{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:08:04Z","timestamp":1791119284941,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2012,9,1]],"date-time":"2012-09-01T00:00:00Z","timestamp":1346457600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Korea government (MEST","award":["2010-0029133"],"award-info":[{"award-number":["2010-0029133"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2012,9]]},"DOI":"10.1016\/j.imlet.2012.05.006","type":"journal-article","created":{"date-parts":[[2012,6,12]],"date-time":"2012-06-12T18:02:11Z","timestamp":1339524131000},"page":"34-40","source":"Crossref","is-referenced-by-count":22,"title":["Pathological effect of IL-17A-producing TCR\u03b3\u03b4+ T cells in mouse genital mucosa against HSV-2 infection"],"prefix":"10.1016","volume":"147","author":[{"given":"Jae-Ouk","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hye-Ran","family":"Cha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Do","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mi-Na","family":"Kweon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2012.05.006_bib0005","doi-asserted-by":"crossref","first-page":"5445","DOI":"10.4049\/jimmunol.150.12.5445","article-title":"CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene","volume":"150","author":"Rouvier","year":"1993","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0010","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1016\/1074-7613(95)90070-5","article-title":"Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor","volume":"3","author":"Yao","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2012.05.006_bib0015","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1146\/annurev.immunol.25.022106.141557","article-title":"IL-17 family cytokines and the expanding diversity of effector T cell lineages","volume":"25","author":"Weaver","year":"2007","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0020","doi-asserted-by":"crossref","first-page":"4137","DOI":"10.4049\/jimmunol.167.8.4137","article-title":"Cutting edge: IL-17F, a novel cytokine selectively expressed in activated T cells and monocytes, regulates angiogenesis and endothelial cell cytokine production","volume":"167","author":"Starnes","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0025","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/j.immuni.2004.08.018","article-title":"Interleukin-17 family members and inflammation","volume":"21","author":"Kolls","year":"2004","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2012.05.006_bib0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/j.immuni.2006.06.002","article-title":"Th17: an effector CD4T cell lineage with regulatory T cell ties","volume":"24","author":"Weaver","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2012.05.006_bib0035","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.cell.2006.07.035","article-title":"The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells","volume":"126","author":"Ivanov","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2012.05.006_bib0040","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1600-065X.2008.00699.x","article-title":"The roles of IL-17A in inflammatory immune responses and host defense against pathogens","volume":"226","author":"Iwakura","year":"2008","journal-title":"Immunol Rev"},{"key":"10.1016\/j.imlet.2012.05.006_bib0045","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s10875-010-9369-6","article-title":"The IL-17 family cytokines in immunity and disease","volume":"30","author":"Pappu","year":"2010","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0050","doi-asserted-by":"crossref","first-page":"4485","DOI":"10.4049\/jimmunol.181.7.4485","article-title":"Hepatitis C virus-specific Th17 cells are suppressed by virus-induced TGF-beta","volume":"181","author":"Rowan","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0055","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/viro.2002.1400","article-title":"Interleukin 17 modulates the immune response to vaccinia virus infection","volume":"299","author":"Patera","year":"2002","journal-title":"Virology"},{"key":"10.1016\/j.imlet.2012.05.006_bib0060","doi-asserted-by":"crossref","first-page":"5301","DOI":"10.4049\/jimmunol.0900995","article-title":"Critical role of IL-17RA in immunopathology of influenza infection","volume":"183","author":"Crowe","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0065","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1128\/JVI.02550-07","article-title":"Virus-specific interleukin-17-producing CD4+ T cells are detectable in early human immunodeficiency virus type 1 infection","volume":"82","author":"Yue","year":"2008","journal-title":"J Virol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0070","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.177.7.4662","article-title":"IL-17 production is dominated by gammadelta T cells rather than CD4T cells during Mycobacterium tuberculosis infection","volume":"177","author":"Lockhart","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0075","doi-asserted-by":"crossref","first-page":"5167","DOI":"10.4049\/jimmunol.180.8.5167","article-title":"Cutting edge: NKT cells constitutively express IL-23 receptor and RORgammat and rapidly produce IL-17 upon receptor ligation in an IL-6-independent fashion","volume":"180","author":"Rachitskaya","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0080","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1038\/nri797","article-title":"Gammadelta T cells: functional plasticity and heterogeneity","volume":"2","author":"Carding","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0085","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1146\/annurev.immunol.18.1.975","article-title":"[gamma][delta] cells: a right time and a right place for a conserved third way of protection","volume":"18","author":"Hayday","year":"2000","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0090","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.coi.2006.06.001","article-title":"Epithelial and mucosal gamma delta T