{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:32:54Z","timestamp":1791419574155,"version":"4.3.3"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,9,1]],"date-time":"2016-09-01T00:00:00Z","timestamp":1472688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Immunology Letters"],"published-print":{"date-parts":[[2016,9]]},"DOI":"10.1016\/j.imlet.2016.07.011","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T18:28:18Z","timestamp":1469644098000},"page":"47-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"special_numbering":"C","title":["Association of interleukin-10 polymorphisms with risk factors of Alzheimer\u2019s disease and other dementias (SADEM study)"],"prefix":"10.1016","volume":"177","author":[{"given":"Gilberto","family":"Vargas-Alarc\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"Ju\u00e1rez-Cedillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7840-983X","authenticated-orcid":false,"given":"Nancy","family":"Mart\u00ednez-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Manuel","family":"Fragoso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6021-8309","authenticated-orcid":false,"given":"Normand","family":"Garc\u00eda-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Ju\u00e1rez-Cedillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.imlet.2016.07.011_bib0005","first-page":"17","article-title":"Propuesta de criterios para el diagnostic cl\u00f1nico del deterioro cognitivo ligero, la demencia y la enfermedad de Alzheimer","volume":"17","author":"Robles","year":"2002","journal-title":"Neurolog\u00f1a"},{"key":"10.1016\/j.imlet.2016.07.011_bib0010","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1194\/jlr.M031963","article-title":"Caspase-1 deficiency in mice reduces intestinal triglyceride absorption and hepatic triglyceride secretion","volume":"54","author":"van Diepen","year":"2013","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.imlet.2016.07.011_bib0015","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/humu.20180","article-title":"TNF polymorphisms in Alzheimer disease and functional implications on CSF beta-amyloid levels","volume":"26","author":"Laws","year":"2005","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.imlet.2016.07.011_bib0020","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/sj.gene.6363964","article-title":"Interleukin-10 promoter polymorphism in sporadic Alzheimer\u2019s disease","volume":"4","author":"Lio","year":"2003","journal-title":"Genes Immun."},{"key":"10.1016\/j.imlet.2016.07.011_bib0025","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.1161\/01.ATV.19.12.2847","article-title":"Interleukin-10 blocks atherosclerotic events in vitro and in vivo","volume":"19","author":"Pinderski Oslund","year":"1999","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"issue":"October","key":"10.1016\/j.imlet.2016.07.011_bib0030","doi-asserted-by":"crossref","first-page":"e17","DOI":"10.1161\/01.RES.85.8.e17","article-title":"Protective role of interleukin-10 in atherosclerosis","volume":"15","author":"Mallat","year":"1999","journal-title":"Circ. Res."},{"key":"10.1016\/j.imlet.2016.07.011_bib0035","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.atherosclerosis.2009.06.032","article-title":"Polymorphism in the IL-10 promoter region and early markers of atherosclerosis: the cardiovascular risk in young Finns study","volume":"208","author":"Heiskanen","year":"2010","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.imlet.2016.07.011_bib0040","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1399-0039.1997.tb02812.x","article-title":"Association between polymorphisms at the human IL-10 locus and systemic lupus erythematosus","volume":"49","author":"Eskdale","year":"1997","journal-title":"Tissue Antigens."},{"key":"10.1016\/j.imlet.2016.07.011_bib0045","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1006\/geno.2002.6820","article-title":"Single-nucleotide polymorphisms in the interleukin-10 gene: differences in frequencies, linkage disequilibrium patterns, and haplotypes in three United States ethnic groups","volume":"80","author":"Lazarus","year":"2002","journal-title":"Genomics"},{"key":"10.1016\/j.imlet.2016.07.011_bib0050","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1002\/hep.510300207","article-title":"Interleukin-10 promoter polymorphism predicts initial response of chronic hepatitis C to interferon alfa","volume":"30","author":"Edwards-Smith","year":"1999","journal-title":"Hepatology"},{"key":"10.1016\/j.imlet.2016.07.011_bib0055","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/1529-0131(200101)44:1<176::AID-ANR23>3.0.CO;2-K","article-title":"Genetic association between interleukin-10 promoter region polymorphisms and primary Sj\u00f6gren's syndrome","volume":"44","author":"Hulkkonen","year":"2001","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imlet.2016.07.011_bib0060","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jns.2010.12.005","article-title":"The \u22121082G\/A polymorphism in IL-10 gene is associated with risk of Alzheimer's disease: a meta-analysis","volume":"15","author":"Zhang","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.imlet.2016.07.011_bib0065","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1016\/j.neurobiolaging.2004.08.010","article-title":"The