{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:50:29Z","timestamp":1740109829330,"version":"3.37.3"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,4,1]],"date-time":"2016-04-01T00:00:00Z","timestamp":1459468800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100009750","name":"Medical Center, University of Rochester","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2016,4]]},"DOI":"10.1016\/j.imlet.2016.02.015","type":"journal-article","created":{"date-parts":[[2016,2,26]],"date-time":"2016-02-26T08:54:15Z","timestamp":1456476855000},"page":"67-78","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells"],"prefix":"10.1016","volume":"172","author":[{"given":"Luojing","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Oleksyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"Pulvino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Ryan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chyuan-sheng","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian","family":"Poligone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice P.","family":"Pentland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Ritchlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiyong","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2016.02.015_bib0005","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1038\/nri2656","article-title":"The follicular versus marginal zone B lymphocyte cell fate decision","volume":"9","author":"Pillai","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0010","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.coi.2008.03.014","article-title":"Peripheral B cell subsets","volume":"20","author":"Allman","year":"2008","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0015","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.4049\/jimmunol.168.5.2101","article-title":"Transitional B lymphocyte subsets operate as distinct checkpoints in murine splenic B cell development","volume":"168","author":"Su","year":"2002","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0020","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.4049\/jimmunol.151.9.4431","article-title":"Peripheral B cell maturation. II. Heat-stable antigen(hi) splenic B cells are an immature developmental intermediate in the production of long-lived marrow-derived B cells","volume":"151","author":"Allman","year":"1993","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0025","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1002\/art.37825","article-title":"Protein kinase Cbeta is required for lupus development in Sle mice","volume":"65","author":"Oleksyn","year":"2013","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imlet.2016.02.015_bib0030","doi-asserted-by":"crossref","first-page":"3268","DOI":"10.4049\/jimmunol.172.5.3268","article-title":"Lymphoma B cells evade apoptosis through the TNF family members BAFF\/BLyS and APRIL","volume":"172","author":"He","year":"2004","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0035","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1084\/jem.20081399","article-title":"B cell antigen receptor signal strength and peripheral B cell development are regulated by a 9-O-acetyl sialic acid esterase","volume":"206","author":"Cariappa","year":"2009","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.02.015_bib0040","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/MOH.0000000000000045","article-title":"Rational combination therapies targeting survival signaling in aggressive B-cell leukemia\/lymphoma","volume":"21","author":"Waibel","year":"2014","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0045","doi-asserted-by":"crossref","first-page":"21737","DOI":"10.1074\/jbc.M008069200","article-title":"Protein kinase C-associated kinase (PKK) a novel membrane-associated, ankyrin repeat-containing protein kinase","volume":"276","author":"Chen","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.015_bib0050","doi-asserted-by":"crossref","first-page":"36350","DOI":"10.1074\/jbc.M004771200","article-title":"DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis","volume":"275","author":"Bhr","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.015_bib0055","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/cmi.2010.10","article-title":"Receptor-interacting protein (RIP) kinase family","volume":"7","author":"Zhang","year":"2010","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0060","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1084\/jem.20020408","article-title":"Protein kinase C beta controls nuclear factor kappaB activation in B cells through selective regulation of the IkappaB kinase alpha","volume":"195","author":"Saijo","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.02.015_bib0065","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/ni823","article-title":"PKC-beta controls I kappa B kinase lipid raft recruitment and activation in response to BCR signaling","volume":"3","author":"Su","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0070","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.coi.2004.03.012","article-title":"Protein kinase C family functions in B-cell activation","volume":"16","author":"Guo","year":"2004","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0075","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.3892\/ijo.2014.2578","article-title":"Protein kinase C-associated kinase regulates NF-kappaB activation through inducing IKK activation","volume":"45","author":"Kim","year":"2014","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0080","doi-asserted-by":"crossref","first-page":"21526","DOI":"10.1074\/jbc.M301575200","article-title":"Protein kinase C-associated kinase can activate NFkappaB in both a kinase-dependent and a kinase-independent manner","volume":"278","author":"Moran","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.015_bib0085","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/embo-reports\/kvf236","article-title":"RIP4 (DIK\/PKK) a novel member of the RIP kinase family, activates NF-kappa B and is processed during apoptosis","volume":"3","author":"Meylan","year":"2002","journal-title":"EMBO Rep."