{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T02:37:07Z","timestamp":1779331027775,"version":"3.51.4"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,17]],"date-time":"2016-02-17T00:00:00Z","timestamp":1455667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.imlet.2016.02.004","type":"journal-article","created":{"date-parts":[[2016,2,20]],"date-time":"2016-02-20T11:44:24Z","timestamp":1455968664000},"page":"40-46","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1"],"prefix":"10.1016","volume":"172","author":[{"given":"Daina","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuning","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E.","family":"Rudd","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2016.02.004_bib0005","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2016.02.004_bib0010","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/nri2986","article-title":"The insider's guide to leukocyte integrin signalling and function","volume":"11","author":"Hogg","year":"2011","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0015","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ceb.2011.10.004","article-title":"Integrin inside-out signaling and the immunological synapse","volume":"24","author":"Springer","year":"2012","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0020","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1083\/jcb.201212037","article-title":"Complete integrin headpiece opening in eight steps","volume":"201","author":"Zhu","year":"2013","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0025","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1126\/science.1084174","article-title":"Bidirectional transmembrane signaling by cytoplasmic domain separation in integrins","volume":"301","author":"Kim","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.imlet.2016.02.004_bib0030","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1038\/nri1646","article-title":"Intracellular signalling controlling integrin activation in lymphocytes","volume":"5","author":"Kinashi","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0035","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1083\/jcb.200404160","article-title":"The primacy of affinity over clustering in regulation of adhesiveness of the integrin {alpha}L{beta}2","volume":"167","author":"Kim","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0040","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/0167-5699(94)90248-8","article-title":"Two-step TCR zeta\/CD3-CD4 and CD28 signaling in T cells: SH2\/SH3 domains, protein-tyrosine and lipid kinases","volume":"15","author":"Rudd","year":"1994","journal-title":"Immunol. Today"},{"key":"10.1016\/j.imlet.2016.02.004_bib0045","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1016\/j.cub.2003.08.005","article-title":"Itk functions to control actin polymerization at the immune synapse through localized activation of Cdc42 and WASP","volume":"13","author":"Labno","year":"2003","journal-title":"Curr. Biol.: CB"},{"key":"10.1016\/j.imlet.2016.02.004_bib0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S1074-7613(02)00291-1","article-title":"Vav1 controls integrin clustering and MHC\/peptide-specific cell adhesion to antigen-presenting cells","volume":"16","author":"Krawczyk","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2016.02.004_bib0055","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0167-5699(97)01037-2","article-title":"Views on Vav","volume":"18","author":"Collins","year":"1997","journal-title":"Immunol. Today"},{"key":"10.1016\/j.imlet.2016.02.004_bib0060","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1083\/jcb.131.6.1867","article-title":"A role for phosphatidylinositol 3-kinase in the regulation of beta 1 integrin activity by the CD2 antigen","volume":"131","author":"Shimizu","year":"1995","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0065","doi-asserted-by":"crossref","first-page":"883","DOI":"10.4049\/jimmunol.156.3.883","article-title":"CD28-mediated up-regulation of beta 1-integrin adhesion involves phosphatidylinositol 3-kinase","volume":"156","author":"Zell","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0070","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1111\/j.1600-065X.2007.00538.x","article-title":"Small GTPases and LFA-1 reciprocally modulate adhesion and signaling","volume":"218","author":"Mor","year":"2007","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.imlet.2016.02.004_bib0075","doi-asserted-by":"crossref","first-page":"2260","DOI":"10.1126\/science.1063397","article-title":"Positive regulation of T cell activation and integrin adhesion by the adapter Fyb\/Slap","volume":"293","author":"Griffiths","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.imlet.2016.02.004_bib0080","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1126\/science.1063486","article-title":"Coupling of the TCR to integrin activation by Slap-130\/Fyb","volume":"293","author":"Peterson","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.imlet.2016.02.004_bib0085","doi-asserted-by":"crossref","first-page":"11527","DOI":"10.1073\/pnas.191378198","article-title":"Adaptor FYB (Fyn-binding protein) regulates integrin-mediated adhesion and mediator release: differential involvement of the FYB SH3 domain","volume":"98","author":"Geng","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imlet.2016.02.004_bib0090","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1128\/MCB.00556-07","article-title":"Functional defects of SKAP-55-deficient T cells identify a regulatory role for the adaptor in LFA-1 adhesion","volume":"27","author":"Wang","year":"2007","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0095","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1038\/ni913","article-title":"SKAP-55 regulates integrin adhesion and formation of T cell-APC conjugates","volume":"4","author":"Wang","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0100","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1084\/jem.20042577","article-title":"An essential role for SKAP-55 in LFA-1 clustering on T cells that cannot be substituted by