{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T15:25:22Z","timestamp":1781018722117,"version":"3.54.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2015,12,1]],"date-time":"2015-12-01T00:00:00Z","timestamp":1448928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30700998"],"award-info":[{"award-number":["30700998"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Jilin Province Science Foundation for Youths","award":["20130522007JH"],"award-info":[{"award-number":["20130522007JH"]}]},{"name":"Key Projects of Science and Technology Bureau of Changchun City","award":["14KG052"],"award-info":[{"award-number":["14KG052"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2015,12]]},"DOI":"10.1016\/j.imlet.2015.10.003","type":"journal-article","created":{"date-parts":[[2015,10,16]],"date-time":"2015-10-16T02:06:13Z","timestamp":1444961173000},"page":"271-278","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Elicitation of HIV-1 neutralizing antibodies by presentation of 4E10 and 10E8 epitopes on Norovirus P particles"],"prefix":"10.1016","volume":"168","author":[{"given":"Yongjiao","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhua","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanshan","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqiu","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongni","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyu","family":"Kuai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaming","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2015.10.003_bib0005","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1126\/science.6601823","article-title":"Isolation of human T-cell leukemia virus in acquired immune deficiency syndrome (AIDS)","volume":"220","author":"Gallo","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.imlet.2015.10.003_bib0010","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/nature12053","article-title":"Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus","volume":"496","author":"Liao","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2015.10.003_bib0015","doi-asserted-by":"crossref","first-page":"e8805","DOI":"10.1371\/journal.pone.0008805","article-title":"Analysis of memory B cell responses and isolation of novel monoclonal antibodies with neutralizing breadth from HIV-1-infected individuals","volume":"5","author":"Corti","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.imlet.2015.10.003_bib0020","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.jim.2007.09.017","article-title":"Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning","volume":"329","author":"Tiller","year":"2008","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.imlet.2015.10.003_bib0025","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0165-2478(01)00274-7","article-title":"The immunology of HIV-infected long-term non-progressors\u2014a current view","volume":"79","author":"Paroli","year":"2001","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imlet.2015.10.003_bib0030","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1128\/JVI.02036-08","article-title":"Factors associated with the development of cross-reactive neutralizing antibodies during human immunodeficiency virus type 1 infection","volume":"83","author":"Sather","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0035","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.coi.2010.02.012","article-title":"Rational antibody-based HIV-1 vaccine design: current approaches and future directions","volume":"22","author":"Walker","year":"2010","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0040","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1128\/JVI.01583-08","article-title":"Frequency and phenotype of human immunodeficiency virus envelope-specific B cells from patients with broadly cross-neutralizing antibodies","volume":"83","author":"Doria-Rose","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0045","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1126\/science.1241144","article-title":"Antibodies in HIV-1 vaccine development and therapy","volume":"341","author":"Klein","year":"2013","journal-title":"Science"},{"issue":"7424","key":"10.1016\/j.imlet.2015.10.003_bib0050","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/nature11544","article-title":"Broad and potent neutralization of HIV-1 by a gp41-specific human antibody","volume":"491","author":"Huang","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2015.10.003_bib0055","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.1128\/JVI.00966-10","article-title":"Crystal structure of PG16 and chimeric dissection with somatically related PG9: structure-function analysis of two quaternary-specific antibodies that effectively neutralize HIV-1","volume":"84","author":"Pancera","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0060","doi-asserted-by":"crossref","first-page":"e1000433","DOI":"10.1371\/journal.ppat.1000433","article-title":"Broadly neutralizing human anti-HIV antibody 2G12 is effective in protection against mucosal SHIV challenge even at low serum neutralizing