},{"key":"10.1016\/j.imlet.2016.02.015_bib0090","doi-asserted-by":"crossref","first-page":"31871","DOI":"10.1074\/jbc.M202222200","article-title":"Protein kinase C-associated kinase (PKK) mediates Bcl10-independent NF-kappa B activation induced by phorbol ester","volume":"277","author":"Muto","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.015_bib0095","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.1182\/blood-2007-05-088591","article-title":"Protein kinase C-associated kinase is required for NF-kappaB signaling and survival in diffuse large B-cell lymphoma cells","volume":"111","author":"Kim","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2016.02.015_bib0100","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.4049\/jimmunol.171.4.1875","article-title":"A catalytically inactive form of protein kinase C-associated kinase\/receptor interacting protein 4 a protein kinase C beta-associated kinase that mediates NF-kappa B activation, interferes with early B cell development","volume":"171","author":"Cariappa","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0105","doi-asserted-by":"crossref","first-page":"1694","DOI":"10.1016\/j.molimm.2005.09.009","article-title":"Protein kinase C-associated kinase is not required for the development of peripheral B lymphocyte populations","volume":"43","author":"Moran","year":"2006","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0110","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1038\/nature08638","article-title":"Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma","volume":"463","author":"Davis","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.imlet.2016.02.015_bib0115","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1084\/jem.194.12.1861","article-title":"Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells","volume":"194","author":"Davis","year":"2001","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.02.015_bib0120","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/cdd.2014.126","article-title":"RIP kinases: key decision makers in cell death and innate immunity","volume":"22","author":"Humphries","year":"2015","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.imlet.2016.02.015_bib0125","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/S0960-9822(02)01075-8","article-title":"RIP4 is an ankyrin repeat-containing kinase essential for keratinocyte differentiation","volume":"12","author":"Holland","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0130","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1084\/jem.192.8.1175","article-title":"Nuclear factor kappa B is required for the development of marginal zone B lymphocytes","volume":"192","author":"Cariappa","year":"2000","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.02.015_bib0135","doi-asserted-by":"crossref","first-page":"1668","DOI":"10.1182\/blood-2012-02-406074","article-title":"Inhibition of proliferation and survival of diffuse large B-cell lymphoma cells by a small-molecule inhibitor of the ubiquitin-conjugating enzyme Ubc13-Uev1A","volume":"120","author":"Pulvino","year":"2012","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2016.02.015_bib0140","doi-asserted-by":"crossref","first-page":"10385","DOI":"10.1074\/jbc.M710231200","article-title":"TRPC3 is the erythropoietin-regulated calcium channel in human erythroid cells","volume":"283","author":"Tong","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.015_bib0145","doi-asserted-by":"crossref","first-page":"3009","DOI":"10.4049\/jimmunol.1101641","article-title":"Essential role for CAML in follicular B cell survival and homeostasis","volume":"188","author":"Zane","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0150","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.imbio.2010.03.012","article-title":"Inositol 1,4,5-trisphosphate 3-kinase B controls survival and prevents anergy in B cells","volume":"216","author":"Marechal","year":"2011","journal-title":"Immunobiology"},{"key":"10.1016\/j.imlet.2016.02.015_bib0155","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.immuni.2005.08.005","article-title":"c-Myb is critical for B cell development and maintenance of follicular B cells","volume":"23","author":"Thomas","year":"2005","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2016.02.015_bib0160","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1002\/eji.200425060","article-title":"A new murine model of humoral immuno-deficiency specifically affects class switching to T-independent antigens","volume":"34","author":"Kuzin","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0165","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1093\/nar\/25.6.1317","article-title":"B lymphocyte-specific, Cre-mediated mutagenesis in mice","volume":"25","author":"Rickert","year":"1997","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.imlet.2016.02.015_bib0170","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1084\/jem.20020907","article-title":"IkappaB kinase signaling is essential for maintenance of mature B cells","volume":"196","author":"Pasparakis","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.02.015_bib0175","doi-asserted-by":"crossref","first-page":"e55378","DOI":"10.1371\/journal.pone.0055378","article-title":"The kinase PDK1 is essential for B-cell receptor mediated survival signaling","volume":"8","author":"Park","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.imlet.2016.02.015_bib0180","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1038\/ni.1609","article-title":"Transcription factor Mef2c is required for B cell proliferation and survival after antigen receptor stimulation","volume":"9","author":"Wilker","year":"2008","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0185","doi-asserted-by":"crossref","first-page":"4566","DOI":"10.1182\/blood-2008-08-176057","article-title":"A critical role of TAK1 in B-cell receptor-mediated nuclear factor kappaB activation","volume":"113","author":"Schuman","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.imlet.2016.02.015_bib0190","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0952-7915(02)00328-X","article-title":"Antigen-dependent B-cell development","volume":"14","author":"Cariappa","year":"2002","journal-title":"Curr. Opin. