{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T11:35:35Z","timestamp":1772105735637,"version":"3.50.1"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,5,9]],"date-time":"2010-05-09T00:00:00Z","timestamp":1273363200000},"content-version":"vor","delay-in-days":342,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.imlet.2009.04.011","type":"journal-article","created":{"date-parts":[[2009,5,10]],"date-time":"2009-05-10T04:16:34Z","timestamp":1241928994000},"page":"88-94","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["TH1\/TH2 balance in concomitant immediate and delayed-type hypersensitivity diseases"],"prefix":"10.1016","volume":"124","author":[{"given":"Luane Marques de","family":"Mello","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique Isabel Silveira","family":"Bechara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirceu","family":"Sol\u00e9","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virmondes","family":"Rodrigues","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2009.04.011_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jtbi.2004.06.013","article-title":"Combining cytokine signaling with T-bet and CAT-3 regulation in Th1 and Th2 differentiation: the model goes cellular decision-making","volume":"231","author":"Yates","year":"2004","journal-title":"J Theor Biol"},{"key":"10.1016\/j.imlet.2009.04.011_bib2","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/S0091-6749(98)70122-8","article-title":"Differential regulation of allergen-specific T(H2)- but not T(H1)-type responses by alveolar macrophages in atopic asthma","volume":"102","author":"Tang","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.imlet.2009.04.011_bib3","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S1081-1206(10)62426-X","article-title":"T-cell subsets (Th1 versus Th2)","volume":"85","author":"Romagnani","year":"2000","journal-title":"Ann Allergy Asthma Immunol"},{"key":"10.1016\/j.imlet.2009.04.011_bib4","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/S0091-6749(98)70092-2","article-title":"Unique profile of IL-4 and IFN-gamma production by peripheral blood mononuclear cells in infants with atopic dermatitis","volume":"102","author":"Kimura","year":"1998","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.imlet.2009.04.011_bib5","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1164\/rccm.200312-1659OC","article-title":"Enhanced generation of helper T type 1 and 2 chemokines in allergen-induced asthma","volume":"169","author":"Liu","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.imlet.2009.04.011_bib6","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1084\/jem.20031368","article-title":"Interleukin 18 acts on memory T helper cells type 1 to induce airway inflammation and hyperresponsiveness in a naive host mouse","volume":"199","author":"Sugimoto","year":"2004","journal-title":"J Exp Med"},{"key":"10.1016\/j.imlet.2009.04.011_bib7","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1097\/00130832-200404000-00008","article-title":"Hygiene hypothesis and endotoxin: what is the evidence?","volume":"4","author":"Eder","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"10.1016\/j.imlet.2009.04.011_bib8","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1034\/j.1398-9995.2003.00282.x","article-title":"T cell activation, from atopy to asthma: more a paradox than a paradigm","volume":"58","author":"El Biaze","year":"2003","journal-title":"Allergy"},{"issue":"Suppl 1","key":"10.1016\/j.imlet.2009.04.011_bib9","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1590\/S0074-02762006000900055","article-title":"Schistosoma mansoni antigen-driven interleukin-10 production in infected asthmatic individuals","volume":"101","author":"Cardoso","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.imlet.2009.04.011_bib10","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.4049\/jimmunol.177.3.1628","article-title":"Intestinal helminths protect in a murine model of asthma","volume":"177","author":"Kitagaki","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2009.04.011_bib11","unstructured":"Sub-Committee On Skin Tests Of The European Academy Of Allergology And Clinical Immunology. Skin tests used in type I allergy testing position paper. Allergy 1989; 44 (Suppl):1\u201359."},{"key":"10.1016\/j.imlet.2009.04.011_bib12","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1600-0536.1997.tb00391.x","article-title":"Proposal for a revised international standard series of patch tests","volume":"36","author":"Lachapelle","year":"1997","journal-title":"Contact Dermatitis"},{"key":"10.1016\/j.imlet.2009.04.011_bib13","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0022-1759(81)90087-9","article-title":"The simple technique goes simultaneous human leukocytes separation","volume":"40","author":"Bicalho","year":"1981","journal-title":"J Immunol Methods"},{"key":"10.1016\/j.imlet.2009.04.011_bib14","first-page":"176","article-title":"Simultaneous occurrence of Hypersensitivities of the Immediate and Late Type: rethinking the paradigm TH1\/TH2","volume":"29","author":"Mello","year":"2006","journal-title":"Rev Bras Allerg Imunopatol"},{"key":"10.1016\/j.imlet.2009.04.011_bib15","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1034\/j.1398-9995.2000.00711.x","article-title":"Cytokine production from peripheral whole blood in atopic and nonatopic asthmatics: relationship with blood and sputum eosinophilia and serum IgE levels","volume":"55","author":"Bettiol","year":"2000","journal-title":"Allergy"},{"key":"10.1016\/j.imlet.2009.04.011_bib16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.jaci.2003.11.025","article-title":"Immunologic influences on allergy and the TH1\/TH2 balances","volume":"113","author":"Romagnani","year":"2004","journal-title":"J Allergy Clin Immunol"},{"issue":"Suppl","key":"10.1016\/j.imlet.2009.04.011_bib17","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1067\/mai.2001.115569","article-title":"Allergic rhinitis: definition, epidemiology, pathophysiology, detection, and diagnosis","volume":"108","author":"Skoner","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.imlet.2009.04.011_bib18","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/j.jaci.2005.02.032","article-title":"Allergy and asthma","volume":"115","author":"Bochner","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.imlet.2009.04.011_bib19","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/0952-7915(95)80094-8","article-title":"Induction of Th2 response in infectious diseases","volume":"7","author":"Pearce","year":"1995","journal-title":"Curr Opin Immun"},{"key":"10.1016\/j.imlet.2009.04.011_bib20","doi-asserted-by":"crossref","first-page":"R75","DOI":"10.1172\/JCI11679","article-title":"JM2, encoding a fork head-related protein, is mutated in X-linked autoimmunity-allergic disregulation syndrome","volume":"106","author":"Chatila","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.imlet.2009.04.011_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1172\/JCI7589","article-title":"CD4(+) T helper cells engineered to produce latent TGF-beta1 reverse allergen-induced airway hyperreactivity and inflammation","volume":"105","author":"Hansen","year":"2000","journal-title":"J Clin Invest"},{"key":"10.1016\/j.imlet.2009.04.011_bib22","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1067\/mai.2002.127512","article-title":"CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation","volume":"110","author":"Oh","year":"2002","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.imlet.2009.04.011_bib23","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.pupt.2004.12.009","article-title":"Immune dysregulation in allergic respiratory disease: the rolls of T regulatory cells","volume":"18","author":"Prescott","year":"2005","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.imlet.2009.04.011_bib24","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1073\/pnas.0703642104","article-title":"Antagonistic nature of T helper 1\/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells","volume":"104","author":"Wei","year":"2007","journal-title":"Proc Nat Acad Sci"},{"key":"10.1016\/j.imlet.2009.04.011_bib25","doi-asserted-by":"crossref","first-page":"14955","DOI":"10.1074\/jbc.M801123200","article-title":"STAT6 inhibits TGF-\u03b21-mediated Foxp3 induction through direct binding to the Foxp3 promoter, which is reverted by retinoic acid receptor","volume":"283","author":"Takaki","year":"2008","journal-title":"J Biol Chem"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247809000984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247809000984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:32:13Z","timestamp":1759044733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247809000984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0165247809000984"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2009.04.011","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"TH1\/TH2 balance in concomitant immediate and delayed-type hypersensitivity diseases","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2009.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}