SKAP-55R","volume":"201","author":"Jo","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.02.004_bib0105","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1084\/jem.20040780","article-title":"ADAP-SLP-76 binding differentially regulates supramolecular activation cluster (SMAC) formation relative to T cell-APC conjugation","volume":"200","author":"Wang","year":"2004","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.02.004_bib0110","doi-asserted-by":"crossref","first-page":"12436","DOI":"10.1073\/pnas.0900510106","article-title":"SLP-76-ADAP adaptor module regulates LFA-1 mediated costimulation and T cell motility","volume":"106","author":"Wang","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imlet.2016.02.004_bib0115","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.immuni.2010.03.007","article-title":"T cell receptor inside-out pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes","volume":"32","author":"Raab","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2016.02.004_bib0120","doi-asserted-by":"crossref","first-page":"29663","DOI":"10.1074\/jbc.M111.222661","article-title":"SKAP1 PH domain determines RAPL membrane localization and Rap1 complex formation for TCR activation of LFA-1","volume":"2011","author":"Raab","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.004_bib0125","doi-asserted-by":"crossref","first-page":"11875","DOI":"10.1074\/jbc.M310717200","article-title":"Rap1-mediated lymphocyte function-associated antigen-1 activation by the T cell antigen receptor is dependent on phospholipase C-gamma1","volume":"279","author":"Katagiri","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.004_bib0130","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1128\/MCB.20.6.1956-1969.2000","article-title":"Rap1 is a potent activation signal for leukocyte function-associated antigen 1 distinct from protein kinase C and phosphatidylinositol-3-OH kinase","volume":"20","author":"Katagiri","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0135","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1083\/jcb.200301133","article-title":"Rap1 translates chemokine signals to integrin activation, cell polarization, and motility across vascular endothelium under flow","volume":"161","author":"Shimonaka","year":"2003","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0140","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1083\/jcb.200311093","article-title":"Rap1 up-regulation and activation on plasma membrane regulates T cell adhesion","volume":"164","author":"Bivona","year":"2004","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0145","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/ni950","article-title":"RAPL, a Rap1-binding molecule that mediates Rap1-induced adhesion through spatial regulation of LFA-1","volume":"4","author":"Katagiri","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0150","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/ni1374","article-title":"Spatiotemporal regulation of the kinase Mst1 by binding protein RAPL is critical for lymphocyte polarity and adhesion","volume":"7","author":"Katagiri","year":"2006","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0155","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.devcel.2004.07.021","article-title":"RIAM, an Ena\/VASP and profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion","volume":"7","author":"Lafuente","year":"2004","journal-title":"Dev. Cell"},{"key":"10.1016\/j.imlet.2016.02.004_bib0160","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1002\/cm.970030509","article-title":"Talin: a cytoskeletal component concentrated in adhesion plaques and other sites of actin-membrane interaction","volume":"3","author":"Burridge","year":"1983","journal-title":"Cell Motil."},{"key":"10.1016\/j.imlet.2016.02.004_bib0165","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1083\/jcb.97.2.359","article-title":"A new protein of adhesion plaques and ruffling membranes","volume":"97","author":"Burridge","year":"1983","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0170","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S1097-2765(02)00823-7","article-title":"Structural determinants of integrin recognition by talin","volume":"11","author":"Garcia-Alvarez","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.imlet.2016.02.004_bib0175","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/347685a0","article-title":"Sequence and domain structure of talin","volume":"347","author":"Rees","year":"1990","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2016.02.004_bib0180","doi-asserted-by":"crossref","first-page":"21749","DOI":"10.1074\/jbc.M111996200","article-title":"The phosphotyrosine binding-like domain of talin activates integrins","volume":"277","author":"Calderwood","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.004_bib0185","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1073\/pnas.83.16.6080","article-title":"The specific direct interaction of helper T cells and antigen-presenting B cells","volume":"83","author":"Kupfer","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imlet.2016.02.004_bib0190","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1084\/jem.163.3.489","article-title":"On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes: unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell","volume":"163","author":"Kupfer","year":"1986","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.02.004_bib0195","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1083\/jcb.200412032","article-title":"A talin-dependent LFA-1 focal zone is formed by rapidly migrating T lymphocytes","volume":"170","author":"Smith","year":"2005","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0200","doi-asserted-by":"crossref","first-page":"7707","DOI":"10.4049\/jimmunol.177.11.7707","article-title":"Talin1 regulates TCR-mediated LFA-1 function","volume":"177","author":"Simonson","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0205","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1038\/sj.emboj.7600285","article-title":"Activation of a vinculin-binding site in the talin rod involves rearrangement of a five-helix bundle","volume":"23","author":"Papagrigoriou","year":"2004","journal-title":"EMBO J."