{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T20:18:30Z","timestamp":1789935510387,"version":"4.0.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2013,1]]},"DOI":"10.1016\/j.imlet.2012.11.008","type":"journal-article","created":{"date-parts":[[2012,11,23]],"date-time":"2012-11-23T17:34:26Z","timestamp":1353692066000},"page":"50-53","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Genetic polymorphisms of interleukin 20 (IL-20) in patients with ulcerative colitis"],"prefix":"10.1016","volume":"149","author":[{"given":"Jes\u00fas K.","family":"Yamamoto-Furusho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge L.","family":"De-Le\u00f3n-Rend\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Garc\u00eda","family":"de la Torre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edith","family":"Alvarez-Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilberto","family":"Vargas-Alarc\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2012.11.008_bib0005","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0198-8859(02)00772-3","article-title":"Clinical and genetic heterogeneity in Mexican patients with ulcerative colitis","volume":"64","author":"Yamamoto-Furusho","year":"2003","journal-title":"Hum Immunol"},{"key":"10.1016\/j.imlet.2012.11.008_bib0010","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.suc.2007.03.005","article-title":"Immunologic and molecular mechanisms in inflammatory bowel disease","volume":"87","author":"Ince","year":"2007","journal-title":"Surg Clin North Am"},{"key":"10.1016\/j.imlet.2012.11.008_bib0015","doi-asserted-by":"crossref","unstructured":"Yamamoto-Furusho JK, Miranda-Perez ME, Fonseca-Camarillo GC, Sanchez-Mu\u00f1oz F, Barreto-Zu\u00f1iga R, Dom\u00ednguez-L\u00f3pez A. Interleukin 21 (IL-21) expression is increased in Rectal Biopsies from Patients with Ulcerative Colitis. Inflam Bowel Dis 2010;16:1090.","DOI":"10.1002\/ibd.21135"},{"key":"10.1016\/j.imlet.2012.11.008_bib0020","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1002\/ibd.21235","article-title":"Colonic epithelial up-regulation of interleukin 22 (IL-22) in patients with ulcerative colitis","volume":"16","author":"Yamamoto-Furusho","year":"2010","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.imlet.2012.11.008_bib0025","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1002\/ibd.21635","article-title":"Role of the interleukin 24 in patients with ulcerative colitis","volume":"17","author":"Fonseca-Camarillo","year":"2011","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.imlet.2012.11.008_bib0030","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/0016-5085(95)90692-4","article-title":"Immunoregulatory role of interleukin 10 in patients with inflammatory bowel disease","volume":"108","author":"Schreiber","year":"1995","journal-title":"Gastroenterology"},{"key":"10.1016\/j.imlet.2012.11.008_bib0035","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1046\/j.1365-2249.2003.02268.x","article-title":"Over-expression of interleukin 10 in mucosal T cells of patients with active ulcerative colitis","volume":"134","author":"Melgar","year":"2003","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.imlet.2012.11.008_bib0040","first-page":"113","article-title":"Intelukin-10 expression with immunorregulatory function in the mucosa of patients with ulcerative colitis","volume":"76","author":"Fonseca-Camarillo","year":"2011","journal-title":"Rev Gastroenterol Mex"},{"key":"10.1016\/j.imlet.2012.11.008_bib0045","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.4049\/jimmunol.164.4.1814","article-title":"Cloning and characterization of IL-10-related T Cell-derived inducible factor (IL-TIF), a novel cytokine structurally related to IL-10 and inducible by IL-9","volume":"164","author":"Dumoutier","year":"2000","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.11.008_bib0050","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1038\/sj.gene.6363714","article-title":"Cloning, expression and initial characterization of interleukin-19 (IL-19), a novel homologue of human interleukin-10 (IL-10)","volume":"1","author":"Gallagher","year":"2000","journal-title":"Genes Immun"},{"key":"10.1016\/j.imlet.2012.11.008_bib0055","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/sj.gene.6364046","article-title":"Polymorphisms in the interleukin 20 gene: relationships to different plaque-type psoriasis","volume":"5","author":"Kingo","year":"2004","journal-title":"Genes Immun"},{"key":"10.1016\/j.imlet.2012.11.008_bib0060","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1097\/01.MIB.0000225339.91484.fc","article-title":"IBSEN Study Group. Ulcerative colitis and clinical course: results of a 5-year population-based follow-up study (the IBSEN study)","volume":"12","author":"Henriksen","year":"2006","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.imlet.2012.11.008_bib0065","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting-out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.imlet.2012.11.008_bib0070","doi-asserted-by":"crossref","first-page":"e16565","DOI":"10.1371\/journal.pone.0016565","article-title":"An investigation of genome-wide studies reported susceptibility loci for ulcerative colitis shows limited replication in north Indians","volume":"6","author":"Juyal","year":"2011","journal-title":"PLoS