{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T01:18:46Z","timestamp":1789867126346,"version":"4.0.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.imlet.2011.02.017","type":"journal-article","created":{"date-parts":[[2011,2,20]],"date-time":"2011-02-20T04:33:52Z","timestamp":1298176432000},"page":"53-61","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":74,"title":["IFN-\u03b3 directly inhibits TNF-\u03b1-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas\/Fas ligand interactions"],"prefix":"10.1016","volume":"137","author":[{"given":"Haruka","family":"Kohara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Kitaura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Fujimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masako","family":"Yoshimatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko","family":"Morita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiko","family":"Eguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ritsuko","family":"Masuyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriaki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2011.02.017_bib0005","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/nature01658","article-title":"Osteoclast differentiation and activation","volume":"423","author":"Boyle","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2011.02.017_bib0010","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1126\/science.289.5484.1504","article-title":"Bone resorption by osteoclasts","volume":"289","author":"Teitelbaum","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.imlet.2011.02.017_bib0015","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1111\/j.0105-2896.2005.00337.x","article-title":"Interplay between interferon and other cytokine systems in bone metabolism","volume":"208","author":"Takayanagi","year":"2005","journal-title":"Immunol Rev"},{"key":"10.1016\/j.imlet.2011.02.017_bib0020","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1084\/jem.191.2.275","article-title":"Tumor necrosis factor alpha stimulates osteoclast differentiation by a mechanism independent of the ODF\/RANKL-RANK interaction","volume":"191","author":"Kobayashi","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.imlet.2011.02.017_bib0025","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1084\/jem.20050978","article-title":"Osteoclast differentiation independent of the TRANCE-RANK-TRAF6 axis","volume":"202","author":"Kim","year":"2005","journal-title":"J Exp Med"},{"key":"10.1016\/j.imlet.2011.02.017_bib0030","doi-asserted-by":"crossref","first-page":"4838","DOI":"10.4049\/jimmunol.173.8.4838","article-title":"Marrow stromal cells and osteoclast precursors differentially contribute to TNF-alpha-induced osteoclastogenesis in vivo","volume":"173","author":"Kitaura","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0035","doi-asserted-by":"crossref","first-page":"3818","DOI":"10.1172\/JCI26132","article-title":"M-CSF mediates TNF-induced inflammatory osteolysis","volume":"115","author":"Kitaura","year":"2005","journal-title":"J Clin Invest"},{"key":"10.1016\/j.imlet.2011.02.017_bib0040","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.cb.09.110193.001533","article-title":"Tumor necrosis factor, other cytokines and disease","volume":"9","author":"Tracey","year":"1993","journal-title":"Ann Rev Cell Biol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0045","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.clim.2007.08.013","article-title":"TNF-alpha blockade in human diseases: mechanisms and future directions","volume":"126","author":"Wong","year":"2008","journal-title":"Clin Immunol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0050","doi-asserted-by":"crossref","first-page":"661","DOI":"10.2165\/00003495-200565050-00006","article-title":"Efficacy, tolerability and cost effectiveness of disease-modifying antirheumatic drugs and biologic agents in rheumatoid arthritis","volume":"65","author":"Nurmohamed","year":"2005","journal-title":"Drugs"},{"key":"10.1016\/j.imlet.2011.02.017_bib0055","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jbspin.2010.03.002","article-title":"Role for interleukin-6 in structural joint damage and systemic bone loss in rheumatoid arthritis","volume":"77","author":"Le Goff","year":"2010","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.imlet.2011.02.017_bib0060","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1172\/JCI5703","article-title":"IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis","volume":"103","author":"Kotake","year":"1999","journal-title":"J Clin Invest"},{"key":"10.1016\/j.imlet.2011.02.017_bib0065","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.4049\/jimmunol.165.9.4957","article-title":"TGF-beta 1 and IFN-gamma direct macrophage activation by TNF-alpha to