{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:26:12Z","timestamp":1780500372321,"version":"3.54.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,6,1]],"date-time":"2013-06-01T00:00:00Z","timestamp":1370044800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2013,6]]},"DOI":"10.1016\/j.imlet.2013.07.002","type":"journal-article","created":{"date-parts":[[2013,7,17]],"date-time":"2013-07-17T23:01:31Z","timestamp":1374102091000},"page":"41-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Genetic variations in toll-like receptor 4 in Mexican-Mestizo patients with intra-abdominal infection and\/or pneumonia"],"prefix":"10.1016","volume":"153","author":[{"given":"Carlos A.","family":"Rodriguez-Osorio","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guadalupe","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaime O.","family":"Herrera-Caceres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz E.","family":"Villegas-Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaquin","family":"Zu\u00f1iga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Ponce-de-Leon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Llorente","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Sifuentes-Osornio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl. 1","key":"10.1016\/j.imlet.2013.07.002_bib0005","first-page":"S64","article-title":"The epidemiology of the systemic inflammatory response","volume":"26","author":"Brun-Buisson","year":"2000","journal-title":"Intensive Care Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0010","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1097\/00003246-200005000-00010","article-title":"Prevalence of infections in intensive care units in Mexico: a multicenter study","volume":"28","author":"Ponce de Leon-Rosales","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0015","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1001\/jama.2009.1754","article-title":"International study of the prevalence and outcomes of infection in intensive care units","volume":"302","author":"Vincent","year":"2009","journal-title":"JAMA"},{"key":"10.1016\/j.imlet.2013.07.002_bib0020","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00003246-200107000-00002","article-title":"Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care","volume":"29","author":"Angus","year":"2001","journal-title":"Crit Care Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0025","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1056\/NEJMoa022139","article-title":"The epidemiology of sepsis in the United States from 1979 through 2000","volume":"348","author":"Martin","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0030","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1189\/jlb.0607380","article-title":"Sepsis: rethinking the approach to clinical research","volume":"83","author":"Marshall","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.imlet.2013.07.002_bib0035","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1042\/BJ20090272","article-title":"Pathogen recognition in the innate immune response","volume":"420","author":"Kumar","year":"2009","journal-title":"Biochem J"},{"key":"10.1016\/j.imlet.2013.07.002_bib0040","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ni.1863","article-title":"The role of pattern-recognition receptors in innate immunity: update on toll-like receptors","volume":"11","author":"Kawai","year":"2010","journal-title":"Nat Immunol"},{"key":"10.1016\/j.imlet.2013.07.002_bib0045","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1126\/science.282.5396.2085","article-title":"Defective LPS signaling in C3H\/HeJ and C57BL\/10ScCr mice: mutations in Tlr4 gene","volume":"282","author":"Poltorak","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.imlet.2013.07.002_bib0050","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/76048","article-title":"TLR4 mutations are associated with endotoxin hyporesponsiveness in humans","volume":"25","author":"Arbour","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.imlet.2013.07.002_bib0055","doi-asserted-by":"crossref","first-page":"979","DOI":"10.3346\/jkms.2006.21.6.979","article-title":"Lack of toll-like receptor 4 and 2 polymorphisms in Korean patients with bacteremia","volume":"21","author":"Yoon","year":"2006","journal-title":"J Korean Med Sci"},{"key":"10.1016\/j.imlet.2013.07.002_bib0060","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1159\/000329492","article-title":"The evolutionary history of TLR4 polymorphisms in Europe","volume":"4","author":"Plantinga","year":"2012","journal-title":"J Innate Immun"},{"key":"10.1016\/j.imlet.2013.07.002_bib0065","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1001\/archinte.162.9.1028","article-title":"Relevance of mutations in the TLR4 receptor in patients with gram-negative septic shock","volume":"162","author":"Lorenz","year":"2002","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0070","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1086\/344893","article-title":"Human