{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T21:56:11Z","timestamp":1791410171239,"version":"4.3.3"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,6,1]],"date-time":"2016-06-01T00:00:00Z","timestamp":1464739200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"China National Natural Science Fund Committee","award":["81172973"],"award-info":[{"award-number":["81172973"]}]},{"name":"China National Natural Science Fund Committee","award":["31270985"],"award-info":[{"award-number":["31270985"]}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2016,6]]},"DOI":"10.1016\/j.imlet.2016.04.008","type":"journal-article","created":{"date-parts":[[2016,4,13]],"date-time":"2016-04-13T19:51:22Z","timestamp":1460577082000},"page":"28-36","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"special_numbering":"C","title":["Oral administration of Lactococcus lactis-expressing heat shock protein 65 and tandemly repeated IA2P2 prevents type 1 diabetes in NOD mice"],"prefix":"10.1016","volume":"174","author":[{"given":"Kun-Feng","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-Rui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo-Liang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi-Ping","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2016.04.008_bib0005","doi-asserted-by":"crossref","first-page":"8000","DOI":"10.1073\/pnas.86.20.8000","article-title":"Pancreatic islet-specific T-cell clones from nonobese diabetic mice","volume":"86","author":"Haskins","year":"1989","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imlet.2016.04.008_bib0010","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1084\/jem.181.5.1923","article-title":"Cytotoxic T cells specific for glutamic acid decarboxylase in autoimmune diabetes","volume":"181","author":"Panina-Bordignon","year":"1995","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.04.008_bib0015","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.jaut.2005.09.018","article-title":"GAD65- and proinsulin-specific CD4+ T-cells detected by MHC class II tetramers in peripheral blood of type 1 diabetes patients and at-risk subjects","volume":"25","author":"Oling","year":"2005","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.imlet.2016.04.008_bib0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1365-2249.2006.03244.x","article-title":"Translational mini-review series on type 1 diabetes: systematic analysis of T cell epitopes in autoimmune diabetes","volume":"148","author":"Di Lorenzo","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0025","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1007\/s11892-004-0062-0","article-title":"T-cell epitopes in type 1 diabetes","volume":"4","author":"Panagiotopoulos","year":"2004","journal-title":"Curr. Diabetes Rep."},{"key":"10.1016\/j.imlet.2016.04.008_bib0030","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.2337\/diab.43.10.1254","article-title":"Antibodies to islet 37k antigen but not to glutamate decarboxylase, discriminate rapid progression to IDDM in endocrine autoimmunity","volume":"43","author":"Christie","year":"1994","journal-title":"Diabetes"},{"key":"10.1016\/j.imlet.2016.04.008_bib0035","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jaut.2005.12.001","article-title":"Monoclonal antibody 76F distinguishes IA-2 from IA-2beta and overlaps an autoantibody epitope","volume":"26","author":"Piquer","year":"2006","journal-title":"J. Autoimmun."},{"key":"10.1016\/j.imlet.2016.04.008_bib0040","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1046\/j.1365-2249.2000.01352.x","article-title":"Mapping of novel autorective epitopes of the diabetes-associated autoantigen IA-2","volume":"122","author":"Seissler","year":"2000","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0045","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1016\/j.intimp.2011.04.012","article-title":"Vaccination of non-obese diabetic mice with a fragment of peptide P277 attenuates insulin-dependent diabetes metllitus","volume":"11","author":"Ma","year":"2011","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0050","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1365-2249.1994.tb06129.x","article-title":"Specificity of antibodies induced after immunization of mice with the mycobacterial heat shock protein of 65kDa","volume":"98","author":"Barrios","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0055","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1016\/j.vaccine.2004.01.060","article-title":"Long lasting specific antibodies against CETP induced by subcutaneous and mucosal administration of a 26-amino acid CETP epitope carried by heat shock protein 65kDa in the absence of adjuvants","volume":"22","author":"Gaofu","year":"2004","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2016.04.008_bib0060","doi-asserted-by":"crossref","first-page":"3312","DOI":"10.1016\/j.vaccine.2010.02.100","article-title":"Hsp65 serves as an immunogenic carrier for a