osteoclastic or cytocidal phenotype","volume":"165","author":"Fox","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0070","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0165-2478(03)00082-8","article-title":"Interleukin-4 directly inhibits tumor necrosis factor-alpha-mediated osteoclast formation in mouse bone marrow macrophages","volume":"88","author":"Kitaura","year":"2003","journal-title":"Immunol Lett"},{"key":"10.1016\/j.imlet.2011.02.017_bib0075","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.bone.2007.05.016","article-title":"Interleukin-10 inhibits RANKL-mediated expression of NFATc1 in part via suppression of c-Fos and c-Jun in RAW264.7 cells and mouse bone marrow cells","volume":"41","author":"Mohamed","year":"2007","journal-title":"Bone"},{"key":"10.1016\/j.imlet.2011.02.017_bib0080","doi-asserted-by":"crossref","first-page":"4915","DOI":"10.4049\/jimmunol.166.8.4915","article-title":"IL-12 alone and in synergy with IL-18 inhibits osteoclast formation in vitro","volume":"166","author":"Horwood","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0085","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/S8756-3282(03)00213-8","article-title":"Inhibition of RANKL-induced osteoclast formation in mouse bone marrow cells by IL-12: involvement of IFN-\u03b3 possibly induced from non-T cell population","volume":"33","author":"Nagata","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.imlet.2011.02.017_bib0090","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.4049\/jimmunol.169.9.4732","article-title":"Effect of IL-12 on TNF-alpha-mediated osteoclast formation in bone marrow cells: apoptosis mediated by Fas\/Fas ligand interaction","volume":"169","author":"Kitaura","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0095","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1365-2567.2006.02538.x","article-title":"Interleukin-4 inhibition of osteoclast differentiation is stronger than that of interleukin-13 and they are equivalent for induction of osteoprotegerin production from osteoblasts","volume":"120","author":"Yamada","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0100","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1084\/jem.185.6.1005","article-title":"Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte\/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation","volume":"185","author":"Udagawa","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.imlet.2011.02.017_bib0105","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.imlet.2006.06.005","article-title":"IL-18 induces apoptosis of adherent bone marrow cells in TNF-alpha mediated osteoclast formation in synergy with IL-12","volume":"107","author":"Kitaura","year":"2006","journal-title":"Immunol Lett"},{"key":"10.1016\/j.imlet.2011.02.017_bib0110","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/nri1961","article-title":"Interferons, immunity and cancer immunoediting","volume":"6","author":"Dunn","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0115","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/j.1749-6632.1998.tb08309.x","article-title":"Immunomodulatory Properties of Interferon-gamma: an update","volume":"856","author":"Billiau","year":"1998","journal-title":"Ann N Y Acad Sci"},{"key":"10.1016\/j.imlet.2011.02.017_bib0120","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1038\/35046102","article-title":"T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma","volume":"408","author":"Takayanagi","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2011.02.017_bib0125","doi-asserted-by":"crossref","first-page":"5507","DOI":"10.4049\/jimmunol.158.11.5507","article-title":"Accelerated collagen-induced arthritis in IFN-gamma receptor-deficient mice","volume":"158","author":"Vermeire","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0130","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1172\/JCI30074","article-title":"IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation","volume":"117","author":"Gao","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.imlet.2011.02.017_bib0135","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.cmet.2008.08.002","article-title":"TRPV4-madiated calcium influx regulates terminal differentiation of osteoclasts","volume":"8","author":"Masuyama","year":"2008","journal-title":"Cell Metab"},{"key":"10.1016\/j.imlet.2011.02.017_bib0140","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1182\/blood.V86.3.883.883","article-title":"Functional expression of Fas antigen (CD95) on hematopoietic progenitor cells","volume":"86","author":"Nagafuji","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2011.02.017_bib0145","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/sj.emboj.7601984","article-title":"Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival","volume":"27","author":"Krum","year":"2008","journal-title":"EMBO