cells","volume":"18","author":"Komori","year":"2006","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0095","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.4049\/jimmunol.153.7.3101","article-title":"Immune protection and control of inflammatory tissue necrosis by gamma delta T cells","volume":"153","author":"Fu","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0100","doi-asserted-by":"crossref","first-page":"2047","DOI":"10.4049\/jimmunol.155.4.2047","article-title":"Bacterial infection of the testis leading to autoaggressive immunity triggers apparently opposed responses of alpha beta and gamma delta T cells","volume":"155","author":"Mukasa","year":"1995","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0105","doi-asserted-by":"crossref","first-page":"5787","DOI":"10.4049\/jimmunol.159.12.5787","article-title":"Evidence that the same gamma delta T cells respond during infection-induced and autoimmune inflammation","volume":"159","author":"Mukasa","year":"1997","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0110","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1084\/jem.185.11.1969","article-title":"T cell receptor-gamma\/delta cells protect mice from herpes simplex virus type 1-induced lethal encephalitis","volume":"185","author":"Sciammas","year":"1997","journal-title":"J Exp Med"},{"key":"10.1016\/j.imlet.2012.05.006_bib0115","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/viro.2000.0628","article-title":"Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model","volume":"278","author":"Jones","year":"2000","journal-title":"Virology"},{"key":"10.1016\/j.imlet.2012.05.006_bib0120","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1128\/JVI.63.12.5258-5267.1989","article-title":"Genetic evidence for multiple nuclear functions of the herpes simplex virus ICP8 DNA-binding protein","volume":"63","author":"Gao","year":"1989","journal-title":"J Virol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0125","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1038\/322836a0","article-title":"Diversity of murine gamma genes and expression in fetal and adult T lymphocytes","volume":"322","author":"Heilig","year":"1986","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2012.05.006_bib0130","doi-asserted-by":"crossref","first-page":"6799","DOI":"10.4049\/jimmunol.0902944","article-title":"Downregulation of Th17 cells in the small intestine by disruption of gut flora in the absence of retinoic acid","volume":"184","author":"Cha","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0135","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.imlet.2012.05.006_bib0140","doi-asserted-by":"crossref","first-page":"559","DOI":"10.4049\/jimmunol.180.1.559","article-title":"Commensal gut flora drives the expansion of proinflammatory CD4T cells in the colonic lamina propria under normal and inflammatory conditions","volume":"180","author":"Niess","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0145","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1074\/jbc.M207577200","article-title":"Interleukin-23 promotes a distinct CD4T cell activation state characterized by the production of interleukin-17","volume":"278","author":"Aggarwal","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.imlet.2012.05.006_bib0150","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/nri1777","article-title":"Mucosal vaccines: the promise and the challenge","volume":"6","author":"Neutra","year":"2006","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0155","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/nri1499","article-title":"War and peace at mucosal surfaces","volume":"4","author":"Sansonetti","year":"2004","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0160","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"Ivanov","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2012.05.006_bib0165","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.chom.2008.09.009","article-title":"Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine","volume":"4","author":"Ivanov","year":"2008","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.imlet.2012.05.006_bib0170","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.immuni.2006.01.001","article-title":"TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells","volume":"24","author":"Veldhoen","year":"2006","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2012.05.006_bib0175","doi-asserted-by":"crossref","first-page":"5940","DOI":"10.4049\/jimmunol.181.9.5940","article-title":"Identification of CD25+ gamma delta T cells as fetal thymus-derived naturally occurring IL-17 producers","volume":"181","author":"Shibata","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0180","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/ni.1717","article-title":"CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets","volume":"10","author":"Ribot","year":"2009","journal-title":"Nat Immunol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0185","doi-asserted-by":"crossref","first-page":"4927","DOI":"10.1128\/JVI.78.9.4927-4930.2004","article-title":"Intraepithelial gammadelta T cells may bridge a gap between innate immunity and acquired immunity to herpes simplex virus type 2","volume":"78","author":"Nishimura","year":"2004","journal-title":"J Virol"},{"key":"10.1016\/j.imlet.2012.05.006_bib0190","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.jri.2003.12.002","article-title":"T-cell-mediated mechanisms involved in resolution of genital herpes simplex virus type 2 (HSV-2) infection of mice","volume":"61","author":"Milligan","year":"2004","journal-title":"J Reprod Immunol"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247812001551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247812001551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,23]],"date-time":"2023-06-23T09:23:03Z","timestamp":1687512183000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247812001551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9]]},"references-count":38,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2012,9]]}},"alternative-id":["S0165247812001551"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2012.05.006","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2012,9]]}}}