{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,9]],"date-time":"2025-11-09T03:36:22Z","timestamp":1762659382276},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Liaoning Province Medical Peak Scientific Research"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.imlet.2014.09.018","type":"journal-article","created":{"date-parts":[[2014,10,8]],"date-time":"2014-10-08T21:15:36Z","timestamp":1412802936000},"page":"258-263","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"PB","title":["CCR5 small interfering RNA ameliorated joint inflammation in rats with adjuvant-induced arthritis"],"prefix":"10.1016","volume":"162","author":[{"given":"Hongmei","family":"Duan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pingting","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuang","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiguo","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2014.09.018_bib0005","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1056\/NEJM199005033221805","article-title":"Rheumatoid arthritis: pathophysiology and implications for therapy","volume":"322","author":"Harris","year":"1990","journal-title":"N Engl J Med"},{"key":"10.1016\/j.imlet.2014.09.018_bib0010","doi-asserted-by":"crossref","first-page":"3537","DOI":"10.1172\/JCI36389","article-title":"Evidence that cytokines play a role in rheumatoid arthritis","volume":"118","author":"Brennan","year":"2008","journal-title":"J Clin Invest"},{"key":"10.1016\/j.imlet.2014.09.018_bib0015","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1136\/ard.2010.134684","article-title":"State-of-the-art: rheumatoid arthritis","volume":"69","author":"McInnes","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.imlet.2014.09.018_bib0020","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1006\/clim.2000.4957","article-title":"CXCR3 and CCR5 ligands in rheumatoid arthritis synovium","volume":"98","author":"Patel","year":"2001","journal-title":"Clin Immunol"},{"key":"10.1016\/j.imlet.2014.09.018_bib0025","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1046\/j.1365-2249.2001.01679.x","article-title":"Surface expression of CC- and CXC-chemokine receptors on leucocyte subsets in inflammatory joint diseases","volume":"126","author":"Bruhl","year":"2001","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.imlet.2014.09.018_bib0030","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1136\/ard.2005.037176","article-title":"Chemokine and chemokine receptor expression in paired peripheral blood mononuclear cells and synovial tissue of patients with rheumatoid arthritis, osteoarthritis, and reactive arthritis","volume":"65","author":"Haringman","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.imlet.2014.09.018_bib0035","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1002\/1529-0131(200105)44:5<1022::AID-ANR181>3.0.CO;2-N","article-title":"Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes\/macrophages in rheumatoid arthritis","volume":"44","author":"Katschke","year":"2001","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.09.018_bib0040","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/1529-0131(199905)42:5<989::AID-ANR18>3.0.CO;2-U","article-title":"Association of rheumatoid arthritis with a functional chemokine receptor, CCR5","volume":"42","author":"Gomez-Reino","year":"1999","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.09.018_bib0045","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/1521-4141(200208)32:8<2124::AID-IMMU2124>3.0.CO;2-S","article-title":"A non-peptide CCR5 antagonist inhibits collagen-induced arthritis by modulating T cell migration without affecting anti-collagen T cell responses","volume":"32","author":"Yang","year":"2002","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.imlet.2014.09.018_bib0050","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1002\/art.20850","article-title":"Inhibition of the development of collagen-induced arthritis in rhesus monkeys by a small molecular weight antagonist of CCR5","volume":"52","author":"Vierboom","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.09.018_bib0055","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1093\/rheumatology\/kei213","article-title":"CCR-5 antagonist inhibits the development of adjuvant arthritis in rats","volume":"45","author":"Okamoto","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.imlet.2014.09.018_bib0060","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2144\/000112167","article-title":"RNAi as a treatment for HIV-1 infection","volume":"40","author":"Rossi","year":"2006","journal-title":"Biotechniques"},{"key":"10.1016\/j.imlet.2014.09.018_bib0065","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1038\/nm725","article-title":"siRNA-directed inhibition of HIV-1 infection","volume":"8","author":"Novina","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.imlet.2014.09.018_bib0070","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1038\/nbt1122","article-title":"Potent and persistent in vivo anti-HBV activity of chemically modified siRNAs","volume":"23","author":"Morrissey","year":"2005","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.imlet.2014.09.018_bib0075","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/nature04263","article-title":"An siRNA-based microbicide protects mice from lethal herpes simplex virus 2 infection","volume":"439","author":"Palliser","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2014.09.018_bib0080","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1002\/art.20975","article-title":"Effects of treatment with small interfering RNA on joint inflammation in mice with collagen-induced arthritis","volume":"52","author":"Schiffelers","year":"2005","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.imlet.2014.09.018_bib0085","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/j.bbrc.2005.08.198","article-title":"Electro-transfer