{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:51:15Z","timestamp":1791143475994,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.imlet.2008.07.009","type":"journal-article","created":{"date-parts":[[2008,8,14]],"date-time":"2008-08-14T09:51:38Z","timestamp":1218707498000},"page":"7-12","source":"Crossref","is-referenced-by-count":37,"title":["Serum cytokine profiles in Beh\u00e7et's disease: Is there a role for IL-15 in pathogenesis?"],"prefix":"10.1016","volume":"121","author":[{"given":"S.J.","family":"Curnow","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Pryce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Modi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Knight","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.E.","family":"Stewart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Fortune","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.R.","family":"Stanford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.I.","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.R.","family":"Wallace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2008.07.009_bib1","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1136\/bjo.87.9.1175","article-title":"Behcet's disease; from hippocrates to the 21st century","volume":"87","author":"Verity","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.imlet.2008.07.009_bib2","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1136\/ard.60.11.996","article-title":"Behcet's disease: infectious aetiology, new autoantigens, and HLA-B51","volume":"60","author":"Direskeneli","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.imlet.2008.07.009_bib3","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1002\/1529-0131(199909)42:9<1967::AID-ANR24>3.0.CO;2-Z","article-title":"Th1 polarization of the immune response in Behcet's disease: putative pathogenic role of interleukin-12","volume":"42","author":"Frassinito","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2008.07.009_bib4","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1136\/bjo.87.10.1264","article-title":"T-bet expression is upregulated in active Behcet's disease","volume":"87","author":"Li","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.imlet.2008.07.009_bib5","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0923-1811(95)00439-4","article-title":"Interleukin-6 (IL-6) in patients with Beh\u00e7et's disease","volume":"11","author":"Yamakawa","year":"1996","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.imlet.2008.07.009_bib6","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1084\/jem.185.3.461","article-title":"IL-6 directs the differentiation of IL-4 producing CD4+ T cells","volume":"185","author":"Rincon","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.imlet.2008.07.009_bib7","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1093\/rheumatology\/keh195","article-title":"Increased entry of CD4+ T cells into the Th1 cytokine effector pathway during T-cell division following stimulation in Behcet's disease","volume":"43","author":"Koarada","year":"2004","journal-title":"Rheumatology"},{"key":"10.1016\/j.imlet.2008.07.009_bib8","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1080\/030097402320318387","article-title":"Cytokine profile in Behcet's disease patients","volume":"31","author":"Hamzaoui","year":"2002","journal-title":"Scand J Rheumatol"},{"key":"10.1016\/j.imlet.2008.07.009_bib9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1136\/ard.55.2.128","article-title":"Neutrophil adhesion to endothelial cells and factors affecting adhesion in patients with Beh\u00e7et's disease","volume":"55","author":"Sahin","year":"1996","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.imlet.2008.07.009_bib10","first-page":"S19","article-title":"Neutrophil activation in Behcet's disease","volume":"19","author":"Eksioglu-Demiralp","year":"2001","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.imlet.2008.07.009_bib11","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1001\/archderm.140.5.570","article-title":"Elevated serum G-CSF levels in patients with active phase of Sweet syndrome and patients with active Behcet's disease: implication in neutrophil apoptosis dysfunction","volume":"140","author":"Kawakami","year":"2004","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.imlet.2008.07.009_bib12","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s004030050219","article-title":"The demonstration of serum interleukin-8 and superoxide dismutase in Adamantiades-Behcet's disease","volume":"298","author":"Wang","year":"1997","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.imlet.2008.07.009_bib13","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s004030000128","article-title":"Adamantiades-Behcet's disease: interleukin-8 is increased in serum of patients with active oral and neurological manifestations and is secreted by small vessel endothelial cells","volume":"292","author":"Zouboulis","year":"2000","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.imlet.2008.07.009_bib14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000018426","article-title":"Adamantiades-Behcet's disease: serum IL-8 is a more reliable marker for disease activity than C-reactive protein and erythrocyte sedimentation rate","volume":"201","author":"Katsantonis","year":"2000","journal-title":"Dermatology"},{"key":"10.1016\/j.imlet.2008.07.009_bib15","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1080\/09629350220131935","article-title":"Serum levels of TNF-alpha, sIL-2R, IL-6 and IL-8 are increased and associated with elevated lipid peroxidation in patients with Behcet's disease","volume":"11","author":"Evereklioglu","year":"2002","journal-title":"Mediat Inflamm"},{"key":"10.1016\/j.imlet.2008.07.009_bib16","first-page":"249","article-title":"IL-8 producing cells in patients with Behcet's disease","volume":"18","author":"Mantas","year":"2000","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.imlet.2008.07.009_bib17","first-page":"1070","article-title":"Criteria for the diagnosis of Behcet's disease","volume":"335","author":"International Study Group for Behcet's disease","year":"1990","journal-title":"Lancet"},{"key":"10.1016\/j.imlet.2008.07.009_bib18","first-page":"931","article-title":"Development of the BD-QoL: a quality of life measure specific to Behcet's