{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:43:15Z","timestamp":1792215795295,"version":"4.4.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunobiology"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.imbio.2026.153258","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:50:21Z","timestamp":1792079421000},"page":"153258","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Putrescine alters the composition of interstitial dendritic cell subsets by suppressing Cybb-dependent oxidative phosphorylation"],"prefix":"10.1016","volume":"231","author":[{"given":"Yue","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziru","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Lian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.imbio.2026.153258_bb0005","doi-asserted-by":"crossref","first-page":"121","DOI":"10.4049\/jimmunol.1900970","article-title":"Merocytic Dendritic Cells Compose a conventional Dendritic Cell Subset with Low Metabolic activity","volume":"205","author":"Audiger","year":"2020","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153258_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.114363","article-title":"The arginase-polyamine signaling axis in immune cells: implications for immune modulation and host-pathogen interactions","volume":"29","author":"Aziz","year":"2026","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.imbio.2026.153258_bb0015","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/imm.13409","article-title":"Metabolomic and lipidomic signatures associated with activation of human cDC1 (BDCA3(+) \/CD141(+) ) dendritic cells","volume":"165","author":"Basit","year":"2022","journal-title":"Immunology"},{"issue":"6","key":"10.1016\/j.imbio.2026.153258_bb0020","doi-asserted-by":"crossref","first-page":"2805","DOI":"10.62347\/BEUV4081","article-title":"Extracellular putrescine can augment the epithelial-mesenchymal transition of gastric cancer cells by promoting MAL2 expression by elevating H3K27ac in its promoter region","volume":"14","author":"Bi","year":"2024","journal-title":"Am. J. Cancer Res."},{"issue":"3","key":"10.1016\/j.imbio.2026.153258_bb0025","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.cell.2019.02.005","article-title":"Unleashing type-2 dendritic cells to drive protective antitumor CD4(+) T cell immunity","volume":"177","author":"Binnewies","year":"2019","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.imbio.2026.153258_bb0035","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1002\/cac2.12596","article-title":"Dysfunction of dendritic cells in tumor microenvironment and immunotherapy","volume":"44","author":"Chen","year":"2024","journal-title":"Cancer Commun."},{"issue":"17","key":"10.1016\/j.imbio.2026.153258_bb0030","doi-asserted-by":"crossref","first-page":"i884","DOI":"10.1093\/bioinformatics\/bty560","article-title":"Fastp: an ultra-fast all-in-one FASTQ preprocessor","volume":"34","author":"Chen","year":"2018","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.imbio.2026.153258_bb0040","doi-asserted-by":"crossref","DOI":"10.3390\/cells11050896","article-title":"Polyamine immunometabolism: central regulators of inflammation, cancer and autoimmunity","volume":"11","author":"Chia","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.imbio.2026.153258_bb0045","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/bs.mie.2019.10.004","article-title":"Isolation of mononuclear phagocytes from the mouse gut","volume":"632","author":"Chiaranunt","year":"2020","journal-title":"Methods Enzymol."},{"issue":"4","key":"10.1016\/j.imbio.2026.153258_bb0050","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.celrep.2016.03.066","article-title":"RUNX2 Mediates Plasmacytoid Dendritic Cell Egress from the Bone Marrow and Controls Viral Immunity","volume":"15","author":"Chopin","year":"2016","journal-title":"Cell Rep."},{"issue":"17","key":"10.1016\/j.imbio.2026.153258_bb0055","doi-asserted-by":"crossref","first-page":"11632","DOI":"10.1021\/acs.jmedchem.3c00770","article-title":"NADPH Oxidases: from Molecular Mechanisms to Current Inhibitors","volume":"66","author":"Cipriano","year":"2023","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.imbio.2026.153258_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.biocel.2021.106038","article-title":"The discovery of indolone GW5074 during a comprehensive search for non-polyamine-based polyamine transport inhibitors","volume":"138","author":"Dobrovolskaite","year":"2021","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.imbio.2026.153258_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.aquatox.2026.107884","article-title":"New insights into polycyclic aromatic hydrocarbons: phenanthrene targets ribosomes to induce neuronal apoptosis","volume":"298","author":"Dong","year":"2026","journal-title":"Aquat. Toxicol."},{"issue":"6","key":"10.1016\/j.imbio.2026.153258_bb0070","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20221472","article-title":"Phagocytosis increases an oxidative metabolic and immune suppressive signature in tumor macrophages","volume":"220","author":"Gonzalez","year":"2023","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.imbio.2026.153258_bb0075","doi-asserted-by":"crossref","first-page":"406","DOI":"10.7150\/ijms.47706","article-title":"DCs-based therapies: potential strategies in severe SARS-CoV-2 infection","volume":"18","author":"Han","year":"2021","journal-title":"Int. J. Med. Sci."