diabetogenic peptide P277 inducing anti-inflammatory immune response in NOD mice by nasal administration","volume":"28","author":"Liang","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2016.04.008_bib0065","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1016\/j.vaccine.2006.11.052","article-title":"Long-lasting specific antibodies against P277 induced by mucosal administration of P277 repeat sequences carried by Hsp65 in the absence of adjuvants","volume":"25","author":"Jin","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.imlet.2016.04.008_bib0070","doi-asserted-by":"crossref","first-page":"7400","DOI":"10.1021\/bi011999l","article-title":"The Mycobacterium leprae hsp65 displays proteolytic activity. Mutagenesis studies indicate that the M. leprae hsp65 proteolytic activity is catalytically related to the HslVU protease","volume":"41","author":"Portaro","year":"2002","journal-title":"Biochemistry"},{"key":"10.1016\/j.imlet.2016.04.008_bib0075","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1128\/AEM.61.7.2771-2774.1995","article-title":"Genetic marking of Lactococcus lactis shows its survival in thw human gastrointestinal tract","volume":"61","author":"Klijn","year":"1995","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0080","doi-asserted-by":"crossref","first-page":"5403","DOI":"10.1128\/IAI.64.12.5403-5405.1996","article-title":"Production of human tumor necrosis factor alpha interleukin-6, and interleukin-10 is induced by lactic acid bacteria","volume":"64","author":"Miettinen","year":"1996","journal-title":"Infect. Immun."},{"key":"10.1016\/j.imlet.2016.04.008_bib0085","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1053\/j.gastro.2007.04.073","article-title":"Induction of ovalbumin-specific tolerance by oral administration of Lactococcus lactis secreting ovalbumin","volume":"133","author":"Huibregtse","year":"2007","journal-title":"Gastroenterology"},{"key":"10.1016\/j.imlet.2016.04.008_bib0090","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1126\/science.289.5483.1352","article-title":"Treatment of murine colitis by Lactococcus lactis secreting interleukin-10","volume":"289","author":"Steidler","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.imlet.2016.04.008_bib0095","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.cgh.2006.03.028","article-title":"A phase I trial with transgenic bacteria expressing interleukin-10 in Crohn\u2019s disease","volume":"4","author":"Braat","year":"2006","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0100","doi-asserted-by":"crossref","first-page":"e105701","DOI":"10.1371\/journal.pone.0105701","article-title":"Expressing HSP65 and tandemly repeated P277 reduces the incidence of type I diabetes in non-obese diabetic mice","volume":"9","author":"Ma","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.imlet.2016.04.008_bib0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1084\/jem.20071878","article-title":"Innocuous IFNgamma induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production","volume":"205","author":"Jain","year":"2008","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.imlet.2016.04.008_bib0110","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/01.mog.0000182862.88798.28","article-title":"Oral tolerance and inflammatory bowel disease","volume":"21","author":"Kraus","year":"2005","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0115","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1196\/annals.1309.053","article-title":"Current issues in the treatment of human diseases by mucosal tolerance","volume":"1029","author":"Weiner","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.imlet.2016.04.008_bib0120","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1600-065X.2010.00970.x","article-title":"Immunology of gut mucosal vaccines","volume":"239","author":"Pasetti","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.imlet.2016.04.008_bib0125","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/00001574-199911000-00016","article-title":"Basic mechanisms and clinical implications of oral tolerance","volume":"15","author":"Mowat","year":"1999","journal-title":"Curr. Opin. Gastroenterol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0130","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1053\/j.gastro.2008.05.037","article-title":"Ovalbumin-protein sigma 1 M-cell targeting facilitates otal tolerance with reduction of antigen-specific CD4+ T cells","volume":"135","author":"Suzuki","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.imlet.2016.04.008_bib0135","first-page":"73","article-title":"Lactic acid bacteria as probiotics","volume":"7","author":"Ljungh","year":"2006","journal-title":"Curr. Issues Intest. Microbiol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0140","doi-asserted-by":"crossref","first-page":"176","DOI":"10.5603\/EP.2014.0024","article-title":"Prognostic markers for the development of type 1 diabetes in first-degree relative of diabetic patients","volume":"65","author":"Siewko","year":"2014","journal-title":"Endokrynol. Pol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0145","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1007\/s00125-005-0004-7","article-title":"Impaired beta cell glucose sensitivity and whole-body insulin sensitivity as predictors of hyperglycaemia in non-diabetic subjects","volume":"48","author":"Walker","year":"2005","journal-title":"Diabetologia"},{"key":"10.1016\/j.imlet.2016.04.008_bib0150","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1097\/00054725-199911000-00009","article-title":"Th1\/Th2 cells","volume":"5","author":"Romagnani","year":"1999","journal-title":"Inflamm. Bowel Dis."