{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T04:09:35Z","timestamp":1745035775247,"version":"3.40.4"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T00:00:00Z","timestamp":1734393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["72304275","82273696"],"award-info":[{"award-number":["72304275","82273696"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Infectious Medicine"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.imj.2024.100159","type":"journal-article","created":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T16:43:39Z","timestamp":1734799419000},"page":"100159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Unveiling the drivers of vancomycin-resistant enterococcus in China: A comprehensive ecological study"],"prefix":"10.1016","volume":"4","author":[{"given":"Jiongjiong","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinying","family":"Du","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiqun","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guangcai","family":"Duan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1797-304X","authenticated-orcid":false,"given":"Haiyan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ligui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imj.2024.100159_bib0001","article-title":"Consumption of systemic antibiotics in India in 2019","volume":"4","author":"Koya","year":"2022","journal-title":"Lancet Reg. Health Southeast Asia"},{"key":"10.1016\/j.imj.2024.100159_bib0002","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2022.157070","article-title":"Antibiotics in urine from general adults in Shenzhen, China: demographic-related difference in exposure levels","volume":"843","author":"Zhong","year":"2022","journal-title":"Sci. Total Environ"},{"issue":"6","key":"10.1016\/j.imj.2024.100159_bib0003","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1093\/aje\/kwk052","article-title":"Relaxing the rule of ten events per variable in Logistic and Cox regression","volume":"165","author":"Vittinghoff","year":"2007","journal-title":"Am. J. Epidemiol"},{"issue":"10325","key":"10.1016\/j.imj.2024.100159_bib0004","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1016\/S0140-6736(21)02724-0","article-title":"Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis","volume":"399","author":"Collaborators","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.imj.2024.100159_bib0005","doi-asserted-by":"crossref","first-page":"i939","DOI":"10.1136\/bmj.i939","article-title":"Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: systematic review and meta-analysis","volume":"352","author":"Bryce","year":"2016","journal-title":"BMJ"},{"issue":"6","key":"10.1016\/j.imj.2024.100159_bib0006","doi-asserted-by":"crossref","first-page":"1695","DOI":"10.1007\/s40121-023-00826-w","article-title":"An economic evaluation estimating the clinical and economic burden of increased vancomycin-resistant Enterococcus faecium infection incidence in Japan","volume":"12","author":"Sugai","year":"2023","journal-title":"Infect. Dis. Ther"},{"issue":"1","key":"10.1016\/j.imj.2024.100159_bib0007","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.jhin.2018.07.018","article-title":"The local hospital milieu and healthcare-associated vancomycin resistant enterococcus acquisition","volume":"101","author":"Zhou","year":"2019","journal-title":"J. Hosp. Infect"},{"key":"10.1016\/j.imj.2024.100159_bib0008","unstructured":"The China national antimicrobial resistance surveillance network -the report on natonal bacterial drug resistance surveillance in 2021 (Abridged edition). 2021. Accessed January 10, 2023. http:\/\/www.carss.cn\/Report\/Details?aId=862."},{"issue":"4","key":"10.1016\/j.imj.2024.100159_bib0009","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1177\/0896860819889774","article-title":"Vancomycin in peritoneal dialysis: clinical pharmacology considerations in therapy","volume":"40","author":"Lam","year":"2020","journal-title":"Perit. Dial. Int. J. Int. Soc. Perit. Dial"},{"issue":"8","key":"10.1016\/j.imj.2024.100159_bib0010","doi-asserted-by":"crossref","first-page":"11054","DOI":"10.1007\/s11356-021-17825-4","article-title":"Antibiotics, antibiotic-resistant bacteria, and resistance genes in aquaculture: risks, current concern, and future thinking","volume":"29","author":"Hossain","year":"2022","journal-title":"Environ. Sci. Pollut. Res. Int"},{"key":"10.1016\/j.imj.2024.100159_bib0011","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.870465","article-title":"Antibiotic