},{"issue":"5","key":"10.1016\/j.imbio.2026.153258_bb0080","doi-asserted-by":"crossref","DOI":"10.3390\/cancers16050981","article-title":"Dendritic Cells in Cancer Immunology and Immunotherapy","volume":"16","author":"Hato","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.imbio.2026.153258_bb0085","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.cmet.2026.04.010","article-title":"Mitochondrial metabolism regulates the immunogenic responsiveness of dendritic cells","volume":"38","author":"Heras-Murillo","year":"2026","journal-title":"Cell Metab."},{"key":"10.1016\/j.imbio.2026.153258_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.109739","article-title":"Putrescine accelerates the differentiation of bone marrow derived dendritic cells via inhibiting phosphorylation of STAT3 at Tyr705","volume":"116","author":"Huang","year":"2023","journal-title":"Int. Immunopharmacol."},{"issue":"119","key":"10.1016\/j.imbio.2026.153258_bb0095","doi-asserted-by":"crossref","first-page":"eaef0098","DOI":"10.1126\/sciimmunol.aef0098","article-title":"Mitochondrial complex I activity promotes antigen cross-presentation in dendritic cells","volume":"11","author":"Khouili","year":"2026","journal-title":"Sci. Immunol."},{"issue":"2","key":"10.1016\/j.imbio.2026.153258_bb0100","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00726-019-02719-0","article-title":"The role of polyamines in the regulation of macrophage polarization and function","volume":"52","author":"Latour","year":"2020","journal-title":"Amino Acids"},{"issue":"1","key":"10.1016\/j.imbio.2026.153258_bb0105","first-page":"1","article-title":"Research progress on mitochondria regulating tumor immunity","volume":"53","author":"Li","year":"2024","journal-title":"Zhejiang Da Xue Xue Bao Yi Xue Ban"},{"issue":"1","key":"10.1016\/j.imbio.2026.153258_bb0110","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s43556-025-00300-8","article-title":"Dendritic cells: understanding ontogeny, subsets, functions, and their clinical applications","volume":"6","author":"Li","year":"2025","journal-title":"Mol Biomed"},{"issue":"4","key":"10.1016\/j.imbio.2026.153258_bb0115","doi-asserted-by":"crossref","first-page":"4583","DOI":"10.18632\/oncotarget.22885","article-title":"Quantitative metabolomics for investigating the value of polyamines in the early diagnosis and therapy of colorectal cancer","volume":"9","author":"Liu","year":"2018","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.imbio.2026.153258_bb0120","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1136\/ard-2022-222728","article-title":"Deciphering the role of cDC2s in Sj\u00f6gren's syndrome: transcriptomic profile links altered antigen processes with IFN signature and autoimmunity","volume":"82","author":"Lopes","year":"2023","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.imbio.2026.153258_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2021.111617","article-title":"Arsenic (III) induces oxidative stress and inflammation in the gills of common carp, which is ameliorated by zinc (II)","volume":"225","author":"Lu","year":"2021","journal-title":"J. Inorg. Biochem."},{"issue":"1","key":"10.1016\/j.imbio.2026.153258_bb0130","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41385-021-00448-w","article-title":"Dendritic cell functions in the inductive and effector sites of intestinal immunity","volume":"15","author":"Luciani","year":"2022","journal-title":"Mucosal Immunol."},{"issue":"6374","key":"10.1016\/j.imbio.2026.153258_bb0135","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan2788","article-title":"Spermidine in health and disease","volume":"359","author":"Madeo","year":"2018","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.imbio.2026.153258_bb0140","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.4049\/jimmunol.1700054","article-title":"CXCL12-CXCR4 Axis is Required for Contact-Mediated Human B Lymphoid and Plasmacytoid Dendritic Cell Differentiation but not T Lymphoid Generation","volume":"199","author":"Minami","year":"2017","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.imbio.2026.153258_bb0145","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.clnu.2004.11.001","article-title":"Polyamines: metabolism and implications in human diseases","volume":"24","author":"Moinard","year":"2005","journal-title":"Clin. Nutr."},{"issue":"6793","key":"10.1016\/j.imbio.2026.153258_bb0150","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1126\/science.aeg4325","article-title":"Mitochondria power immunity against cancer","volume":"392","author":"Molina","year":"2026","journal-title":"Science"},{"key":"10.1016\/j.imbio.2026.153258_bb0155","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2019.00108","article-title":"Polyamines in food","volume":"6","author":"Mu\u00f1oz-Esparza","year":"2019","journal-title":"Front. Nutr."},{"issue":"1","key":"10.1016\/j.imbio.2026.153258_bb0160","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s00281-024-01035-4","article-title":"Role of polyamines in intestinal mucosal barrier function","volume":"47","author":"Nakamura","year":"2025","journal-title":"Semin. Immunopathol."},{"issue":"5","key":"10.1016\/j.imbio.2026.153258_bb0165","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1189\/jlb.1A0616-285R","article-title":"Distinct functions of CXCR4, CCR2, and CX3CR1 direct dendritic cell precursors from the bone marrow to the lung","volume":"101","author":"Nakano","year":"2017","journal-title":"J. Leukoc. Biol."},{"issue":"11","key":"10.1016\/j.imbio.2026.153258_bb0170","doi-asserted-by":"crossref","first-page":"3050","DOI":"10.1002\/eji.200838384","article-title":"CXCL12 is essential for migration of activated Langerhans cells from epidermis to dermis","volume":"38","author":"Ouwehand","year":"2008","journal-title":"Eur. J. Immunol."