association between promoter polymorphism of the interleukin-10 gene and Alzheimer's disease","volume":"26","author":"Ma","year":"2005","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.imlet.2016.07.011_bib0070","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0304-3940(03)00231-3","article-title":"Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease","volume":"342","author":"Depboylu","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.imlet.2016.07.011_bib0075","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.neulet.2003.11.033","article-title":"Promoter haplotypes of interleukin-10 gene and sporadic Alzheimer's disease","volume":"12","author":"Scassellati","year":"2004","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.imlet.2016.07.011_bib0080","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0304-3940(03)00231-3","article-title":"Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease","volume":"15","author":"Depboylu","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.imlet.2016.07.011_bib0085","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1001\/archneur.63.8.1165","article-title":"Tumor necrosis factor alpha and interleukin 10 promoter region polymorphisms and risk of late-onset Alzheimer disease","volume":"63","author":"Ramos","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.imlet.2016.07.011_bib0090","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0304-3940(03)00231-3","article-title":"Lack of association of interleukin-10 promoter region polymorphisms with Alzheimer's disease","volume":"15","author":"Depboylu","year":"2003","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.imlet.2016.07.011_bib0095","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0006-3223(01)01324-5","article-title":"Association between promoter polymorphic haplotypes of interleukin-10 gene and schizophrenia","volume":"51","author":"Chiavetto","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.imlet.2016.07.011_bib0100","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1002\/1529-0131(199806)41:6<1090::AID-ART16>3.0.CO;2-6","article-title":"Interleukin-10 promoter polymorphisms in Southern Chinese patients with systemic lupus erythematosus","volume":"41","author":"Mok","year":"1998","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.imlet.2016.07.011_bib0105","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0304-3835(02)00193-3","article-title":"Interleukin-10 promoter polymorphisms and cervical cancer risk in Korean women","volume":"184","author":"Roh","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.imlet.2016.07.011_bib0110","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000345251","article-title":"Prevalence of mild cognitive impairment and its subtypes in the Mexican population","volume":"34","author":"Juarez-Cedillo","year":"2012","journal-title":"Dement. Geriatr. Cogn. Disord."},{"issue":"2004","key":"10.1016\/j.imlet.2016.07.011_bib0115","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jns.2004.09.011","article-title":"Facts, myths, and controversies in vascular dementia","volume":"15","author":"Rom\u00e1n","year":"2004","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.imlet.2016.07.011_bib0120","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1016\/j.recesp.2013.10.013","article-title":"Epicardial adipose tissue is associated with visceral fat, metabolic syndrome, and insulin resistance in menopausal women","volume":"67","author":"Fern\u00e1ndez Mu\u00f1oz","year":"2014","journal-title":"Rev. Esp. Cardiol."},{"key":"10.1016\/j.imlet.2016.07.011_bib0125","doi-asserted-by":"crossref","first-page":"5444","DOI":"10.1093\/nar\/19.19.5444","article-title":"A rapid non-enzymatic method for thepreparation HMW DNA from blood for RFLP studies","volume":"19","author":"Lahiri","year":"1991","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.imlet.2016.07.011_bib0130","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/bioinformatics\/bth457","article-title":"Haploview: analysis and visualization of LD and haplotype maps","volume":"21","author":"Barrett","year":"2005","journal-title":"Bioinformatics"},{"key":"10.1016\/j.imlet.2016.07.011_bib0135","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1093\/bib\/3.2.146","article-title":"Genetic association studies: design, analysis and interpretation","volume":"3","author":"Lewis","year":"2002","journal-title":"Brief. Bioinform."},{"key":"10.1016\/j.imlet.2016.07.011_bib0140","unstructured":"Stata Statistical Software: Release 13 [computer program]. College Station, TX: StataCorp (2013)."},{"key":"10.1016\/j.imlet.2016.07.011_bib0145","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.biopsych.2010.06.012","article-title":"A metaanalysis of cytokines in Alzheimer's disease","volume":"68","author":"Swardfager","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.imlet.2016.07.011_bib0150","doi-asserted-by":"crossref","first-page":"751","DOI":"10.3233\/JAD-2012-111838","article-title":"Association between interleukin-10 polymorphisms and Alzheimer's disease: a systematic review and meta-analysis","volume":"29","author":"Di Bona","year":"2012","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.imlet.2016.07.011_bib0155","first-page":"2010","article-title":"Intereleukin-10 promoter polymorphism in mild cognitive impairment and in its clinical evolution","volume":"20","author":"Arosio","year":"2010","journal-title":"Int J Alzheimers Dis."