consumption patterns in European countries might be associated with the prevalence of type 1 and 2 diabetes","volume":"13","author":"Tern\u00e1k","year":"2022","journal-title":"Front. Endocrinol"},{"issue":"15","key":"10.1016\/j.imj.2024.100159_bib0012","doi-asserted-by":"crossref","first-page":"E3463","DOI":"10.1073\/pnas.1717295115","article-title":"Global increase and geographic convergence in antibiotic consumption between 2000 and 2015","volume":"115","author":"Klein","year":"2018","journal-title":"Proc. Natl. Acad. Sci. U S A"},{"key":"10.1016\/j.imj.2024.100159_bib0013","article-title":"The association between ambient temperature and antimicrobial resistance of Klebsiella pneumoniae in China: a difference-in-differences analysis, front","volume":"11","author":"Zeng","year":"2023","journal-title":"Public Health"},{"year":"1859","series-title":"On the Origin of Species by Means of Natural Selection","author":"Darwin","key":"10.1016\/j.imj.2024.100159_bib0014"},{"issue":"1","key":"10.1016\/j.imj.2024.100159_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/ice.2019.296","article-title":"Antimicrobial-resistant pathogens associated with adult healthcare-associated infections: summary of data reported to the National Healthcare Safety Network, 2015\u20132017","volume":"41","author":"Weiner-Lastinger","year":"2020","journal-title":"Infect. Control Hosp. Epidemiol"},{"issue":"Suppl 1","key":"10.1016\/j.imj.2024.100159_bib0016","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1093\/milmed\/usaa229","article-title":"Epidemiology and outcomes of vancomycin-resistant Enterococcus infections in the U.S. Military Health System","volume":"186","author":"Stagliano","year":"2021","journal-title":"Mil. Med"},{"issue":"1","key":"10.1016\/j.imj.2024.100159_bib0017","doi-asserted-by":"crossref","first-page":"9788","DOI":"10.1038\/s41598-019-46078-y","article-title":"Antibiotic drug-resistance as a complex system driven by socio-economic growth and antibiotic misuse","volume":"9","author":"Malik","year":"2019","journal-title":"Sci. Rep"},{"issue":"2","key":"10.1016\/j.imj.2024.100159_bib0018","doi-asserted-by":"crossref","first-page":"333","DOI":"10.3390\/antibiotics12020333","article-title":"Soil component: a potential factor affecting the occurrence and spread of antibiotic resistance genes","volume":"12","author":"Shi","year":"2023","journal-title":"Antibiotics"},{"issue":"1","key":"10.1016\/j.imj.2024.100159_bib0019","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12941-017-0251-8","article-title":"Intensive care antibiotic consumption and resistance patterns: a cross-correlation analysis","volume":"16","author":"Baditoiu","year":"2017","journal-title":"Ann. Clin. Microbiol. Antimicrob"},{"issue":"9459","key":"10.1016\/j.imj.2024.100159_bib0020","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/S0140-6736(05)17907-0","article-title":"Outpatient antibiotic use in Europe and association with resistance: a cross-national database study","volume":"365","author":"Goossens","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.imj.2024.100159_bib0021","article-title":"Association between antibiotic resistance and increasing ambient temperature in China: an ecological study with nationwide panel data","volume":"30","author":"Li","year":"2022","journal-title":"Lancet Reg. Health West. Pac"},{"issue":"Pt 1","key":"10.1016\/j.imj.2024.100159_bib0022","article-title":"Antibiotics, antibiotic resistance and associated risk in natural springs from an agroecosystem environment","volume":"857","author":"Gros","year":"2023","journal-title":"Sci. Total Environ"},{"issue":"2","key":"10.1016\/j.imj.2024.100159_bib0023","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1093\/cid\/ciy903","article-title":"Linezolid- and vancomycin-resistant Enterococcus faecium in solid organ transplant recipients: infection control and antimicrobial stewardship using whole genome sequencing","volume":"69","author":"Abbo","year":"2019","journal-title":"Clin. Infect. Dis"},{"issue":"1","key":"10.1016\/j.imj.2024.100159_bib0024","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s13756-019-0655-7","article-title":"Widespread illegal sales of antibiotics in Chinese pharmacies \u2014 A nationwide cross-sectional study","volume":"9","author":"Chen","year":"2020","journal-title":"Antimicrob. Resist. Infect. Control"},{"key":"10.1016\/j.imj.2024.100159_bib0025","article-title":"Trends and socioeconomic, demographic, and environmental factors