titers","volume":"5","author":"Hessell","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.imlet.2015.10.003_bib0065","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1084\/jem.20122824","article-title":"Engineering envelope protein to activate germline B cell receptors of broadly neutralizing anti-CD4 binding site antibodies","volume":"210","author":"McGuire","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2015.10.003_bib0070","doi-asserted-by":"crossref","first-page":"9057","DOI":"10.1073\/pnas.0901474106","article-title":"Broadly neutralizing anti-HIV-1 antibodies disrupt a hinge-related function of gp41 at the membrane interface","volume":"106","author":"Song","year":"2009","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.imlet.2015.10.003_bib0075","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.tim.2004.04.005","article-title":"Norovirus disease: changing epidemiology and host susceptibility factors","volume":"12","author":"Hutson","year":"2004","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0080","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1126\/science.286.5438.287","article-title":"X-ray crystallographic structure of the Norwalk virus capsid","volume":"286","author":"Prasad","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.imlet.2015.10.003_bib0085","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2217\/nnm.12.62","article-title":"Norovirus P particle: a subviral nanoparticle for vaccine development against norovirus, rotavirus and influenza virus","volume":"7","author":"Tan","year":"2012","journal-title":"Nanomedicine"},{"key":"10.1016\/j.imlet.2015.10.003_bib0090","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1128\/JVI.01835-10","article-title":"Norovirus P particle, a novel platform for vaccine development and antibody production","volume":"85","author":"Tan","year":"2011","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0095","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.virol.2008.08.047","article-title":"Noroviral P particle: structure, function and applications in virus-host interaction","volume":"382","author":"Tan","year":"2008","journal-title":"Virology"},{"key":"10.1016\/j.imlet.2015.10.003_bib0100","doi-asserted-by":"crossref","first-page":"7670","DOI":"10.1016\/j.vaccine.2011.07.139","article-title":"A candidate dual vaccine against influenza and noroviruses","volume":"29","author":"Xia","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2015.10.003_bib0105","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.molimm.2012.03.015","article-title":"A novel disulfide-stabilized single-chain variable antibody fragment against rabies virus G protein with enhanced in vivo neutralizing potency","volume":"51","author":"Duan","year":"2012","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0110","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.2174\/0929866521666140616120955","article-title":"Development of a Norovirus P particle platform for eliciting neutralizing antibody responses to the membrane proximal external region of human immunodeficiency virus type 1 envelope","volume":"21","author":"Zang","year":"2014","journal-title":"Protein Pept. Lett."},{"key":"10.1016\/j.imlet.2015.10.003_bib0115","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1016\/j.bbamem.2012.07.020","article-title":"HIV-1 variants with a single-point mutation in the gp41 pocket region exhibiting different susceptibility to HIV fusion inhibitors with pocket-or membrane-binding domain","volume":"1818","author":"Lu","year":"2012","journal-title":"Biochim. Biophys. Acta (BBA)-Biomembr."},{"key":"10.1016\/j.imlet.2015.10.003_bib0120","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1002\/psc.2526","article-title":"Multiple antigen peptide mimetics containing gp41 membrane-proximal external region elicit broad neutralizing antibodies against human immunodeficiency virus type 1 in guinea pigs","volume":"19","author":"Zhang","year":"2013","journal-title":"J. Pept. Sci."},{"key":"10.1016\/j.imlet.2015.10.003_bib0125","doi-asserted-by":"crossref","first-page":"10108","DOI":"10.1128\/JVI.79.16.10108-10125.2005","article-title":"Human immunodeficiency virus type 1 env clones from acute and early subtype B infections for standardized assessments of vaccine-elicited neutralizing antibodies","volume":"79","author":"Li","year":"2005","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0130","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1211s64","article-title":"Evaluating neutralizing antibodies against HIV, SIV, and SHIV in luciferase reporter gene assays","author":"Montefiori","year":"2005","journal-title":"Curr. Adv. Immunol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0135","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1128\/JVI.02108-09","article-title":"Tiered categorization of a diverse panel of HIV-1 Env pseudoviruses for assessment of neutralizing antibodies","volume":"84","author":"Seaman","year":"2010","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0140","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1126\/science.1254426","article-title":"Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions","volume":"346","author":"Munro","year":"2014","journal-title":"Science"},{"issue":"7523","key":"10.1016\/j.imlet.2015.10.003_bib0145","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1038\/nature13808","article-title":"Structure