{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:04:54Z","timestamp":1791223494791,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"2-3","license":[{"start":{"date-parts":[[2004,5,1]],"date-time":"2004-05-01T00:00:00Z","timestamp":1083369600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2004,5]]},"DOI":"10.1016\/j.imlet.2004.01.010","type":"journal-article","created":{"date-parts":[[2004,2,23]],"date-time":"2004-02-23T20:13:22Z","timestamp":1077567202000},"page":"115-122","source":"Crossref","is-referenced-by-count":43,"title":["Induction of cellular immune response and anti-Salmonella enterica serovar typhi bactericidal antibodies in healthy volunteers by immunization with a vaccine candidate against typhoid fever"],"prefix":"10.1016","volume":"93","author":[{"given":"Rosa Mar\u0131\u0301a","family":"Salazar-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Maldonado-Bernal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora Elena","family":"Ram\u0131\u0301rez-Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Rios-Sarabia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Beltr\u00e1n-Nava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Casta\u00f1\u00f3n-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noem\u0131\u0301","family":"Castillo-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 A","family":"Palma-Aguirre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Carrera-Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constantino","family":"L\u00f3pez-Mac\u0131\u0301as","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armando","family":"Isibasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2004.01.010_BIB1","first-page":"339","volume":"26","author":"Garmory","year":"2002","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.imlet.2004.01.010_BIB2","unstructured":"Levine, MM. In: Plotkin, SA, Orenstein WA, editors. Typhoid fever vaccines. London: Saunders; 1999. p. 781\u2013814."},{"key":"10.1016\/j.imlet.2004.01.010_BIB3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/S0035-9203(98)90891-4","article-title":"Community-acquired septicaemia in southern Viet Nam: the importance of multidrug-resistant Salmonella typhi","volume":"92","author":"Hoa","year":"1998","journal-title":"Trans. R. Soc. Trop. Med. Hyg."},{"key":"10.1016\/j.imlet.2004.01.010_BIB4","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S0140-6736(05)78338-0","article-title":"Epidemic ciprofloxacin-resistant Salmonella typhi in Tajikistan","volume":"351","author":"Murdoch","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.imlet.2004.01.010_BIB5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1016\/S0140-6736(05)79356-9","article-title":"Quinolone-resistant Salmonella typhi in Vietnam","volume":"351","author":"Parry","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.imlet.2004.01.010_BIB6","first-page":"62","article-title":"The morbidity and mortality of enteric fever in British Guiana","volume":"11","author":"Ashcroft","year":"1962","journal-title":"West Indian Med. J."},{"key":"10.1016\/j.imlet.2004.01.010_BIB7","doi-asserted-by":"crossref","first-page":"644","DOI":"10.4269\/ajtmh.2000.62.644","article-title":"The epidemiology of typhoid fever in the Dong Thap Province, Mekong Delta region of Vietnam","volume":"62","author":"Lin","year":"2000","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"10.1016\/j.imlet.2004.01.010_BIB8","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1097\/00006454-200105000-00010","article-title":"Typhoid fever in Bangladesh: implications for vaccination policy","volume":"20","author":"Saha","year":"2001","journal-title":"Pediatr. Infect. Dis. J."},{"key":"10.1016\/j.imlet.2004.01.010_BIB9","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/S0140-6736(98)09001-1","article-title":"Typhoid fever in children aged less than 5 years","volume":"354","author":"Sinha","year":"1999","journal-title":"Lancet"},{"issue":"Suppl 2","key":"10.1016\/j.imlet.2004.01.010_BIB10","doi-asserted-by":"crossref","first-page":"S22","DOI":"10.1016\/S0264-410X(99)00231-5","article-title":"Duration of efficacy of Ty21a, attenuated Salmonella typhi live oral vaccine","volume":"17","author":"Levine","year":"1999","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2004.01.010_BIB11","doi-asserted-by":"crossref","first-page":"4291","DOI":"10.1128\/IAI.59.11.4291-4293.1991","article-title":"Immunogenicity of Salmonella typhi Ty21a vaccine for young children","volume":"59","author":"Murphy","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2004.01.010_BIB12","doi-asserted-by":"crossref","unstructured":"Simanjuntak CH, Paleologo FP, Punjabi NH, Darmowigoto R, Soeprawoto, Totosudirjo H, et al. Oral immunisation against typhoid fever in Indonesia with Ty21a vaccine. Lancet 