disease","volume":"31","author":"Gilworth","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.imlet.2008.07.009_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S1043-6618(02)00264-5","article-title":"Azathioprine and anti-TNF therapies in Crohn's disease: a review of pharmacology, clinical efficacy and safety","volume":"47","author":"Arnott","year":"2003","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.imlet.2008.07.009_bib20","first-page":"1250","article-title":"Interleukin-8: the major neutrophil chemotaxin in a case of psuedogout","volume":"20","author":"Miller","year":"1993","journal-title":"J Rheumatol"},{"key":"10.1016\/j.imlet.2008.07.009_bib21","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.4049\/jimmunol.175.9.6133","article-title":"CD8+ and CD56+ T cells are cytotoxic effectors in patients with active Behcet's uveitis","volume":"175","author":"Ahn","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2008.07.009_bib22","doi-asserted-by":"crossref","first-page":"4322","DOI":"10.4049\/jimmunol.160.9.4322","article-title":"IL-15 enhances the response of human \u03b3\u03b4 T cells to nonpeptide microbial antigens","volume":"160","author":"Gracia","year":"1998","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2008.07.009_bib23","first-page":"588","article-title":"Increased peripheral blood gamma-delta+ T cells and natural killer cells in Behcet's disease","volume":"19","author":"Suzuki","year":"1992","journal-title":"J Rheumatol"},{"key":"10.1016\/j.imlet.2008.07.009_bib24","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1046\/j.1365-2249.1999.01069.x","article-title":"Gamma-delta+ T cells and natural killer cells in Behcet's disease(BD) and recurrent aphthous stomatitis (RAS)","volume":"118","author":"Freysdottir","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.imlet.2008.07.009_bib25","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1067\/mlc.2003.1","article-title":"Expansion of \u03b3\u03b4 T cells in Behcet's disease: role of disease activity and microbial flora in oral ulcers","volume":"141","author":"Banks","year":"2003","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.imlet.2008.07.009_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1076\/ocii.6.3.139.4035","article-title":"Proliferative responses of CD8+ \u03b3\u03b4 T cells to Streptococcus sanguis in patients with Behcet's disease","volume":"6","author":"Nishida","year":"1998","journal-title":"Ocular Immunol Inflamm"},{"key":"10.1016\/j.imlet.2008.07.009_bib27","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1111\/j.1365-2249.1997.274-ce1159.x","article-title":"Role of \u03b3\u03b4 T lymphocytes in the development of Behcet's disease","volume":"107","author":"Yamashita","year":"1997","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.imlet.2008.07.009_bib28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/S0165-5728(02)00208-4","article-title":"V\u03b39V\u03b42 T cells recovered from eyes of patients with Behcet's disease recognize non-peptide prenyl pyrophosphate antigens","volume":"130","author":"Verjans","year":"2002","journal-title":"J Neuroimmunol"},{"key":"10.1016\/j.imlet.2008.07.009_bib29","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.ajo.2006.04.016","article-title":"Intraocular cytokine environment in active Behcet's uveitis","volume":"142","author":"Ahn","year":"2006","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.imlet.2008.07.009_bib30","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1111\/j.1365-3083.2006.01844.x","article-title":"Levels of IL-15 in serum and cerebrospinal fluid of patients with Behcet's disease","volume":"64","author":"Hamzaoui","year":"2006","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.imlet.2008.07.009_bib31","first-page":"639","article-title":"Increased serum levels of interleukin-15 in rheumatoid arthritis with long-term disease","volume":"21","author":"Gonzalez-Alvaro","year":"2003","journal-title":"Clin Exp Rheumatol"},{"key":"10.1016\/j.imlet.2008.07.009_bib32","doi-asserted-by":"crossref","first-page":"4225","DOI":"10.4049\/jimmunol.172.7.4225","article-title":"Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signalling","volume":"172","author":"Neely","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2008.07.009_bib33","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1002\/art.10815","article-title":"Behcet's disease and TNF: a missing genetic link","volume":"48","author":"Ahmad","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2008.07.009_bib34","first-page":"264","article-title":"HLA and tumour necrosis factor (TNF) polymorphisms in ocular Behcet's disease","volume":"54","author":"Verity","year":"1999","journal-title":"Tissue Ageing"},{"key":"10.1016\/j.imlet.2008.07.009_bib35","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0923-1811(96)00588-9","article-title":"Characteristics of T cell lines established from skin lesions of Behcet's disease","volume":"15","author":"Mochizuki","year":"1997","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.imlet.2008.07.009_bib36","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/bj20030407","article-title":"Principles of interleukin (IL)-6-type cytokine signalling and its regulation","volume":"374","author":"Heinrich","year":"2003","journal-title":"Biochem J"},{"key":"10.1016\/j.imlet.2008.07.009_bib37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/j.cyto.2003.09.003","article-title":"Cytokine profile in patients with Behcet's disease treated with infliximab","volume":"24","author":"Misumi","year":"2003","journal-title":"Cytokine"},{"issue":"Suppl. 38","key":"10.1016\/j.imlet.2008.07.009_bib38","first-page":"S20","article-title":"Cytokines, cytokine antagonists and soluble adhesion molecules in patients with ocular Behcet's disease treated with human recombinant interferon-alpha2a. Results of an open study and a review of the literature","volume":"23","author":"Kotter","year":"2005","journal-title":"Clin Exp Rheumatol"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247808001880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247808001880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,19]],"date-time":"2023-05-19T16:11:16Z","timestamp":1684512676000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247808001880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0165247808001880"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2008.07.009","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}