},{"key":"10.1016\/j.imlet.2016.07.011_bib0160","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1111\/j.1600-0404.2009.01230.x","article-title":"The combinations of TNFalpha-308 and IL-6-174 or IL-10 \u22121082 genes polymorphisms suggest an association with susceptibility to sporadic lateonset Alzheimer's disease","volume":"120","author":"Vural","year":"2009","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.imlet.2016.07.011_bib0165","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jns.2010.12.005","article-title":"The \u22121082G\/A polymorphism in IL-10 gene is associated with risk of Alzheimer's disease: a meta-analysis","volume":"303","author":"Zhang","year":"2011","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.imlet.2016.07.011_bib0170","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/sj.gene.6363964","article-title":"Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease","volume":"4","author":"Lio","year":"2003","journal-title":"Genes Immun."},{"key":"10.1016\/j.imlet.2016.07.011_bib0175","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/nrg2933","article-title":"Cleft lip and palate: understanding genetic and environmental influences","volume":"12","author":"Dixon","year":"2011","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.imlet.2016.07.011_bib0180","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s10072-010-0221-9","article-title":"Cytokine polymorphisms and Alzheimer disease: possible associations","volume":"31","author":"Ribizzi","year":"2010","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.imlet.2016.07.011_bib0185","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.neulet.2010.07.051","article-title":"The interleukin-6 gene \u2212572C\/G promoter polymorphism modifies Alzheimer's risk in APOE epsilon 4 carriers","volume":"482","author":"Wang","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.imlet.2016.07.011_bib0190","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jns.2010.04.001","article-title":"The MTHFR C677T polymorphism contributes to an increased risk for vascular dementia: a meta-analysis","volume":"294","author":"Liu","year":"2010","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.imlet.2016.07.011_bib0195","first-page":"1778","article-title":"Hypometabolism exceeds atrophy in presymptomatic early-onset familial Alzheimer\u2019s disease","volume":"47","author":"Mosconi","year":"2006","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.imlet.2016.07.011_bib0200","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1001\/jama.1995.03520360056039","article-title":"Apolipoprotein E. type 4 allele and cerebral glucose metabolism in relatives at risk for familial Alzheimer disease","volume":"273","author":"Small","year":"1995","journal-title":"JAMA"},{"key":"10.1016\/j.imlet.2016.07.011_bib0205","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.bbadis.2014.05.025","article-title":"Early alterations in energy metabolism in the hippocampus of APPSwe\/PS1dE9 mouse model of Alzheimer\u2019s disease","volume":"1842","author":"Pedros","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.imlet.2016.07.011_bib0210","doi-asserted-by":"crossref","first-page":"14670","DOI":"10.1073\/pnas.0903563106","article-title":"Mitochondrial bioenergetic deficit precedes Alzheimer\u2019s pathology in female mouse model of Alzheimer\u2019s disease","volume":"106","author":"Yao","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.imlet.2016.07.011_bib0215","first-page":"565","article-title":"Impaired mitochondrial energy metabolism as a novel risk factor for selective onset and progression of dementia in oldest-old subjects","volume":"5","author":"Zhao","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."}],"container-title":["Immunology Letters"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247816301262?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165247816301262?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,9,11]],"date-time":"2019-09-11T16:31:08Z","timestamp":1568219468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165247816301262"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9]]},"references-count":43,"alternative-id":["S0165247816301262"],"URL":"https:\/\/doi.org\/10.1016\/j.imlet.2016.07.011","relation":{},"ISSN":["0165-2478"],"issn-type":[{"value":"0165-2478","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of interleukin-10 polymorphisms with risk factors of Alzheimer\u2019s disease and other dementias (SADEM study)","name":"articletitle","label":"Article Title"},{"value":"Immunology Letters","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.imlet.2016.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 European Federation of Immunological Societies. Published by Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}