J"},{"key":"10.1016\/j.imlet.2011.02.017_bib0150","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1016\/j.bone.2009.07.079","article-title":"IL-12 inhibits TNF-alpha induced osteoclastogenesis via a T cell-independent mechanism in vivo","volume":"45","author":"Yoshimatsu","year":"2009","journal-title":"Bone"},{"key":"10.1016\/j.imlet.2011.02.017_bib0155","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1182\/blood-2004-07-2782","article-title":"Stabilization of IFN-gamma mRNA by MAPK p38 in IL-12- and IL-18-stimulated human NK cells","volume":"105","author":"Mavropoulos","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2011.02.017_bib0160","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4049\/jimmunol.168.3.1146","article-title":"Synergy of IL-12 and IL-18 for IFN-gamma gene expression: IL-12-induced STAT4 contributes to IFN-gamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1","volume":"168","author":"Nakahira","year":"2002","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2011.02.017_bib0165","doi-asserted-by":"crossref","first-page":"12281","DOI":"10.1073\/pnas.182618999","article-title":"STAT4 serine phosphorylation is critical for IL-12-induced IFN-gamma production but not for cell proliferation","volume":"99","author":"Morinobu","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.imlet.2011.02.017_bib0170","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.bbrc.2008.08.077","article-title":"Bone marrow stromal cells induce apoptosis of lymphoma cells in the presence of IFNgamma and TNF by producing nitric oxide","volume":"375","author":"Xu","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.imlet.2011.02.017_bib0175","first-page":"444","article-title":"Prolonged decrease of serum calcium concentration by murine gamma-interferon in hypercalcemic, human tumor (EC-GI)-bearing nude mice","volume":"52","author":"Sato","year":"1992","journal-title":"Cancer Res"},{"key":"10.1016\/j.imlet.2011.02.017_bib0180","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/BF01533380","article-title":"Comparative study of inhibitory effects by murine interferon gamma and a new bisphosphonate (alendronate) in hypercalcemic, nude mice bearing human tumor (LJC-1-JCK)","volume":"39","author":"Tohkin","year":"1994","journal-title":"Cancer Immunol Immunother"},{"key":"10.1016\/j.imlet.2011.02.017_bib0185","first-page":"384","article-title":"Combination macrophage-colony stimulating factor and interferon-gamma administration ameliorates the osteopetrotic condition in microphthalmic (mi\/mi) mice","volume":"33","author":"Rodriguiz","year":"1993","journal-title":"Pediatr Res"},{"key":"10.1016\/j.imlet.2011.02.017_bib0190","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1089\/107999000414826","article-title":"IFN-gamma enhances osteoclast generation in cultures of peripheral blood from osteopetrotic patients and normalizes superoxide production","volume":"20","author":"Madyastha","year":"2000","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.imlet.2011.02.017_bib0195","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1210\/endo.135.3.8070349","article-title":"Interferon-gamma causes loss of bone volume in vivo and fails to ameliorate cyclosporin A-induced osteopenia","volume":"135","author":"Mann","year":"1994","journal-title":"Endocrinology"},{"key":"10.1016\/j.imlet.2011.02.017_bib0200","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S8756-3282(99)00182-9","article-title":"Interferon-alpha, unlike interferon-gamma, does not cause bone loss in the rat","volume":"25","author":"Goodman","year":"1999","journal-title":"Bone"},{"key":"10.1016\/j.imlet.2011.02.017_bib0205","doi-asserted-by":"crossref","first-page":"3353","DOI":"10.1002\/eji.200526141","article-title":"IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL","volume":"35","author":"Kotake","year":"2005","journal-title":"Eur J Immunol"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247811000575?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247811000575?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:33:07Z","timestamp":1759044787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247811000575"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":41,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0165247811000575"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2011.02.017","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IFN-\u03b3 directly inhibits TNF-\u03b1-induced osteoclastogenesis in vitro and in vivo and induces apoptosis mediated by Fas\/Fas ligand interactions","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2011.02.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2011 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}