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0195","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.4049\/jimmunol.179.4.2270","article-title":"The recirculating B cell pool contains two functionally distinct long-lived, posttransitional, follicular B cell populations","volume":"179","author":"Cariappa","year":"2007","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0200","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1084\/jem.20051038","article-title":"Characterization of marginal zone B cell precursors","volume":"202","author":"Srivastava","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.02.015_bib0205","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.iy.11.040193.002441","article-title":"Origin of murine B cell lineages","volume":"11","author":"Kantor","year":"1993","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0210","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1038\/nri1629","article-title":"Control of lymphocyte development by nuclear factor-kappaB","volume":"5","author":"Siebenlist","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0215","doi-asserted-by":"crossref","first-page":"43654","DOI":"10.1074\/jbc.M307318200","article-title":"Phospholipase Cgamma2 provides survival signals via Bcl2 and A1 in different subpopulations of B cells","volume":"278","author":"Wen","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.imlet.2016.02.015_bib0220","doi-asserted-by":"crossref","first-page":"5720","DOI":"10.4049\/jimmunol.1302643","article-title":"Protein phosphatase 6 controls BCR-induced apoptosis of WEHI-231 cells by regulating ubiquitination of Bcl-xL","volume":"192","author":"Kajihara","year":"2014","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0225","doi-asserted-by":"crossref","first-page":"4918","DOI":"10.4049\/jimmunol.157.11.4918","article-title":"CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL","volume":"157","author":"Yi","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0230","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/ni0302-221","article-title":"NF-kappaB at the crossroads of life and death","volume":"3","author":"Karin","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0235","doi-asserted-by":"crossref","first-page":"R94","DOI":"10.1016\/S0960-9822(06)00046-7","article-title":"Activate NF-kappa B or die?","volume":"7","author":"Baichwal","year":"1997","journal-title":"Curr. Biol."},{"key":"10.1016\/j.imlet.2016.02.015_bib0240","doi-asserted-by":"crossref","first-page":"4682","DOI":"10.1002\/j.1460-2075.1996.tb00845.x","article-title":"Inhibition of NF-kappaB\/Rel induces apoptosis of murine B cells","volume":"15","author":"Wu","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.imlet.2016.02.015_bib0245","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.cell.2009.08.041","article-title":"PI3 kinase signals BCR-dependent mature B cell survival","volume":"139","author":"Srinivasan","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.imlet.2016.02.015_bib0250","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1126\/science.273.5276.788","article-title":"Immunodeficiency in protein kinase cbeta-deficient mice","volume":"273","author":"Leitges","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.imlet.2016.02.015_bib0255","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S1074-7613(03)00148-1","article-title":"The MAGUK family protein CARD11 is essential for lymphocyte activation","volume":"18","author":"Hara","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2016.02.015_bib0260","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/S1074-7613(03)00141-9","article-title":"Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis","volume":"18","author":"Jun","year":"2003","journal-title":"Immunity"},{"key":"10.1016\/j.imlet.2016.02.015_bib0265","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.imlet.2006.01.006","article-title":"Selective role of PKCbeta enzymatic function in regulating cell survival mediated by B cell antigen receptor cross-linking","volume":"105","author":"Venkataraman","year":"2006","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.imlet.2016.02.015_bib0270","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1126\/science.1232253","article-title":"Phosphorylation of Dishevelled by protein kinase RIPK4 regulates Wnt signaling","volume":"339","author":"Huang","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.imlet.2016.02.015_bib0275","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1038\/jid.2014.428","article-title":"PKK suppresses tumor growth and is decreased in squamous cell carcinoma of the skin","volume":"135","author":"Poligone","year":"2015","journal-title":"J. Invest. Dermatol."},{"unstructured":"L. Chen, D. Oleksyn, M. Pulvino, I. Sanz, D. Ryan, C. Ryan, C. Lin, B. Poligone, A.P. Pentland, C. Ritchlin, J. Zhao, PKK deficiency leads to a reduction in recirculating mature B cells in bone marrow, peripheral blood and lymph nodes compared with the wildtype littermates, Data in Brief Submitted.","key":"10.1016\/j.imlet.2016.02.015_bib0280"}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247816300244?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247816300244?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T01:20:44Z","timestamp":1692235244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247816300244"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,4]]},"references-count":56,"alternative-id":["S0165247816300244"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2016.02.015","relation":{},"ISSN":["0165-2478"],"issn-type":[{"type":"print","value":"0165-2478"}],"subject":[],"published":{"date-parts":[[2016,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A critical role for the protein kinase PKK in the maintenance of recirculating mature B cells and the development of B1 cells","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2016.02.015","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}