},{"issue":"8","key":"10.1016\/j.imbio.2026.153258_bb0175","doi-asserted-by":"crossref","first-page":"883","DOI":"10.18632\/oncotarget.26608","article-title":"Oxygen in the tumor microenvironment: effects on dendritic cell function","volume":"10","author":"Paardekooper","year":"2019","journal-title":"Oncotarget"},{"issue":"16","key":"10.1016\/j.imbio.2026.153258_bb0180","doi-asserted-by":"crossref","first-page":"4186","DOI":"10.1016\/j.cell.2021.06.007","article-title":"Polyamine metabolism is a central determinant of helper T cell lineage fidelity","volume":"184","author":"Puleston","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.imbio.2026.153258_bb0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbpa.2024.102461","article-title":"Specific signaling by nicotinamide adenine dinucleotide oxidases - Role of their site of action","volume":"81","author":"Schr\u00f6der","year":"2024","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.imbio.2026.153258_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2026.117767","article-title":"Modulation of thrombin-induced human platelet activation and oxidative stress by polyamines","volume":"247","author":"Signorello","year":"2026","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.imbio.2026.153258_bb0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1010572","article-title":"Role of the microbiome and its metabolites in ankylosing spondylitis","volume":"13","author":"Song","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2026.153258_bb0200","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.20663","article-title":"Multiomics analysis of polyamine metabolism in colorectal cancer, highlighting the key role of extracellular putrescine in impairing CXCR6(+)CD8(+) T cell anti-tumor activity","volume":"14","author":"Tan","year":"2026","journal-title":"PeerJ"},{"key":"10.1016\/j.imbio.2026.153258_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2025.103948","article-title":"NADPH oxidase isoform NOX-2 deficiency affects mitochondrial oxygen consumption and metabolic flexibility","volume":"88","author":"Thetchinamoorthy","year":"2025","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.imbio.2026.153258_bb0210","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4049\/jimmunol.1200802","article-title":"Constitutive plasmacytoid dendritic cell migration to the splenic white pulp is cooperatively regulated by CCR7- and CXCR4-mediated signaling","volume":"189","author":"Umemoto","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.imbio.2026.153258_bb0220","article-title":"Cell atlas of the immune microenvironment in gastrointestinal cancers: dendritic cells and beyond","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.imbio.2026.153258_bb0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2021.101146","article-title":"High throughput proteomic and metabolic profiling identified target correction of metabolic abnormalities as a novel therapeutic approach in head and neck paraganglioma","volume":"14","author":"Wang","year":"2021","journal-title":"Transl. Oncol."},{"issue":"5","key":"10.1016\/j.imbio.2026.153258_bb0225","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1097\/00054725-200409000-00006","article-title":"Intracellular polyamine levels of intestinal epithelial cells in inflammatory bowel disease","volume":"10","author":"Weiss","year":"2004","journal-title":"Inflamm. Bowel Dis."},{"issue":"1","key":"10.1016\/j.imbio.2026.153258_bb0230","doi-asserted-by":"crossref","DOI":"10.4110\/in.2019.19.e6","article-title":"The Role of Plasmacytoid Dendritic Cells in Gut Health","volume":"19","author":"Won","year":"2019","journal-title":"Immune Netw."},{"key":"10.1016\/j.imbio.2026.153258_bb0235","article-title":"Polyamine metabolism and anti-tumor immunity","volume":"16","author":"Wu","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.imbio.2026.153258_bb0240","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.aninu.2025.10.004","article-title":"Role of gut microbiota metabolites in maintaining intestinal health and preventing weaning-associated diarrhea in piglets","volume":"25","author":"Wu","year":"2026","journal-title":"Anim. Nutr."},{"issue":"3","key":"10.1016\/j.imbio.2026.153258_bb0245","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1152\/physrev.00026.2013","article-title":"Mitochondrial reactive oxygen species (ROS) and ROS-induced ROS release","volume":"94","author":"Zorov","year":"2014","journal-title":"Physiol. Rev."}],"container-title":["Immunobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017129852600104X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S017129852600104X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:16:21Z","timestamp":1792214181000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S017129852600104X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":49,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S017129852600104X"],"URL":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153258","relation":{},"ISSN":["0171-2985"],"issn-type":[{"value":"0171-2985","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Putrescine alters the composition of interstitial dendritic cell subsets by suppressing Cybb-dependent oxidative phosphorylation","name":"articletitle","label":"Article Title"},{"value":"Immunobiology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imbio.2026.153258","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier GmbH.","name":"copyright","label":"Copyright"}],"article-number":"153258"}}