toll-like receptor 4 mutations but not CD14 polymorphisms are associated with an increased risk of gram-negative infections","volume":"186","author":"Agnese","year":"2002","journal-title":"J Infect Dis"},{"key":"10.1016\/j.imlet.2013.07.002_bib0075","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.gene.2012.04.027","article-title":"Lack of association between TLR4 Asp299Gly and Thr399Ile polymorphisms and sepsis susceptibility: a meta-analysis","volume":"501","author":"Zhu","year":"2012","journal-title":"Gene"},{"key":"10.1016\/j.imlet.2013.07.002_bib0080","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/01.CCM.0000050454.01978.3B","article-title":"2001 SCCM\/ESICM\/ACCP\/ATS\/SIS International Sepsis Definitions Conference","volume":"31","author":"Levy","year":"2003","journal-title":"Crit Care Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1086\/649554","article-title":"Diagnosis and management of complicated intra-abdominal infection in adults and children: guidelines by the Surgical Infection Society and the Infectious Diseases Society of America","volume":"50","author":"Solomkin","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"Suppl. 2","key":"10.1016\/j.imlet.2013.07.002_bib0090","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1086\/511159","article-title":"Infectious Diseases Society of America\/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults","volume":"44","author":"Mandell","year":"2007","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.imlet.2013.07.002_bib0095","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1164\/rccm.200405-644ST","article-title":"Guidelines for the management of adults with hospital-acquired, ventilator-associated, and healthcare-associated pneumonia","volume":"171","author":"American Thoracic Society, Infectious Diseases Society of America","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0100","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1097\/00003246-199811000-00016","article-title":"Use of the SOFA score to assess the incidence of organ dysfunction\/failure in intensive care units: results of a multicenter, prospective study. Working group on \u201csepsis-related problems\u201d of the European Society of Intensive Care Medicine","volume":"26","author":"Vincent","year":"1998","journal-title":"Crit Care Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0105","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jcrc.2004.09.007","article-title":"A systematic review of the Charlson comorbidity index using Canadian administrative databases: a perspective on risk adjustment in critical care research","volume":"20","author":"Needham","year":"2005","journal-title":"J Crit Care"},{"key":"10.1016\/j.imlet.2013.07.002_bib0110","series-title":"Manual of clinical microbiology","first-page":"291","article-title":"Specimen collection, transport and processing: bacteriology","author":"Thomson","year":"2007"},{"key":"10.1016\/j.imlet.2013.07.002_bib0115","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1136\/jmg.2004.021600","article-title":"TLR4 and TNF-alpha polymorphisms are associated with an increased risk for severe sepsis following burn injury","volume":"41","author":"Barber","year":"2004","journal-title":"J Med Genet"},{"key":"10.1016\/j.imlet.2013.07.002_bib0120","series-title":"QUANTO 1. 1: a computer program for power and sample size calculations for genetic-epidemiology studies","author":"Gauderman","year":"2006"},{"key":"10.1016\/j.imlet.2013.07.002_bib0125","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2249.2004.02383.x","article-title":"Toll-like receptor (TLR) 2 and 4 mutations in periodontal disease","volume":"135","author":"Folwaczny","year":"2004","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.imlet.2013.07.002_bib0130","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/s00414-004-0488-6","article-title":"Characterisation of three Amerindian populations from Hidalgo State (Mexico) by 15 STR-PCR polymorphisms","volume":"119","author":"Barrot","year":"2005","journal-title":"Int J Legal Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0135","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0379-0738(00)00422-9","article-title":"Population data of 13 STRS in southern Spain (Andalusia)","volume":"119","author":"Sanz","year":"2001","journal-title":"Forensic Sci Int"},{"key":"10.1016\/j.imlet.2013.07.002_bib0140","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00414-004-0505-9","article-title":"The Fang population of equatorial Guinea characterised by 15 STR-PCR polymorphisms","volume":"119","author":"Calzada","year":"2005","journal-title":"Int J Legal Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0145","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1038\/sj.icb.7100155","article-title":"Clinical relevance of TLR2, TLR4, CD14 and FcgammaRIIA gene polymorphisms in Streptococcus pneumoniae infection","volume":"86","author":"Yuan","year":"2008","journal-title":"Immunol Cell