},{"key":"10.1016\/j.imlet.2016.04.008_bib0155","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1365-2249.2007.03356.x","article-title":"The role of T helper 17 (Th17) and regulatory T cell (Treg) in human organ transplantation and autoimmune disease","volume":"148","author":"Afzali","year":"2007","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0160","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1615\/CritRevImmunol.v25.i2.10","article-title":"Th1 and Th2 lymphocytes in autoimmune disease","volume":"25","author":"Crane","year":"2005","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0165","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.4049\/jimmunol.1000462","article-title":"Type 1 diabetes in BioBreeding rats is critically linked to an imbalance between Th17 and regulatory T cells and altered TCR repertoire","volume":"185","author":"van den Brandt","year":"2010","journal-title":"J. Immunol"},{"key":"10.1016\/j.imlet.2016.04.008_bib0170","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1111\/j.1365-2249.1994.tb05503.x","article-title":"Cross-regulatory role of interferon-gamma (IFN-gamma), IL-4 and IL-10 in schistosome egg granuloma formation: in vivo regulation of Th activity and inflammation","volume":"98","author":"Chensue","year":"1994","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0175","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.cyto.2006.04.012","article-title":"TH1\/TH2 cytokine balance in patients with both type 1 diabetes mellitus and asthma","volume":"34","author":"Rachmiel","year":"2006","journal-title":"Cytokine"},{"key":"10.1016\/j.imlet.2016.04.008_bib0180","first-page":"29","article-title":"Cytokines and T regulatory cells in the pathogenesis of type 1 diabetes","author":"Kikodze","year":"2013","journal-title":"Georgian Med. News"},{"key":"10.1016\/j.imlet.2016.04.008_bib0185","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/eji.200838475","article-title":"Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells","volume":"39","author":"Martin-Orozco","year":"2009","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0190","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s10875-011-9549-z","article-title":"A distinct role of CD4+ Th17- and Th17-stimulated CD8+ CTL in the pathogenesis of type 1 diabetes and experimental autoimmune encephalomyelitis","volume":"31","author":"Ankathatti Munegowda","year":"2011","journal-title":"J. Clin. Immunol."},{"key":"10.1016\/j.imlet.2016.04.008_bib0195","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.2337\/db11-0090","article-title":"Expansion of Th17 cells and fuctional defects in T regulatory cells are key features of the pancreatic lymph nodes in patients with type 1 diabetes","volume":"60","author":"Ferraro","year":"2011","journal-title":"Diabetes"},{"key":"10.1016\/j.imlet.2016.04.008_bib0200","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.4049\/jimmunol.1000788","article-title":"IL-17 immunity in human type 1 diabetes","volume":"185","author":"Honkanen","year":"2010","journal-title":"J. Immunol"},{"key":"10.1016\/j.imlet.2016.04.008_bib0205","doi-asserted-by":"crossref","first-page":"26R","DOI":"10.1203\/PDR.0b013e31819e76c7","article-title":"The T(reg)\/Th17 cell balance: a new paradigm for autoimmunity","volume":"65","author":"Eisenstein","year":"2009","journal-title":"Pediatr. Res."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247816300591?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247816300591?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,9,18]],"date-time":"2020-09-18T15:17:35Z","timestamp":1600442255000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247816300591"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,6]]},"references-count":41,"alternative-id":["S0165247816300591"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2016.04.008","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2016,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oral administration of Lactococcus lactis-expressing heat shock protein 65 and tandemly repeated IA2P2 prevents type 1 diabetes in NOD mice","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2016.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}