},{"key":"10.1016\/j.imlet.2016.02.004_bib0210","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cell.2006.10.048","article-title":"et al. Structural basis of integrin activation by talin","volume":"128","author":"Wegener","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2016.02.004_bib0215","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/S0021-9258(20)71208-1","article-title":"Identification of two proteins (actin-binding protein and P235) that are hydrolyzed by endogenous Ca2+-dependent protease during platelet aggregation","volume":"260","author":"Fox","year":"1985","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.004_bib0220","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/ncb1175","article-title":"Calpain-mediated proteolysis of talin regulates adhesion dynamics","volume":"6","author":"Franco","year":"2004","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0225","doi-asserted-by":"crossref","first-page":"28164","DOI":"10.1074\/jbc.M104161200","article-title":"Calpain cleavage promotes talin binding to the beta 3 integrin cytoplasmic domain","volume":"276","author":"Yan","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.004_bib0230","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1074\/jbc.M807117200","article-title":"RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences","volume":"284","author":"Lee","year":"2009","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.004_bib0235","doi-asserted-by":"crossref","first-page":"21170","DOI":"10.1074\/jbc.274.30.21170","article-title":"FYN-T-FYB-SLP-76 interactions define a T-cell receptor zeta\/CD3-mediated tyrosine phosphorylation pathway that up-regulates interleukin 2 transcription in T-cells","volume":"274","author":"Raab","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.004_bib0240","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1126\/science.1131078","article-title":"Reversal of the TCR stop signal by CTLA-4","volume":"313","author":"Schneider","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.imlet.2016.02.004_bib0245","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1182\/blood-2012-04-421420","article-title":"Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal","volume":"120","author":"Lu","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2016.02.004_bib0250","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S1074-7613(00)80422-7","article-title":"Regulation of Vav-SLP-76 binding by ZAP-70 and its relevance to TCR zeta\/CD3 induction of interleukin-2","volume":"6","author":"Raab","year":"1997","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2016.02.004_bib0255","doi-asserted-by":"crossref","first-page":"4560","DOI":"10.1182\/blood-2012-04-421420","article-title":"Murine regulatory T cells differ from conventional T cells in resisting the CTLA-4 reversal of TCR stop-signal","volume":"120","author":"Lu","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2016.02.004_bib0260","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1242\/jcs.00876","article-title":"T-cell integrins: more than just sticking points","volume":"116","author":"Hogg","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.imlet.2016.02.004_bib0265","author":"Pfaff","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.004_bib0270","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nrm3624","article-title":"Talins and kindlins: partners in integrin-mediated adhesion","volume":"14","author":"Calderwood","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0275","doi-asserted-by":"crossref","first-page":"3215","DOI":"10.4049\/jimmunol.156.9.3215","article-title":"Proteolytic cleavage of alpha-actinin by calpain in T cells stimulated with anti-CD3 monoclonal antibody","volume":"156","author":"Selliah","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0280","doi-asserted-by":"crossref","first-page":"6256","DOI":"10.4049\/jimmunol.1102028","article-title":"Contact-dependent T cell activation and T cell stopping require talin1","volume":"187","author":"Wernimont","year":"2011","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0285","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1146\/annurev.immunol.19.1.375","article-title":"The immunological synapse","volume":"19","author":"Bromley","year":"2001","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0290","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1038\/nri1245","article-title":"T-cell-antigen recognition and the immunological synapse","volume":"3","author":"Huppa","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0295","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1016\/j.cub.2006.08.035","article-title":"Reconstructing and deconstructing agonist-induced activation of integrin alphaIIbbeta3","volume":"16","author":"Han","year":"2006","journal-title":"Curr. Biol.: CB"},{"key":"10.1016\/j.imlet.2016.02.004_bib0300","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/978-1-4684-5679-0_47","article-title":"The calpain-calpastatin system in hematopoietic cells","volume":"255","author":"Murachi","year":"1989","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.imlet.2016.02.004_bib0305","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1096\/fasebj.1.2.2886390","article-title":"Calcium-dependent proteases: an enzyme system active at cellular membranes?","volume":"1","author":"Mellgren","year":"1987","journal-title":"FASEB J."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016524781630013X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016524781630013X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T23:33:51Z","timestamp":1692228831000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016524781630013X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":61,"alternative-id":["S016524781630013X"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2016.02.004","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Non-cleavable talin rescues defect in the T-cell conjugation of T-cells deficient in the immune adaptor SKAP1","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2016.02.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier B.V. on behalf of European Federation of Immunological Societies.","name":"copyright","label":"Copyright"}]}}