{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T19:35:09Z","timestamp":1792784109279,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001862","name":"The Swedish Research Council","doi-asserted-by":"crossref","award":["521-2004-5891"],"award-info":[{"award-number":["521-2004-5891"]}],"id":[{"id":"10.13039\/501100001862","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The King Gustaf V's 80 years Foundation"},{"DOI":"10.13039\/501100007949","name":"The Swedish Rheumatism Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"crossref"}]},{"name":"O. & E. Ericsson Foundation"},{"name":"S. & O. Wallenius Foundation"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2014,11]]},"DOI":"10.1016\/j.imlet.2014.08.016","type":"journal-article","created":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T08:51:16Z","timestamp":1409907076000},"page":"200-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"PA","title":["Dysregulated Fc receptor function in active rheumatoid arthritis"],"prefix":"10.1016","volume":"162","author":[{"given":"Sofia E.","family":"Magnusson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik","family":"Wennerberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Matt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulla","family":"Lindqvist","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Kleinau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2014.08.016_bib0005","first-page":"129","article-title":"Isotype-specific measurement of rheumatoid factor with reference to clinical features of rheumatoid arthritis","volume":"12","author":"Tarkowski","year":"1983","journal-title":"J Clin Lab Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0010","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1172\/JCI1316","article-title":"Citrulline is an essential constituent of antigenic determinants recognized by rheumatoid arthritis-specific autoantibodies","volume":"101","author":"Schellekens","year":"1998","journal-title":"J Clin Invest"},{"key":"10.1016\/j.imlet.2014.08.016_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-2776(08)60671-9","article-title":"Molecular basis of Fc receptor function","volume":"57","author":"Hulett","year":"1994","journal-title":"Adv Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0020","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1084\/jem.191.9.1611","article-title":"Induction and suppression of collagen-induced arthritis is dependent on distinct Fc gamma receptors","volume":"191","author":"Kleinau","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.imlet.2014.08.016_bib0025","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1002\/1529-0131(200004)43:4<740::AID-ANR4>3.0.CO;2-0","article-title":"Role of Fc receptor gamma chain in inflammation and cartilage damage during experimental antigen-induced arthritis","volume":"43","author":"van Lent","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.08.016_bib0030","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1002\/1521-4141(2002010)32:10<2915::AID-IMMU2915>3.0.CO;2-4","article-title":"Expression of Fc\u03b3RIII is required for development of collagen-induced arthritis","volume":"32","author":"Diaz de Stahl","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0035","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S1074-7613(02)00294-7","article-title":"FcgammaRI (CD64) contributes substantially to severity of arthritis, hypersensitivity responses, and protection from bacterial infection","volume":"16","author":"Ioan-Facsinay","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2014.08.016_bib0040","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.1002\/art.21344","article-title":"Development of spontaneous multisystem autoimmune disease and hypersensitivity to antibody-induced inflammation in Fcgamma receptor IIa-transgenic mice","volume":"52","author":"Tan Sardjono","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.08.016_bib0045","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-3083.2006.01749.x","article-title":"IgG immune complex-binding in macrophages from arthritis-susceptible and arthritis-resistant mice following collagen type II immunization","volume":"63","author":"Thorvaldson","year":"2006","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0050","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/1529-0131(200004)43:4<735::AID-ANR3>3.0.CO;2-Q","article-title":"Involvement of Fcgamma receptor IIIA genotypes in susceptibility to rheumatoid arthritis","volume":"43","author":"Nieto","year":"2000","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.08.016_bib0055","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1002\/1529-0131(200010)43:10<2328::AID-ANR21>3.0.CO;2-Z","article-title":"Fcgamma receptor type IIIA is associated with rheumatoid arthritis in two distinct ethnic groups","volume":"43","author":"Morgan","year":"2000","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.imlet.2014.08.016_bib0060","doi-asserted-by":"crossref","DOI":"10.1186\/ar1847","article-title":"Analysis of Fcgamma receptor haplotypes in rheumatoid arthritis: FCGR3A remains a major susceptibility gene at this locus, with an additional contribution from