Biol"},{"key":"10.1016\/j.imlet.2013.07.002_bib0150","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/sj.gene.6364428","article-title":"Polymorphisms in toll-like receptors-2 and -4 are not associated with disease manifestations in acute Q fever","volume":"8","author":"Everett","year":"2007","journal-title":"Genes Immun"},{"key":"10.1016\/j.imlet.2013.07.002_bib0155","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1002\/jcla.2075","article-title":"Simple genotype analysis of the Asp299Gly polymorphism of the toll-like receptor-4 gene that is associated with lipopolysaccharide hyporesponsiveness","volume":"16","author":"Okayama","year":"2002","journal-title":"J Clin Lab Anal"},{"key":"10.1016\/j.imlet.2013.07.002_bib0160","doi-asserted-by":"crossref","first-page":"16645","DOI":"10.1073\/pnas.0704828104","article-title":"TLR4 polymorphisms, infectious diseases, and evolutionary pressure during migration of modern humans","volume":"104","author":"Ferwerda","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.imlet.2013.07.002_bib0165","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/ni.2284","article-title":"Genetic variation in toll-like receptors and disease susceptibility","volume":"13","author":"Netea","year":"2012","journal-title":"Nat Immunol"},{"key":"10.1016\/j.imlet.2013.07.002_bib0170","series-title":"Historia verdadera de la conquista de la nueva Espa\u00f1a: 1517\u20131521","author":"Diaz-del-Castillo","year":"2012"},{"key":"10.1016\/j.imlet.2013.07.002_bib0175","doi-asserted-by":"crossref","first-page":"e1000037","DOI":"10.1371\/journal.pgen.1000037","article-title":"Geographic patterns of genome admixture in Latin American Mestizos","volume":"4","author":"Wang","year":"2008","journal-title":"PLoS Genet"},{"key":"10.1016\/j.imlet.2013.07.002_bib0180","doi-asserted-by":"crossref","first-page":"e1000562","DOI":"10.1371\/journal.pgen.1000562","article-title":"Evolutionary dynamics of human toll-like receptors and their different contributions to host defense","volume":"5","author":"Barreiro","year":"2009","journal-title":"PLoS Genet"},{"key":"10.1016\/j.imlet.2013.07.002_bib0185","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1744-313X.2011.01035.x","article-title":"Low frequency of Toll-like receptors 2 and 4 gene polymorphisms in Mexican patients and their association with type 2 diabetes","volume":"38","author":"Maldonado-Bernal","year":"2011","journal-title":"Int J Immunogenet"},{"key":"10.1016\/j.imlet.2013.07.002_bib0190","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1186\/1471-2407-7-70","article-title":"Assessment of the toll-like receptor 4 Asp299Gly, Thr399Ile and interleukin-8 -251 polymorphisms in the risk for the development of distal gastric cancer","volume":"7","author":"Garza-Gonzalez","year":"2007","journal-title":"BMC Cancer"},{"key":"10.1016\/j.imlet.2013.07.002_bib0195","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.imlet.2004.10.017","article-title":"Tumor necrosis factor-alpha promoter polymorphism in Mexican patients with Chagas\u2019 disease","volume":"98","author":"Rodriguez-Perez","year":"2005","journal-title":"Immunol Lett"},{"key":"10.1016\/j.imlet.2013.07.002_bib0200","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1164\/ajrccm.163.7.2004023","article-title":"Major histocompatibility complex and tumor necrosis factor-alpha polymorphisms in pigeon breeder's disease","volume":"163","author":"Camarena","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.imlet.2013.07.002_bib0205","doi-asserted-by":"crossref","first-page":"R227","DOI":"10.1186\/cc10467","article-title":"Leptin and leptin receptor polymorphisms are associated with poor outcome (death) in patients with non-appendicular secondary peritonitis","volume":"15","author":"Bracho-Riquelme","year":"2011","journal-title":"Crit Care"},{"key":"10.1016\/j.imlet.2013.07.002_bib0210","doi-asserted-by":"crossref","first-page":"8611","DOI":"10.1073\/pnas.0903045106","article-title":"Analysis of genomic diversity in Mexican Mestizo populations to develop genomic medicine in Mexico","volume":"106","author":"Silva-Zolezzi","year":"2009","journal-title":"Proc Natl Acad Sci U S A"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247813000941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247813000941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T07:33:29Z","timestamp":1759044809000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247813000941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6]]},"references-count":42,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,6]]}},"alternative-id":["S0165247813000941"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2013.07.002","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2013,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genetic variations in toll-like receptor 4 in Mexican-Mestizo patients with intra-abdominal infection and\/or pneumonia","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2013.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}