1991;338:1055\u20139.","DOI":"10.1016\/0140-6736(91)91910-M"},{"key":"10.1016\/j.imlet.2004.01.010_BIB13","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0264-410X(94)90194-5","article-title":"Clinical and serological responses following primary and booster immunization with Salmonella typhi Vi capsular polysaccharide vaccines","volume":"12","author":"Keitel","year":"1994","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2004.01.010_BIB14","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S0140-6736(87)91316-X","article-title":"Protective activity of Vi capsular polysaccharide vaccine against typhoid fever","volume":"2","author":"Klugman","year":"1987","journal-title":"Lancet"},{"key":"10.1016\/j.imlet.2004.01.010_BIB15","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/0264-410X(95)00186-5","article-title":"Immunogenicity, efficacy and serological correlate of protection of Salmonella typhi Vi capsular polysaccharide vaccine three years after immunization","volume":"14","author":"Klugman","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2004.01.010_BIB16","doi-asserted-by":"crossref","first-page":"5806","DOI":"10.1128\/IAI.67.11.5806-5810.1999","article-title":"Safety and immunogenicity of Vi conjugate vaccines for typhoid fever in adults, teenagers, and 2- to 4-year-old children in Vietnam","volume":"67","author":"Kossaczka","year":"1999","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2004.01.010_BIB17","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1056\/NEJM200104263441701","article-title":"The efficacy of a Salmonella typhi Vi conjugate vaccine in two-to-five-year-old children","volume":"344","author":"Lin","year":"2001","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.imlet.2004.01.010_BIB18","first-page":"164","article-title":"Emergence of Salmonella typhi Vi antigen-negative strains in an epidemic of multidrug-resistant typhoid fever cases in Calcutta","volume":"13","author":"Saha","year":"2000","journal-title":"Indian Natl. Med. J. India"},{"key":"10.1016\/j.imlet.2004.01.010_BIB19","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0022-2836(83)80275-7","article-title":"Two-dimensional crystal packing of matrix porin. A channel forming protein in Escherichia coli outer membranes","volume":"165","author":"Dorset","year":"1983","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.imlet.2004.01.010_BIB20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1128\/MMBR.49.1.1-32.1985","article-title":"Molecular basis of bacterial outer membrane permeability","volume":"49","author":"Nikaido","year":"1985","journal-title":"Microbiol. Rev."},{"key":"10.1016\/j.imlet.2004.01.010_BIB21","doi-asserted-by":"crossref","first-page":"2953","DOI":"10.1128\/IAI.56.11.2953-2959.1988","article-title":"Protection against Salmonella typhi infection in mice after immunization with outer membrane proteins isolated from Salmonella typhi 9,12,d, Vi","volume":"56","author":"Isibasi","year":"1988","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2004.01.010_BIB22","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/0264-410X(92)90041-H","article-title":"Active protection of mice against Salmonella typhi by immunization with strain-specific porins","volume":"10","author":"Isibasi","year":"1992","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2004.01.010_BIB23","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1128\/IAI.52.1.209-212.1986","article-title":"Antibodies to porin antigens of Salmonella typhi induced during typhoid infection in humans","volume":"52","author":"Calderon","year":"1986","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2004.01.010_BIB24","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1128\/JCM.27.7.1640-1645.1989","article-title":"Immunoblot detection of class-specific humoral immune response to outer membrane proteins isolated from Salmonella typhi in humans with typhoid fever","volume":"27","author":"Ortiz","year":"1989","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.imlet.2004.01.010_BIB25","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3109\/00365549309169673","article-title":"Human cell mediated immunity to porins from Salmonella typhi","volume":"25","author":"Blanco","year":"1993","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.imlet.2004.01.010_BIB26","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0076-6879(83)97122-7","article-title":"Proteins forming large channels from bacterial and mitochondrial outer membranes: porins and phage lambda receptor protein","volume":"97","author":"Nikaido","year":"1983","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.imlet.2004.01.010_BIB27","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/0304-4165(72)90340-6","article-title":"Picogram-sensitive assay for endotoxin: gelation of Limulus polyphemus blood cell lysate induced by purified lipopolysaccharides and lipid A from Gram-negative bacteria","volume":"261","author":"Yin","year":"1972","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.imlet.2004.01.010_BIB28","unstructured":"Farmacopea de los Estados Unidos Mexicanos, 79\u0304 Edici\u00f3n Comisi\u00f3n Permanente de la Farmacopea de los Estados Unidos Mexicanos, Secretar\u0131\u0301a de Salud, M\u00e9xico D.F. 2000;1808\u201315."