and immune recognition of trimeric pre-fusion HIV-1","volume":"514","author":"Pancera","year":"2014","journal-title":"Env. Nature"},{"key":"10.1016\/j.imlet.2015.10.003_bib0150","doi-asserted-by":"crossref","first-page":"3511","DOI":"10.1128\/JVI.76.7.3511-3521.2002","article-title":"Solid-phase proteoliposomes containing human immunodeficiency virus envelope glycoproteins","volume":"76","author":"Grundner","year":"2002","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0155","doi-asserted-by":"crossref","first-page":"35015","DOI":"10.1074\/jbc.M114.591826","article-title":"Dramatic potentiation of the antiviral activity of HIV antibodies by cholesterol conjugation","volume":"289","author":"Lacek","year":"2014","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2015.10.003_bib0160","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1128\/JVI.02664-13","article-title":"Mechanism of HIV-1 neutralization by antibodies targeting a membrane-proximal region of gp41","volume":"88","author":"Chen","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0165","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1146\/annurev-immunol-032712-095916","article-title":"Broadly neutralizing antiviral antibodies","volume":"31","author":"Corti","year":"2013","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0170","doi-asserted-by":"crossref","first-page":"e1003202","DOI":"10.1371\/journal.ppat.1003202","article-title":"A gp41 MPER-specific llama VHH requires a hydrophobic CDR3 for neutralization but not for antigen recognition","volume":"9","author":"Hulsik","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.imlet.2015.10.003_bib0175","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.jmb.2003.10.007","article-title":"Expressed murine and human CDR-H3 intervals of equal length exhibit distinct repertoires that differ in their amino acid composition and predicted range of structures","volume":"334","author":"Zemlin","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0180","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0165-2478(02)00043-3","article-title":"Mucosal DNA vaccination with highly attenuated Shigella is superior to attenuated Salmonella and comparable to intramuscular DNA vaccination for T cells against HIV","volume":"82","author":"Vecino","year":"2002","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imlet.2015.10.003_bib0185","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1089\/aid.2013.0191","article-title":"Immunization with hybrid proteins containing the membrane proximal external region of HIV-1","volume":"30","author":"Strasz","year":"2014","journal-title":"AIDS Res. Hum. Retroviruses"},{"key":"10.1016\/j.imlet.2015.10.003_bib0190","doi-asserted-by":"crossref","first-page":"5087","DOI":"10.1128\/JVI.00184-09","article-title":"Broad neutralization of human immunodeficiency virus type 1 (HIV-1) elicited from human rhinoviruses that display the HIV-1 gp41 ELDKWA epitope","volume":"83","author":"Arnold","year":"2009","journal-title":"J. Virol."},{"key":"10.1016\/j.imlet.2015.10.003_bib0195","doi-asserted-by":"crossref","first-page":"e14813","DOI":"10.1371\/journal.pone.0014813","article-title":"Induction of HIV neutralizing antibodies against the MPER of the HIV envelope protein by HA\/gp41 chimeric protein-based DNA and VLP vaccines","volume":"6","author":"Ye","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.imlet.2015.10.003_bib0200","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12929-014-0079-x","article-title":"Development and immunological assessment of VLP-based immunogens exposing the membrane-proximal region of the HIV-1 gp41 protein","volume":"21","author":"Benen","year":"2014","journal-title":"J. Biomed. Sci."},{"key":"10.1016\/j.imlet.2015.10.003_bib0205","doi-asserted-by":"crossref","first-page":"e113463","DOI":"10.1371\/journal.pone.0113463","article-title":"Multimeric scaffolds displaying the HIV-1 envelope MPER induce MPER-specific antibodies and cross-neutralizing antibodies when co-immunized with gp160 DNA","volume":"9","author":"Krebs","year":"2014","journal-title":"PLoS One"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247815300444?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247815300444?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T10:38:01Z","timestamp":1653302281000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247815300444"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,12]]},"references-count":41,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,12]]}},"alternative-id":["S0165247815300444"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2015.10.003","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2015,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elicitation of HIV-1 neutralizing antibodies by presentation of 4E10 and 10E8 epitopes on Norovirus P particles","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2015.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}