111\/j.1440-1843.2004.00657.x","article-title":"Glutathione-S-transferase gene polymorphisms (GSTT1, GSTM1, GSTP1) as increased risk factors for asthma","volume":"9","author":"Tamer","year":"2004","journal-title":"Respirology"},{"key":"10.1016\/j.imbio.2026.153249_bb0205","series-title":"R: A Language and Environment for Statistical Computing","author":"Team, R.C","year":"2024"},{"issue":"6220","key":"10.1016\/j.imbio.2026.153249_bb0210","doi-asserted-by":"crossref","DOI":"10.1126\/science.1260419","article-title":"Proteomics. Tissue-based map of the human proteome","volume":"347","author":"Uhlen","year":"2015","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.imbio.2026.153249_bb0215","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1093\/carcin\/19.2.275","article-title":"Human glutathione S-transferase P1 polymorphisms: relationship to lung tissue enzyme activity and population frequency distribution","volume":"19","author":"Watson","year":"1998","journal-title":"Carcinogenesis"}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000951?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0171298526000951?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:30:37Z","timestamp":1792027837000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0171298526000951"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S0171298526000951"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153249","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"GSTP1 homozygous Val105\/Val105 polymorphism is predominant in late vs early onset asthma","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153249","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153249"}}