},{"key":"10.1016\/j.imlet.2004.01.010_BIB29","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0264-410X(96)00001-1","article-title":"Phase I clinical trial with a hexavalent PorA containing meningococcal outer membrane vesicle vaccine","volume":"14","author":"Peeters","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2004.01.010_BIB30","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1016\/S0264-410X(01)00198-0","article-title":"IgG antibody subclass responses determined by immunoblot in infants\u2019 sera following vaccination with a meningococcal recombinant hexavalent PorA OMV vaccine","volume":"19","author":"Martin","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2004.01.010_BIB31","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/0264-410X(96)00054-0","article-title":"Safety and immunogenicity of a Pseudomonas aeruginosa outer membrane protein I vaccine in human volunteers","volume":"14","author":"von Specht","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2004.01.010_BIB32","first-page":"547","article-title":"Basic epidemiologic aspects of some transmissible diseases in population protected by the Mexican Social Security Institute","volume":"22","author":"de la Loza","year":"1980","journal-title":"Salud Publica Mex."},{"key":"10.1016\/j.imlet.2004.01.010_BIB33","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1111\/j.1365-2958.1992.tb01514.x","article-title":"Monoclonal antibodies specific to porin of Haemophilus influenzae type b: localization of their cognate epitopes and tests of their biological activities","volume":"6","author":"Srikumar","year":"1992","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.imlet.2004.01.010_BIB34","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0264-410X(01)00371-1","article-title":"Serum bactericidal activity and isotype distribution of antibodies in toddlers and schoolchildren after vaccination with RIVM hexavalent PorA vesicle vaccine","volume":"20","author":"de Kleijn","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2004.01.010_BIB35","doi-asserted-by":"crossref","first-page":"3712","DOI":"10.1128\/IAI.62.9.3712-3722.1994","article-title":"Mapping of bactericidal epitopes on the P2 porin protein of nontypeable Haemophilus influenzae","volume":"62","author":"Haase","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2004.01.010_BIB36","doi-asserted-by":"crossref","first-page":"4028","DOI":"10.1128\/IAI.70.8.4028-4034.2002","article-title":"Immunization with the recombinant PorB outer membrane protein induces a bactericidal immune response against Neisseria meningitidis","volume":"70","author":"Wright","year":"2002","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2004.01.010_BIB37","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1046\/j.1365-2567.1998.00492.x","article-title":"Th1 and Th2 cell involvement in immune response to Salmonella typhimurium porins","volume":"94","author":"Galdiero","year":"1998","journal-title":"Immunology"},{"key":"10.1016\/j.imlet.2004.01.010_BIB38","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/jlb.67.4.457","article-title":"Immune response to infection with Salmonella typhimurium in mice","volume":"67","author":"Mittrucker","year":"2000","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.imlet.2004.01.010_BIB39","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1128\/IAI.66.3.959-965.1998","article-title":"Human T-cell responses after vaccination with the Norwegian group B meningococcal outer membrane vesicle vaccine","volume":"66","author":"Naess","year":"1998","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2004.01.010_BIB40","doi-asserted-by":"crossref","first-page":"5622","DOI":"10.1128\/IAI.70.10.5622-5627.2002","article-title":"Oral immunization with a Salmonella enterica serovar typhi vaccine induces specific circulating mucosa-homing CD4(+) and CD8(+) T cells in humans","volume":"70","author":"Lundin","year":"2002","journal-title":"Infect. Immun."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247804000136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247804000136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,31]],"date-time":"2020-03-31T01:48:51Z","timestamp":1585619331000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247804000136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":40,"aliases":["10.1016\/s0165-2478(04)00013-6"],"journal-issue":{"issue":"2-3","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["S0165247804000136"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2004.01.010","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2004,5]]}}}