{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:37:25Z","timestamp":1789663045714,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"1-2","content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1016\/j.imlet.2013.09.016","type":"journal-article","created":{"date-parts":[[2013,10,8]],"date-time":"2013-10-08T18:45:47Z","timestamp":1381257947000},"page":"31-35","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation"],"prefix":"10.1016","volume":"155","author":[{"given":"Enrico","family":"Velardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jarrod A.","family":"Dudakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel R.M.","family":"van den Brink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2013.09.016_bib0005","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1097\/MOH.0b013e328353bc7d","article-title":"Immune reconstitution after hematopoietic cell transplantation","volume":"19","author":"Bosch","year":"2012","journal-title":"Current Opinion in Hematology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0010","first-page":"65","article-title":"Immune reconstitution following T-cell depleted bone marrow transplantation: effect of age and posttransplant graft rejection prophylaxis","volume":"3","author":"Small","year":"1997","journal-title":"Biology of Blood and Marrow Transplantation"},{"key":"10.1016\/j.imlet.2013.09.016_bib0015","first-page":"413","article-title":"T cell reconstitution after bone marrow transplantation into adult patients does not resemble T cell development in early life","volume":"16","author":"Storek","year":"1995","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.imlet.2013.09.016_bib0020","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1172\/JCI200522492","article-title":"Age-dependent incidence, time course, and consequences of thymic renewal in adults","volume":"115","author":"Hakim","year":"2005","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.imlet.2013.09.016_bib0025","series-title":"Current use and outcome of hematopoietic stem cell transplantation: CIBMTR Summary Slides","author":"Pasquini","year":"2012"},{"key":"10.1016\/j.imlet.2013.09.016_bib0030","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/nri1781","article-title":"Journey through the thymus: stromal guides for T-cell development and selection","volume":"6","author":"Takahama","year":"2006","journal-title":"Nature Reviews Immunology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0035","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.3324\/haematol.2011.047696","article-title":"Insufficient recovery of thymopoiesis predicts for opportunistic infections in allogeneic hematopoietic stem cell transplant recipients","volume":"96","author":"Wils","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.imlet.2013.09.016_bib0040","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0065-230X(04)91003-2","article-title":"Keratinocyte growth factor\/fibroblast growth factor 7, a homeostatic factor with therapeutic potential for epithelial protection and repair","volume":"91","author":"Finch","year":"2004","journal-title":"Advances in Cancer Research"},{"key":"10.1016\/j.imlet.2013.09.016_bib0045","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1182\/blood-2005-07-2831","article-title":"Keratinocyte growth factor (KGF) is required for postnatal thymic regeneration","volume":"107","author":"Alpdogan","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2013.09.016_bib0050","doi-asserted-by":"crossref","first-page":"4592","DOI":"10.1182\/blood.V99.12.4592","article-title":"Protection from thymic epithelial cell injury by keratinocyte growth factor: a new approach to improve thymic and peripheral T-cell reconstitution after bone marrow transplantation","volume":"99","author":"Min","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2013.09.016_bib0055","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.3109\/10428194.2011.573037","article-title":"Keratinocyte growth factor enhanced immune reconstitution in murine allogeneic umbilical cord blood cell transplant","volume":"52","author":"Wang","year":"2011","journal-title":"Leukemia & Lymphoma"},{"key":"10.1016\/j.imlet.2013.09.016_bib0060","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1182\/blood-2006-10-049767","article-title":"Keratinocyte growth factor (KGF) enhances postnatal T-cell development via enhancements in proliferation and function of thymic epithelial cells","volume":"109","author":"Rossi","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2013.09.016_bib0065","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1182\/blood-2006-12-065623","article-title":"Keratinocyte growth factor augments immune reconstitution after autologous hematopoietic progenitor cell transplantation in rhesus macaques","volume":"110","author":"Seggewiss","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2013.09.016_bib0070","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/bmt.2012.115","article-title":"Palifermin is efficacious in recipients of TBI-based but not chemotherapy-based allogeneic hematopoietic stem cell transplants","volume":"48","author":"Goldberg","year":"2013","journal-title":"Bone Marrow Transplantation"},{"key":"10.1016\/j.imlet.2013.09.016_bib0075","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.it.2004.11.002","article-title":"IL-7 and IL-15: therapeutic cytokines for immunodeficiency","volume":"26","author":"Alpdogan","year":"2005","journal-title":"Trends in Immunology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0080","doi-asserted-by":"crossref","first-page":"2256","DOI":"10.1182\/blood.V98.7.2256","article-title":"Administration of interleukin-7 after allogeneic bone marrow transplantation improves immune reconstitution without aggravating graft-versus-host disease","volume":"98","author":"Alpdogan","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2013.09.016_bib0085","doi-asserted-by":"crossref","first-page":"7172","DOI":"10.1073\/pnas.93.14.7172","article-title":"Interleukin 7 receptor-deficient mice lack gammadelta T cells","volume":"93","author":"Maki","year":"1996","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"key":"10.1016\/j.imlet.2013.09.016_bib0090","first-page":"67","article-title":"The genetic basis of severe combined immunodeficiency and its variants","volume":"5","author":"Tasher","year":"2012","journal-title":"Application of Clinical Genetics"},{"key":"10.1016\/j.imlet.2013.09.016_bib0095","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1158\/1078-0432.CCR-09-1303","article-title":"Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy","volume":"16","author":"Sportes","year":"2010","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"key":"10.1016\/j.imlet.2013.09.016_bib0100","doi-asserted-by":"crossref","first-page":"4882","DOI":"10.1182\/blood-2012-06-437236","article-title":"Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation","volume":"120","author":"Perales","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2013.09.016_bib0105","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.cellimm.2007.10.007","article-title":"The role of sex steroids and