associated with antimicrobial resistance: a longitudinal analysis in 39 hospitals in Chile 2008\u20132017","volume":"21","author":"Allel","year":"2023","journal-title":"Lancet Reg. Health Am"},{"issue":"2018","key":"10.1016\/j.imj.2024.100159_bib0026","article-title":"Vancomycin-resistant enterococci and its associated risk factors among HIV-positive and -negative clients attending dessie referral hospital, northeast Ethiopia","author":"Ali","year":"2018","journal-title":"Int. J. Microbiol"},{"issue":"1","key":"10.1016\/j.imj.2024.100159_bib0027","doi-asserted-by":"crossref","first-page":"lxac003","DOI":"10.1093\/jambio\/lxac003","article-title":"Association between antimicrobial consumption and resistance rate of Escherichia coli hospital settings","volume":"134","author":"Abdullah","year":"2023","journal-title":"J. Appl. Microbiol"},{"issue":"Suppl 1","key":"10.1016\/j.imj.2024.100159_bib0028","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jiph.2023.11.009","article-title":"Knowledge, attitudes, and practices regarding antibiotic use among the population of the Republic of Serbia \u2014 A cross-sectional study","volume":"16","author":"Belamari\u0107","year":"2023","journal-title":"J. Infect. Public Health"},{"issue":"1","key":"10.1016\/j.imj.2024.100159_bib0029","doi-asserted-by":"crossref","first-page":"71","DOI":"10.4103\/ijmr.IJMR_2063_16","article-title":"Vancomycin-resistant enterococci & healthcare-associated risk factors in paediatric intensive care unit","volume":"149","author":"Agarwal","year":"2019","journal-title":"Indian J. Med. Res"},{"issue":"4","key":"10.1016\/j.imj.2024.100159_bib0030","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/ph15040393","article-title":"Antibiotic resistance in the drinking water: old and new strategies to remove antibiotics, resistant bacteria, and resistance genes","volume":"15","author":"Duarte","year":"2022","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.imj.2024.100159_bib0031","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.2147\/IDR.S205596","article-title":"Genetic characterization of two vancomycin-resistant Staphylococcus aureus isolates in Kerman","volume":"12","author":"Ziasistani","year":"2019","journal-title":"Iran, Infect. Drug Resist"},{"issue":"7","key":"10.1016\/j.imj.2024.100159_bib0032","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3390\/antibiotics11070957","article-title":"Trends of fixed-dose combination antibiotic consumption in hospitals in China: analysis of data from the center for antibacterial surveillance, 2013\u20132019","volume":"11","author":"Wushouer","year":"2022","journal-title":"Antibiotics"},{"key":"10.1016\/j.imj.2024.100159_bib0033","doi-asserted-by":"crossref","DOI":"10.1016\/j.watres.2020.116455","article-title":"Antibiotics and antibiotic resistant genes (ARGs) in groundwater: a global review on dissemination, sources, interactions, environmental and human health risks","volume":"187","author":"Zainab","year":"2020","journal-title":"Water Res"},{"issue":"1","key":"10.1016\/j.imj.2024.100159_bib0034","first-page":"23","article-title":"Antibiotic consumption in Vanuatu before and during the COVID-19 pandemic, 2018 to 2021: an interrupted time series analysis Trop","volume":"8","author":"Foxlee","year":"2022","journal-title":"Med. Infect. Dis"},{"key":"10.1016\/j.imj.2024.100159_bib0035","article-title":"Climate change and antibiotic resistance: a deadly combination","volume":"8","author":"Burnham","year":"2021","journal-title":"Ther. Adv. Infect. Dis"}],"container-title":["Infectious Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772431X2400073X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2772431X2400073X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T22:08:31Z","timestamp":1745014111000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2772431X2400073X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2772431X2400073X"],"URL":"https:\/\/doi.org\/10.1016\/j.imj.2024.100159","relation":{},"ISSN":["2772-431X"],"issn-type":[{"type":"print","value":"2772-431X"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Unveiling the drivers of vancomycin-resistant enterococcus in China: A comprehensive ecological study","name":"articletitle","label":"Article Title"},{"value":"Infectious Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imj.2024.100159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd on behalf of Tsinghua University Press.","name":"copyright","label":"Copyright"}],"article-number":"100159"}}