FCGR3B","volume":"8","author":"Morgan","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.imlet.2014.08.016_bib0065","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1111\/j.1365-2249.2006.03021.x","article-title":"Association of rheumatoid factor production with FcgammaRIIIa polymorphism in Taiwanese rheumatoid arthritis","volume":"144","author":"Chen","year":"2006","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0070","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/rheumatology\/keg174","article-title":"Fcgamma receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti-rheumatic drugs","volume":"42","author":"Wijngaarden","year":"2003","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.imlet.2014.08.016_bib0075","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1002\/art.10871","article-title":"Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase","volume":"48","author":"Blom","year":"2003","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.08.016_bib0080","doi-asserted-by":"crossref","first-page":"R51","DOI":"10.1186\/ar2206","article-title":"High synovial expression of the inhibitory FcgammaRIIb in rheumatoid arthritis","volume":"9","author":"Magnusson","year":"2007","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.imlet.2014.08.016_bib0085","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.clim.2010.08.006","article-title":"Down regulation of Fc and complement receptors on B cells in rheumatoid arthritis","volume":"137","author":"Prokopec","year":"2010","journal-title":"Clin Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0090","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/ard.50.5.284","article-title":"Uptake and degradation of soluble aggregates of IgG by monocytes of patients with rheumatoid arthritis: relation to disease activity","volume":"50","author":"Heurkens","year":"1991","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.imlet.2014.08.016_bib0095","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1007\/BF00915250","article-title":"In vitro studies on the Fc-receptor function of mononuclear phagocytes in rheumatoid arthritis: relation between the Fc-receptor blockade and the concanavalin A-binding capacity of autologous immunoglobulin G","volume":"6","author":"Malaise","year":"1986","journal-title":"J Clin Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0100","first-page":"1436","article-title":"IgG 1 subclass specificity for IgG rheumatoid factors in patients with rheumatoid arthritis","volume":"26","author":"Miyata","year":"1999","journal-title":"J Rheumatol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0105","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1046\/j.1365-2249.2000.01207.x","article-title":"Immunosuppressant effect of gold on IgG subclasses and IgE; evidence for sparing of Th2 responses","volume":"120","author":"Kiely","year":"2000","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0110","first-page":"2090","article-title":"IgG subclasses of antibodies to type II collagen in rheumatoid arthritis differ from those in systemic lupus erythematosus and other connective tissue diseases","volume":"24","author":"Cook","year":"1997","journal-title":"J Rheumatol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0115","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.1182\/blood-2008-09-179754","article-title":"Specificity and affinity of human Fcgamma receptors and their polymorphic variants for human IgG subclasses","volume":"113","author":"Bruhns","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2014.08.016_bib0120","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/art.1780310302","article-title":"The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis","volume":"31","author":"Arnett","year":"1988","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.08.016_bib0125","doi-asserted-by":"crossref","first-page":"531","DOI":"10.4049\/jimmunol.166.1.531","article-title":"Differential modulation of stimulatory and inhibitory Fc gamma receptors on human monocytes by Th1 and Th2 cytokines","volume":"166","author":"Pricop","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0130","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.imlet.2005.06.022","article-title":"Fc receptors and their interaction with complement in autoimmunity","volume":"100","author":"Schmidt","year":"2005","journal-title":"Immunol Lett"},{"key":"10.1016\/j.imlet.2014.08.016_bib0135","doi-asserted-by":"crossref","first-page":"3878","DOI":"10.1002\/art.20672","article-title":"A shift in the balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis","volume":"50","author":"Wijngaarden","year":"2004","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.08.016_bib0140","doi-asserted-by":"crossref","first-page":"158514","DOI":"10.1155\/2010\/158514","article-title":"Circulating cytokine profiles and their relationships with autoantibodies, acute phase reactants, and disease activity in patients with rheumatoid arthritis","volume":"2010","author":"Meyer","year":"2010","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.imlet.2014.08.016_bib0145","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.4049\/jimmunol.1303272","article-title":"FcgammaRIIb on myeloid cells rather than on B cells protects from collagen-induced