gonadectomy in the control of thymic involution","volume":"252","author":"Hince","year":"2008","journal-title":"Cellular Immunology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0110","doi-asserted-by":"crossref","first-page":"6247","DOI":"10.4049\/jimmunol.0802446","article-title":"Withdrawal of sex steroids reverses age- and chemotherapy-related defects in bone marrow lymphopoiesis","volume":"182","author":"Dudakov","year":"2009","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0115","doi-asserted-by":"crossref","first-page":"5846","DOI":"10.4049\/jimmunol.0801458","article-title":"Luteinizing hormone-releasing hormone enhances T cell recovery following allogeneic bone marrow transplantation","volume":"182","author":"Goldberg","year":"2009","journal-title":"Journal of Immunology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0120","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1158\/1078-0432.CCR-07-1784","article-title":"Enhanced immune system regeneration in humans following allogeneic or autologous hemopoietic stem cell transplantation by temporary sex steroid blockade","volume":"14","author":"Sutherland","year":"2008","journal-title":"Clinical Cancer Research: An Official Journal of the American Association for Cancer Research"},{"key":"10.1016\/j.imlet.2013.09.016_bib0125","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.coph.2010.04.015","article-title":"Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways","volume":"10","author":"Taub","year":"2010","journal-title":"Current Opinion in Pharmacology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0130","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S0301-472X(03)00196-6","article-title":"Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice","volume":"31","author":"Chen","year":"2003","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0135","first-page":"1085","article-title":"Growth hormone enhances thymic function in HIV-1-infected adults","volume":"118","author":"Napolitano","year":"2008","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.imlet.2013.09.016_bib0140","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bcmd.2004.08.007","article-title":"Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment","volume":"33","author":"De Smedt","year":"2004","journal-title":"Blood Cells, Molecules & Diseases"},{"key":"10.1016\/j.imlet.2013.09.016_bib0145","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1182\/blood-2004-04-1293","article-title":"Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro","volume":"105","author":"La Motte-Mohs","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2013.09.016_bib0150","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/nm1463","article-title":"Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation","volume":"12","author":"Zakrzewski","year":"2006","journal-title":"Nature Medicine"},{"key":"10.1016\/j.imlet.2013.09.016_bib0155","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00281-008-0138-z","article-title":"Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation in mouse and man","volume":"30","author":"Holland","year":"2008","journal-title":"Seminars in Immunopathology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0160","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1038\/nbt1395","article-title":"Tumor immunotherapy across MHC barriers using allogeneic T-cell precursors","volume":"26","author":"Zakrzewski","year":"2008","journal-title":"Nature Biotechnology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0165","first-page":"91","article-title":"The role of nutrition in enhancing immunity in aging","volume":"3","author":"Pae","year":"2012","journal-title":"Aging and Disease"},{"key":"10.1016\/j.imlet.2013.09.016_bib0170","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.coi.2010.06.010","article-title":"Thymic fatness and approaches to enhance thymopoietic fitness in aging","volume":"22","author":"Dixit","year":"2010","journal-title":"Current Opinion in Immunology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0175","doi-asserted-by":"crossref","first-page":"3803","DOI":"10.1182\/blood-2009-03-213595","article-title":"Obesity accelerates thymic aging","volume":"114","author":"Yang","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2013.09.016_bib0180","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/S0301-472X(03)00238-8","article-title":"Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction","volume":"31","author":"Chen","year":"2003","journal-title":"Experimental Hematology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0185","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.1099196","article-title":"Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase","volume":"305","author":"Cohen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.imlet.2013.09.016_bib0190","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/imr.12027","article-title":"IL-22, not simply a Th17 cytokine","volume":"252","author":"Rutz","year":"2013","journal-title":"Immunological Reviews"},{"key":"10.1016\/j.imlet.2013.09.016_bib0195","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/ni.2025","article-title":"Border patrol: regulation of immunity, inflammation and tissue homeostasis at barrier surfaces by IL-22","volume":"12","author":"Sonnenberg","year":"2011","journal-title":"Nature Immunology"},{"key":"10.1016\/j.imlet.2013.09.016_bib0200","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1126\/science.1218004","article-title":"Interleukin-22 drives endogenous thymic regeneration in mice","volume":"336","author":"Dudakov","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.imlet.2013.09.016_bib0205","doi-asserted-by":"crossref","first-page":"5734","DOI":"10.1182\/blood-2008-01-136531","article-title":"Keratinocyte growth factor and androgen blockade work in concert to protect against conditioning regimen-induced thymic epithelial damage and enhance T-cell reconstitution after murine bone marrow transplantation","volume":"111","author":"Kelly","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2013.09.016_bib0210","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1182\/blood-2009-05-223198","article-title":"Short-term inhibition of p53 combined with keratinocyte growth factor improves thymic epithelial cell recovery and enhances T-cell reconstitution after murine bone marrow transplantation","volume":"115","author":"Kelly","year":"2010","journal-title":"Blood"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247813001399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247813001399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T09:50:55Z","timestamp":1539337855000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247813001399"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,9]]},"references-count":42,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["S0165247813001399"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2013.09.016","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2013,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2013.09.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}