of small interfering RNA ameliorated arthritis in rats","volume":"336","author":"Inoue","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.imlet.2014.09.018_bib0090","doi-asserted-by":"crossref","first-page":"e78619","DOI":"10.1371\/journal.pone.0078619","article-title":"Systemic delivery of small interfering RNA targeting the interleukin-2\/15 receptor beta chain prevents disease progression in experimental arthritis","volume":"8","author":"Zhang","year":"2013","journal-title":"PLOS ONE"},{"key":"10.1016\/j.imlet.2014.09.018_bib0095","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/nm1076","article-title":"RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia","volume":"10","author":"Xia","year":"2004","journal-title":"Nat Med"},{"key":"10.1016\/j.imlet.2014.09.018_bib0100","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/nm1207","article-title":"Lentiviral-mediated silencing of SOD1 through RNA interference retards disease onset and progression in a mouse model of ALS","volume":"11","author":"Raoul","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.imlet.2014.09.018_bib0105","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1038\/sj.gt.3302694","article-title":"Prospects of RNA interference therapy for cancer","volume":"13","author":"Pai","year":"2006","journal-title":"Gene Ther"},{"key":"10.1016\/j.imlet.2014.09.018_bib0110","doi-asserted-by":"crossref","first-page":"6910","DOI":"10.1158\/0008-5472.CAN-05-0530","article-title":"Therapeutic EphA2 gene targeting in vivo using neutral liposomal small interfering RNA delivery","volume":"65","author":"Landen","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.imlet.2014.09.018_bib0115","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.tibtech.2010.07.009","article-title":"RNAi and small interfering RNAs in human disease therapeutic applications","volume":"28","author":"Lares","year":"2010","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.imlet.2014.09.018_bib0120","doi-asserted-by":"crossref","first-page":"R114","DOI":"10.1186\/ar1039","article-title":"Susceptibility to collagen-induced arthritis is modulated by TGFbeta responsiveness of T cells","volume":"6","author":"Schramm","year":"2004","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.imlet.2014.09.018_bib0125","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1084\/jem.146.3.857","article-title":"Autoimmunity to type II collagen an experimental model of arthritis","volume":"146","author":"Trentham","year":"1977","journal-title":"J Exp Med"},{"key":"10.1016\/j.imlet.2014.09.018_bib0130","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1016\/S0006-291X(02)00386-8","article-title":"Successful genetic transduction in vivo into synovium by means of electroporation","volume":"293","author":"Ohashi","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.imlet.2014.09.018_bib0135","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1038\/gt.2009.66","article-title":"Therapeutic silencing of an endogenous gene by siRNA cream in an arthritis model mouse","volume":"16","author":"Takanashi","year":"2009","journal-title":"Gene Ther"},{"key":"10.1016\/j.imlet.2014.09.018_bib0140","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3109\/s10165-008-0131-3","article-title":"Comparison of anti-rheumatic effects of local RNAi-based therapy in collagen induced arthritis rats using various cytokine genes as molecular targets","volume":"19","author":"Inoue","year":"2009","journal-title":"Mod Rheumatol"},{"key":"10.1016\/j.imlet.2014.09.018_bib0145","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1002\/art.38328","article-title":"Activation of spinal NF-kappaB\/p65 contributes to peripheral inflammation and hyperalgesia in rat adjuvant-induced arthritis","volume":"66","author":"Luo","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.imlet.2014.09.018_bib0150","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1126\/science.286.5448.2244","article-title":"Gene therapy death prompts review of adenovirus vector","volume":"286","author":"Marshall","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.imlet.2014.09.018_bib0155","doi-asserted-by":"crossref","first-page":"3623","DOI":"10.1172\/JCI33494","article-title":"Nonviral delivery of synthetic siRNAs in vivo","volume":"117","author":"Akhtar","year":"2007","journal-title":"J Clin Invest"},{"key":"10.1016\/j.imlet.2014.09.018_bib0160","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1111\/j.1365-2249.1994.tb06069.x","article-title":"Accelerated onset of collagen-induced arthritis by remote inflammation","volume":"97","author":"Joosten","year":"1994","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.imlet.2014.09.018_bib0165","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1136\/ard.2010.131235","article-title":"CCR5 blockade in rheumatoid arthritis: a randomised, double-blind, placebo-controlled clinical trial","volume":"69","author":"van Kuijk","year":"2010","journal-title":"Ann Rheum Dis"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247814002089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247814002089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,15]],"date-time":"2019-08-15T21:04:31Z","timestamp":1565903071000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247814002089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0165247814002089"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2014.09.018","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CCR5 small interfering RNA ameliorated joint inflammation in rats with adjuvant-induced arthritis","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2014.09.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}