ONE"},{"key":"10.1016\/j.imlet.2012.11.008_bib0075","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/ng.717","article-title":"Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci","volume":"42","author":"Franke","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.imlet.2012.11.008_bib0080","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/ng.549","article-title":"Genome-wide association identifies multiple ulcerative colitis susceptibility loci","volume":"42","author":"McGovern","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.imlet.2012.11.008_bib0085","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1038\/ng.553","article-title":"Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL)","volume":"42","author":"Franke","year":"2010","journal-title":"Nat Genet"},{"key":"10.1016\/j.imlet.2012.11.008_bib0090","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1038\/ng.221","article-title":"Sequence variants in IL10, ARPC2 and multiple other loci contribute to ulcerative colitis susceptibility","volume":"40","author":"Franke","year":"2008","journal-title":"Nat Genet"},{"key":"10.1016\/j.imlet.2012.11.008_bib0095","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.humimm.2011.08.013","article-title":"\u00c1lvarez-Le\u00f3n E, Fragoso JM, Gozalishvilli A, Vallejo M, Vargas-Alarc\u00f3n G. Protective role of interleukin-19 gene polymorphisms in patients with ulcerative colitis","volume":"72","author":"Yamamoto-Furusho","year":"2011","journal-title":"Hum Immunol"},{"key":"10.1016\/j.imlet.2012.11.008_bib0100","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/sj.gene.6364141","article-title":"Combined haplotype analysis of the interleukin-19 and -20 genes: relationship to plaque-type psoriasis","volume":"5","author":"Koks","year":"2004","journal-title":"Genes Immun"},{"key":"10.1016\/j.imlet.2012.11.008_bib0105","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/j.1365-2133.2006.07731.x","article-title":"Association analysis of IL19, IL20 and IL24 genes in palmoplantar pustulosis","volume":"156","author":"Kingo","year":"2007","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.imlet.2012.11.008_bib0110","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1111\/j.1744-313X.2008.00770.x","article-title":"Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome","volume":"35","author":"Truelove","year":"2008","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.imlet.2012.11.008_bib0115","doi-asserted-by":"crossref","first-page":"3545","DOI":"10.4049\/jimmunol.167.7.3545","article-title":"Cutting edge: STAT activation by IL-19, IL-20 and mda-7 through IL-20 receptor complexes of two types","volume":"167","author":"Dumoutier","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2012.11.008_bib0120","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1007\/s11373-006-9087-5","article-title":"IL-20: biological functions and clinical implications","volume":"13","author":"Wei","year":"2006","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.imlet.2012.11.008_bib0125","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.clim.2005.06.012","article-title":"Detection of IL-20 and its receptors on psoriatic skin","volume":"117","author":"Wei","year":"2005","journal-title":"Clin Immunol"},{"key":"10.1016\/j.imlet.2012.11.008_bib0130","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1002\/art.22039","article-title":"Function of interleukin-20 as a proinflammatory molecule in rheumatoid and experimental arthritis","volume":"54","author":"Hsu","year":"2006","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2012.11.008_bib0135","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1161\/01.ATV.0000237564.81178.bb","article-title":"IL-20 and atherosclerosis: another brick in the wall","volume":"26","author":"Caligiuri","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.imlet.2012.11.008_bib0140","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1038\/gene.2008.28","article-title":"Interleukin-20 induced cell death in renal epithelial cells and was associated with acute renal failure","volume":"9","author":"Li","year":"2008","journal-title":"Genes Immun"},{"key":"10.1016\/j.imlet.2012.11.008_bib0145","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.imlet.2004.05.015","article-title":"Polymorphisms in the promoter region of tumor necrosis factor alpha (TNF-alpha) and the HLA-DRB1 locus in Mexican Mestizo patients with ulcerative colitis","volume":"95","author":"Yamamoto-Furusho","year":"2004","journal-title":"Immunol Lett"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247812002453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247812002453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:33:11Z","timestamp":1759044791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247812002453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,1]]},"references-count":29,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,1]]}},"alternative-id":["S0165247812002453"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2012.11.008","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2013,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic polymorphisms of interleukin 20 (IL-20) in patients with ulcerative colitis","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2012.11.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}