arthritis","volume":"192","author":"Yilmaz-Elis","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0150","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1182\/blood-2012-07-442541","article-title":"The high-affinity human IgG receptor FcgammaRI (CD64) promotes IgG-mediated inflammation, anaphylaxis, and antitumor immunotherapy","volume":"121","author":"Mancardi","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2014.08.016_bib0155","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1046\/j.1365-2249.1999.00817.x","article-title":"Monocyte activation in rheumatoid arthritis (RA): increased integrin, Fc gamma and complement receptor expression and the effect of glucocorticoids","volume":"115","author":"Torsteinsdottir","year":"1999","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0160","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1093\/rheumatology\/keh112","article-title":"Expression of Fcgamma and complement receptors on peripheral blood monocytes in systemic lupus erythematosus and rheumatoid arthritis","volume":"43","author":"Hepburn","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.imlet.2014.08.016_bib0165","first-page":"2347","article-title":"Enhanced Fcgamma receptor I, alphaMbeta2 integrin receptor expression by monocytes and neutrophils in rheumatoid arthritis: interaction with platelets","volume":"31","author":"Bunescu","year":"2004","journal-title":"J Rheumatol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0170","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1136\/ard.2010.142091","article-title":"Fcgamma receptor profile of monocytes and macrophages from rheumatoid arthritis patients and their response to immune complexes formed with autoantibodies to citrullinated proteins","volume":"70","author":"Laurent","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.imlet.2014.08.016_bib0175","doi-asserted-by":"crossref","first-page":"4509","DOI":"10.4049\/jimmunol.0900153","article-title":"The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease","volume":"183","author":"Wenink","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0180","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1002\/art.10545","article-title":"CD14+, CD16+ blood monocytes and joint inflammation in rheumatoid arthritis","volume":"46","author":"Kawanaka","year":"2002","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.08.016_bib0185","doi-asserted-by":"crossref","first-page":"1890","DOI":"10.1073\/pnas.89.5.1890","article-title":"Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes","volume":"89","author":"Rousset","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.imlet.2014.08.016_bib0190","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1002\/art.1780381210","article-title":"Terminal differentiation of spontaneous rheumatoid factor-secreting B cells from rheumatoid arthritis patients depends on endogenous interleukin-10","volume":"38","author":"Perez","year":"1995","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.08.016_bib0195","doi-asserted-by":"crossref","first-page":"3084","DOI":"10.1182\/blood-2011-08-376046","article-title":"IgG1 and IVIg induce inhibitory ITAM signaling through FcgammaRIII controlling inflammatory responses","volume":"119","author":"Aloulou","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2014.08.016_bib0200","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1046\/j.1423-0410.2001.00081.x","article-title":"Fcgamma receptor-mediated immune phagocytosis depends on the class of FcgammaR and on the immunoglobulin-coated target cell","volume":"81","author":"Flesch","year":"2001","journal-title":"Vox Sang"},{"key":"10.1016\/j.imlet.2014.08.016_bib0205","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1246-7820(01)00215-4","article-title":"Section 1C: assessment of the functional activity and IgG Fc receptor utilisation of 64 IgG Rh monoclonal antibodies. Coordinator's report","volume":"9","author":"Kumpel","year":"2002","journal-title":"Transfus Clin Biol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0210","doi-asserted-by":"crossref","first-page":"5654","DOI":"10.4049\/jimmunol.0803942","article-title":"Phagocytosis in macrophages lacking Cbl reveals an unsuspected role for Fc gamma receptor signaling and actin assembly in target binding","volume":"182","author":"Dale","year":"2009","journal-title":"J Immunol"},{"key":"10.1016\/j.imlet.2014.08.016_bib0215","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.cyto.2008.01.006","article-title":"LPS\/TLR4 signal transduction pathway","volume":"42","author":"Lu","year":"2008","journal-title":"Cytokine"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247814001862?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247814001862?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T01:50:48Z","timestamp":1589248248000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247814001862"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11]]},"references-count":43,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["S0165247814001862"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2014.08.016","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dysregulated Fc receptor function in active rheumatoid arthritis","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2014.08.016","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}